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东北农业科学 2021年第2期46卷 70-72,111页

作者：李东庭陈姗姗赵春波张露文孙凯张越宋述尧吉林农业大学园艺学院长春130118 吉林省农业科学院经济植物研究所吉林公主岭136100 长春市土壤肥料工作站长春130011

为明确生物炭对基质理化性质的影响及辣椒育苗效应,本试验设置0、0.1%、0.5%、0.9%、1.3%、1.7%、2.1%的生物炭施用量(W∶W,%),以传统的田园土草炭蛭石混合基质做对照,进行温室基质育苗试验。结果表明,生物炭添加可增大基质孔隙度、EC值... 详细信息

为明确生物炭对基质理化性质的影响及辣椒育苗效应,本试验设置0、0.1%、0.5%、0.9%、1.3%、1.7%、2.1%的生物炭施用量(W∶W,%),以传统的田园土草炭蛭石混合基质做对照,进行温室基质育苗试验。结果表明,生物炭添加可增大基质孔隙度、EC值,降低基质水气比,优化基质的遴选。随生物炭增加,辣椒幼苗长势呈现先升高后下降趋势,且各处理均优于对照。生物炭添加量为0.9%时辣椒长势最好,地上部干重、叶绿素含量、壮苗指数均达到最大值(1.53 g、2.59 g、0.418),促进幼苗生长。

关键词：辣椒育苗基质生物炭

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CT-guided percutaneous radiofrequency ablation for lung neoplasms adjacent to the pericardium

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LUNG CANCER 2018年 122卷 25-31页

作者： Mu, luwen Pan, Tao Lyu, Ning Sun, Lin Li, Shaolong Xie, Qiankun Deng, Haijing Wu, Peihong Liu, Hui zhao, Ming Sun Yat Sen Univ Dept Vasc Intervent Radiol Affiliated Hosp 3 Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Minimally Invas Intervent Div Ctr Canc Guangzhou Guangdong Peoples R China Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China Guangzhou Guangdong Peoples R China Guangdong Prov Emergency Hosp Dept Med Imaging Guangdong Prov Gen Hosp 2 Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Med Oncol Reg Ctr Canc Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Dept Radiat Oncol Ctr Canc Guangzhou Guangdong Peoples R China

Objective: To assess the safety and effectiveness of computed-tomography-guided (CT-guided) percutaneous radiofrequency ablation (RFA) for lung neoplasms adjacent to the pericardium. Materials and methods: This retrospective study was approved by the institutional ethics committee, and all patients provided written informed consent. Between January 1, 2012 and March 31, 2016, 49 consecutive patients (32 men and 17 women;mean age 47.9 years;range 16-67 years) with 51 tumors (mean diameter 17.7 +/- 7.2 mm;range 4-30 mm) located within 10 mm of the pericardium underwent percutaneous CT-guided RFA. The technical success rate, local progression-free survival (LPFS), risk factors for local progression, and safety of this technique were evaluated. Results: The technical success rate was 96.1% (49/51), and the LPFS was 98.0%, 93.0%, 84.0%, and 77.0% at 3, 6, 12, and 24 months, respectively. A tumor size > 2.0 cm (p = .045) and the primary lung tumor types (p = .013) were associated with local progression. No treatment-related deaths occurred. The incidence of major complications was 15.7%;complications included pneumothorax (5.9%, 3/51), pleural effusion (3.9%, 2/51), pneumonitis (3.9%, 2/51), and hemothorax (2.0%, 1/51). Conclusion: Percutaneous CT-guided RFA can be a safe and effective option for the treatment of lung malignancies adjacent to the pericardium.

关键词： Radiofrequency ablation Lung malignancies Pericardium Complications Local progression-free survival

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安全管理视域下高校视频监控系统的建设探究

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信息通信 2020年第8期33卷 149-151页

作者：林传銮戴文坤林鲁文黄航赵巍福建师范大学保卫处闽江学院新华都商学院福建福州350108

为应对新时期日趋复杂的校园安全局势,保障良好的教育环境,结合快速发展的信息技术,利用视频监控系统优化校园安全管理模式,使其朝着可视化、技术化、制度化的方向改进。以视频监控系统建设为例,根据校园安全管理工作目标,分析已有建设... 详细信息

为应对新时期日趋复杂的校园安全局势,保障良好的教育环境,结合快速发展的信息技术,利用视频监控系统优化校园安全管理模式,使其朝着可视化、技术化、制度化的方向改进。以视频监控系统建设为例,根据校园安全管理工作目标,分析已有建设问题,提出"总体设计-规划建设-施工监管-健全体系"四个步骤建设策略,保障校园师生正常的学习和生活秩序。

关键词：安全管理高校视频监控四个步骤建设

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Mechanism and prognostic value of indoleamine 2,3-dioxygenase 1 expressed in hepatocellular carcinoma

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CANCER SCIENCE 2018年第12期109卷 3726-3736页

作者： Li, Shaolong Han, Xue Lyu, Ning Xie, Qiankun Deng, Haijing Mu, luwen Pan, Tao Huang, Xin Wang, Xia Shi, Yuanyuan zhao, Ming Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Minimally Invas Intervent Div Canc Ctr Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Ctr Canc VIP Reg Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Dept Vasc Intervent Radiol Affiliated Hosp 3 Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Dept Hepatobilliary Oncol Canc Ctr Guangzhou Guangdong Peoples R China Guangzhou Med Univ Affiliated Hosp 2 Dept Pathol Guangzhou Guangdong Peoples R China Sun Yat Sen Mem Hosp Dept Obstet & Gynecol Guangzhou Guangdong Peoples R China

Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-metabolizing enzyme that is widely distributed in normal or malignant tissues and contributes to immunologic tolerance and immune escape. However, in hepatocellular carcinoma (HCC), the characteristics and mechanism of IDO1 expression have not been well defined. In this study, IDO1 expression in tumor cells (T-IDO1) was frequently detected (109/112) by immunohistochemistry in formalin-fixed paraffin-embedded specimens from HCC patients, and the expression patterns were mostly focal (102/109). Expression of T-IDO1 was significantly associated with the infiltration of CD8+ T cells (P = .043), as well as younger age (<50 years old, P = .02). It was also found that IDO1 had diffuse expression in inflammatory cells in all specimens, which were defined as antigen-presenting cells. Significant correlations among IDO1, IFNG, and CD8A transcriptional levels were observed in freshly resected HCC specimens;moreover, no constitutive IDO1 expression was detected in HCC cell lines until stimulated by interferon-gamma through the JAK2-STAT1 signaling pathway, but not type I interferon. Survival analyses showed that increased T-IDO1 and CD8+ T cell infiltration were significantly associated with superior overall survival (OS) (T-IDO1, P = .003;CD8+ T cells, P = .004), and T-IDO1 expression is an independent prognosis factor in both OS and disease-free survival (OS, P = .007;disease-free survival, P = .044). These findings indicated that T-IDO1 expression in HCC is common and is dominantly driven by the host antitumor immune response, which is a favorable prognostic factor in HCC.

关键词： CD8 HCC IDO1 IFN-gamma inducible expression

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针刺结合康复训练对脑卒中后吞咽功能障碍的疗效的系统评价与meta分析

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华西医学 2019年第5期34卷 531-538页

作者：唐强赵晓倩朱路文黑龙江中医药大学附属第二医院康复科哈尔滨150001 黑龙江中医药大学第二临床医学院哈尔滨150040

目的系统评价针刺结合康复训练对比单纯康复训练或针刺治疗脑卒中后吞咽功能障碍的有效性,明确针刺结合康复训练的疗效是否优于单纯的康复训练或针刺治疗。方法计算机检索中国知网、万方数据、重庆维普、PubMed、Cochrance Library、Emb... 详细信息

目的系统评价针刺结合康复训练对比单纯康复训练或针刺治疗脑卒中后吞咽功能障碍的有效性,明确针刺结合康复训练的疗效是否优于单纯的康复训练或针刺治疗。方法计算机检索中国知网、万方数据、重庆维普、PubMed、Cochrance Library、Embase 6个数据库关于针刺结合康复训练治疗卒中后吞咽功能障碍的随机对照试验,检索时间限定为2010年1月1日—2018年12月31日。对检索文献进行纳入、排除、筛选后,采用RevMan 5.3软件进行meta分析。结果共纳入22项研究,包括1 987例患者。各研究的对照均为单纯的康复训练或康复训练结合假针刺,无单纯针刺为对照的研究。Meta分析结果显示:与单纯的康复训练治疗相比,针刺结合康复训练治疗脑卒中后吞咽功能障碍的有效率更高[17项研究,比值比=3.66,95%置信区间(confidence interval,CI)(2.66,5.05),P<0.000 01],治疗后视频透视吞咽功能检查评分更高[8项研究,均数差(mean difference,MD)=2.31分,95%CI(1.75,2.87)分,P<0.000 01],标准吞咽功能评定量表评分更低[6项研究,MD=-3.20分,95%CI(-3.78,-2.61)分,P<0.000 01],洼田饮水试验评分更低[6项研究,MD=-0.65分,95%CI(-0.91,-0.39)分,P<0.000 01]。结论针刺结合康复训练可有效治疗卒中后吞咽功能障碍,且疗效优于单纯康复训练。但受纳入文献质量和样本量限制,以上结果和结论仍需要高质量和大样本的研究加以验证。

关键词：针刺康复训练脑卒中吞咽困难系统评价 Meta分析

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Percutaneous CT-guided radiofrequency ablation for patients with extrahepatic oligometastases of hepatocellular carcinoma: long-term results

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INTERNATIONAL JOURNAL OF HYPERTHERMIA 2018年第1期34卷 59-67页

作者： Mu, luwen Sun, Lin Pan, Tao Lyu, Ning Li, Shaolong Li, Xishan Wang, Jianpeng Xie, Qiankun Deng, Haijing Zheng, Lie Peng, Jianhong Shen, Lujun Fan, Weijun Wu, Peihong zhao, Ming Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Canc Ctr Minimally Invas Intervent Div Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Affiliated Hosp 3 Dept Vasc Intervent Radiol Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Canc Ctr Dept Med Imaging Guangzhou Guangdong Peoples R China Guangdong Prov Emergency Hosp Guangdong Prov Gen Hosp 2 Dept Med Imaging Guangzhou Guangdong Peoples R China Guangzhou Med Univ Guangzhou Peoples Hosp 1 Dept Intervent Radiol Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Affiliated Foshan Hosp Peoples Hosp Foshan 1 Target & Intervent Therapy Dept Oncol Foshan Peoples R China Sun Yat Sen Univ Canc Ctr Dept Colorectal Surg Guangzhou Guangdong Peoples R China

Background: The aim of this study was to evaluate the therapeutic outcome of percutaneous computed tomography (CT)-guided radiofrequency ablation (RFA) for extrahepatic oligometastases of hepatocellular carcinoma (HCC). Methods: Institutional review board approval was obtained for this retrospective study, and all patients provided written informed consent. Between April 2004 and December 2015, 116 oligometastases (diameter, 5-50 mm;20.3 +/- 10.4) in 79 consecutive HCC patients (73 men and 6 women;average age, 50.3 years +/- 13.0) were treated with RFA. We focussed on patients with 1-3 extrahepatic metastases (EHM) confined to 1-2 organs (including the lung, adrenal gland, bone, lymph node and pleura/peritoneum) who were treated naive with curative intent. Survival, technical success and safety were evaluated. The log-rank test and Cox proportional hazards regression models were used to analyse the survival data. Results: No immediate technical failure occurred, and at 1 month, the technique effectiveness rate was determined to be 95.8%. After a median follow-up time of 28.0 months (range, 6-108 months), the 1-, 2- and 3-year overall survival (OS) rates were 91, 70 and 48%, respectively, with a median survival time of 33.5 months. Time to unoligometastatic progression (TTUP) of less than 6 months (p < 0.001) and a Child-Pugh score of more than 5 (p = 0.001) were significant indicators of shorter OS. The 1-, 2- and 3-year disease free survival (DFS) rates were 34, 21 and 8%, respectively, with a median DFS time of 6.8 months. DFS was better for those with lung metastases (p = 0.006). Major complication occurred in nine (9.5%, 9/95) RFA sessions without treatment-related mortality. Conclusions: CT-guided RFA for oligometastatic HCC may provide favourable efficacy and technical success with a minimally invasive approach.

关键词： Hepatocellular carcinoma radiofrequency ablation extrahepatic metastases oligometastases overall survival time to unoligometastatic progression

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A Support Vector Data Description Approach to NLOS Identification in UWB Positioning

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MATHEMATICAL PROBLEMS IN ENGINEERING 2014年第1期2014卷 1-6页

作者： Tian, Shiwei zhao, luwen Li, Guangxia PLA Univ Sci & Technol Coll Commun Engn Nanjing 210007 Jiangsu Peoples R China

Non-line-of-sight (NLOS) propagation is one of the most important challenges in radio positioning, and, in recent years, significant attention has been drawn to the identification and mitigation of NLOS signals. This paper focuses on the identification of NLOS signals. The authors consider the NLOS identification problem as a one-class classification problem and apply the support vector data description (SVDD), providing accurate data descriptions utilizing kernel techniques, to perform NLOS identification in ultrawide bandwidth (UWB) positioning. Our work is based on the fact that some features extracted from the received signal waveforms, such as the kurtosis, the mean excess delay spread, and the root mean square delay spread, are different between line-of-sight (LOS) and NLOS signals. Numerical simulations are performed to demonstrate the performance, using a dataset derived from a measurement campaign.

关键词： SUPPORT vector machines DESCRIPTIVE statistics LINE-of-sight radio links THEORY of wave motion ULTRA-wideband devices

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WSSS4LUAD: Grand Challenge on Weakly-supervised Tissue Semantic Segmentation for Lung Adenocarcinoma

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arXiv 2022年

作者： Han, Chu Pan, Xipeng Yan, Lixu Lin, Huan Li, Bingbing Yao, Su Lv, Shanshan Shi, Zhenwei Mai, Jinhai Lin, Jiatai zhao, Bingchao Xu, Zeyan Wang, Zhizhen Wang, Yumeng Zhang, Yuan Wang, Huihui Zhu, Chao Lin, Chunhui Mao, Lijian Wu, Min Duan, luwen Zhu, Jingsong Hu, Dong Fang, Zijie Chen, Yang Zhang, Yongbing Li, Yi Zou, Yiwen Yu, Yiduo Li, Xiaomeng Li, Haiming Cui, Yanfen Han, Guoqiang Xu, Yan Xu, Jun Yang, Huihua Li, Chunming Liu, Zhenbing Lu, Cheng Chen, Xin Liang, Changhong Zhang, Qingling Liu, Zaiyi The Department of Radiology Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou510080 China Guangdong Prov. Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou510080 China The Department of Pathology Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou510080 China The School of Computer Science and Information Security Guilin University of Electronic Technology Guangxi541004 China The Department of Pathology Guangdong Provicial People's Hospital Ganzhou Hospital Ganzhou China The College of Artificial Intelligence Beijing University of Posts and Telecommunications Beijing100876 China The School of Computer Science and Engineering South China University of Technology Guangzhou510640 China The Institute for AI in Medicine School of Artificial Intelligence Nanjing University of Information Science and Technology Nanjing210044 China The School of Biological Science and Medical Engineering State Key Laboratory of Software Development Environment Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education Research Institute of Beihang University in Shenzhen Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing100191 China The Department of Radiology Guangzhou First People's Hospital Hospital of South China University of Technology Guangzhou510180 China The Zhejiang Dahua Technology Co. Ltd Zhejiang310053 China The School of Biomedical Engineering University of Science and Technology of China Hefei230022 China The Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen China Electronic and Computer Engineering & Computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong Hong Kong The School of Automation Science and Engineering Xi'An Jiaotong University Xian710049 Chi

Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma (LUAD) is the most common subtype. Exploiting the potential value of the histopathology images can promote precision medicine in oncology. Tissue segmentation is the basic upstream task of histopathology image analysis. Existing deep learning models have achieved superior segmentation performance but require sufficient pixel-level annotations, which is time-consuming and expensive. To enrich the label resources of LUAD and to alleviate the annotation efforts, we organize this challenge WSSS4LUAD to call for the outstanding weakly-supervised semantic segmentation (WSSS) techniques for histopathology images of LUAD. Participants have to design the algorithm to segment tumor epithelial, tumor-associated stroma and normal tissue with only patch-level labels. This challenge includes 10,091 patch-level annotations (the training set) and over 130 million labeled pixels (the validation and test sets), from 87 WSIs (67 from GDPH, 20 from TCGA). All the labels were generated by a pathologist-in-the-loop pipeline with the help of AI models and checked by the label review board. Among 532 registrations, 28 teams submitted the results in the test phase with over 1,000 submissions. Finally, the first place team achieved mIoU of 0.8413 (tumor: 0.8389, stroma: 0.7931, normal: 0.8919). According to the technical reports of the top-tier teams, CAM is still the most popular approach in WSSS. Cutmix data augmentation has been widely adopted to generate more reliable samples. With the success of this challenge, we believe that WSSS approaches with patch-level annotations can be a complement to the traditional pixel annotations while reducing the annotation efforts. The entire dataset has been released to encourage more researches on computational pathology in LUAD and more novel WSSS techniques. © 2022, CC BY.

关键词： Semantic Segmentation

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Impact of multimorbidity on health service use and catastrophic health expenditure in China: an analysis of data from a nationwide longitudinal survey

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Lancet, The 2019年 394卷 S69-S69页

作者： zhao, Yang, PhD Zhang, Lin, PhD zhao, Siqi, MSc Zhang, luwen, PhD The Nossal Institute for Global Health The University of Melbourne Melbourne VIC Australia WHO Collaborating Centre on Implementation Research for Prevention and Control of Noncommunicable Diseases Melbourne VIC Australia Peking Union Medical College School of Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Yantaishan Hospital of Yantai Yantai Shandong China School of Health Services Management Southern Medical University Guangzhou Guangdong China

AbstractBackgroundMultimorbidity (the presence of two or more chronic conditions) is a significant contributor to inequalities in health care and has become the major unaddressed challenge for the health system in China. We assessed the distribution of multimorbidity in relation to economic status and the relationships between multimorbidity, health-care use, and catastrophic health expenditure in China. MethodsWe conducted a longitudinal study using three waves of data (2011, 2013, and 2015) from the China Health and Retirement Longitudinal Study (CHARLS), including 12 096 participants aged 45 years and older. Random effects logistic regression models were used to determine the sociodemographic correlates of multimorbidity, including age, sex, marital status, education, residence location, socioeconomic status quartiles (yearly per-capita household consumption expenditure), health insurance, and geographical region. Negative binomial regression models were used to assess the relationship between multimorbidity and outpatient visits, as well as days of hospitalisation. Multivariate logistic regression models were used to estimate the effect of multimorbidity on catastrophic health expenditure, defined as the point at which annual household health payments exceeded 40% of non-food household expenditure. The Biomedical Ethics Review Committee of Peking University approved the CHARLS study (approval number IRB00001052–11015), and all interviewees were required to provide informed consent. FindingsOf 12 096 participants, 5566 (46·0%) in 2011, 6069 (50·2%) in 2013, and 7399 (61·2%) in 2015 had two or more chronic diseases. The onset of multimorbidity occurred 5–10 years earlier in people in the highest economic quartile group than in the lowest group. Multimorbidity was positively associated with health service use, including outpatient visits (coefficient 0·25, 95% CI 0·24–0·27) and days of hospitalisation (0·31, 0·31–0·35). Multimorbidity was associated with an increas

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日本高等药学教育改革对我国临床药学教育的启示

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药学教育 2021年第6期37卷 1-6,17页

作者：聂小燕唐宁佳李潇潇张婧媛翟所迪蒲小平李晨曦崔爽韩健赵帼英管晓东史录文北京大学药学院北京大学第三医院药剂科北京大学研究生院医学部分院北京100191

日本先发展传统药学教育,再发展专业学位药学教育,之后探索培养学术型与应用型相结合的复合型药学人才,其药学教育改革与发展历程对我国药学教育的发展具有重要的借鉴意义。通过文献调研、访谈等方法,系统分析日本药学教育改革历程、人... 详细信息

日本先发展传统药学教育,再发展专业学位药学教育,之后探索培养学术型与应用型相结合的复合型药学人才,其药学教育改革与发展历程对我国药学教育的发展具有重要的借鉴意义。通过文献调研、访谈等方法,系统分析日本药学教育改革历程、人才培养规模与就业去向,从改革需求、人才培养规模与特点、未来发展趋势等角度对日本药学教育改革进行深入分析,以期为我国临床药学人才培养与改革提供参考。

关键词：药学教育临床药学药学六年制日本

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