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JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION 2024年第11期119卷 467-480页

作者： Cao, luwen Han, Qixin Luo, Rong xu, Li Jia, Weikuan Shandong Normal Univ Sch Informat Sci & Engn Jinan 250358 Peoples R China Qilu Univ Technol Shandong Acad Sci State Key Lab Biobased Mat & Green Papermaking Jinan 25035 Peoples R China Zaozhuang Univ Sch Informat Sci & Engn Zaozhuang 277160 Peoples R China

In the leather manufacturing industry, the detection of surface defects is crucial for ensuring product quality. Traditional manual inspection methods are subjective, inefficient, and susceptible to environmental influences, and can no longer meet the demands for high efficiency and quality in modern leather production. Therefore, developing a fast, accurate, and automated defect detection system has become an urgent need in the industry. Against this backdrop, this paper conducts an in-depth study and targeted optimization of the YOLOv8 algorithm, proposing a novel wet blue leather surface defect detection model, ACI-Net, to enhance detection accuracy and robustness. To address the challenge of distinguishing defects from similar background textures, this study introduces the ACMix attention module. This module effectively captures long-range dependencies in images, significantly improving the accuracy of defect recognition. The study incorporates the MetaNeXtStage module, which focuses on the effective integration of multi-scale features, enabling the model to precisely identify a wide range of defect sizes, thereby enhancing overall detection performance. Comparative experiments demonstrate that this algorithm surpasses existing models in defect detection, achieving accuracy rates of 86.2%, 99%, and 88.8% for brand, broken hole, and broken surface, respectively, thus meeting the dual requirements for precision and robustness in industrial applications.

关键词： Leather

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Regulation of Structure and Anion-Exchange Performance of Layered Double Hydroxide: Function of the Metal Cation Composition of a Brucite-like Layer

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MATERIALS 2022年第22期15卷 7983-7983页

作者： Tang, luwen Xie, Xiangli Li, Cunjun xu, Yanqi Zhu, Wenfeng Wang, Linjiang Guilin Univ Technol Coll Mat Sci & Engn Guilin 541004 Peoples R China Guilin Univ Technol Coll Mech & Control Engn Guilin 541004 Peoples R China Guilin Univ Technol Guangxi Key Lab New Energy & Bldg Energy Saving Guilin 541004 Peoples R China Guilin Univ Technol Coll Chem & Bioengn Guilin 541004 Peoples R China Guilin Univ Technol Key Lab New Technol Proc Nonferrous Met & Mat Minist Educ Guilin 541004 Peoples R China Guilin Univ Technol Collaborat Innovat Ctr Explorat Nonferrous Met De Guilin 541004 Peoples R China

As anion-exchange materials, layered double hydroxides (LDHs) have attracted increasing attention in the fields of selective adsorption and separation, controlled drug release, and environmental remediation. The metal cation composition of the laminate is the essential factor that determines the anion-exchange performance of LDHs. Herein, we review the regulating effects of the metal cation composition on the anion-exchange properties and LDH structure. Specifically, the internal factors affecting the anion-exchange performance of LDHs were analyzed and summarized. These include the intercalation driving force, interlayer domain environment, and LDH morphology, which significantly affect the anion selectivity, anion-exchange capacity, and anion arrangement. By changing the species, valence state, size, and mole ratio of the metal cations, the structural characteristics, charge density, and interlayer spacing of LDHs can be adjusted, which affect the anion-exchange performance of LDHs. The present challenges and future prospects of LDHs are also discussed. To the best of our knowledge, this is the first review to summarize the essential relationship between the metal ion composition and anion-exchange performance of laminates, providing important insights for regulating the anion-exchange performance of LDHs.

关键词： layered double hydroxide metal cation composition structure regulation anion-exchange performance interlayer domain intercalation driving force

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miR-15a-5p Regulates Oxaliplatin Resistance in Colorectal Cancer through the Wnt/β-catenin Pathway

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Medicinal Plant 2022年第3期13卷 9-13,17页

作者： Yanjie HUANG Tong xu luwen WEN Qi FENG Jining ZHENG Chengde Medical College Chengde 067000 China

[Objectives]To explore the effects and mechanism of miR-15a-5p on oxaliplatin resistance in colorectal cancer HCT116/L cells.[Methods]The expression of miR-15a-5p in colorectal cancer sensitive cells HCT116 and resistant cells HCT116/L was detected by RT-qPCR method;the effect of oxaliplatin on the proliferation of HCT116 and HCT116/L cells was detected by MTT,and its IC_(50) and drug resistance fold of HCT116/L cells were calculated;the expressions of Wnt3a,β-Catenin and P-gp in HCT116 and HCT116/L cells were detected by Western Blot ***-116/L cells were divided into 5 groups:blank control group HCT116/L,control group 1 transfected with miR-15a-5p mimics NC,experimental group 1 transfected with miR-15a-5p mimics,control group 2 transfected with miR-15a-5p inhibitor NC,and experimental group 2 transfected with miR-15a-5p *** expression of miR-15a-5p in each group was detected by RT-qPCR method and the transfection efficiency was *** effect of different concentrations of oxaliplatin on the proliferation of cells in each group after transfection was detected by MTT and the half inhibitory concentration(50%inhibiting concentration,IC_(50))was *** expressions of Wnt3a,β-catenin and P-gp in each group after transfection were detected by Western Blot method,and the expressions of Wnt3a,β-catenin and MDR1 mRNA in each group after transfection were detected by RT-qPCR method.[Results](i)RT-qPCR results showed that the expression of miR-15a-5p in HCT116/L cells was(0.16±0.05)significantly lower than that in HCT116 cells(P<0.05).(ii)The IC50 of oxaliplatin for HCT-116 cells and HCT116/L cells detected by MTT method were(13.51±2.62)and(103.08±12.29)μg/mL,*** drug resistance index of HCT116/L was 7.63.(iii)Western Blot results showed that the expressions of Wnt3a,β-catenin and P-gp in HCT116/L cells were significantly higher than those in HCT-116 cells(P<0.05).(iv)After successful transfection,the IC50 of miR-15a-5p mimics group

关键词： Colorectal cancer miR-15a-5p Wnt/β-catenin P-gp

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Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin in Hepatocellular Cancer with Extrahepatic Spread

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JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY 2019年第3期30卷 349-357页

作者： Lyu, Ning Kong, Yanan Pan, Tao Mu, luwen Li, Shaolong Liu, Yaru Deng, Haijing Li, Jibin Shi, Ming xu, Li Guo, Rongping Chen, Minshan Wu, Peihong Zhao, Ming Sun Yat Sen Univ Canc Ctr Dept Minimally Invas Intervent Radiol 651 Dongfeng Rd East Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Canc Ctr Dept Med Imaging 651 Dongfeng Rd East Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Canc Ctr Dept Breast Oncol Ctr Med Imaging & Intervent Radiol 651 Dongfeng Rd East Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Canc Ctr State Key Lab Oncol South China Dept Clin Res 651 Dongfeng Rd East Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Canc Ctr Dept Hepatobiliary Oncol 651 Dongfeng Rd East Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Affiliated Hosp 3 Dept Vasc Intervent Radiol Guangzhou Guangdong Peoples R China

Purpose: To compare treatment with hepatic arterial infusion of chemotherapy (HAIC) in patients with advanced hepatocellular carcinoma (HCC) with both extrahepatic spread (EHS) and intrahepatic tumor and patients with intrahepatic tumor only. Materials and Methods: This single-center retrospective study comprised 116 patients with advanced HCC with both intrahepatic tumor and EHS (EHS group;n = 50) or with intrahepatic tumor only (non-EHS group;n = 66) treated with HAIC including oxaliplatin, fluorouracil, and leucovorin between June 2014 and July 2016. Overall survival (OS) and radiologic responses to treatment were determined and compared between the 2 groups. Results: Both the objective response rate and the clinical benefit rate were higher in the non-EHS group than in the EHS group (37.9% vs 16% objective response rate, P =.010;81.8% vs 62% clinical benefit rate, P = .017). Median OS was not statistically different between the 2 groups (14.8 months vs 9.8 months, P = .068). Subgroup analysis of OS found Mat patients with lung metastases survived for a shorter time (OS 7 months) than patients with other metastatic sites (P = .003) and patients free of metastases (P = .001). Conclusions: HAIC is a potential treatment option for advanced HCC with limited extrahepatic metastases in a population with hepatitis B virus infection.

关键词： CI confidence interval CR complete response EHS extrahepatic spread FU fluorouracil HAI hepatic arterial infusion HAIC hepatic arterial infusion chemotherapy HBV hepatitis B virus HCC hepatocellular carcinoma HR hazard ratio LV leucovorin MVI macrovascular invasion ORR objective response rate OS overall survival OXA oxaliplatin PR partial response SD stable disease

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The succession of GH6 cellulase-producing microbial communities and temporal profile of GH6 gene abundance during vermicomposting of maize stover and cow dung

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BIORESOURCE TECHNOLOGY 2022年第PartB期344卷 126242-126242页

作者： Chen, Yuxiang Zhang, Yan Shi, Xiong xu, Lixin Zhang, Lei Zhang, luwen Jilin Univ Coll Biol & Agr Engn Changchun 130022 Peoples R China Mississippi State Univ Costal Res & Extens Ctr Pascagoula MS 39567 USA Jilin Univ Coll Life Sci Changchun 130012 Peoples R China

Vermicomposting eco-friendly converts lignocellulosic wastes into bio-organic fertilizer. Cellulose is the most abundant carbohydrate in lignocellulose. Glycoside hydrolase family 6 (GH6) plays a key role in the early step of cellulose degradation, which is essential for stabilizing lignocellulose. This study intends to quantify the abundance of GH6 gene and to clarify the succession of GH6 cellulase-producing microbial communities during vermicomposting. 100% of maize stover (A) and maize stover and cow dung at 60:40 ratio (B) were used. The results showed that different native genera were observed in the starting materials. Cellulomonas and Cellulosimicrobium were dominant genera harboring GH6 gene. The peak relative abundance of Cellulomonas was 76% and 30% in B and A during vermicomposting phase, and the corresponding values of Cellulosimicrobium was 36% and 37%. Earthworms increased the abundance of GH6 gene, which reached 1.51E + 09 from 3.46E + 08 copies/g in B. The results partially interpreted promoting effect of earthworms.

关键词： GH6 cellulase GH6 gene Functional microbial community Vermicomposting Maize stover

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Continuous Sensing of Water Temperature in a Reservoir with Grid Inversion Method Based on Acoustic Tomography System

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REMOTE SENSING 2021年第13期13卷 2633-2633页

作者： Huang, Haocai xu, Shijie Xie, Xinyi Guo, Yong Meng, luwen Li, Guangming Zhejiang Univ Ocean Coll Zhoushan 316021 Peoples R China Qingdao Natl Lab Marine Sci & Technol Lab Marine Geol Qingdao 266061 Peoples R China Natl Innovat Inst Def Technol Beijing 100071 Peoples R China

The continuous sensing of water parameters is of great importance to the study of dynamic processes in the ocean, coastal areas, and inland waters. Conventional fixed-point and ship-based observing systems cannot provide sufficient sampling of rapidly varying processes, especially for small-scale phenomena. Acoustic tomography can achieve the sensing of water parameter variations over time by continuously using sound wave propagation information. A multi-station acoustic tomography experiment was carried out in a reservoir with three sound stations for water temperature observation. Specifically, multi-path propagation sound waves were identified with ray tracing using high-precision topography data obtained with ship-mounted ADCP. A new grid inverse method is proposed in this paper for water temperature profiling along a vertical slice. The progression of water temperature variation in three vertical slices between acoustic stations was mapped by solving an inverse problem. The reliability and adaptability of the grid method developed in this research are verified by comparison with layer-averaged water temperature results. The grid method can be further developed for the 3D mapping of water parameters over time, especially in small-scale water areas, where sufficient multi-path propagation sound waves can be obtained.

关键词： water temperature acoustic tomography small scale continuous observation progress sensing

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Extended characterization of IL-33/ST2 as a predictor for wound age determination in skin wound tissue samples of humans and mice

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INTERNATIONAL JOURNAL OF LEGAL MEDICINE 2023年第4期137卷 1287-1299页

作者： Gao, Yuan Cai, Luwei Li, Dongya Li, Lili Wu, Yulu Ren, Wenjing Song, Yirui Zhu, luwen Wu, Youzhuang xu, Heng Luo, Chengliang Wang, Tao Lei, Ziguang Tao, Luyang Soochow Univ Sch Basic Med & Biol Sci Dept Forens Med Suzhou 215123 Peoples R China Wenzhou Med Univ Dept Forens Sci Wenzhou 325035 Zhejiang Peoples R China Xuzhou Med Univ Dept Orthoped Affiliated Hosp Xuzhou 221000 Jiangsu Peoples R China Childrens Hosp Soochow Univ Dept Child & Adolescent Healthcare Suzhou 215021 Jiangsu Peoples R China

Interleukin (IL)-33, an important inflammatory cytokine, is highly expressed in skin wound tissue and serum of humans and mice, and plays an essential role in the process of skin wound healing (SWH) dependent on the IL-33/suppression of tumorigenicity 2 (ST2) pathway. However, whether IL-33 and ST2 themselves, as well as their interaction, can be applied for skin wound age determination in forensic practice remains incompletely characterized. Human skin samples with injured intervals of a few minutes to 24 hours (hs) and mouse skin samples with injured intervals of 1 h to 14 days (ds) were collected. Herein, the results demonstrated that IL-33 and ST2 are increased in the human skin wounds, and that in mice skin wounds, there is an increase over time, with IL-33 expression peaking at 24 hs and 10 ds, and ST2 expression peaking at 12 hs and 7 ds. Notably, the relative quantity of IL-33 and ST2 proteins < 0.35 suggested a wound age of 3 hs;their relative quantity > 1.0 suggested a wound age of 24 hs post-mouse skin wounds. In addition, immunofluorescent staining results showed that IL-33 and ST2 were consistently expressed in the cytoplasm of F4/80-positive macrophages and CD31-positive vascular endothelial cells with or without skin wounds, whereas nuclear localization of IL-33 was absent in alpha-SMA-positive myofibroblasts with skin wounds. Interestingly, IL-33 administration facilitated the wound area closure by increasing the proliferation of cytokeratin (K) 14 -positive keratinocytes and vimentin-positive fibroblasts. In contrast, treating with its antagonist (i.e., anti-IL-33) or receptor antagonist (e.g., anti-ST2) exacerbated the aforementioned pathological changes. Moreover, treatment with IL-33 combined with anti-IL-33 or anti-ST2 reversed the effect of IL-33 on facilitating skin wound closure, suggesting that IL-33 administration facilitated skin wound closure through the IL-33/ST2 signaling pathway. Collectively, these findings indicate that the detection

关键词： Skin wound healing Interleukin-33 ST2 Wound age determination and Forensic Practice

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TeleChat: An Open-source Billingual Large Language Model 10

TeleChat: An Open-source Billingual Large Language Model

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10th SIGHAN Workshop on Chinese Language Processing, SIGHAN 2024

作者： Wang, Zihan Liu, XinZhang Liu, Shixuan Yao, Yitong Huang, Yuyao Li, Mengxiang He, Zhongjiang Li, Yongxiang Pu, luwen xu, Huinan Wang, Chao Song, Shuangyong China Telecom Corp Ltd China

ISBN: (纸本)9798891761551

In this paper, we present TeleChat, a collection of large language models (LLMs) with parameters of 7 billion and 12 billion. TeleChat is initially pretrained on an extensive corpus containing a diverse collection of texts from both English and Chinese languages, encompassing trillions of tokens. Subsequently, the model undergoes fine-tuning to align with human preferences, following a detailed methodology that we describe. We evaluate the performance of TeleChat on various tasks, including general dialogue generation, language understanding, mathematics, reasoning, code generation, and knowledge-based question answering. Our findings indicate that TeleChat achieves state-of-the-art performance to other open-source models of similar size across a wide range of public benchmarks. To support future research and applications utilizing LLMs, we release the fine-tuned model checkpoints of TeleChat-7B and TeleChat-12B, along with code and a portion of our filtered high-quality pretraining data, to the public community1 © 2024 Association for Computational Linguistics

关键词： Computational linguistics

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Design of flexible resistance sensor based on mesh convex microstructure

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JOURNAL OF PHYSICS D-APPLIED PHYSICS 2022年第31期55卷 315401-315401页

作者： xu, Jing Ma, Jingxuan Lian, Jiadi Liao, Yihong Wang, luwen Dong, Linxi Sun, Hui Hangzhou Dianzi Univ Sch Mech Engn 2 Baiyang St Hangzhou 310018 Peoples R China China Jiliang Univ Sch Mech Engn Hangzhou 310018 Peoples R China Inst Flexible Elect Technol Tsinghua 23rd St Hangzhou 310018 Zhejiang Peoples R China Hangzhou Dianzi Univ Sch Elect Informat Hangzhou 310018 Peoples R China Shandong Univ Sch Space Sci & Phys Weihai 264209 Peoples R China

To solve the problems of large volume and poor flexibility of the traditional pressure sensor prepared by rigid materials, a flexible pressure resistance sensor with mesh convex platform microstructure has been prepared by using polydimethylsiloxane (PDMS) as a substrate and graphene as a conductive functional layer. The preparation process of the graphene conductive layer of the flexible sensor and PDMS substrate are optimized. And the effect of the concentration of graphene on the sensitivity of the sensor is investigated. The experimental results show that the addition of polyurethane to graphene and the hydrophilic treatment of the PDMS can improve the stability of the sensitivity of the sensor. Excessive graphene blocks microstructural gaps, leading to enhanced microstructural resistance to deformation which will reduce sensitivity. The experimental results show that the thicker the PDMS, the smaller the microstructural deformation, resulting in lower sensitivity. Based on the theoretical basis of elastic mechanics, the calculated results show that the microstructural strain decreases with the thickness of PDMS, consistent with the experimental results. Finally, the performance of PDMS microstructure sensor with thickness of 0.2 mm has been tested. The sensor has a high linear sensitivity (0.152 kPa(-1)) and a wide linear dynamic response range (0-4 kPa), along with a fast response time of 83 ms and reliable stability. The sensor has been attached to the index finger joint for bending test and fixed to the left hand pulse detection beat, which shows the sensor is able to detect human physiological activity.

关键词： flexible sensor microstructure PDMS graphene piezoresistive characteristics sensitivity

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ROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule

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SCIENCE ADVANCES 2020年第41期6卷 7422-7422页

作者： Liu, Di Shu, Gaofeng Jin, Feiyang Qi, Jing xu, Xiaoling Du, Yan Yu, Hui Wang, Jun Sun, Mingchen You, Yuchan Zhu, Minxia Chen, Meixuan Zhu, luwen Shen, Qiying Ying, Xiaoying Lou, xuefang Jiang, Saiping Du, Yongzhong Zhejiang Univ Coll Pharmaceut Sci Inst Pharmaceut 866 Yu Hang Tang Rd Hangzhou 310058 Peoples R China Zhejiang Univ Affiliated Hosp 1 Coll Med Dept Pharm 79 Qingchun Rd Hangzhou 310003 Peoples R China Zhejiang Univ City Coll Sch Med Hangzhou 310015 Peoples R China

The development of drugs with rapid distribution in the kidney and long-term retention in the renal tubule is a breakthrough for enhanced treatment of acute kidney injury ( AKI). Here, l-serine-modified chitosan (SC) was synthesized as a potential AKI kidney-targeting agent due to the native cationic property of chitosan and specific interaction between kidney injury molecule-1 (Kim-1) and serine. Results indicated that SC was rapidly accumulated and long-term retained in ischemia-reperfusion-induced AKI kidneys, especially in renal tubules, which was possibly due to the specific interactions between SC and Kim-1. SC-TK-SS31 was then prepared by conjugating SS31, a mitochondria-targeted antioxidant, to SC via reactive oxygen species (ROS)-sensitive thioketal linker. Because of the effective renal distribution combined with ROS-responsive drug release behavior, the administration of SC-TK-SS31 led to an enhanced therapeutic effect of SS31 by protecting mitochondria from damage and reducing the oxidative stress, inflammation, and cell apoptosis.

关键词： Chitosan

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