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中华医院管理杂志 2020年第5期36卷 379-382页

作者：朱先张露文向前南方医科大学南方医院卫生经济管理科广州510515 南方医科大学卫生管理学院广州510515

科室运营分析是医院实行精细化管理的基础。作者简要分析了传统科室运营分析中存在的问题,提出了基于业财融合视角的科室运营分析是克服传统运营分析问题的良方,并以某大型综合性医院的影像中心为例,基于业财融合的理念,使用流程分析法... 详细信息

科室运营分析是医院实行精细化管理的基础。作者简要分析了传统科室运营分析中存在的问题,提出了基于业财融合视角的科室运营分析是克服传统运营分析问题的良方,并以某大型综合性医院的影像中心为例,基于业财融合的理念,使用流程分析法和标杆比较法,进行运营分析实践探索,提出科室运营改进建议。实践表明,建立与业务相结合的科室运营分析体系,可以提升精细化管理水平,推动医院长期、稳定发展。

关键词：财务管理,医院业财融合影像科室运营分析精细化管理

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护士医院伦理氛围感知现状及其影响因素

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河南医学研究 2023年第11期32卷 1960-1965页

作者：宋晓慧张栌文陈苗苗王慧慧徐会娟新密市中医院河南郑州452370 郑州大学河南郑州450000 河南省医学科学院河南郑州450000

目的了解护士的医院伦理氛围感知现状及其影响因素。方法采用一般资料调查表和护士医院伦理氛围感知量表,在河南省9家二级医院抽取了350名护士进行问卷调查。结果护士医院伦理氛围感知量表得分为(4.33±0.43)分;不同科室、聘任... 详细信息

目的了解护士的医院伦理氛围感知现状及其影响因素。方法采用一般资料调查表和护士医院伦理氛围感知量表,在河南省9家二级医院抽取了350名护士进行问卷调查。结果护士医院伦理氛围感知量表得分为(4.33±0.43)分;不同科室、聘任方式、子女状况、每日睡眠时间和每月培训次数的护士医院伦理氛围感知量表得分差异有统计学意义(P<0.05),多因素线性回归显示科室、子女状况、每日睡眠时间、每月培训次数是护士医院伦理氛围感知的影响因素(P<0.05)。结论科室、睡眠时间及伦理相关的培训次数是影响护士医院伦理氛围感知的因素,建议医院相关部门进一步重视人文关怀氛围,降低护士工作强度,加强伦理道德相关培训,从而提高护士的医院伦理氛围感知水平。

关键词：护士伦理氛围现状

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Effect of qigong on pain and disability in patients with chronic non-specific low back pain: a systematic review and meta-analysis of randomized controlled trials

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JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 2025年第1期20卷 1-15页

作者： Yu, Donghui Wu, Minmin zhang, Jiongliang Song, Wenjing Zhu, luwen Heilongjiang Univ Chinese Med Harbin Peoples R China Heilongjiang Univ Chinese Med Affiliated Hosp 2 Harbin Peoples R China

Background Chronic non-specific low back pain (CNLBP) is a common health problem worldwide. Patients with CNLBP often suffer from persistent pain, with a few being disabled by their pain, affecting their daily functioning and social participation. This study aims to systematically evaluate the effects of pain and dysfunction in Qigong patients with chronic non-specific back pain through systematic evaluation and gathered analysis of random control test data. Methods We searched nine databases from their inception dates until April 2024. Relevant randomized controlled trials (RCTs) were included. Patients were assessed for pain using the Visual Analog Scale and Numeric Pain Rating Scale and for disability using the Oswestry Disability Index and Roland-Morris disability questionnaire. The risk of bias was assessed using the Cochrane Collaboration tool. CMA V3.0 was used to analyze data. Results Sixteen RCTs involving 1175 participants were included. These studies have different designs, and the participants are mainly around 60 years old. The results showed that the qigong practice improved pain significantly more than the control measures ([Mean Difference MD] = - 1.34, 95% confidence intervals [CI] - 1.76 to - 0.92, p < 0.001 Minimal Clinically Important Differences MCID = 1.5), and the efficacy of short-term interventions (MD = - 1.88, 95% CI - 2.87 to - 0.9, p < 0.001) was superior to that of long-term interventions (MD = - 1.07, 95% CI - 1.49 to - 0.65, p < 0.001). For improvement in the degree of dysfunction, qigong practice showed a higher effect size (MD = - 5.88, 95% CI - 7.98 to - 3.78, p < 0.001 MCID = 5) than that observed in the control group. Conclusion Qigong practice is effective in improving disability in patients with CNLBP, but has no significant effect on improving pain. However, due to the high heterogeneity, the results need to be interpreted with caution.

关键词： Qigong Chronic non-specific low back pain Rehabilitation Meta-analysis

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ALKBH1 knockdown promotes the growth, migration and invasion of HTR-8/SVneo cells through regulating the m5C modification PSMD14

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SCIENTIFIC REPORTS 2025年第1期15卷 1-9页

作者： zhang, Caili Li, Jie Wang, luwen Yang, Peifeng Luo, Xiaohua Zhengzhou Univ Maternal & Child Hosp Henan Prov Dept Obstet & Gynecol Affiliated Hosp 3 10 Kangfuqian St Zhengzhou City 450001 Henan Peoples R China

Preeclampsia (PE) is a pregnancy disease characterized by insufficient invasion and growth of trophoblast cells. adeno-associated virus encoding alkB homolog 1 (ALKBH1) is a demethylase in 5-methylcytosine (m5C) methylation modification. This study was performed to explore the role of ALKBH1 in hypoxia treated human extravasated trophoblast cells. Hypoxia treated human extravasated trophoblast cells (HTR-8/SVneo) was used to simulate the occurrence of PE in vitro. The cells phenotype was detected by CCK-8 and Transwell assays. The m5c levels and m5C levels of PSMD14 were analyzed by m5C dot blot and M5C Me-RIP assays. Then, the interaction between ALKBH1 and PSMD14 were confirmed by RIP and dual-luciferase reporter assays. ALKBH1 was up-regulated in hypoxia treated HTR-8/SVneo cells. Additionally, ALKBH1 knockdown increased the m5C contents, cell viability, migration and invasion abilities of hypoxia treated HTR-8/SVneo cells. Furthermore, ALKBH1 knockdown increased the m5C and mRNA levels, and mRNA stability of PSMD14. RIP and dual-luciferase reporter assays demonstrated that ALKBH1 interacted with PSMD14. Besides, PSMD14 knockdown reversed the effects of ALKBH1 silencing on cell viability, migration and invasion abilities of hypoxia treated HTR-8/SVneo cells. ALKBH1 mediated m5C levels were decreased in the hypoxia treated HTR-8/SVneo cells, which further decreased the cell viability, migration and invasion abilities through targeting the PSMD14 levels.

关键词： Preeclampsia ALKBH1 5-methylcytosine methylation modification PSMD14

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Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci

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NEUROPSYCHOPHARMACOLOGY 2020年第7期45卷 1196-1206页

作者： Liu, Weipeng Li, Wenqiang Cai, Xin Yang, Zhihui Li, Huijuan Su, Xi Song, Meng Zhou, Dong-Sheng Li, Xingxing zhang, Chen Shao, Minglong zhang, luwen Yang, Yongfeng zhang, Yan Zhao, Jingyuan Chang, Hong Yao, Yong-Gang Fang, Yiru Lv, Luxian Li, Ming Xiao, Xiao Chinese Acad Sci Chinese Acad Sci & Yunnan Prov Kunming Inst Zool Key Lab Anim Models & Human Dis Mech Kunming Yunnan Peoples R China Univ Chinese Acad Sci Kunming Coll Life Sci Kunming Yunnan Peoples R China Xinxiang Med Univ Affiliated Hosp 2 Henan Mental Hosp Xinxiang Henan Peoples R China Xinxiang Med Univ Henan Key Lab Biol Psychiat Int Joint Res Lab Psychiat & Neurosci Henan Xinxiang Henan Peoples R China Ningbo Kangning Hosp Dept Psychiat Ningbo Zhejiang Peoples R China Shanghai Jiao Tong Univ Sch Med Shanghai Mental Hlth Ctr Shanghai Peoples R China Chinese Acad Sci CAS Ctr Excellence Brain Sci & Intelligence Techn Shanghai Peoples R China Chinese Acad Sci Kunming Inst Zool KIZ CUHK Joint Lab Bioresources & Mol Res Common Kunming Yunnan Peoples R China Henan Prov Peoples Hosp Zhengzhou Henan Peoples R China

Genome-wide association studies (GWAS) have reported substantial single-nucleotide polymorphisms (SNPs) associated with major depressive disorder (MDD), but the underlying functional variations in the GWAS risk loci are unclear. Here we show that the European MDD genome-wide risk-associated allele of rs12129573 at 1p31.1 is associated with MDD in Han Chinese, and this SNP is in strong linkage disequilibrium (LD) with a human-unique Alu insertion polymorphism (rs70959274) in the 5 ' flanking region of a long non-coding RNA (lncRNA) LINC01360 (Long Intergenic Non-Protein Coding RNA 1360), which is preferably expressed in human testis in the currently available expression datasets. The risk allele at rs12129573 is almost completely linked with the absence of this Alu insertion. The Alu insertion polymorphism (rs70959274) is significantly associated with a lower RNA level of LINC01360 and acts as a transcription silencer likely through modulating the methylation of its internal CpG sites. Luciferase assays confirm that the presence of Alu insertion at rs70959274 suppresses transcriptional activities in human cells, and deletion of the Alu insertion through CRISPR/Cas9-directed genome editing increases RNA expression of LINC01360. Deletion of the Alu insertion in human cells also leads to dysregulation of gene expression, biological processes and pathways relevant to MDD, such as the alterations of mRNA levels of DRD2 and FLOT1, transcription of genes involved in synaptic transmission, neurogenesis, learning or memory, and the PI3K-Akt signaling pathway. In summary, we identify a human-unique DNA repetitive polymorphism in robust LD with the MDD risk-associated SNP at the prominent 1p31.1 GWAS loci, and offer insights into the molecular basis of the illness.

关键词： Depression Epigenetics Functional genomics Gene regulation

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HSP90 inhibitors 17-AAG and VER-82576 inhibit porcine deltacoronavirus replication in vitro

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VETERINARY MICROBIOLOGY 2022年第0期265卷 109316-109316页

作者： Zhao, Yujia Xiao, Dai zhang, luwen Song, Daili Chen, Rui Li, Shiqian Liao, Yijie Wen, Yimin Liu, Weizhe Yu, Enbo Wen, Yiping Wu, Rui Zhao, Qin Du, Senyan Wen, Xintian Cao, Sanjie Huang, Xiaobo Sichuan Agr Univ Coll Vet Med Res Ctr Swine Dis Chengdu 611130 Peoples R China Minist Agr Sichuan Sci Observat Expt Stn Vet Drugs & Vet Dia Chengdu 611130 Peoples R China Sichuan Agr Univ Natl Anim Expt Teaching Demonstrat Ctr Chengdu 611130 Peoples R China

Porcine deltacoronavirus (PDCoV) is highly pathogenic to piglets, and no specific drugs or vaccines are available for the prevention and treatment of PDCoV infection, the need for antiviral therapies is pressing. HSP90 inhibitors have potent inhibitory effects against the replication of numerous viruses, hence we evaluated three HSP90 inhibitors, 17-AAG, VER-82576, and KW-2478, for their effects on PDCoV infection in vitro. We evaluated their effectivenesses at suppressing PDCoV by qRT-PCR, western blot, and TCID50 assay, and found that 17-AAG and VER-82576 inhibited PDCoV at the early stage of replication, while KW-2478 showed no significant antiviral activity at any stage of infection. These results indicated that the PDCoV-inhibitory effects of 17-AAG and VER82576 might be exerted by targeting host cell factor HSP90AB1 but not HSP90AA1. Further study showed that HSP90AB1 mRNA and protein levels were not significantly different in 17-AAG and VER-82576-treated cells versus control cells. 17-AAG and VER-82576 were also evaluated for their effects on the expressions of TNF-alpha, IL 6, and IL-12, which are PDCoV-induced proinflammatory cytokines. We found that both 17-AAG and VER-82576 inhibited the expressions of TNF-alpha, IL-6, and IL-12 to varying degrees, but in a dose dependent manner. From our data we can conclude that the HSP90 inhibitors 17-AAG and VER-82576 are promising candidates for the treatment of PDCoV infection.

关键词： HSP90 inhibitors PDCoV Antiviral effect Proinflammatory cytokines

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肠外营养专用输液器输注性能试验

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医疗装备 2023年第10期36卷 22-26页

作者：高娜孙慧杰张露文聂佳祺李坎园吴其玉李帆山东省医疗器械和药品包装检验研究院山东济南250000 武汉智迅创源科技发展股份有限公司湖北武汉430040

该研究提出一种适用于输注含脂肪乳的肠外营养液专用输液器产品,同时通过比较不同药液过滤器材质、不同结构的输液器输注性能,研究微观截留机理,提出适用于输注肠外营养液的专用输液器产品优势,并建立肠外营养专用输液器输注试验方法,... 详细信息

该研究提出一种适用于输注含脂肪乳的肠外营养液专用输液器产品,同时通过比较不同药液过滤器材质、不同结构的输液器输注性能,研究微观截留机理,提出适用于输注肠外营养液的专用输液器产品优势,并建立肠外营养专用输液器输注试验方法,得到满足临床要求的输注性能指标。通过宏观试验分析输注肠外营养液在完成输注量不同阶段0、500、1500 ml后的输液流速变化和微观药液膜截留分析,药液过滤器的不同材质和面积大小对输注肠外营养液影响较大,同时根据试验结果结合临床需求,完善输注性能试验方法,制定临床安全使用肠外营养专用输液器的输注性能指标。肠外营养专用输液器产品提出和对应方法、指标的建立可为临床输注肠外营养液提供保障,并为肠外营养专用输液器行业标准的建立提供支撑,从而保障用械的安全性、可靠性。

关键词：肠外营养专用输液器肠外营养液输注性能试验研究

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基于生境适宜性和水资源约束的宁夏稻改旱研究

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地理空间信息 2024年第8期22卷 50-53,71页

作者：王嘉宁唐谊娟眭颖菲张露文包玉斌顾继升北京师范大学地理科学学部北京100875 宁夏回族自治区遥感调查院宁夏银川750021

从气候条件、立地条件、土壤条件、灌排条件4个方面综合筛选土地适宜性评价因子,使用多指标综合评价方法测算水稻、小麦、春玉米土地适宜性,进而考虑水资源约束和水稻对于盐碱化耕地的改良作用,进行水稻种植布局优化。结果显示:(1)适宜... 详细信息

从气候条件、立地条件、土壤条件、灌排条件4个方面综合筛选土地适宜性评价因子,使用多指标综合评价方法测算水稻、小麦、春玉米土地适宜性,进而考虑水资源约束和水稻对于盐碱化耕地的改良作用,进行水稻种植布局优化。结果显示:(1)适宜种植水稻、小麦、春玉米的耕地分别占各种植面积的71.01%、80.81%和38.85%。(2)假设缩减的水稻面积全部改为玉米,至少需要缩减1005.23 km^(2),此时能够节省水资源8.93亿m^(3),达到最低节水要求。若缩减的水稻面积全部改种小麦,则缩减的水稻面积至少为1129.47 km^(2)。当缩减面积介于1005.23 km^(2)与1129.47 km^(2)之间时,缩减的水稻必须部分转为小麦,部分转为玉米。无论哪种情况,转换为玉米的面积越多,节约的水资源量最大。

关键词：宁夏稻改旱土地适宜性评价种植结构优化水资源约束

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空气污染物与消化系统癌症之间的关联:系统综述

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公共卫生与预防医学 2023年第4期34卷 1-6页

作者：杨翠红顾文涛申郁冰张璐雯陈王跃姜晶梅中国医学科学院基础医学研究所/北京协和医学院基础学院流行病与卫生统计学系北京100005

目的了解空气污染物与消化系统癌症之间关系,为未来的相关研究和消化系统癌症防控提供参考依据。方法通过数据库PubMed,web of science和Embase,检索1970—2022年间英语发表的所有相关文献,采用Meta分析来探索具体空气污染物对消化系统... 详细信息

目的了解空气污染物与消化系统癌症之间关系,为未来的相关研究和消化系统癌症防控提供参考依据。方法通过数据库PubMed,web of science和Embase,检索1970—2022年间英语发表的所有相关文献,采用Meta分析来探索具体空气污染物对消化系统癌症的影响。结果PM_(2.5)能够增加总的消化系统癌症11%(1.05~1.17)的发病或死亡风险。但从合并分析来看,PM_(2.5)仅与肝癌的风险增加有关,合并RR值(95%CI)为1.31(1.19~1.46),而与其他特定消化系统癌症的关联差异无统计学意义(P>0.05)。NO_(2)增加总的消化系统癌症3%(1.00~1.07)的发病或死亡风险。结论对于特定消化系统癌症,PM_(2.5)对肝癌的影响最为明显,而NO_(2)与癌症的关系研究还需要更多研究证据加以支撑,目前已经观察到NO_(2)对总的消化系统癌症存在负面影响。此研究为PM_(2.5)和NO_(2)浓度较高的国家和地区防控消化系统癌症提出启示。

关键词：空气污染物消化系统癌症系统综述 Meta分析

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Network Public Opinion Prediction Based on Conformable Fractional Non-homogeneous Discrete Grey Model

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ENGINEERING LETTERS 2023年第1期31卷 19-19页

作者： Tong, Qiujuan Wang, luwen Li, Linna zhang, Jianke Xian Univ Posts & Telecommun Coll Sci Xian 710121 Peoples R China Xian Univ Posts & Telecommun Coll Comp Sci & Technol Xian 710121 Peoples R China

the traditional grey model assumes that the original data series conforms to the homogeneous exponential trend rather than the non-homogeneous exponential trend. However, compared with the integer-order gray model, the fractional-order gray model is more efficient and flexible in time series forecasting. Hence, in this paper, a conformable fractional order calculus is introduced to extend the integer order gray model into a fractional order gray model. A conformable fractional non-homogeneous exponential discrete grey model (abbreviated as CFNDGM) is proposed, and the particle swarm algorithm is further developed to optimize its order. Specifically, we first use the Baidu index generated by "Xi'an Epidemic" and "MU5735" to build a model. Then use the least squares method to solve the model parameters, obtain the predicted simulation value through the response expression, and finally obtain the data prediction result. The simulation validates that the prediction accuracy of the fractional order non-homogeneous grey model is higher than that of the integer order non-homogeneous grey model.

关键词： internet opinion forecasting CFNDGM model fractional calculus fractional accumulation non-homogeneous index

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