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Prognostic and Clinicopathological Significance of C-Reactive Protein to Albumin Ratio in Patients with Bile Duct Cancer: A Meta-Analysis

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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 2024年第10期76卷 914-926页

作者： Dai, Menglu zhao, Xiaohui Yu, Aijun zhao, luwen Kang, Qingmin Yan, Shujun Zhang, Xuejun Liu, Jinlong Huzhou Univ Huzhou Cent Hosp Affiliated Cent Hosp Clin Lab Huzhou 313000 Zhejiang Peoples R China Chengde Med Univ Affiliated Hosp Dept Gen Surg 1 Chengde Hebei Peoples R China Chengde Med Univ Affiliated Hosp Dept Gynecol 1 Chengde Hebei Peoples R China Sixth Hosp Chengde Dept Gen Surg Chengde Hebei Peoples R China

Recent studies have explored the prognostic role of the C-reactive protein to albumin ratio (CAR) in patients with bile duct cancer (BTC), but the results have been inconsistent. This study aimed to provide insight into the prognostic significance of the CAR in BTC prior to treatment using a meta-analysis. Summarized hazard ratios (HRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for prognosis and clinicopathological features using fixed or random effects models. Fourteen studies with a total of 1,543 subjects were included in this meta-analysis. Elevated CAR was significantly associated with poor overall survival (HR = 2.17, 95% CI = 1.81-2.60, P < 0.001) and decreased disease-free survival or recurrence-free survival (HR = 2.53, 95% CI = 1.98-3.25, P < 0.001) in BTC. In addition, high CAR was significantly associated with the presence of lymph node metastasis (OR = 1.54, 95% CI = 1.12- 2.13, P = 0.008), bile duct invasion (OR = 2.64, 95% CI = 1.54-4.54, P < 0.001), and tumor stages III-IV (OR = 3.11, 95% CI = 1.05-9.20, P = 0.040). However, there was no significant association between CAR and sex, microvascular invasion, or resection. An elevated CAR was significantly related to worse long-term and short-term survival and advanced clinicopathological features of BTC. CAR could serve as a valuable, noninvasive prognostic marker in patients with BTC.

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MAID: Model Attribution via Inverse Diffusion

MAID: Model Attribution via Inverse Diffusion

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2025 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2025

作者： Zhu, Luyu Ye, Kai Yao, Jiayu Li, Chenxi zhao, luwen Cao, Yuxin Wang, Derui Hao, Jie Beijing University of Posts and Telecommunications China The University of Hong Kong Hong Kong National University of Singapore Singapore CSIRO's Data61 Australia

ISBN: (纸本)9798350368741

The surge in AI-generated images, blending authentic and synthetic content, raises security concerns and complicates model attribution, especially with limited transparency. Existing methods either struggle to attribute across multiple frameworks or rely on additional conditions, such as textual descriptions and white-box access to the source model, limiting their practicality and effectiveness in real-world scenarios. To address this gap, we introduce Model Attribution via Inverse Diffusion (MAID), the first framework-agnostic and self-sufficient approach that leverages the source model features extracted by diffusion models, which also works for images generated from GANs. By employing the inverse diffusion process, we are able to utilize pre-trained Diffusion Models as Denoising Autoencoders, mapping images into a latent space and extracting the Diffusion Model Activations (DMA). This mapping effectively captures the unique characteristics of images originating from different source models, including authentic images, which showcase distinct latent Gaussian signatures. Experimental results show that, even in data-asymmetric unfair comparisons, the attribution classifier trained with our proposed DMA achieves approximately 15% and 3% higher ACC compared to SOTA methods on the DiffusionForensics and Artifact datasets, respectively. The code is available at https://***/Zhu-Luyu/MAID. © 2025 IEEE.

关键词： Deepfake Diffusion Model Model Attribution

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2024中国国际纺织机械展览会暨ITMA亚洲展览会染色机械述评

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针织工业 2024年第11期 38-46页

作者：蔡再生王杰赵露雯丁艳楠国家染整工程中心生态纺织教育部重点实验室上海201620 东华大学化学化工与生物工程学院上海201620

综述了2024中国国际纺织机械展览会暨ITMA亚洲展览会染色机械相关情况。对本届展会展出的多种染色机械、小样机及试验设备和染化料自动配送系统进行重点介绍。指出本次展会染色设备紧密贴合绿色、科技、高效的发展主题,正向数字化、智... 详细信息

综述了2024中国国际纺织机械展览会暨ITMA亚洲展览会染色机械相关情况。对本届展会展出的多种染色机械、小样机及试验设备和染化料自动配送系统进行重点介绍。指出本次展会染色设备紧密贴合绿色、科技、高效的发展主题,正向数字化、智能化方向发展。

关键词：展览会 ITMA 染色机械检测设备染化料自动配选系统

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MAID: Model Attribution via Inverse Diffusion

MAID: Model Attribution via Inverse Diffusion

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： Luyu Zhu Kai Ye Jiayu Yao Chenxi Li luwen zhao Yuxin Cao Derui Wang Jie Hao Beijing University of Posts and Telecommunications China The University of Hong Kong Hong Kong SAR National University of Singapore Singapore CSIRO’s Data61 Australia

ISBN: (数字)9798350368741

ISBN: (纸本)9798350368758

关键词： Limiting Noise reduction Autoencoders Diffusion processes Feature extraction Diffusion models Security Surges Speech processing Glass box

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SOX2 knockdown slows cholangiocarcinoma progression through inhibition of transcriptional activation of lncRNA PVT1

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BIOCHEMICAL JOURNAL 2020年第18期477卷 3527-3540页

作者： Yu, Aijun zhao, luwen Kang, Qingmin Li, Jian Chen, Kai Fu, Hua Chengde Med Univ First Dept Gen Surg 1 Affiliated Hosp Chengde 067000 Peoples R China Chengde Med Univ Dept Gynecol 1 Affiliated Hosp Chengde 067000 Peoples R China

Cholangiocarcinoma (CCA) has accounted for a high rate of mortality and morbidity in the recent years. Long non-coding RNAs (lncRNAs) play an important role in different cellular environments, including cancer. As such, they have been used as potential targets during CCA therapy. The objective of this study was to investigate the effects of lncRNA PVT1 on CCA and its mechanisms behind lncRNA PVT1 regulation. The interactions among SOX2, lncRNA PVT1, miR-186 and SEMA4D were verified by chromatin immunoprecipitation, RNA immunoprecipitation and dual luciferase reporter gene assay. Gain- and loss-of-function experiments were conducted to explore the modulatory effects of SOX2, lncRNA PVT1, miR-186 and SEMA4D on cell viability, migration and invasion of CCA by CCK-8 and Transwell assays. In vivo effects of lncRNA PVT1 or SEMA4D were studied in a nude mouse model. MiR-186 was poorly expressed while SOX2, lncRNA PVT1 and SEMA4D were highly expressed in CCA cells. SOX2 induced the transcriptional activation of lncRNA PVT1 expression to promote proliferation, migration and invasion of CCA cells. LncRNA PVT1 bound to miR-186 and miR-186 was found to target SEMA4D. The overexpression of lncRNA PVT1 and SEMA4D, as well as the inhibition of miR-186 led to elevated CCA cell proliferation, migration and invasion. In vivo experiments confirmed the inhibitory role of lncRNA PVT1 knockdown or SEMA4D knockdown in CCA. All in all, SOX2 down-regulated miR-186 through the transcriptional activation of lncRNA PVT1, whereas elevating SEMA4D expression, thus promoting the progression of CCA.

关键词： SRY-box transcription factor 2 cholangiocarcinoma long non-coding RNA plasmacytoma variant translocation 1 microRNA-186 semaphorin 4D

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Transcription factor HIF1α promotes proliferation, migration, and invasion of cholangiocarcinoma via long noncoding RNA H19/microRNA-612/Bcl-2 axis

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TRANSLATIONAL RESEARCH 2020年 224卷 26-39页

作者： Yu, Aijun zhao, luwen Kang, Qingmin Li, Jian Chen, Kai Fu, Hua Chengde Med Univ Dept Gen Surg 1 Affiliated Hosp 36 Nanyingzi St Chengde 067000 Hebei Peoples R China Chengde Med Univ Dept Gynecol 1 Affiliated Hosp Chengde Peoples R China

Cholangiocarcinoma, which is the most common invasive malignant tumor of the biliary tract, has poor prognosis. There is evidence suggesting that hypoxia-induc-ible factor 1 alpha (HIF1 alpha) plays an important role in cholangiocarcinoma. Also, micro-RNA-612 (miR-612) is another key regulator of cholangiocarcinoma. In this study, we investigate the scantly documented interaction of HIF1 alpha and miR-612 in cholangiocarcinoma. We first undertook microarray-based cholangiocarcinoma gene expression profiles to screen out the differentially expressed long noncoding RNAs (lncRNAs) and genes. We used reverse transcription quantitative polymerase chain reaction to detect the expression of HIF1 alpha in normal bile duct and cholangiocarci-noma tissues, and in corresponding cells lines. Cell counting kit 8, scratch, and Transwell assays were used to detect the proliferation, migration and invasion of cholangiocarcinoma cells. Cell cycle distribution and apoptosis were detected by flow cytometry. ChIP, dual luciferase reporter gene assay, RNA pull-down, and RNA immunoprecipitation were used to verify relationship between HIF1 alpha and lncRNA H19, and lncRNA H19 and miR-612. We also monitored tumor formation in nude mice to verify the effect of HIF1 alpha on cholangiocarcinoma. HIF1 alpha expression was elevated in cholangiocarcinoma tissues and cells. Silencing HIF1 alpha reduced proliferation, migration, and invasion of cholangiocarcinoma cells. HIF1 alpha transcriptionally activated the expression of lncRNA H19. Overexpression of miR-612 could rescue the proliferation, migration and invasion of cholangiocarcinoma cells caused by lncRNA H19 overexpression. Taken together, HIF1 alpha activated lncRNA H19-mediated miR-612/Bcl-2 pathway to promote cholangiocarcinoma, suggesting a promising therapeutic target for cholangiocarcinoma.

关键词： Bcl-2 B-cell lymphoma 2 EZH2 Enhancer of zeste homologue 2 GEO Gene Expression Omnibus HIF1α Hypoxia-inducible factor 1α HRE Hypoxia-response element LncRNA H19 Long non-coding RNA H19 MiR-612 MicroRNA-612 VEGF Vascular endothelial growth factor

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锥形束CT图像引导在胸部肿瘤患者放疗摆位中的实施效果

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世界复合医学（中英文） 2024年第7期10卷 152-154页

作者：刘雪徐嘉赵鲁文曹县人民医院山东菏泽274400

目的分析在胸部肿瘤患者放疗摆位中应用锥形束CT图像引导的效果。方法选择2020年1月—2023年7月曹县人民医院收治的40例胸部肿瘤患者为研究对象,所有患者均接受常规电子射野影像仪图像检查与锥形束CT图像检查,分别作为对照组与研究组,... 详细信息

目的分析在胸部肿瘤患者放疗摆位中应用锥形束CT图像引导的效果。方法选择2020年1月—2023年7月曹县人民医院收治的40例胸部肿瘤患者为研究对象,所有患者均接受常规电子射野影像仪图像检查与锥形束CT图像检查,分别作为对照组与研究组,比较两组不同方向摆位偏差、时间相关指标。结果研究组患者的不同方向摆位偏差均低于对照组低,差异有统计学意义(P均<0.05)。研究组的摆位时间为(150.52±14.29)s,长于对照组的(49.53±15.29)s,差异有统计学意义(t=30.519,P<0.05)。两组图像获取时间比较,差异无统计学意义(P>0.05)。结论在胸部肿瘤患者放疗摆位中实施锥形束CT图像检查可减少方向摆位偏差。

关键词：锥形束CT图像引导胸部肿瘤放疗

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LncRNA LINC01061 sponges miR-612 to regulate the oncogenic role of SEMA4D in cholangiocarcinoma

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2019年第2期513卷 465-471页

作者： Yu, Aijun zhao, luwen Kang, Qingmin Chen, Kai Li, Jian Fu, Hua Liu, Jinlong Zhang, Xuejun Chengde Med Coll Affiliated Hosp Dept Gen Surg 1 Chengde 067000 Hebei Peoples R China Chengde Med Coll Affiliated Hosp Dept Gynecol 1 Chengde 067000 Hebei Peoples R China

Cholangiocarcinoma (CCA) is the most usual malignancy of biliary tract, possessing a relatively low overall survival rate due to limited treatment options. Recently, long non-coding RNAs (lncRNAs) have, been testified to have marked regulatory impacts on human cancers. The purpose of this paper is to explore the potent regulation mechanism of LINC01061 involved in CCA. Firstly, it was observed that LINC01061 expression was heightened in CCA cell lines, whose knockdown suppressed cell proliferation, induced cell apoptosis and restrained cell migration. Besides, LINC01061 existing in the cytoplasm of CCA cells interacted with miR-612. Moreover, subsequent experiments affirmed that LINC01061 regulated SEMA4D expression by acting as a competing endogenous RNA (ceRNA) of miR-612. At last, rescue assays validated that SEMA4D overexpression restored the repression caused by LINC01061 silence on the biological activities of CCA containing cell proliferation, apoptosis and migration. To sum up, our present exploration demonstrated that LINC01061 sponges miR-612 so as to upregulate SEMA4D expression for the progression of CCA, suggesting an optional promising and effective target for the therapy of patients with CCA. (C) 2019 Elsevier Inc. All rights reserved.

关键词： Cholangiocarcinoma (CCA) LINC01061 miR-612 SEMA4D

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替罗非班叠加双抗血小板治疗急性脑梗死的效果和安全性评价

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航空航天医学杂志 2025年第4期36卷 394-397页

作者：牛忠江程瑶赵璐闻哈尔滨二四二医院神经内科黑龙江哈尔滨150066

目的研究急性脑梗死采用替罗非班与双抗血小板联合方案的效果和安全性。方法选取我院急性脑梗死患者,纳入时间:2023年01月~2023年12月,共计100例,分为对照组(n=50)和观察组(n=50),随机分组采用数字表法。对照组行双抗血小板治疗,观察组... 详细信息

目的研究急性脑梗死采用替罗非班与双抗血小板联合方案的效果和安全性。方法选取我院急性脑梗死患者,纳入时间:2023年01月~2023年12月,共计100例,分为对照组(n=50)和观察组(n=50),随机分组采用数字表法。对照组行双抗血小板治疗,观察组再联合替罗非班治疗,比较两组临床疗效,对比两组治疗前后血小板粘附性(PAdT)与血小板聚集率(PAgT),比较两组治疗前后血管内皮功能[内皮素-1(ET-1)、一氧化氮(NO)]、血液流变学[全血高切粘度(HBV)、纤维蛋白原(FIB)、血浆粘度(PV)、全血低切粘度(LBV)]、神经功能[美国国立卫生研究院卒中量表(NIHSS)]与生活质量[Barthel指数(BI)],观察安全性。结果观察组总有效率为98.00%,高于对照组的86.00%(P<0.05)。较治疗前,两组治疗后PAdT、PAgT降低(P<0.05);较对照组,观察组治疗后PAdT、PAgT更低(P<0.05)。较治疗前,两组治疗后NO水平升高(P<0.05),ET-1水平降低(P<0.05),观察组更优(P<0.05)。较治疗前,两组治疗后PV、HBV、LBV及FIB降低(P<0.05);较对照组,观察组治疗后PV、HBV、LBV及FIB更低(P<0.05)。较治疗前,两组治疗后BI指数升高(P<0.05),NIHSS评分降低(P<0.05);较对照组,观察组治疗后BI指数更高(P<0.05),NIHSS评分更低(P<0.05)。两组均未发生严重不良反应(P>0.05)。结论急性脑梗死患者采用替罗非班与双抗血小板联合方案,可使血小板聚集受抑,改善血液流变学,保护血管内皮功能,减轻神经功能受损程度,提升生活质量,安全性高。

关键词：替罗非班双抗血小板阿司匹林氯吡格雷急性脑梗死

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Effect of Dual-frequency ultrasonic on subcooled water freezing

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INTERNATIONAL JOURNAL OF REFRIGERATION 2023年 154卷 1-8页

作者： Zilei, zhao Runfa, Zhou Zhenghao, Jin luwen, Qin Shuhong, Li Yanjun, Li Southeast Univ Sch Energy & Environm Nanjing 210096 Peoples R China Jiangsu Prod Qual Testing & Inspect Inst Nanjing 210007 Peoples R China

Ultrasonic-assisted freezing has received much attention for its outstanding capability to improve freezing performance. However, most researchers focus only on single-frequency ultrasound, lacking research on dualfrequency or multi-frequency ultrasound. Based on the relevant theory of the promotion of solution crystallization by ultrasound wave, this paper experimentally studied the subcooling degree and time of water freezing under the action of ultrasound. The experimental study was carried out on the production of ice from water by using different ultrasonic waves under a specific power. The results show that the effect of ultrasound with specific frequency combinations can improve the speed of water freezing and reduce the subcooling degree. When the experimental conditions are 28+33 kHz and 60 W, the comprehensive performance is the best. Compared with the condition without ultrasound, the subcooling degree is reduced by 5.28 K, and the time required for the complete solidification of water into ice was reduced by a duration of 60 s.

关键词： ultrasonic wave freezing ice subcooling degree

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