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Assessment of the spatial association between multiple pollutants of surface water and digestive cancer incidence in China: A novel application of spatial machine learning

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ECOLOGICAL INDICATORS 2023年第1期154卷

作者： Gu, Wentao Xue, Fang Han, Wei Wang, Zixing zhao, Jing Zhang, luwen Yang, Cuihong Jiang, Jingmei Chinese Acad Med Sci Inst Basic Med Sci Dept Epidemiol & Biostat Beijing Peoples R China Peking Union Med Coll Sch Basic Med Beijing Peoples R China

Surface water pollution and digestive cancers are concerning environmental health issues. Multiple pollutants of surface water coexist within unique geospatial heterogeneous contexts of surface water flow, which can lead to complex patterns of impact on cancer incidence. This complexity has posed challenges to comprehensive assessment. In this study, we integrated nationwide surface water data of 21 pollutants collected from 3632 sections of nine large river basins and cancer incidence data for six digestive cancers covering 381.6 million people in China. Local Moran's I method was used to assess the patterns of spatial aggregation of each surface water pollutant separately to observe the local spatial nonstationarity and heterogeneity of the pollutant con-centrations in different spatial areas. A geographically weighted random forest (GWRF) model, a spatial machine learning approach, was applied to address the spatial heterogeneity of the pollutants and assess their association with cancer incidence. Goodness-of-fit and overall performance of the GWRF model were assessed by the local statistics in the out-of-bag set, such as the mean local pseudo-R2, increase in mean squared error, and local re-siduals in each local model. Compared with the aspatial random forest model, the GWRF model had better performance (mean local pseudo-R2 ranged from 0.16 (gallbladder cancer) to 0.60 (pancreatic cancer)). Surface water pollution was associated with digestive cancer incidence mainly in the Songhua and Liaohe, Haihe, and Huaihe River Basins. By focusing on these areas, we identified key pollutants specific to different cancer types. Incidence of oesophageal, stomach, colorectal, gallbladder, and pancreatic cancer was associated with common pollutants such as fluoride and arsenic. Our assessment provides targets for the government and environmental health specialists to take tailored actions to control pollution and effectively prevent cancer incidence.

关键词： Digestive cancer Surface water pollutant Spatial machine learning Spatial association China

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Fetal birthweight and maternal urinary incontinence in Chinese primiparas: a population-based study

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BMC PUBLIC HEALTH 2025年第1期25卷 1-12页

作者： Du, Yanrong Wang, Peicheng Chen, Yanhua Liu, Qing Wang, luwen Jin, Hangmei Gong, Liyan Xie, Jingyan Lai, Ting Li, Aiyang Liu, Lubin Zhou, Lifei Luan, Yanqiu Wang, Lin Li, Xiaoli Luo, Xiping Fu, Yingjie Niu, Jumin zhao, Wen Liu, Qiming zhao, Renfeng Pang, Haiyu Zhu, Jiming Zhu, Lan Tsinghua Univ Vanke Sch Publ Hlth Beijing Peoples R China Univ Liverpool Dept Publ Hlth Policy & Syst Liverpool England Gansu Prov Cent Hosp Gansu Prov Matern & Child Care Hosp Dept thorac Surg Lanzhou Peoples R China Zhengzhou Univ Affiliated Hosp 3 Dept Gynecol Zhengzhou Peoples R China Zhejiang Univ Womens Hosp Dept Gynecol Sch Med Hangzhou Peoples R China Hubei Matern & Childcare Hosp Hubei Prov Women & Children Hosp Dept Pelv Floor Rehabil Wuhan Peoples R China Nanjing Med Univ Nanjing Hosp 1 Dept Gynecol Nanjing Peoples R China Guiyang Maternal & Child Hlth Care Hosp Dept Gynecol Guiyang Peoples R China Beijing Miyun Dist Hosp Beijing Peoples R China Chongqing Med Univ Women & Childrens Hosp Dept Obstet & Gynecol Chongqing Peoples R China Shijiazhuang Maternal & Child Hlth Hosp Dept Gynecol Shijiazhuang Peoples R China Beijing Dongcheng Dist Maternal & Child Hlth Hosp Beijing Peoples R China Peoples Hosp Xinjiang Uygur Autonomous Reg Dept Gynecol Urumqi Peoples R China Shanxi Maternal & Child Hlth Hosp Dept Gynecol Taiyuan Peoples R China Guangdong Prov Women & Children Hosp Dept Gynecol Guangzhou Peoples R China Harbin Maternal & Child Hlth Care & Family Plannin Minist Womens Hlth Hangzhou 310008 Peoples R China Shenyang Womens & Childrens Hosp Dept Gynecol Shenyang Peoples R China Haidian Dist Maternal & Child Hlth Care Hosp Beijing Peoples R China Maternal & Child Hlth Hosp Yanqing Dist Dept Gynecol & Obstet Beijing 102100 Peoples R China Guangxi Acad Med Sci Peoples Hosp Guangxi Zhuang Autonomous Reg Dept Cardiol Nanning Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Peking Union Med Coll Hosp State Key Lab Common Mech Res Major Dis Inst Clin MedNatl Infrastructures Translat Med Beijing 100730 Peoples R China Tsinghua Univ Beijing Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Peking Union Med Coll Hosp Natl Clin Res Ctr Obstet & Gynecol Dis Dept Obstet & GynecolState Key Lab Common Mech Re Beijing

BackgroundUrinary incontinence (UI) is commonly linked to pregnancy and obstetric factors, but the association between fetal birthweight and maternal UI remains contentious. This study investigates the association between fetal birthweight and maternal UI and its subtypes in Chinese ***-sectional data from 54,346 women aged 20 years and above were obtained from the 2019-2021 National Urinary Incontinence Survey. Restricted cubic spline (RCS) regression analysis and threshold effect analysis were used to explore the association between fetal birthweight and urinary incontinence and its *** 19,365 primiparas, the prevalence of UI was 14.5%. Adjusted analyses revealed that each 1.0 kg increase in birthweight correlated with a 32% (95% CI: 1.21-1.44) increased risk of UI. Categorical analysis indicated that women in the highest birthweight tertile (3.4-6.0 kg) faced a higher risk of UI compared to those in the lowest tertile (0.5-3.0 kg) (adjusted OR, 1.42;95% CI: 1.28-1.57). RCS regression highlighted non-linear associations between birthweight and the risk of any type of UI, urgency UI (UUI), and mixed UI (MUI), with a significant turning point at 3.9 kg for overall UI risk. Subgroup analyses revealed interactions between birthweight tertiles and modifiable risk factors like physical activity, as well as clinical risk factors like *** findings underscore the independent association between fetal birthweight and UI in Chinese primiparas, emphasizing the importance of considering various factors when assessing this relationship. A non-linear association exists between birthweight and any type of UI, UUI, and MUI, respectively. This study offers novel insights into the potential classification strategies for fetal birthweight and call for future research to validate and comprehend the clinical implications.

关键词： Chinese primiparas Urgency urinary incontinence Mixed urinary incontinence Modifiable risk factors

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Prediction of complications associated with general surgery using a Bayesian network

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SURGERY 2023年第5期174卷 1227-1234页

作者： Yu, Xiaochu Chen, Wangyue Han, Wei Wu, Peng Shen, Yubing Huang, Yuguang Xin, Shijie Wu, Shizheng zhao, Shengxiu Sun, Hong Lei, Guanghua Wang, Zixing Xue, Fang Zhang, luwen Gu, Wentao Jiang, Jingmei Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Nephrol Beijing Peoples R China Chinese Acad Med Sci Peking Union Med Coll Sch Basic Med Inst Basic Med SciDept Epidemiol & Biostat Beijing Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Anaesthesiol Beijing Peoples R China China Med Univ Hosp 1 Dept Vasc & Thyroid Surg Shenyang Liaoning Peoples R China Qinghai Prov Peoples Hosp Inst Geriatr Xining Peoples R China Qinghai Prov Peoples Hosp Dept Nursing Xining Peoples R China Cent South Univ Xiangya Hosp Dept Otolaryngol Skull Base Surg Changsha Hunan Peoples R China Cent South Univ Xiangya Hosp Dept Orthopaed Changsha Hunan Peoples R China Chinese Acad Med Sci Peking Union Med Coll Sch Basic Med Inst Basic Med SciDept Epidemiol & Biostat 5 Dongdan Santiao St Beijing 100005 Peoples R China

Background: Numerous attempts have been made to identify risk factors for surgery complications, but few studies have identified accurate methods of predicting complex outcomes involving multiple complications. Methods: We performed a prospective cohort study of general surgical inpatients who attended 4 regionally representative hospitals in China from January to June 2015 and January to June 2016. The risk factors were identified using logistic regression. A Bayesian network model, consisting of directed arcs and nodes, was used to analyze the relationships between risk factors and complications. Probability ratios for complications for a given node state relative to the baseline probability were calculated to quantify the potential effects of risk factors on complications or of complications on other complications. Results: We recruited 19,223 participants and identified 21 nodes, representing 9 risk factors and 12 complications, and 55 direct relationships between these. Respiratory failure was at the center of the network, directly affected by 5 risk factors, and directly affected 7 complications. Cardiopulmonary resuscitation and sepsis or septic shock also directly affected death. The area under the receiver operating characteristic curve for the ability of the network to predict complications was >0.7. Notably, the probability of other severe complications or death significantly increased when a severe complication occurred. Most importantly, there was a 141-fold higher risk of death when cardiopulmonary resuscitation was required. Conclusion: We have created a Bayesian network that displays how risk factors affect complications and their interrelationships and permits the accurate prediction of complications and the creation of appropriate preventive guidelines.

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System Report for CCL23-Eval Task 1:Named Entity Recognition for Ancient Books based on Continual Pre-training Method and Context Augmentation Strategy 22

System Report for CCL23-Eval Task 1:Named Entity Recognition...

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22nd Chinese National Conference on Computational Linguistics, CCL 2023

作者： Wang, Shiquan Shi, Lingling Pu, luwen Fang, Ruiyu zhao, Yu Song, Shuangyong China Telecom Corporation Ltd. Data&AI Technology Company Beijing China

ISBN: (纸本)9781713889908

This article describes the entry system submitted by our team in the CCL23 ancient book named entity recognition evaluation. The task aims to automatically identify important entities of the basic elements of events such as names of people, titles of books, and official titles in ancient texts, and divide them into open tracks and closed tracks according to whether the model parameters used are greater than 10b. In this task, we first use the domain data and task data related to ancient books to continuously pre-train and fine-tune the open source pre-training model, which significantly improves the performance of the pedestal model on the task of named entity recognition in ancient books. Secondly, an untrusted entity screening algorithm based on pair-wise voting is proposed to obtain candidate entities, and the context enhancement strategy is used to correct entity recognition for candidate entities. In the final evaluation, our system ranked second in the closed circuit with an F1 score of 95.8727. © 2023 China National Conference on Computational Linguistics.

关键词： Computational linguistics

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The effect of multimorbidity on functional limitations and depression amongst middle-aged and older population in China: a nationwide longitudinal study

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AGE AND AGEING 2021年第1期50卷 190-197页

作者： zhao, Yang William Haregu, Tilahun Nigatu He, Li Lu, Shurong Katar, Ameera Wang, Haipeng Yao, Zhibin Zhang, luwen Univ Melbourne Melbourne Sch Populat & Global Hlth Melbourne Vic Australia Peking Univ Hlth Sci Ctr George Inst Global Hlth Beijing Peoples R China Beijing Normal Univ Coll Phys Educ & Sport Beijing Peoples R China Shandong Univ Sch Hlth Care Management Jinan Peoples R China Shandong Univ NHC Key Lab Hlth Econ & Policy Res Jinan Peoples R China Sun Yat Sen Univ Zhongshan Sch Med Dept Anat & Neurobiol Guangzhou Peoples R China Southern Med Univ Sch Hlth Serv Management Guangzhou Peoples R China

Background: multimorbidity contributes to a large portion of the disease burden in low- and middle-income countries. However, limited research has been undertaken in China. This study has investigated the prevalence of multimorbidity and the associations of multimorbidity with activities of daily living (ADL), instrumental activities of daily living (IADL) and depression in China. Methods: the study participants included 10,055 adults aged 45 years and older from three rounds of the China Health and Retirement Longitudinal Study 2011-2015. Random-effects logistic regression models were used to examine the association of multimorbidity with ADL limitation, IADL limitation and mental disease. Results: the prevalence of multimorbidity amongst adults in China aged 45 years and older was 62.1% in 2015. The prevalence of multimorbidity was increased with older age, among women, in a higher socio-economic group and in the most deprived regions. Multimorbidity is associated with an increased likelihood of experiencing ADL limitation (adjusted odds ratio [AOR]=5.738, 95% confidence intervals (CI)=5.733, 5.744) and IADL limitation (AOR=2.590, 95% CI=2.588, 2.592) and depression (AOR=3.352, 95% CI=3.350, 3.354). Rural-urban disparities in functional difficulties and depression were also found amongst patients with multimorbidity. Conclusions: the burden of multimorbidity is high in China, particularly amongst the older population. Multimorbidity is associated with higher levels of functional limitations and depression. China healthcare reforms should introduce integrated care models and patient-centred healthcare delivery. The increasing need for reorientation of healthcare resources considering the distribution of multimorbidity and its adverse effect requires more attention from health policymakers in China and other developing countries.

关键词： multimorbidity functional limitation depression older people longitudinal study

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Starch phosphate carbamate hydrogel based slow-release urea formulation with good water retentivity

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2021年第0期190卷 189-197页

作者： Dong, Guohua Mu, Zhonghua Liu, Dongni Shang, luwen Zhang, Wenzhi Gao, Yueyue zhao, Ming Zhang, Xiaohong Chen, Shijie Wei, Minghui Qiqihar Univ Coll Chem & Chem Engn Heilongjiang Ind Hemp Proc Technol Innovat Ctr Qiqihar 161006 Peoples R China Henan Univ Key Lab Photovolta Mat Kaifeng 475004 Peoples R China

In this work, a novel starch phosphate carbamate hydrogel (SPC-Hydrogel) and its corresponding urea hydrogel (SPCU-Hydrogel) slow-release fertilizer (SRF) were prepared by one-step free radical copolymerization of SPC and acrylamide (AM) without and with urea addition. A series of characterization measurements including FTIR, XRD, EDS, XPS are utilized to confirm the successful formation of the SPC-Hydrogel. The SEM shows SPCHydrogel has a porous three-dimensional network architecture. Furthermore, SPC-Hydrogel matrix exhibits superior water absorbency achieving 80.2 g/g than that (70.5 g/g) of the native starch hydrogel (NS-Hydrogel) and desirable water retention capacity in soil with a weight loss of only 48% for 13 days. Compared with pure urea and NS based urea hydrogel (NSU-Hydrogel), the SPCU-Hydrogel releases 50.3% for 15 h, achieving an almost complete release more than 25 h in aqueous phase. While only 46.6% of urea is released in 20 days which extends about 30 days in soil column assays. The maize seedlings growth assays also present an intuitive evaluation on the prominent soil water holding and plant growth promotion role of SPCU-Hydrogel. In conclusion, the present work has demonstrated a novel strategy via preparing biomass hydrogel SRF to enhance the utilization effectiveness of fertilizer and retain soil humidity.

关键词： Starch phosphate carbamate Hydrogel Slow-release fertilizer

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淮河流域地表水污染与癌症的空间关联

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中国医学科学院学报 2024年第6期46卷 849-861页

作者：赵婧韩伟郭晓波张璐雯薛芳姜晶梅中国医学科学院基础医学研究所、北京协和医学院基础学院流行病与卫生统计学系北京100005 中国医学科学院、北京协和医学院环境与健康科学中心北京100005

目的揭示淮河流域关键污染物的空间聚集模式,并基于污染分级进一步量化非消化道癌症风险和癌症负担,为淮河流域水污染的深化治理提供靶目标和数据支持。方法选取淮河流域2021年地表水质及2019年肿瘤登记年报的7种癌症发病数据,采用随机... 详细信息

目的揭示淮河流域关键污染物的空间聚集模式,并基于污染分级进一步量化非消化道癌症风险和癌症负担,为淮河流域水污染的深化治理提供靶目标和数据支持。方法选取淮河流域2021年地表水质及2019年肿瘤登记年报的7种癌症发病数据,采用随机森林-SHapley加性解释分析筛选关键污染物,基于空间分析划分污染分级,并计算其癌症风险和人群归因分数。结果筛选出5个关键污染物,分别为总磷、总氮、化学需氧量、5日生化需氧量及砷,并将其联合效应划分为3个污染分级,结果显示与低污染地区相比,高污染地区的5种癌症发病风险显著增加,包括肺癌(RR=1.26,95%CI=1.06~1.50)、乳腺癌(女性)(RR=1.46,95%CI=1.21~1.77)、胰腺癌(RR=1.46,95%CI=1.06~2.01)、脑癌(RR=1.44,95%CI=1.05~1.98)和胆囊癌(RR=1.60,95%CI=1.03~2.50),且人群归因分数几乎均超过5%。结论地表水污染的潜在癌症风险和负担不容忽视,唯有各行业密切合作,通过进一步制定政策法规、加强环境治理和进行公众健康干预,才能从根本上应对这一挑战。

关键词：淮河流域地表水污染空间分布模式污染分级癌症

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Pulmonary artery dilatation in different causes of pulmonary hypertension

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PULMONARY CIRCULATION 2023年第4期13卷 e12313-e12313页

作者： Xi, Qunying Liu, Zhihong Xiong, Changming Luo, Qin zhao, Zhihui zhao, Qing Yang, Tao Zeng, Qixian Li, Pingwei Qiu, luwen Chinese Acad Med Sci Fuwai Hosp Pulm Vasc Dis Ward Shenzhen Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Fuwai Hosp Ctr Pulm Vasc Dis Natl Ctr Cardiovasc Dis Beijing Peoples R China Chinese Acad Med Sci Fuwai Hosp Ctr Pulm Vasc Dis 167 Beilishi Rd Beijing 100037 Peoples R China

Pulmonary artery (PA) dilatation is commonly observed in patients with pulmonary hypertension (PH). However, the clinical aspects of PA dilatation in various etiology of PH remain unknown. In this study, we investigated the clinical and imaging characteristics of 1018 patients with different subtypes of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The independent determinants for all-cause death were identified using univariate and multivariate Cox proportional hazard models. PA dilatation was identified in 88.8% of the patients, and 27.2% had a PA diameter/ascending aorta diameter ratio greater than 1.5. PA diameter was shown to be significantly correlated with hemodynamic parameters and symptom duration in idiopathic PAH patients. PA diameter only correlated with pulmonary circulation volume in patients with PAH associated with congenital heart disease. PA diameter correlated with symptom duration and right ventricular end-diastolic dimension in CTEPH patients. PA diameter correlated with right ventricular end-diastolic dimension in patients with PAH associated with connective tissue disease. Only 6-min walk distance, but not PA dilatation, predicts all-cause death independently. In conclusion, PA dilatation is a common finding in PH patients. The clinical feature of PA dilatation varies greatly between PH types. PA dilatation is not associated with all-cause death.

关键词： clinical characteristics clinical classification pulmonary artery dilatation pulmonary hypertension

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Prediction of myofascial pelvic pain syndrome based on random forest model

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HELIYON 2024年第11期10卷 e31928页

作者： Yu, Hang zhao, Hongguo Liu, Dongxia Dong, Yanhua Nai, Manman Song, Yikun Liu, Jiaxi Wang, luwen Li, Lei Li, Xinbin Zhengzhou Univ Affiliated Hosp 3 Dept Obstet & Gynecol Zhengzhou 450052 Peoples R China Northwestern Polytech Univ Sch Marine Sci & Technol Xian 710072 Peoples R China

Objective: The objective is to construct a random forest model for predicting the occurrence of Myofascial pelvic pain syndrome (MPPS) and compare its performance with a logistic regression model to demonstrate the superiority of the random forest model. Methods: We retrospectively analyze the clinical data of female patients who underwent pelvic floor screening due to chronic pelvic pain at the Pelvic Floor Rehabilitation Center of the Third Affiliated Hospital of Zhengzhou University from January 2021 to December 2023. A total of 543 female patients meeting the study's inclusion and exclusion criteria are randomly selected from this dataset and allocated to the MPPS group. Furthermore, 702 healthy female patients who underwent pelvic floor screening during routine physical examinations within the same timeframe are randomly selected and assigned to the non-MPPS group. Chi-square test and rank-sum test are used to select demographic variables, pelvic floor pressure assessment data variables, and modified Oxford muscle strength grading data for logistic univariate analysis. The selected variables are further subjected to multivariate logistic regression analysis, and a random forest model is also established. The predictive performance of the two models is evaluated by comparing their accuracy, sensitivity, specificity, precision, receiver operating characteristic (ROC) curve, and area under the curve (AUC) area. Results: Based on a dataset of 1245 cases, we implement the random forest algorithm for the first time in the screening of MPPS. In this investigation, the Logistic regression model forecasts the accuracy, sensitivity, specificity, and precision of MPPS at 69.96 %, 57.46 %, 79.63 %, and 68.57 % respectively, with an AUC of the ROC curve at 0.755. Conversely, the random forest prediction model exhibits accuracy, sensitivity, specificity, and precision rates of 87.11 %, 90.66 %, 90.91 %, and 83.51 % respectively, with an AUC of the ROC curve at 0.942. The ran

关键词： Myofascial pelvic pain syndrome Random forest Logistic regression Modified Oxford muscle strength grading Pelvic floor pressure assessment

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深水工况下弧面胸墙沉箱堤的反射形态分析

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海洋工程 2023年第2期41卷 153-160页

作者：任丽婷蒋学炼赵悦郄禄文刘俊涛天津城建大学天津市土木建筑结构防护与加固重点实验室天津300384 天津水运工程勘察设计院有限公司天津300456 南京水利科学研究院江苏南京210029 河北大学建筑工程学院河北保定071002

为推广应用新型弧面胸墙沉箱堤,结合模型试验和数值模拟对比分析了深水工况下弧面胸墙沉箱堤和削角胸墙沉箱堤的反射形态。波面和波压的数值结果与试验数据吻合良好,验证了数值方法的有效性。反射系数表明,入射波浪在与弧面胸墙沉箱堤... 详细信息

为推广应用新型弧面胸墙沉箱堤,结合模型试验和数值模拟对比分析了深水工况下弧面胸墙沉箱堤和削角胸墙沉箱堤的反射形态。波面和波压的数值结果与试验数据吻合良好,验证了数值方法的有效性。反射系数表明,入射波浪在与弧面胸墙沉箱堤相互作用过程中的能量损耗最小,其反射强于削角胸墙沉箱堤。波面和流速包络图显示,两种堤型均在堤前形成了部分立波系统,腹点和节点以四分之一波长的距离增量交替出现,胸墙和直立部分产生的反射波存在相位差,导致初始腹点的位置向海侧偏移。弧面胸墙沉箱堤前叠合波的相位差影响最小,腹点包络高度最大,节点包络高度最小,反射效应最明显。两种堤型前中下层水流的周期平均速度均较小且对称,表明底床泥沙不会产生趋势性输移,但迎浪基床上方的环流系统可能引起局部冲刷。相对而言,弧面胸墙沉箱堤前的环流强度最弱,更有利于冲刷防护。

关键词：弧面胸墙沉箱堤削角胸墙沉箱堤 RANS-VOF模型反射形态周期平均速度场

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