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Two-dimensional materials for future information technology: status and prospects

Science China(Information Sciences) 2024年第6期67卷 1-147页

作者： Hao QIU Zhihao YU Tiange zhao Qi ZHANG Mingsheng XU Peifeng LI Taotao LI Wenzhong BAO Yang CHAI Shula CHEN Yiqi CHEN Hui-Ming CHENG Daoxin DAI Zengfeng DI Zhuo DONG Xidong DUAN Yuhan FENG Yu FU Jingshu GUO Pengwen GUO Yue HAO Jun HE Xiao HE Jingyi HU Weida HU Zehua HU Xinyue HUANG Ziyang HUANG Ali IMRAN Ziqiang KONG Jia LI Qian LI Weisheng LI Lei LIAO Bilu LIU Can LIU Chunsen LIU Guanyu LIU Kaihui LIU Liwei LIU Sheng LIU Yuan LIU Donglin LU Likuan MA Feng MIAO Zhenhua NI Jing NING Anlian PAN Tian-Ling REN Haowen SHU Litao SUN Yue SUN Quanyang TAO Zi-Ao TIAN Dong WANG Hao WANG Haomin WANG Jialong WANG Junyong WANG Wenhui WANG Xingjun WANG Yeliang WANG Yuwei WANG Zhenyu WANG Yao WE... Department of Applied Physics The Hong Kong Polytechnic University Key Laboratory for Micro-Nano Physics and Technology of Hunan Province College of Materials Science and EngineeringHunan University College of Integrated Circuits Zhejiang University Shenzhen Geim Graphene Center Shenzhen Key Laboratory of Layered Materials for Value-Added ApplicationsTsinghua-Berkeley Shenzhen Institute & Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua University State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZijingang CampusZhejiang University National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics (SINANO)Chinese Academy of Sciences College of Chemistry and Chemical Engineering Hunan University Key Laboratory of Quantum State Construction and Manipulation (Ministry of Education) Department of PhysicsRenmin University of China School of Integrated Circuits Beijing National Research Center for Information Science and Technology (BNRist)Tsinghua University School of Electronic Science and Engineering Nanjing University The State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology Shaanxi Joint Key Laboratory of GrapheneSchool of MicroelectronicsXidian University Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan University School of Integrated Circuits Huazhong University of Science and Technology Center for Nanochemistry (CNC) Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking University State Key Laboratory for Artificial Microstruct

Over the past 70 years, the semiconductor industry has undergone transformative changes,largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensional(2D) materials like transition metal dichalcogenides(TMDs) and graphene are pivotal in overcoming the limitations of silicon-based technologies, offering innovative approaches in transistor design and functionality, enabling atomic-thin channel transistors and monolithic 3D integration. We review the important progress in the application of 2D materials in future information technology, focusing in particular on microelectronics and optoelectronics. We comprehensively summarize the key advancements across material production, characterization metrology, electronic devices, optoelectronic devices, and heterogeneous integration on silicon. A strategic roadmap and key challenges for the transition of 2D materials from basic research to industrial development are outlined. To facilitate such a transition, key technologies and tools dedicated to 2D materials must be developed to meet industrial standards, and the employment of AI in material growth, characterizations, and circuit design will be essential. It is time for academia to actively engage with industry to drive the next 10 years of 2D material research.

关键词： two-dimensional (2D) materials information technology production technology standardization of characterization microelectronic devices optoelectronic devices multi-functional integration

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Hepatic arterial infusion of oxaliplatin plus fluorouracil/leucovorin vs. sorafenib for advanced hepatocellular carcinoma

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JOURNAL OF HEPATOLOGY 2018年第1期69卷 60-69页

作者： Lyu, Ning Kong, Yanan Mu, luwen Lin, Youen Li, Jibin Liu, Yaru Zhang, Zhenfeng Zheng, Lie Deng, Haijing Li, Shaolong Xie, Qiankun Guo, Rongping Shi, Ming Xu, Li Cai, Xiuyu Wu, Peihong zhao, Ming Sun Yat Sen Univ Minimally Invas Intervent Div Dept Med Imaging & Intervent Radiol Ctr Canc Guangzhou Guangdong Peoples R China Sun Yat Sen Univ State Key Lab Oncol South China Ctr Canc Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Jieyang Affiliated Hosp Dept Intervent Radiol Jieyang Peoples R China Sun Yat Sen Univ Dept Clin Res Ctr Canc Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Med Imaging Div Dept Med Imaging & Intervent Radiol Ctr Canc Guangzhou Guangdong Peoples R China Sun Yat Sen Univ Dept Hepatobiliary Oncol Ctr Canc Guangzhou Guangdong Peoples R China

Background & Aims: To compare the overall survival (OS) and disease progression free survival (PFS) in patients with advanced hepatocellular carcinoma (Ad-HCC) who are undergoing hepatic arterial infusion (HAI) of oxaliplatin, fluorouracil/leucovorin (FOLFOX) treatment vs. sorafenib. Methods: This retrospective study was approved by the ethical review committee, and informed consent was obtained from all patients before treatment. HAI of FOLFOX (HAIF) was recommended as an alternative treatment option for patients who refused sorafenib. Of the 412 patients with Ad-HCC (376 men and 36 women) between Jan 2012 to Dec 2015, 232 patients were treated with sorafenib;180 patients were given HAIF therapy. The median age was 51 years (range, 16-82 years). Propensity-score matched estimates were used to reduce bias when evaluating survival. Survival curves were calculated by performing the Kaplan-Meier method and compared by using the log-rank test and Cox regression models. Results: The median PFS and OS in the HAIF group were significantly longer than those in the sorafenib group (PFS 7.1 vs. 3.3 months [RECIST]/7.4 vs. 3.6 months [mRECIST], respectively;OS 14.5 vs. 7.0 months;p < 0.001 for each). In the propensity-score matched cohorts (147 pairs), both PFS and OS in the HAIF group were longer than those in the sorafenib group (p < 0.001). At multivariate analysis, HAIF treatment was an independent factor for PFS (hazard ratio [HR] 0.389 [RECIST]/0.402 [mRECIST];p < 0.001 for each) and OS (HR 0.129;p < 0.001). Conclusion: HAIF therapy may improve survival compared to sorafenib in patients with Ad-HCC. A prospective randomized trial is ongoing to confirm this finding. Lay summary: We compared the hepatic arterial infusion of FOLFOX (a combination chemotherapy) with sorafenib (a tyrosine kinase inhibitor) in patients with advanced hepatocellular carcinoma, retrospectively. It was found that hepatic arterial infusion of FOLFOX therapy may improve both progression free and ove

关键词： Hepatocellular carcinoma Sorafenib Arterial infusion chemotherapy FOLFOX Oxaliplatin Fluorouracil

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Dimension Effect on Breakdown Voltage of Partial SOI LDMOS

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IEEE JOURNAL OF THE ELECTRON DEVICES SOCIETY 2017年第3期5卷 157-163页

作者： Hu, Yue Liu, Huazhen Xu, Qianqian Wang, luwen Wang, Jing Chen, Shichang zhao, Peng Wang, Ying Wang, Gaofeng Hangzhou Dianzi Univ Minist Educ Key Lab RF Circuits & Syst Hangzhou 310018 Zhejiang Peoples R China

Dimension effect on breakdown voltage (BV) of lateral double-diffused metal-oxide-semiconductor field-effect transistor in partial silicon-on-insulator (PSOI) technology is comprehensively studied. The maximum BV (BVmax) is examined under various settings of the device length L and the active silicon film thickness t. It is shown that there exists an optimal pair of (L, t) for PSOI at which the highest BV can be achieved. The ratio of L/t is better chosen between 5 and 7 for the device designs, in particular, L/t = 6 can be considered as the optimal one theoretically. Moreover, impacts of the silicon window length L-w and the drift doping concentration N-dr on the BV, the on-resistance (R-on) and the figure-of-merit (= BV2/R-on) are also carefully studied.

关键词： LDMOS partial silicon-on-insulator (PSOI) breakdown voltage on-resistance

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不同形状疏水性微肋阵内流场Micro-PIV流动可视化研究

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南京师范大学学报（工程技术版） 2019年第2期19卷 7-17,24页

作者：秦露雯华君叶张秀强赵孝保祝叶南京师范大学能源与机械工程学院江苏南京210042 南京师范大学江苏省能源系统过程转化与减排技术工程实验室江苏南京210042

运用Micro-PIV显微粒子图像测速系统对不同截面形状、不同接触角微肋阵的流动特性展开可视化研究.通过制备接触角为83°、99.5°、121.5°、151.5°的疏水表面,研究Re数为100~450时工质绕流圆形、椭圆形和菱形微肋阵速... 详细信息

运用Micro-PIV显微粒子图像测速系统对不同截面形状、不同接触角微肋阵的流动特性展开可视化研究.通过制备接触角为83°、99.5°、121.5°、151.5°的疏水表面,研究Re数为100~450时工质绕流圆形、椭圆形和菱形微肋阵速度与流线变化,并对流场进行分析.实验结果表明,在圆形微肋阵中尾涡的出现相比于宏观尺度有明显延迟,直到Re达到250时在中间的圆柱尾部才出现对称漩涡.对比3种形状微肋阵可发现,椭圆形具有的流线型结构和菱形具有的细长结构不易发生边界层分离.在经过疏水性处理后,圆形针肋尾部的边界层分离明显延迟,接触角为151.5°的表面边界层最晚分离.

关键词：疏水性微肋阵微肋阵接触角流场 Micro-PIV系统

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夹脊电针结合神经松动术对兔坐骨神经损伤后下肢运动功能的影响及其相关机制

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中华物理医学与康复杂志 2019年第2期41卷 139-145页

作者：王艳郭子楠董传菲朱路文刘波陈慧杰赵彬裴飞陈程程黑龙江中医药大学附属第二医院康复中心哈尔滨150001 黑龙江中医药大学研究生院康复医学与理疗学专业哈尔滨150040

目的夹脊电针结合神经松动术对兔坐骨神经损伤后下肢运动功能以及Ras相关C3肉毒素底物1的mRNA和蛋白表达的影响。方法采用随机数表法将180只新西兰家兔分为正常对照组、模型对照组、夹脊电针组、神经松动术组、夹脊电针结合神经松动术... 详细信息

目的夹脊电针结合神经松动术对兔坐骨神经损伤后下肢运动功能以及Ras相关C3肉毒素底物1的mRNA和蛋白表达的影响。方法采用随机数表法将180只新西兰家兔分为正常对照组、模型对照组、夹脊电针组、神经松动术组、夹脊电针结合神经松动术组。每组36只,再按取材时间点分为治疗1周、2周、4 周后共3个亚组,每个亚组12只新西兰家兔。模型对照组、夹脊电针组、神经松动术组、夹脊电针结合神经松动术组均采用钳夹法造成坐骨神经损伤模型,正常对照组、模型对照组不做任何干预,神经松动术组行神经松动术治疗,夹脊电针组进行夹脊电针治疗,夹脊电针结合神经松动术组进行夹脊电针和神经松动术治疗。于治疗1、2、4周后采用趾张反射评分和改良的Tarlov评分评定5组大鼠新西兰家兔的下肢功能恢复情况。并于治疗1、2、4周后,每组均抽取12只新西兰家兔放血处死后取坐骨神经和相应节段脊髓(L4-L6段),采用聚合酶链反应(PCR)检测和免疫印迹(Western blot)检测Ras相关C3肉毒素底物1 mRNA及蛋白的表达。结果治疗后1、2、4周后,夹脊电针组、神经松动术组和夹脊电针结合神经松动术组新西兰家兔的坐骨神经功能均优于模型对照组同时间点,但均弱于正常对照组同时间点,差异均有统计学意义(P<0.05);且夹脊电针结合神经松动术组各时间点的坐骨神经功能均优于夹脊电针组和神经松动术组同时间点,差异均有统计学意义(P<0.05)。经PCR灰度分析,治疗1、2、4周后,夹脊电针结合神经松动术组节段脊髓和坐骨神经中Ras相关C3肉毒素底物1mRNA的表达量高于夹脊电针组和神经松动术组同时间点,差异均有统计学意义(P<0.01)。经Western blot灰度分析,治疗1周后,夹脊电针结合神经松动术组节段脊髓Ras相关C3肉毒素底物1蛋白的表达量显著高于夹脊电针组,差异有统计学意义(P<0.01);治疗2、4周后,夹脊电针结合神经松动术组节段脊髓Ras相关C3肉毒素底物1蛋白的表达量显著高于夹脊电针组和神经松动术组同时间点,差异均有统计学意义(P<0.01)。经Western blot灰度分析,治疗2、4周后,夹脊电针结合神经松动术组坐骨神经中Ras相关C3肉毒素底物1蛋白的表达量显著高于夹脊电针组和神经松动术组同时间点,差异均有统计学意义(P<0.01)。结论神经松动术结合夹脊电针治疗可促进坐骨神经损伤后轴突再生的作用,其作用机制可能与上调损伤的坐骨神经和相应脊髓节段Ras相关C3肉毒素底物1基因以及蛋白的表达有关。

关键词：坐骨神经损伤夹脊电针神经松动术 Ras相关C3肉毒素底物1

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推拿联合康复训练治疗孤独症脾失健运型厌食的临床研究

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针灸临床杂志 2019年第4期35卷 17-20页

作者：张春艳朱路文王艳赵晓倩唐强黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001

目的:观察推拿联合康复训练治疗孤独症脾失健运型厌食的临床疗效。方法:将52例孤独症共患脾失健运型厌食患儿随机分为两组,对照组26例进行康复训练,治疗组26例在对照组的基础上联合益气健脾推拿治疗,对治疗前和治疗后的临床症状积分、AB... 详细信息

目的:观察推拿联合康复训练治疗孤独症脾失健运型厌食的临床疗效。方法:将52例孤独症共患脾失健运型厌食患儿随机分为两组,对照组26例进行康复训练,治疗组26例在对照组的基础上联合益气健脾推拿治疗,对治疗前和治疗后的临床症状积分、ABC、CARS评分及治疗后厌食疗效评估以判断临床治疗有效性。结果:8周后,两组临床积分及厌食症有效率均显著优于治疗前(P <0. 05),治疗组较对照组改善显著(P <0. 05)。两组CARS和ABC评分均高于治疗前(P <0. 05),且治疗组高于对照组(P <0. 05)。结论:益气健脾推拿法联合康复训练能治疗孤独症脾失健运型厌食问题,并且能改善孤独症的整体病情。

关键词：孤独症推拿康复训练脾失健运厌食

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腹腔镜评估晚期卵巢癌患者能否行满意的肿瘤细胞减灭术的Meta分析

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中国医药导报 2016年第29期13卷 56-62页

作者：赵鲁文于爱军张玉娟宋晓莉毛淑芳承德医学院附属医院妇科河北承德067000 承德医学院附属医院外一科河北承德067000 河北省丰宁满族自治县医院妇产科河北承德068350 承德医学院预防医学教研室河北承德067000

目的评价腹腔镜对晚期卵巢癌患者能否行满意的肿瘤细胞减灭术的诊断价值。方法计算机检索Pub Med、Embase、Cochrane Library、中国知网(CNKI)、中国生物医学文摘数据库(CBM)、万方全文数据库。检索时间从1990-01-01到2016-06-01。提取... 详细信息

目的评价腹腔镜对晚期卵巢癌患者能否行满意的肿瘤细胞减灭术的诊断价值。方法计算机检索Pub Med、Embase、Cochrane Library、中国知网(CNKI)、中国生物医学文摘数据库(CBM)、万方全文数据库。检索时间从1990-01-01到2016-06-01。提取相关数据并应用QUADAS-2工具评价文献质量。对所有研究予以加权定量合并,计算敏感度、特异度及其95%CI。绘制综合受试者工作特征曲线(SROC)。对纳入文献行敏感性分析。结果本研究共纳入11篇文献,累计腹腔镜评估1279例患者。敏感度对数与(1-特异度)对数的Spearman相关系数=-0.336,P=0.312,提示纳入研究不存在阈值效应。汇总敏感度、特异度、诊断比值比分别为100%(95%CI:99%~100%)、79%(95%CI:76%~82%)、326.43(95%CI:125.53~848.85)。SROC曲线下面积(AUC)=0.9917(SE=0.0072)。敏感性分析显示纳入的11篇文献稳定性好,结果可信。结论腹腔镜对晚期卵巢癌患者能否行满意的肿瘤细胞减灭术的评估效能较高,是一种很有前途的探查方式。

关键词：晚期卵巢癌肿瘤细胞减灭术腹腔镜 Meta分析

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Low loss and high permittivity composites based on poly(vinylidene fluoride-chlorotrifluoroethylene) and lead lanthanum zirconate titanate

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CERAMICS INTERNATIONAL 2017年第1期43卷 1504-1508页

作者： Wen, Fei Liu, Xiaoyang Xu, Zhuo Tang, Hua Bai, Wangfeng zhao, Wen-Sheng Zheng, Peng Wang, luwen Wang, Gaofeng Hangzhou Dianzi Univ Coll Elect & Informat Minist Educ Key Lab RF Circuits & Syst Hangzhou 310018 Peoples R China Xi An Jiao Tong Univ Elect Mat Res Lab Key Lab Minist Educ Xian 710049 Peoples R China Xi An Jiao Tong Univ Int Ctr Dielect Res Xian 710049 Peoples R China

Lanthanum doped lead zirconate titanate stannate antiferroelectric ceramic (Pb0.97La0.02)(Zr0.63Sn0.3Ti0.07)O-3 (PLZST) is proposed as an inorganic filler. P(VDF-CTFE)/PLZST composites with various compositions are fabricated via the solution cast process. The dielectric permittivity of the composites is significantly increased and the inherent loss is reduced in a wide range of frequencies at the same time. At 100 Hz, the 40% PLZST loaded composite shows a dielectric permittivity of 28 (3 times more than that of the neat polymer), and a low loss of 0.045 (near half of that in the neat polymer). The low loss of the composite is most likely due to the slower increasing rate of the conductivity by comparison to the dielectric permittivity.

关键词： Ceramic composites Low dielectric loss High permittivity P(VDF-CTFE)

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中文版MMAS-8测量类风湿关节炎患者用药依从性的信效度分析

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中国药房 2018年第2期29卷 263-268页

作者：吴凡赵金霞王天晟邵宏史录文北京大学药学院药事管理与临床药学系北京100191 北京大学第三医院风湿免疫科北京100191

目的:考察中文版8条目Morisky用药依从性量表(MMAS-8)测量类风湿关节炎(RA)患者用药依从性的信效度。方法:利用中文版MMAS-8就中国风湿病公众论坛微信公众号上发布的招募信息与电子版问卷作出回应的200例RA患者进行用药依从性评价,分析... 详细信息

目的:考察中文版8条目Morisky用药依从性量表(MMAS-8)测量类风湿关节炎(RA)患者用药依从性的信效度。方法:利用中文版MMAS-8就中国风湿病公众论坛微信公众号上发布的招募信息与电子版问卷作出回应的200例RA患者进行用药依从性评价,分析上述量表的项目、同质性、信度和效度。结果:量表总得分前后27%的两个极端组的8条目平均分的Levene法F检验差异均有统计学意义(P<0.001),方差不相等t检验差异均有统计学意义(P<0.001);7条目与总分的相关系数均大于0.400,且8条目与总分均显著相关(P<0.001);内部一致性系数(Cronbach’sα)为0.657,标准化Cronbach’sα为0.662;结构效度(KMO值为0.638,Bartlett’s球形检验值为246.278),采用因素分析法共提取3个公共因子,可解释总方差的58.846%;聚合效度方面中文版MMAS-8总分与用药依从性视觉模拟评分的Pearson相关系数为0.435(P<0.001)。结论:中文版MMAS-8用于测量RA患者的信效度较好。

关键词： 8条目Morisky用药依从性量表中文版类风湿关节炎用药依从性信度效度

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漏电断路器性能测试实验台研制

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实验技术与管理 2018年第7期35卷 86-89页

作者：高瑜赵建文宋璐雯魏振龙高梅西安科技大学电控学院陕西西安710054

研制一套漏电断路器测试实验台,以三相异步电动机为负载,可以测试出电动机工作电流、漏电动作电流和漏电动作时间。测试表明,实验台可以检测出漏电断路器是否合格。

关键词：漏电断路器脱扣电路漏电电流动作时间

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