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ENGLISH WORLD-WIDE 2025年第1期46卷 93-121页

作者： huang, Nick Lin, Li Han, Kunmei Hing, Jia Wen Cao, luwen Ooi, Vincent Bao, Zhiming Natl Univ Singapore Singapore Singapore East China Univ Polit Sci & Law Shanghai Peoples R China

Treebanks (parsed corpora) play an important role in linguistic research, but creating high-quality parses can be very labor-intensive. This paper discusses the prospects of creating such parses in the context of New Englishes and what kinds of research insights parses can deliver. We present Singapore English as a case study. We suggest that despite the many contact-derived lexical and grammatical properties of Singapore English, it is quite feasible to apply an off-the-shelf American English parser to generate parses of Singapore English. In addition, we present an exploratory analysis of noun phrases in a Singapore English treebank, to illustrate the potential of parses and treebanks in research on World Englishes.

关键词： treebank corpus World Englishes syntactic parsing variation Singapore English New Englishes language contact

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Super-Amphiphilic Na2Ti3O7 Nanofibrous Film Enabling Water-Oil Miscibility

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ADVANCED MATERIALS INTERFACES 2022年第32期9卷

作者： Hu, Conghu Hua, Licheng huang, Bin Zhou, luwen Li, Jinbang Du, Jianke Ningbo Univ Sch Mech Engn & Mech Smart Mat & Adv Struct Lab Ningbo 315211 Zhejiang Peoples R China Ningbo Univ Sch Mech Engn & Mech Minist Educ Key Lab Impact & Safety Engn Ningbo 315211 Zhejiang Peoples R China Nanjing Univ Aeronaut & Astronaut Minist Educ Key Lab Intelligent Nano Mat & Devices Nanjing 210016 Peoples R China Ningbo Univ Sch Mech Engn & Mech Ningbo 315211 Zhejiang Peoples R China

Due to their extraordinary affinity for both water and oil, super-amphiphilic materials have garnered considerable interest. A Na2Ti3O7 (NTO) film with super-amphiphilic properties that enable water and oil miscibility is offered. Multiple nanofibrous 3D porous nanostructures compose the super-amphiphilic NTO layer. Up to 32-36 times its weight, the film has a high absorption capacity for water and poly-alpha-olefin (PAO). The average miscibility ratio of water to oil in the film is approximate to 6:5. The discovery of NTO nanofibrous film's super-amphiphilic behavior has significant implications for the development of superwetting materials and their potential applications in the oil emulsion purification and catalyst anchoring industries.

关键词： miscibility nanofilm porous nanostructures super-amphiphilic materials

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Association of α-Klotho with anti-aging effects of Ganoderma lucidum in animal models

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JOURNAL OF ETHNOPHARMACOLOGY 2025年 345卷 119597页

作者： Liu, Xiaojing Zhao, Jiamin Liu, Jia huang, Yan Deng, Wei Yan, luwen Cui, Ming Pan, Xinhua Xiao, Huiwen Liu, Xingzhong Nankai Univ Coll Life Sci Dept Microbiol State Key Lab Med Chem BiolKey Lab Mol Microbiol 94 Weijin Rd Tianjin 300071 Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Inst Radiat Med Tianjin Key Lab Radiat Med & Mol Nucl Med 238 Baidi Rd Tianjin 300192 Peoples R China Jiangxi Xiankelai Biotechnol Co Ltd 10 Shacheng Rd Jiujiang 332000 Peoples R China

Ethnopharmacological relevance: Aging is a complex, universal process characterized by structural and functional decline across multiple organs. Ganoderma lucidum (G. lucidum), a renowned traditional Chinese medicinal fungus, has long been recognized for its anti-aging properties. However, the underlying mechanisms remain incompletely understood. Aim of the study: This study aimed to investigate the anti-aging effects of G. lucidum and its underlying mechanisms. Materials and methods: We investigated the anti-aging effects of G. lucidum sporoderm-broken spore powder (GlSBSP) on Caenorhabditis elegans (C. elegans) lifespan and aging across multiple organs using natural aging, Dgalactose (D-gal)-induced aging, and radiation-induced premature senescence mouse models. In C. elegans, we assessed lifespan, reproductive capacity, body length, pharyngeal pumping, body bends, fat and lipofuscin levels, as well as reactive oxygen species (ROS) accumulation. In mice, histopathological staining, complete blood counts, and enzyme-linked immunosorbent assay (ELISA) were used to evaluate tissue damage, while quantitative real-time PCR (RT-qPCR) was employed to access small intestine barrier integrity. Western blot (WB) and immunohistochemistry (IHC) were utilized to analyze the distribution of alpha Klotho (alpha-Klotho) in the kidney, blood, and urine. Results: Gl-SBSP significantly extended C. elegans lifespan, improved reproductive capacity and mobility, and reduced lipofuscin and ROS levels. In naturally aged mice, Gl-SBSP enhanced physical appearance and performance. Additionally, Gl-SBSP alleviated aging-related structural and functional decline in multiple organs, including the colon, spleen, kidneys, liver, and small intestine, across all aging models. Biochemical analyses revealed that Gl-SBSP increased transmembrane alpha-Klotho (m alpha-Klotho) and soluble alpha-Klotho (s alpha-Klotho) levels in kidney tissue and elevated s alpha-Klotho levels in serum and urine. Conclu

关键词： Ganoderma lucidum Aging Functional decline alpha-Klotho Aging mouse model

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PicT: A Slim Weakly Supervised Vision Transformer for Pavement Distress Classification 22

PicT: A Slim Weakly Supervised Vision Transformer for Paveme...

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30th ACM International Conference on Multimedia (MM)

作者： Tang, Wenhao huang, Sheng Zhang, Xiaoxian huangfu, luwen Chongqing Univ Sch Big Data & Software Engn Chongqing Peoples R China Chongqing Univ Minist Educ Key Lab Dependable Serv Comp Cyber Phys Soc Chongqing Peoples R China San Diego State Univ Fowler Coll Business San Diego CA 92182 USA San Diego State Univ Ctr Human Dynam Mobile Age San Diego CA 92182 USA

ISBN: (纸本)9781450392037

Automatic pavement distress classification facilitates improving the efficiency of pavement maintenance and reducing the cost of labor and resources. A recently influential branch of this task divides the pavement image into patches and infers the patch labels for addressing these issues from the perspective of multi-instance learning. However, these methods neglect the correlation between patches and suffer from a low efficiency in the model optimization and inference. As a representative approach of vision Transformer, Swin Transformer is able to address both of these issues. It first provides a succinct and efficient framework for encoding the divided patches as visual tokens, then employs self-attention to model their relations. Built upon Swin Transformer, we present a novel vision Transformer named Pavement Image Classification Transformer (PicT) for pavement distress classification. In order to better exploit the discriminative information of pavement images at the patch level, the Patch Labeling Teacher is proposed to leverage a teacher model to dynamically generate pseudo labels of patches from image labels during each iteration, and guides the model to learn the discriminative features of patches via patch label inference in a weakly supervised manner. The broad classification head of Swin Transformer may dilute the discriminative features of distressed patches in the feature aggregation step due to the small distressed area ratio of the pavement image. To overcome this drawback, we present a Patch Refiner to cluster patches into different groups and only select the highest distress-risk group to yield a slim head for the final image classification. We evaluate our method on a large-scale bituminous pavement distress dataset named CQU-BPDD. Extensive results demonstrate the superiority of our method over baselines and also show that PicT outperforms the second-best performed model by a large margin of +2.4% in P@R on detection task, +3.9% in F1 on recognit

关键词： Pavement Distress Classification Deep Learning Image Classification Transformers Weakly Supervised Learning

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50-Fold Adjuvant and 20-Fold Antigen Vaccine Dose Sparing from Nanoliposome Display of a Stabilized Malarial Protein Antigen

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ACS NANO 2025年第10期19卷 10103-10112页

作者： Song, Yiting huang, Wei-Chiao Ivanochko, Danton Long, Carole Li, Qinzhe Zhou, luwen Julien, Jean-Philippe Miura, Kazutoyo Lovell, Jonathan F. SUNY Buffalo Dept Biomed Engn Buffalo NY 14260 USA Hosp Sick Children Res Inst Program Mol Med Toronto ON M5G 0A4 Canada NIAID Lab Malaria & Vector Res NIH Rockville MD 20852 USA

Displaying soluble vaccine protein antigens onto the surface of adjuvanted nanoliposomes can enhance the magnitude of elicited antibody responses. In this study, we examine this approach with respect to dose sparing, for not only the antigen component but also the adjuvant dose in the vaccine. Using a structurally stabilized Pfs48/45 derived malarial protein as a model antigen, we confirmed the protein rapidly displayed on the surface of immunogenic liposomes containing cobalt porphyrin phospholipid (CoPoP;for antigen display via His-tag interaction) along with the immunostimulatory adjuvants monophosphoryl lipid A (MPLA) and QS-21. Mice were immunized with a fixed protein antigen dose with varying adjuvant doses to estimate the extent of adjuvant sparing. In mice vaccinated at a fixed protein antigen dose, liposome-bound Pfs48/45 achieved superior antibody IgG titers compared to the soluble (nonbound) form at all assessed adjuvant doses, reflecting MPLA and QS-21 adjuvant dose sparing of at least 50-fold. The primary driver of adjuvant sparing in these conditions was presentation of the antigen in a nanoparticle format, and potent responses were achieved even without co-delivery of antigen and adjuvant within the same particle, provided that adjuvant and liposome-displayed antigen were co-administered to the same injection site. By keeping the adjuvant dose fixed and varying the antigen dose in a comparable experimental design, similar to 20-fold antigen dose sparing was observed with liposome display. This case study illustrates the potential of antigen-display nanotechnologies, such as CoPoP nanoliposomes, to achieve substantial adjuvant and antigen dose sparing, which could theoretically facilitate the deployment of future vaccines.

关键词： Vaccine Malaria Antigen Sparing Adjuvant Sparing Liposome

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Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction

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NATURE COMMUNICATIONS 2025年第1期16卷 1-21页

作者： Zhu, luwen Hu, Jiahao Wu, Xiaochuan Zhang, Jucong Xu, Xinyi huang, Xiajie Tian, Bing Zhao, Chun-Xia Du, Yongzhong Wu, Liming Zhejiang Univ Affiliated Hosp 4 Int Inst MedSch Med Ctr Metab Res Hangzhou 322000 Peoples R China Zhejiang Univ Inst Pharmaceut Coll Pharmaceut Sci State Key Lab Adv Drug Delivery & Release Syst Hangzhou 310058 Peoples R China Zhejiang Univ Inst Biophys Coll Life Sci Hangzhou 310058 Zhejiang Peoples R China Univ Adelaide Sch Chem Engn Adelaide SA Australia

Ferroptosis and pyroptosis, as emerging regulated forms of cell death capable of overcoming apoptotic resistance, demonstrate promising potential in tumor therapy. Given that iron manipulation and reactive oxygen species elevation serve as common stimuli for both processes, inducing lysosomal membrane permeabilization (LMP) with ensuing release of lysosomal contents (including iron ions and cathepsins) is anticipated to realize dual induction of ferroptosis/pyroptosis. Herein, we report a folic acid and croconaine molecule-functionalized upconversion nanoparticle (UCNP-Cro/FA) that is able to mobilize intracellular stores of endogenous iron and spatiotemporally control the lysosome-intrinsic Fenton chemistry, thereby triggering LMP-associated cell death. The process of endogenous iron mobilization occurs through two key steps: Cro-mediated coordination of abundant Fe3+ ions within lysosomes, followed by UV-emitting upconversion core-mediated photoreduction, resulting in Fe2+ ions release. Both in vitro and in vivo experiments show that UCNP-Cro/FA + NIR treatment effectively boost LMP by endogenous iron-mediated center dot OH production, ultimately triggering irreversible tumor cell death via ferroptosis and Caspase-1/GSDMD-dependent pyroptosis pathways. Moreover, this process potentiates tumor immunogenicity, holding promise for tumor immunotherapy. Overall, this work proposes a feasible tumor therapy strategy that integrates ferroptosis and pyroptosis through the efficient application and activation of endogenous iron.

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Tagging Singapore English

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WORLD ENGLISHES 2023年第4期42卷 624-641页

作者： Lin, Li Han, Kunmei Hing, Jiawen Cao, luwen Ooi, Vincent huang, Nick Bao, Zhiming Natl Univ Singapore Dept English Linguist & Theatre Studies Block AS57 Arts Link Singapore 117570 Singapore

It is well-known that Outer Circle English has undergone extensive contact-induced lexical and grammatical restructuring. Is it possible to use common NLP tools developed for Inner Circle English to process Outer Circle English texts? Here, we report our experience of using the Stanford PoS tagger to tag the Singaporean component of the International Corpus of English (ICE-SIN). We isolate two major contact-related causes of tagging errors: (1) lexical and grammatical loans directly borrowed from the local languages;and (2) English-origin words with new grammatical meanings acquired from the local languages. While the first type may be easy to overcome, the latter type is intractable, creating an extra layer of morphosyntactic complexity. We achieved comparable accuracy rates in the more formal registers, and a lower but still decent 88% in the informal register of private conversations. A tagged ICE-SIN allows us to investigate lexical and grammatical restructuring at unprecedented levels of detail.

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WEAKLY SUPERVISED PATCH LABEL INFERENCE NETWORK WITH IMAGE PYRAMID FOR PAVEMENT DISEASES RECOGNITION IN THE WILD

WEAKLY SUPERVISED PATCH LABEL INFERENCE NETWORK WITH IMAGE P...

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IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

作者： huang, Guixin huang, Sheng huangfu, luwen Yang, Dan Minist Educ Key Lab Dependable Serv Comp Cyber Phys Soc Chongqing 40044 Peoples R China Chongqing Univ Chongqing 400044 Peoples R China San Diego State Univ San Diego CA 92182 USA

ISBN: (纸本)9781728176055

Automatic pavement disease recognition is vital for pavement maintenance and management. In this paper, we present an end-to-end deep learning approach named Weakly Supervised Patch Label Inference Network with Image Pyramid (WSPLIN-IP) for recognizing various types of pavement diseases that are not just limited to the specific ones, such as crack and pothole. WSPLIN-IP first divides the pavement image into patches with an image pyramid for fully exploiting the resolution and scale information. Then, a Patch Label Inference Network (PLIN) is employed for inferring the labels of these patches constrained with a patch label sparsity loss. Finally, the patch labels are fed into a Comprehensive Decision Network (CDN) for disease recognition. Since only the image label is available during whole training, the training of PLIN is conducted in a weakly supervised way under the guidance of CDN and the trained PLIN can provide the interpretable intermediate information. We evaluate our method on a large-scale Bituminous Pavement Disease Dataset named CQU-BPDD whose samples are acquired in the real world. Extensive results demonstrate the superiority of our method over baselines.

关键词： Pavement Disease Recognition Convolutional Neural Networks Image Classification Image Pyramid Weakly Supervised Learning

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Boosting Multi-Label Image Classification with Complementary Parallel Self-Distillation 31

Boosting Multi-Label Image Classification with Complementary...

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31st International Joint Conference on Artificial Intelligence (IJCAI)

作者： Xu, Jiazhi huang, Sheng Zhou, Fengtao huangfu, luwen Zeng, Daniel Liu, Bo Chongqing Univ Sch Big Data & Software Engn Chongqing Peoples R China San Diego State Univ Fowler Coll Business San Diego CA USA San Diego State Univ CHDMA San Diego CA USA Chinese Acad Sci Inst Automat Beijing Peoples R China JD Finance Amer Corp Mountain View CA USA

ISBN: (纸本)9781956792003

Multi-Label Image Classification (MLIC) approaches usually exploit label correlations to achieve good performance. However, emphasizing correlation like co-occurrence may overlook discriminative features and lead to model overfitting. In this study, we propose a generic framework named Parallel Self-Distillation (PSD) for boosting MLIC models. PSD decomposes the original MLIC task into several simpler MLIC sub-tasks via two elaborated complementary task decomposition strategies named Co-occurrence Graph Partition (CGP) and Dis-occurrence Graph Partition (DGP). Then, the MLIC models of fewer categories are trained with these sub-tasks in parallel for respectively learning the joint patterns and the category-specific patterns of labels. Finally, knowledge distillation is leveraged to learn a compact global ensemble of full categories with these learned patterns for reconciling the label correlation exploitation and model overfitting. Extensive results on MS-COCO and NUS-WIDE datasets demonstrate that our framework can be easily plugged into many MLIC approaches and improve performances of recent state-of-the-art approaches. The source code is released at https://***/Robbie-Xu/CPSD.

关键词： Image classification

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p38α deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine production

COMMUNICATIONS BIOLOGY

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COMMUNICATIONS BIOLOGY 2024年第1期7卷 999页

作者： Zheng, Tingting Deng, Jiaqi Wen, Jiahong Xiao, Shuxiu huang, Haiyong Shang, Jiawen Zhang, luwen Chen, Huan Li, Jingyu Wang, Yanyan Ouyang, Suidong Yang, Meng Otsu, Kinya Liu, Xinguang huang, Gonghua Guangdong Med Univ Dongguan Affiliated Hosp 1 Guangdong Prov Key Lab Med Mol Diagnost Dongguan Peoples R China Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Shanghai Peoples R China Osaka Univ Grad Sch Med Dept Cardiovasc Med Osaka Japan Kings Coll London Cardiovasc Div London England Guangdong Med Univ Inst Aging Res Inst Biochem & Mol Biol Guangdong Prov Key Lab Med Mol Diagnost Dongguan Peoples R China

Psoriasis is characterized by keratinocyte (KC) hyperproliferation and inflammatory cell infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse psoriasiform model, p38 activity is significantly elevated in KCs and p38 alpha specific deletion in KCs ameliorates skin inflammation. p38 alpha signaling promotes KC proliferation and psoriasis-related proinflammatory gene expression during psoriasis development. Mechanistically, p38 alpha enhances KC proliferation and production of inflammatory cytokines and chemokines by activating STAT3. While p38 alpha signaling in KCs does not affect the expression of IL-23 and IL-17, it substantially amplifies the IL-23/IL-17 pathogenic axis in psoriasis. The therapeutic effect of IL-17 neutralization is associated with decreased p38 and STAT3 activities in KCs and targeting the p38 alpha-STAT3 axis in KCs ameliorates the severity of psoriasis. As IL-17 also highly activates p38 and STAT3 in KCs, our findings reveal a sustained signaling circuit important for psoriasis development, highlighting p38 alpha-STAT3 axis as an important target for psoriasis treatment. p38 alpha signaling promotes keratinocyte proliferation and psoriasis-related proinflammatory gene expression in psoriasis by activating STAT3, and further amplifies the IL-23/IL-17 pathogenic axis.

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