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Spatial association of surface water quality and human cancer in China

NPJ CLEAN WATER 2023年第1期6卷 53页

作者： Wang, Zixing Gu, Wentao Guo, Xiaobo Xue, Fang zhao, Jing Han, Wei Li, Hairong Chen, Wangyue Hu, Yaoda Yang, Cuihong Zhang, luwen Wu, Peng Chen, Yali zhao, Yujie Du, Jin Jiang, Jingmei Chinese Acad Med Sci Inst Basic Med Sci Dept Epidemiol & Biostat 5 Dongdansantiao Beijing 100005 Peoples R China Peking Union Med Coll Sch Basic Med 5 Dongdansantiao Beijing 100005 Peoples R China Chinese Acad Sci Inst Geog Sci & Nat Resources Res Key Lab Land Surface Pattern & Simulat 11 A Datun Rd Beijing 100101 Peoples R China Univ Chinese Acad Sci Coll Resources & Environm 19 A Yuquan Rd Beijing 100049 Peoples R China

Little is known about the association between surface water quality and cancer incidence, especially in China. Drinking water quality has been linked to the incidence of several cancers in individual-level studies. However, few studies have attempted to examine multiple pollutants and multiple cancers at population level. This study used water monitoring and population-level cancer data from across China to examine spatial associations between water pollutants and types of cancer. We found a "dose-response" relationship between the number of pollutants present at high levels and cancer incidence. These results provide evidence of a nationwide spatial association between water quality and cancer in China. The precise relationship varies with cancers and pollutants. However, the overall consistency of the "dose-response" relationship suggests that surface water quality is an important factor in cancer incidence. Our findings highlight new issues such as the changing effects when different pollutants co-exist and an increasing number of new cancer cases partially attributable to poor water quality. Our work also points to some ways to deal with these challenges.

关键词： Water quality

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Spatial consistency of co-exposure to air and surface water pollution and cancer in China

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NATURE COMMUNICATIONS 2024年第1期15卷 7813页

作者： Jiang, Jingmei Zhang, luwen Wang, Zixing Gu, Wentao Yang, Cuihong Shen, Yubing zhao, Jing Han, Wei Hu, Yaoda Xue, Fang Chen, Wangyue Guo, Xiaobo Li, Hairong Wu, Peng Chen, Yali zhao, Yujie Du, Jin Jiang, Chengyu Chinese Acad Med Sci Peking Union Med Coll Inst Basic Med Sci Dept Epidemiol & Biostat Beijing Peoples R China Peking Union Med Coll Sch Basic Med Beijing Peoples R China Chinese Acad Med Sci Peking Union Med Coll Ctr Environm & Hlth Sci Beijing Peoples R China Chinese Acad Sci Inst Geog Sci & Nat Resources Res Key Lab Land Surface Pattern & Simulat Beijing Peoples R China Univ Chinese Acad Sci Coll Resources & Environm Beijing Peoples R China Chinese Acad Med Sci Peking Union Med Coll Dept Biochem State Key Lab Med Mol BiolInst Basic Med Sci Beijing Peoples R China

Humans can be exposed to multiple pollutants in the air and surface water. These environments are non-static, trans-boundary and correlated, creating a complex network, and significant challenges for research on environmental hazards, especially in real-world cancer research. This article reports on a large study (377 million people in 30 provinces of China) that evaluated the combined impact of air and surface water pollution on cancer. We formulate a spatial evaluation system and a common grading scale for co-pollution measurement, and validate assumptions that air and surface water environments are spatially connected and that cancers of different types tend to cluster in areas where these environments are poorer. We observe "dose-response" relationships in both the number of affected cancer types and the cancer incidence with an increase in degree of co-pollution. We estimate that 62,847 (7.4%) new cases of cancer registered in China in 2016 were attributable to air and surface water pollution, and the majority (69.7%) of these excess cases occurred in areas with the highest level of co-pollution. The findings clearly show that the environment cannot be considered as a set of separate entities. They also support the development of policies for cooperative environmental governance and disease prevention. Dissecting the associations between exposure to environmental pollution and cancer risk remains crucial. Here, the authors evaluate the impact of air and water pollution on cancer incidence in China using a spatial evaluation system and show that most excess cancer cases occurred in areas with the highest level of co-pollution.

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The Fractional CO2 Laser for the Treatment of Genitourinary Syndrome of Menopause: A Prospective Multicenter Cohort Study

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LASERS IN SURGERY AND MEDICINE 2021年第5期53卷 647-653页

作者： Li, Jingran Li, Huan Zhou, Yanfei Xie, Meiqing Miao, Yali Wang, luwen zhao, Yan Ying, Ting Hu, Yan Chen, Yu Chen, Yaxiao Sun, Xiuli Wang, Jianliu Peking Univ Dept Obstet & Gynecol Peoples Hosp South St Beijing 100044 Peoples R China Peking Univ Dept Obstet & Gynecol Shenzhen Hosp Lianhua Rd Shenzhen 518036 Guangdong Peoples R China Changsha Hosp Matern & Child Healthcare Dept Obstet & Gynecol Chengnan East Rd Changsha 410007 Hunan Peoples R China Sun Yat Sen Univ Dept Obstet & Gynecol Sun Yat Sen Mem Hosp Yanjiang West Rd Guangzhou 510120 Guangdong Peoples R China West China Second Univ Hosp Dept Obstet & Gynecol Renmin South Rd Chengdu 610041 Sichuan Peoples R China Zhengzhou Univ Dept Obstet & Gynecol Affiliated Hosp 3 Kangfuqian St Zhengzhou 450008 Henan Peoples R China Puyang Oilfield Gen Hosp Dept Obstet & Gynecol Daqing Rd Puyang 457000 Henan Peoples R China Liuzhou Matern & Child Healthcare Dept Obstet & Gynecol Sanzhong Rd Liuzhou 545001 Guangxi Peoples R China

Background and Objectives Genitourinary syndrome of menopause (GSM) is a common condition affecting of most postmenopausal women, which greatly impacks the quality of life,and need to treat. This prospective multicenter cohort study aimed to compare the efficacy and safety of the fractional carbon dioxide (CO2) laser with that of topical estrogen for vaginal treatment and relieving symptoms of genitourinary syndrome of menopause (GSM). Study Design/Materials and Methods This study included 162 postmenopausal patients who received vaginal laser or topical Estriol cream therapy between January 2017 and May 2019 at eight study centers in China. The degree of GSM-related symptoms (vaginal burning, dryness, and dyspareunia) was evaluated using the Vaginal Health Index score (VHIS) and Visual Analog Scale (VAS) at baseline, 1, 3, 6, and 12 months posttreatment. The primary endpoint was the improvement in vaginal burning, dryness, and dyspareunia at 6 months after treatment. Multivariate logistic regression was used to compare the rate of improvement in the two groups. Results At baseline, the laser and control groups showed no significant difference in the mean age, time after menopause, and the VHIS (all P > 0.05). In the laser group, compared with baseline, significant differences were seen in the VHIS after the first or second treatment session and at 1, 3, 6, and 12 months posttreatment (P < 0.01). In the control group, compared with baseline, the VHIS showed significant differences after 1, 3, and 6 months of treatment (P < 0.05). However, there was no significant difference after 3 and 6 months of follow-up between the two groups (P > 0.05). The VHIS scores were significantly higher after 1 month (16.63 +/- 2.79 vs. 15.57 +/- 2.43) and 12 months (15.72 +/- 2.59 vs. 12.12 +/- 4.08) of treatment in both the groups (P < 0.05). At 6 months after treatment, both groups showed improvement in vaginal burning, vaginal dryness, and dyspareunia (P > 0.05). The VAS findings at

关键词： genitourinary syndrome of menopause vulvovaginal atrophy vaginal burning fractional CO2 laser vaginal laser treatment

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干旱提高北苍术药材质量的生物学机制

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中国实验方剂学杂志 2023年第13期29卷 180-187页

作者：赵楷姚杰于鹏程宋孝文姚瑶何录文孟祥才黑龙江中医药大学哈尔滨150040

目的:探讨干旱胁迫提高北苍术药材质量的生物学机制,建立优质药材生产新方法。方法:采用0(CK)、5%、10%、20%聚乙二醇6000(PEG-6000)溶液浸泡北苍术鲜根,比较北苍术内活性氧(ROS)含量、抗氧化酶活性、初生代谢、次生代谢产物关键酶活性... 详细信息

目的:探讨干旱胁迫提高北苍术药材质量的生物学机制,建立优质药材生产新方法。方法:采用0(CK)、5%、10%、20%聚乙二醇6000(PEG-6000)溶液浸泡北苍术鲜根,比较北苍术内活性氧(ROS)含量、抗氧化酶活性、初生代谢、次生代谢产物关键酶活性及次生代谢产物含量的变化。结果:与对照组相比,20%PEG在处理第2天时超氧阴离子自由基(O^(-)_(2)·)、过氧化氢(H_(2)O_(2))、丙二醛(MDA)含量显著升高,分别提高172.5%、56.9%、14.7%;超氧化物歧化酶(SOD)活性无显著变化,过氧化物酶(POD)活性降低,过氧化氢酶(CAT)活性提高10.8%;3-羟基-3-甲基戊二酰辅酶A还原酶(HMGR)活性提高49.9%,而磷酸烯醇式丙酮酸羧化酶(PEPC)、乙酰辅酶A羧化酶(ACC)活性分别提高12.1%和19.0%;苍术素、β-桉叶醇、苍术酮、白术内酯Ⅱ分别提高了51.0%、36.9%、47.1%和91.5%。通过模拟干旱胁迫可引起北苍术鲜根ROS迸发,诱导出植物干旱状态下的生理状态,抗氧化系统发生较大变化,短时间内促进次生代谢产物大量合成。结论:采用PEG-6000模拟干旱胁迫可大幅度提高栽培北苍术的质量。

关键词：北苍术干旱胁迫活性氧次生代谢产物药材质量

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Construction and evaluation of networks among multiple postoperative complications

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COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 2023年 232卷 107439-107439页

作者： Shen, Yubing Zhang, luwen Wu, Peng Huang, Yuguang Xin, Shijie Zhang, Qiang zhao, Shengxiu Sun, Hong Lei, Guanghua Zhang, Taiping Han, Wei Wang, Zixing Jiang, Jingmei Yu, Xiaochu Chinese Acad Med Sci Inst Basic Med Sci Peking Union Med Coll Sch Basic MedDept Epidemiol & Biostat 5 Dongdansantiao St Beijing 100005 Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Anaesthesiol Beijing Peoples R China China Med Univ Hosp 1 Dept Vasc & Thyroid Surg Shenyang Liaoning Peoples R China Qinghai Prov Peoples Hosp Dept Neurosurg Xining Qinghai Peoples R China Qinghai Prov Peoples Hosp Dept Nursing Xining Qinghai Peoples R China Cent South Univ Dept Otolaryngol Head & Neck Surg Xiangya Hosp Changsha Hunan Peoples R China Cent South Univ Dept Orthopaed Xiangya Hosp Changsha Hunan Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg Beijing Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Nephrol 1 ShuaiFuYuan Beijing 100730 Peoples R China

Background and objective: Postoperative complications confer an increased risk of reoperation, prolonged length of hospital stay, and increased mortality. Many studies have attempted to identify the complex as-sociations among complications to preemptively interrupt their progression, but few studies have looked at complications as a whole to reveal and quantify their possible trajectories of progression. The main ob-jective of this study was to construct and quantify the association network among multiple postoperative complications from a comprehensive perspective to elucidate the possible evolution ***: In this study, a Bayesian network model was proposed to analyze the associations among 15 complications. Prior evidence and score-based hill-climbing algorithms were used to build the structure. The severity of complications was graded according to their connection to death, with the association between them quantified using conditional probabilities. The data of surgical inpatients used in this study were collected from four regionally representative academic/teaching hospitals in a prospective cohort study in ***: In the network obtained, 15 nodes represented complications or death, and 35 arcs with arrows represented the directly dependent relationship between them. With three grades classified on that ba-sis, the correlation coefficients of complications within grades increased with increased grade, ranging from -0.11 to -0.06, 0.16, and 0.21 to 0.4 in grade 1 to grade 3, respectively. Moreover, the probabil-ity of each complication in the network increased with the occurrence of any other complication, even mild complications. Most seriously, once cardiac arrest requiring cardiopulmonary resuscitation occurs, the probability of death will be up to 88.1%.Conclusions: The present evolving network can facilitate the identification of strong associations among specific complications and provides a basis for the development of targeted m

关键词： Postoperative complications Bayes? theorem Complication grading Network analysis Probability inference

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Maize starch derived boron doped carbon spheres via facile solvothermal route as the photoluminescence sensor for determination of pH and Cr(VI)

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NANOTECHNOLOGY 2022年第27期33卷 275707-275707页

作者： Zhang, Wenzhi Hao, Lijuan Shang, luwen Chai, Dong-Feng Gao, Yueyue Li, Jinlong zhao, Ming Liu, Rong Zhang, Zhuanfang Dong, Guohua Qiqihar Univ Coll Chem & Chem Engn Qiqihar 161006 Peoples R China Henan Univ Key Lab Photovolta Mat Kaifeng 475004 Peoples R China Qiqihar Univ Heilongjiang Prov Key Lab Catalyt Synth Fine Chem Qiqihar 161006 Peoples R China Qiqihar Univ Technol Innovat Ctr Ind Hemp State Market Regulat Qiqihar 161006 Peoples R China

In this work, a kind of boron doped carbon spheres (B-CSs) was successfully synthesized utilizing maize starch as carbon source and boric acid as dopant via facile solvothermal method. The chemical structure of the prepared B-CSs was systemically investigated by TEM, FT-IR, XRD, XPS and EDS. The synthesized B-CSs feature spherical structure with average size of similar to 254 nm and exhibit strong photoluminescence (PL) with maximum emission at a wavelength of similar to 453 nm under irradiation at 350 nm, leading to a quantum yield of 6.2%. Furthermore, the aqueous pH and Cr(VI) has a significantly various impact on the PL intensity of B-CSs, which can be flexibly utilized as the PL sensor for detection aqueous pH and Cr(VI) in aqueous. Particularly, the B-CSs have a desirable sensitivity and selectivity for detection of Cr(VI) with a low detection limit of similar to 0.34 mu mol l(-1). Conclusively, our work provides a novel and dual-functional fluorescent sensor for detection of the pH and toxic metal ions in water environment.

关键词： maize starch boron doped carbon spheres Cr(VI) photoluminescence sensor

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Characterization, phylogenetic analysis, and pathogenicity of a novel genotype 2 porcine Enterovirus G

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VIRUS RESEARCH 2023年第1期335卷 199185页

作者： Xiao, Dai Zhang, luwen Li, Shiqian Liang, Yixiao Wu, Rui Wen, Yiping Yan, Qigui Du, Senyan zhao, Qin Han, Xinfeng Song, Jianling Cao, Sanjie Huang, Xiaobo Sichuan Agr Univ Coll Vet Med Res Ctr Swine Dis Chengdu 611130 Peoples R China Minist Agr Sichuan Sci observat Expt Stn Vet Drugs & Vet Diag Chengdu 611130 Peoples R China Yunnan Anim Sci & Vet Inst Yunnan Trop & Subtrop Anim Virus Dis Lab Kunming 650224 Peoples R China

Enterovirus G belongs to the family Picornaviridae and are associated with a variety of animal diseases. We isolated and characterized a novel EV-G2 strain, CHN-SCMY2021, the first genotype 2 strain isolated in China. CHN-SCMY2021 is about 25 nm diameter with morphology typical of picornaviruses and its genome is 7341 nucleotides. Sequence alignment and phylogenetic analysis based on VP1 indicated that this isolate is a genotype 2 strain. The whole genome similarity between CHN-SCMY2021 and other EV-G genotype 2 strains is 78.3-86.4%, the greatest similarity is to EVG/Porcine/JPN/Iba26-506/2014/G2 (LC316792.1). Recombination analysis indicated that CHN-SCMY2021 resulted from recombination between 714,171/CaoLanh_VN (KT265894.2) and LP 54 (AF363455.1). Except for ST cells, CHN-SCMY2021 has a broad spectrum of cellular adaptations, which are susceptible to BHK-21, PK-15, IPEC-J2, LLC-PK and Vero cells. In piglets, CHN-SCMY2021 causes mild diarrhea and thinning of the intestinal wall. The virus was mainly distributed to intestinal tissue but was also found in heart, liver, spleen, lung, kidney, brain, and spinal cord. CHN-SCMY2021 is the first systematically characterized EV-G genotype 2 strain from China, our results enrich the information on the epidemiology, molecular evolution and pathogenicity associated with EV-G.

关键词： Enterovirus G Genotype 2 Virus isolation Phylogenetic analysis Pathogenicity

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Potentially inappropriate medications among older patients with Parkinson's disease: a cross-sectional analysis of a national health insurance database in China

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BMC GERIATRICS 2023年第1期23卷 827-827页

作者： Fu, Mengyuan Li, Can zhao, Zinan Ling, Kexin Gong, Zhiwen Li, Huangqianyu Li, Ting Li, Jianchun Cao, Weihang Hu, Xin Shi, luwen Jin, Pengfei Guan, Xiaodong Peking Univ Sch Pharmaceut Sci Dept Pharm Adm & Clin Pharm Beijing Peoples R China Peking Univ Int Res Ctr Med Adm Beijing Peoples R China Beijing Hosp Dept Pharm Beijing Peoples R China Natl Ctr Gerontol Beijing Peoples R China Chinese Acad Med Sci Inst Geriatr Med Beijing Peoples R China Beijing Hosp Beijing Key Lab Assessment Clin Drugs Risk & Indiv Beijing 100730 Peoples R China

BackgroundWith the rapid aging trend of China's population, the issue of drug rational use in older adults has become more and more prominent. Parkinson's disease (PD) is the one of the most common age-related neurodegenerative disorders. Pharmaceutical treatment plays a cardinal role in alleviating motor and non-motor symptoms to improve the quality of life of patients with PD. Patients with PD have complex medical needs yet little is known about the use of potentially inappropriate medications (PIM) among them in China. We quantify the prevalence of PIM use and identify its predictors among older persons with PD in *** conducted a cross-sectional analysis using a national representative database of all medical insurance beneficiaries across China, extracting records of ambulatory visits of older adults with PD between 2015 and 2017. Beneficiaries aged 65 and above were eligible for inclusion. The prevalence of patients exposed to overall PIMs and PIMs related to motor and cognitive impairment was calculated based on Beers Criteria 2015 version. Potential predictors of PIM concerning patients' characteristics were estimated using multivariate logistic *** total of 14,452 older adults with PD were included. In total, 8,356 (57.8%) patients received at least one PIM;2,464 (17.1%) patients received at least one motor-impairing PIM and 6,201 (42.9%) patients received at least one cognition-impairing PIM. The prevalence of overall PIM use was higher in patients of older age group (54.7% [65-74] vs. 59.5% [75-84;OR, 1.22;95% CI, 1.14-1.31] vs.65.5% [>= 85;OR, 1.58;95% CI, 1.38-1.80) and females (61.4% [female] vs. 55.0% [males;OR, 0.77;95% CI, 0.72-0.82).ConclusionsPrescribing PIMs for older adults with PD was common in China, especially for females and older age groups, yet younger patients were more inclined to be prescribed with motor or cognition-impaired PIMs. Our findings represent a clear target awaiting multidimensional efforts to prom

关键词： Parkinson's disease Potentially inappropriate medication PIM Motor impairment Cognitive impairment

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Pb(Sc_(1/2)Ta_(1/2))O_(3)铁电陶瓷的制备及热膨胀性能研究

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兵器材料科学与工程 2023年第5期46卷 7-11页

作者：赵永秀何春香高文杰宋璐雯杨龙海西安科技大学电气与控制工程学院陕西西安710054 西安市电气设备状态监测与供电安全重点实验室陕西西安710054

由于Pb(Sc_(1/2)Ta_(1/2))O_(3)弛豫铁电陶瓷较高的烧结温度易导致Pb挥发,固相法制备难。首先,采用钨锰铁矿法合成纯相结构的ScTaO4和Pb(Sc_(1/2)Ta_(1/2))O_(3)粉体。其次,分别采用直接埋烧法、PbO过量法、两步烧结法对陶瓷的制备工艺... 详细信息

由于Pb(Sc_(1/2)Ta_(1/2))O_(3)弛豫铁电陶瓷较高的烧结温度易导致Pb挥发,固相法制备难。首先,采用钨锰铁矿法合成纯相结构的ScTaO4和Pb(Sc_(1/2)Ta_(1/2))O_(3)粉体。其次,分别采用直接埋烧法、PbO过量法、两步烧结法对陶瓷的制备工艺进行探索。最后,对陶瓷的热膨胀性能进行分析。结果表明:直接埋烧法和PbO过量法产生了大量焦绿石相和钽氧化物,合成的主晶相较少。两步烧结法有效抑制了Pb的挥发,制备的陶瓷以立方钙钛矿相为主。随温度升高,热应变呈现升高趋势,在-150~150℃内,其值为正。热膨胀率与温度的关系图为V型,约为-30℃时热膨胀系数最低,其值为负。

关键词： Pb(Sc_(1/2)Ta_(1/2))O_(3)陶瓷相结构两步烧结法热膨胀性能

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Identification Model for Needy Undergraduates Based on FFM

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Applied Mathematics 2020年第1期11卷 8-22页

作者： luwen Hu Xiaoyong zhao Shihao Fan Yufeng Gui College of Science Wuhan University of Technology Wuhan China Shanghai Xuhui High School Shanghai China

In recent years, as the enrollment rate of Chinese colleges has increased year by year, the identification of needy undergraduates has become increasingly important. However, the traditional way to identify college students with financial difficulties mainly relies on manual review and collective voting, which easily causes subjectivity and randomness. To alleviate the problem above, this paper establishes an automatic identification model for needy undergraduates based on the 1842 questionnaires collected from undergraduates in WHUT. Firstly, this paper filters the questionnaire preliminary using the local outlier factor algorithm. Secondly, this paper combines mutual information, Spearman rank correlation coefficient and distance correlation coefficient by rank-sum ratio to select features for eliminating noise from irrelevant features. Thirdly, this paper trains filed-aware factor machine model and compares it with other models, such as Logistic Regression, SVM, etc. Eventually, this paper finds that filed-aware factor machine performers much better than other models in the identification of needy undergraduates, and prominent features affecting the identification of needy undergraduates are the year of the family income, cost of living provided parents, etc.

关键词： Local Outlier Factor Rank-Sum Ratio Field-Aware Factor Machine Identification Model for Needy Undergraduates

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