作者：
Lv, NingKong, YananMu, luwenPan, TaoXie, Qiankunzhao, MingSun Yat Sen Univ
Dept Med Imaging & Intervent Radiol Collaborat Innovat Ctr Canc Med State Key Lab Oncol South ChinaCanc Ctr 651 Dongfeng Rd East Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ
Dept Breast Oncol Collaborat Innovat Ctr Canc Med State Key Lab Oncol South ChinaCanc Ctr 651 Dongfeng Rd East Guangzhou 510060 Guangdong Peoples R China
Pain is one of the most common side effects of transcatheter arterial chemoembolization (TACE) treatment. This study aimed to assess the analgesic effect of parecoxib sodium for postoperative pain control in patients ...
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Pain is one of the most common side effects of transcatheter arterial chemoembolization (TACE) treatment. This study aimed to assess the analgesic effect of parecoxib sodium for postoperative pain control in patients with inoperable hepatocellular carcinoma (HCC) undergoing TACE. This randomized placebo-controlled prospective clinical study was conducted at a single cancer centre. Patients were randomly assigned to receive parecoxib sodium (experimental group;n = 60) or 0.9 % sodium chloride (control group;n = 60) 1 h before TACE and once every 12 h for 2 days after TACE. Pain level, morphine consumption, adverse events, and quality of life were evaluated and compared between the two groups. Pain scores, percentage distribution of pain categories, and morphine consumption were significantly lower in the experimental group than in the control group (P < 0.05). Fever score comparisons revealed significantly better body temperature balance in the experimental group than in the control group (P = 0.024). Quality-of-life scores in the experimental group were significantly better than those in the control group (P < 0.05). Our results demonstrate that the perioperative administration of parecoxib significantly improved its effectiveness in the control of postoperative pain after TACE. aEuro cent Perioperative administration of parecoxib is effective for control of pain after TACE. aEuro cent COX-2 inhibitors provide effective and safe pain control. aEuro cent Parecoxib helps improve quality-of-life after TACE for patients with inoperable hepatocellular carcinoma.
In the present study, a rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of saquinavir in mice plasma and brain was developed, validated, and applied to a preliminary sc...
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In the present study, a rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of saquinavir in mice plasma and brain was developed, validated, and applied to a preliminary screening study evaluating the effect of bioflavonoids on the brain distribution of saquinavir in mice. Saquinavir and the internal standard（ritonavir） were isolated from plasma and homogenized brain tissue matrices using a liquid-liquid extraction procedure, and the chromatographic separation was accomplished by using a reversed phase C18 column（150 mm×2.1 mm, 5.0 μm）. The analyte was detected by a triple-quadrupole tandem mass spectrometer via electrospray ionization, and multiple reaction monitoring was employed to select both saquinavir and ritonavir in the positive ion mode. A linear dynamic range of 0.1–10 ng/m L for plasma samples was established and the lower limit of quantification was 0.1 ng/m L. The intra- and inter-day precision were 7.5%–12.1%, and the accuracies ranged from 90.5% to 107.2% for plasma. A linear dynamic range of 0.1–10 ng/g for brain samples was established and the lower limit of quantification was 0.1 ng/g. The intra- and inter-day precision were 7.3%–11.9%, and the accuracies ranged from 90.8% to 107.4% for brain tissue samples. This method was successfully applied a preliminary screen of 19 bioflavonoids on the brain distribution of saquinavir in mice, and biochanin A shows the strongest effect.
This paper presents a high-frequency equivalent circuit model for on-chip coupled carbon nanotube (CNT) interconnects up to 100 GHz. By simplifying the circuit model, the S-parameters of on-chip coupled interconnects ...
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This paper presents a high-frequency equivalent circuit model for on-chip coupled carbon nanotube (CNT) interconnects up to 100 GHz. By simplifying the circuit model, the S-parameters of on-chip coupled interconnects can be acquired and validated by comparing with the full-wave electromagnetic simulations. By virtue of effective complex conductivity, the high-frequency behaviors of coupled CNT interconnects are captured and studied, with the impacts of kinetic inductance treated appropriately.
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