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Clinical outcomes of modified transarterial chemoembolization vs. drug-eluting bead transarterial chemoembolization as initial treatment for single hepatocellular carcinoma: a propensity score matching analysis

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ANNALS OF MEDICINE 2024年第1期56卷 2423787页

作者： Chang, Boyang zhou, Churen Liu, Chengcheng Mu, luwen Huang, Mingsheng Bai, Mingjun Sun Yat Sen Univ Affiliated Hosp 3 Dept Intervent Radiol Guangzhou 510630 Guangdong Peoples R China Sun Yat Sen Univ Affiliated Hosp 3 Dept Hematol Guangzhou Guangdong Peoples R China

Background & aims: Optimizing transarterial chemoembolization (TACE) can enhance treatment efficacy for hepatocellular carcinoma (HCC). This study compares modified TACE (M-TACE), which combines a lipiodol-based emulsion and drug-eluting beads, with drug-eluting bead TACE (DEB-TACE) as initial therapies for solitary HCC. Methods: In this retrospective study, 185 patients undergoing M-TACE or DEB-TACE were evaluated. Propensity score matching was used to create 69 balanced pairs. Initial tumor response, repeated treatments within six months, local tumor progression (LTP), overall survival (OS), and adverse events (AEs) were assessed. Results: M-TACE exhibited significantly higher initial complete response (CR) rates (39.1% vs. 23.2%, p = 0.043) and fewer repeated treatments within six months (1.7 +/- 0.9 vs. 2.1 +/- 0.7;p = 0.033) compared to DEB-TACE. LTP rates were notably lower with M-TACE at 12 months (39.1% vs. 65.2%, p = 0.002), and median time to LTP was prolonged with M-TACE (13.3 vs. 8.2 months, p = 0.038). Stratified analysis revealed a significantly longer OS in individuals achieving a CR after the initial M-TACE (50.5 vs. 33.4 months, p = 0.043). However, the overall study population did not exhibit a significant difference in OS between the two groups. Comparable AEs (all p > 0.05) were observed. Conclusions: M-TACE showed higher initial CR rates, lower LTP rates, and extended time to LTP compared to DEB-TACE, indicating its potential to enhance TACE effectiveness for solitary HCC.

关键词： Carcinoma hepatocellular treatment outcome chemoembolization therapeutic

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Strong concordance between percent inhibition in oocyst and sporozoite intensities in a Plasmodium falciparum standard membrane-feeding assay

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PARASITES & VECTORS 2019年第1期12卷 1-8页

作者： Miura, Kazutoyo Swihart, Bruce J. Deng, Bingbing zhou, luwen Pham, Thao P. Diouf, Ababacar Fay, Michael P. Long, Carole A. NIAID Lab Malaria & Vector Res NIH 12735 Twinbrook Pkwy Rockville MD 20852 USA NIAID Biostat Res Branch NIH 5601 Fishers Lane Rockville MD 20852 USA

BackgroundEffective malaria transmission-blocking vaccines (TBVs) can support malaria eradication programmes, and the standard membrane-feeding assay (SMFA) has been used as a gold standard assay for TBV development. However, in SMFA, the inhibitory activity is commonly measured at oocyst stage of parasites, while it is the sporozoites which transmit malaria from a mosquito to a human. A handful of studies have shown that there is a positive correlation between oocyst and sporozoite intensities. However, no study has been completed to compare inhibition levels in oocyst and sporozoite intensities in the presence of transmission-blocking (TB) *** falciparum NF54 gametocytes were fed to Anopheles stephensi mosquitoes with or without anti-Pfs25 or anti-Pfs48/45 TB antibodies in 15 independent assays. For each group, a portion of the mosquitoes was dissected for oocyst counts (day 8 after feed), and a portion of the remaining mosquitoes was dissected for sporozoite counts (day 16). This study covered a large range of oocyst and sporozoite intensities: 0.2 to 80.5 on average for oocysts, and 141 to 77,417 for sporozoites. The sporozoite data were well explained by a zero-inflated negative binomial model, regardless of the presence or absence of TB antibodies. Inhibition levels in both oocyst and sporozoite intensities were determined within the same groups in 9 independent assays. When the level of inhibition in sporozoite number (expressed as Log Mean Ratio, LMR;average number in a control group was divided by the one in a test group, then took a log of the ratio) was plotted against LMR in oocyst number, the best-fit slope of a linear regression was not different from 1 (the best estimate, 1.08;95% confidence interval, 0.87 to 1.29). Furthermore, a Bland-Altman analysis showed a strong agreement between inhibitions in oocysts and in *** results indicate that percent inhibition in oocyst intensity of a test sample can be d

关键词： Malaria Transmission-blocking vaccine Standard membrane-feeding assay Oocyst Sporozoite

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Parameters optimization of the parallel and series mode ultrasonic atomizer on the ammonia-water absorption system

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INTERNATIONAL JOURNAL OF THERMAL SCIENCES 2024年 199卷

作者： zhou, Runfa Gu, Renjie Wang, Minqi Qin, luwen Li, Shuhong Zhang, Houlei Li, Yanjun Southeast Univ Sch Energy & Environm Nanjing 210096 Jiangsu Peoples R China Nanjing Univ Sci & Technol Sch Energy & Power Engn Nanjing 210092 Jiangsu Peoples R China Jiangsu Prod Qual Testing & Inspection Inst Nanjing 210007 Jiangsu Peoples R China Jiangsu Sunpower Technol Co Ltd Nanjing 211112 Jiangsu Peoples R China

The application of the ammonia-water absorption refrigeration systems is limited by the absorption effect of the absorber. Installing atomizer at the absorber can significantly enlarge the liquid-vapor contact area. In this paper, we develop a mathematical model of system energy consumption coupled to absorption process, in which the effect of the atomizer on the mass and heat transfer is taken into account. The effect of the droplet parameters on the absorption effect and the energy efficiency of the system are discussed separately for the parallel and series installing strategies. Although the size reduction can improve the absorption effect, the increment of ammonia absorbed rate changes insignificantly with a smaller diameter of droplets. For each droplet diameter, a larger atomization ratio for the series model implies better absorption, but there is an optimal atomization ratio for the parallel model to reach the maximum ammonia absorbed rate, and the relationship between the droplets diameter and atomization ratio is also introduced. Meanwhile, the primary energy efficiency is used as an evaluation metric, then the droplets parameters in parallel and series modes are optimized by taking into account the energy input of the atomizer. The optimal parameter combination of parallel model is droplets diameter of 12.4 mu m and atomization ratio of 0.823. At this time, the atomizer power is 0.51 W, and the system PEE is increased by 35.99 %. Whereas, the optimal atomizer power is a function of the droplet size in the series mode. As the droplets diameter of 0-100 mu m, the optimal atomizer power decreased and the maximum value of the PEE increased with the droplet diameter.

关键词： Absorption refrigeration system Falling film absorber Ultrasonic atomizer Ammonia absorbed rate

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Effect of Dual-frequency ultrasonic on subcooled water freezing

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INTERNATIONAL JOURNAL OF REFRIGERATION 2023年 154卷 1-8页

作者： Zilei, Zhao Runfa, zhou Zhenghao, Jin luwen, Qin Shuhong, Li Yanjun, Li Southeast Univ Sch Energy & Environm Nanjing 210096 Peoples R China Jiangsu Prod Qual Testing & Inspect Inst Nanjing 210007 Peoples R China

Ultrasonic-assisted freezing has received much attention for its outstanding capability to improve freezing performance. However, most researchers focus only on single-frequency ultrasound, lacking research on dualfrequency or multi-frequency ultrasound. Based on the relevant theory of the promotion of solution crystallization by ultrasound wave, this paper experimentally studied the subcooling degree and time of water freezing under the action of ultrasound. The experimental study was carried out on the production of ice from water by using different ultrasonic waves under a specific power. The results show that the effect of ultrasound with specific frequency combinations can improve the speed of water freezing and reduce the subcooling degree. When the experimental conditions are 28+33 kHz and 60 W, the comprehensive performance is the best. Compared with the condition without ultrasound, the subcooling degree is reduced by 5.28 K, and the time required for the complete solidification of water into ice was reduced by a duration of 60 s.

关键词： ultrasonic wave freezing ice subcooling degree

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3D Simulation of Edge Diffraction of Sound Barrier in Substation 6

3D Simulation of Edge Diffraction of Sound Barrier in Substa...

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6th International Conference on Energy, Power and Grid, ICEPG 2024

作者： zhou, Yuxin Ou, Quanye Xu, luwen Wang, Guangming State Grid Chongqing Electric Power Research Institute Chongqing China Northwestern Polytechnical University School of Marine Science and Technology Xi'an China

ISBN: (纸本)9798350377798

With the development of urbanization, substations have started to be built in urban areas where the population is concentrated. In order to effectively control the noise pollution from substations, sound barriers are built inside the substations to block the propagation of noise, so the sound insulation value of the sound barriers becomes an important indicator. However, the edge diffraction phenomenon will lead to errors between the real sound attenuation and the laboratory measurement value. The classical geometrical diffraction theory is a commonly used method to estimate the sound attenuation from edge of the barrier. However, it is a 2D model which cannot be used for 3D problem. In order to correctly estimate the sound attenuation in a 3D environment, this paper conducts relevant research. Firstly, it investigates the influencing factors of sound attenuation caused by the edge diffraction. Then, a 3D simulation model based on the classical 2D geometric diffraction theory is proposed. The accuracy of the model is verified by simulation test and experimental test for barriers with different shapes. The results show that the model is capable of giving satisfied estimations of the edge diffraction from the sound barrier in substation. © 2024 IEEE.

关键词： Sound insulation

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Exercise preconditioning mitigates Ischemia-Reperfusion injury in rats by enhancing mitochondrial respiration

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NEUROSCIENCE 2024年 562卷 64-74页

作者： Liang, Runyu Hou, Xinlei zhou, Daguo Zhu, luwen Teng, Lili Song, Wenjing Tang, Qiang Heilongjiang Univ Chinese Med Harbin Peoples R China Heilongjiang Univ Chinese Med Affiliated Hosp 2 Harbin Peoples R China Xiamen Univ Xiangan Hosp Xiamen Peoples R China

Cerebral ischemia and subsequent reperfusion damage are prevalent in clinical practice, linked to numerous neurodegenerative diseases. Cerebral ischemia deprives brain tissue of essential oxygen and nutrients, disrupting energy metabolism and causing cellular dysfunction. Although reperfusion theoretically aids recovery, it instead initiates complex injury responses such as oxidative stress, apoptosis, and inflammation, worsening brain damage. Recent research suggests that enhancing neuronal energy status by modulating energy metabolism pathways can effectively counter these effects. For instance, boosting mitochondrial function, improving energy provision, and decreasing harmful metabolites can mitigate oxidative stress and cellular injury. This study investigated the protective effects of exercise preconditioning against ischemia-reperfusion injury in rats. It was observed that exercise enhances energy levels and mitochondrial respiration by upregulating the expression of COX4 and NAMPT proteins and activating AMPK and mitochondrial complex V. This process facilitates metabolic reprogramming characterized by the promotion of oxidative phosphorylation (OXPHOS) and the pentose phosphate pathway (PPP), alongside a reduction in glycolysis. Such reprogramming reduces harmful metabolites, mitigating apoptosis and oxidative stress, and is a key factor in alleviating acute ischemic hypoxia-induced brain damage. These findings introduce a novel therapeutic approach for ischemic brain reperfusion injury, underscoring the crucial role of ATP production and metabolic regulation in neuroprotection.

关键词： Cerebral Ischemia/Reperfusion Exercise preconditioning Metabolic reprogramming Oxidative stress Apoptosis

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Identification of domains within Pfs230 that elicit transmission blocking antibody responses

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VACCINE 2019年第13期37卷 1799-1806页

作者： Tachibana, Mayumi Miura, Kazutoyo Takashima, Eizo Morita, Masayuki Nagaoka, Hikaru zhou, luwen Long, Carole A. King, C. Richter Torii, Motomi Tsuboi, Takafumi Ishino, Tomoko Ehime Univ Proteosci Ctr Div Mol Parasitol Toon Ehime 7910295 Japan NIAID Lab Malaria & Vector Res NIH 12735 Twinbrook Pkwy Rockville MD 20852 USA Ehime Univ Proteosci Ctr Div Malaria Res Bukyo Cho Matsuyama Ehime 7908577 Japan PATHs Malaria Vaccine Initiat MVI Washington DC 20001 USA

A transmission-blocking vaccine (TBV) against Plasmodium falciparum is likely to be a valuable tool in a malaria eradication program. Pfs230 is one of the major TBV candidates, and multiple Pfs230-based vaccines induced antibodies, which prevented oocyst formation in mosquitoes as determined by a standard membrane-feeding assay (SMFA). Pfs230 is a >300 kDa protein consisting of 14 cysteine motif (CM) domains, and the size and cysteine-rich nature of the molecule have hampered its production as an intact protein. Except for one early study with maltose-binding protein fusion Pfs230 constructs expressed in Esherichia coli, all other studies have focused on only the first four CM domains in the Pfs230 molecule. To identify all possible TBV candidate domains, we systematically produced either single-CM-domain (a total of 14), 2-CM-domain (7), or 4-CM-domain (6) recombinant protein fragments using a eukaryotic wheat germ cell-free expression system (WGCFS). In addition, two more constructs which covered previously published regions, and an N-terminal prodomain construct spanning the natural cleavage site of Pfs230 were produced. Antisera against each fragment were generated in mice and we evaluated the reactivity to native Pfs230 protein by Western blots and immunofluorescence assay (IFA), and functionality by SMFA. All 30 WGCFS-produced Pfs230 constructs were immunogenic in mice. Approximately half of the mouse antibodies specifically recognized native Pfs230 by Western blots with variable band intensities. Among them, seven antibodies showed higher reactivities against native Pfs230 determined by IFA. Interestingly, antibodies against all protein fragments containing CM domain 1 displayed strong inhibitions in SMFA, while antibodies generated using constructs without CM domain 1 showed no inhibition. The results strongly support the concept that future Pfs230-based vaccine development should focus on the Pfs230 CM domain 1. (C) 2019 The Authors. Published by Elsevier L

关键词： Malaria Pfs230 Plasmodium falciparum Transmission-blocking vaccine Wheat germ cell-free system

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Wood-derived carbon electrode modified with sulfuric acid-dispersed graphene oxide for high-performance supercapacitors

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JOURNAL OF ENERGY STORAGE 2025年 117卷

作者： Fan, luwen Sun, Jingru Shi, Huimin Qu, Hongyang Yang, Jie Li, Chuanpeng Mu, Jiajia zhou, Xiaoming Sheng, Lizhi Beihua Univ Coll Mat Sci & Engn Dept Mat Jilin 132013 Peoples R China Beihua Univ Wood Mat Sci & Engn Key Lab Jilin Prov Jilin 132013 Peoples R China Natl Univ Singapore Dept Mat Sci & Engn Singapore 117574 Singapore Beihua Univ Coll Sci Jilin 132013 Peoples R China Jilin Inst Chem Technol Key Lab Special Funct Mat Jilin Prov Univ Jilin 132022 Peoples R China

Nowadays, wood has gained popularity in the field of energy storage due to its availability, renewability and environmental friendliness. The original hierarchical porous structure of wood can be well preserved after carbonization, and carbonized wood (CW) exhibits excellent electrical conductivity and low curvature. This makes CW suitable for direct use as both an active material and a current collector in supercapacitors. However, the pore size of CW is relatively large, leading to inefficient use of pores space and limiting the number of active sites, thus reducing its specific capacity. To optimize the utilization of CW's channel space, we investigated the filling of its channels with reduced graphene oxide (RGO) and prepared the RGO@CW electrode. To prevent RGO stacking and aggregation within the CW channels, sulfuric acid was added to the graphene oxide (GO) impregnation solution, and investigated the effects of varying sulfuric acid concentrations on the electrochemical performance of the produced electrode. The prepared HRGO/CW-1 electrode demonstrated an area specific capacitance of up to 4680 mF cm- 2 at a current density of 5 mA cm- 2. The assembled symmetric supercapacitors (SSCs) exhibited excellent energy densities in both neutral and alkaline systems, reaching 12.12 Wh kg- 1 (0.85 mWh cm- 2) and 3.35 Wh kg- 1 (0.23 mWh cm- 2), respectively. Moreover, the SSCs maintained 97.6 % of their capacity after 20,000 cycles in a 1 M Na2SO4 electrolyte, indicating their excellent cycle stability. This study not only enhances the understanding of wood as an energy storage medium, but also provides valuable insights for sustainable energy storage solutions.

关键词： Carbonized wood Pore structure Reduced graphene oxide Supercapacitor

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Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages

COMMUNICATIONS BIOLOGY

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COMMUNICATIONS BIOLOGY 2022年第1期5卷 773页

作者： Huang, Wei-Chiao Mabrouk, Moustafa T. zhou, luwen Baba, Minami Tachibana, Mayumi Torii, Motomi Takashima, Eizo Locke, Emily Plieskatt, Jordan King, C. Richter Coelho, Camila H. Duffy, Patrick E. Long, Carole Tsuboi, Takafumi Miura, Kazutoyo Wu, Yimin Ishino, Tomoko Lovell, Jonathan F. SUNY Buffalo Dept Biomed Engn Univ Buffalo Buffalo NY 14260 USA Natl Inst Allergy & Infect Dis Natl Inst Hlth Lab Malaria & Vector Res Rockville MD 20852 USA Ehime Univ Div Mol Parasitol Proteo Sci Ctr Toon Ehime 7910295 Japan Ehime Univ Div Malaria Res Proteo Sci Ctr Matsuyama Ehime 7908577 Japan PATHs Malaria Vaccine Initiat MVI Washington DC 20001 USA Natl Inst Allergy & Infect Dis Natl Inst Hlth Lab Malaria Immunol & Vaccinol Rockville MD 20852 USA Tokyo Med & Dent Univ Dept Parasitol & Trop Med Bunkyo Ku Tokyo 1138510 Japan

Co-display of two P. falciparum malaria vaccine antigens (Pfs230D1+ and CSP) on the surface of immunogenic liposomes results in functional immune responses upon immunization of mice and rabbits. Combining both antigens produces immune responses that both block transmission and prevent infection. A vaccine targeting multiple stages of the Plasmodium falciparum parasite life cycle is desirable. The sporozoite surface Circumsporozoite Protein (CSP) is the target of leading anti-infective P. falciparum pre-erythrocytic vaccines. Pfs230, a sexual-stage P. falciparum surface protein, is currently in trials as the basis for a transmission-blocking vaccine, which inhibits parasite development in the mosquito vector. Here, recombinant full-length CSP and a Pfs230 fragment (Pfs230D1+) are co-displayed on immunogenic liposomes to induce immunity against both infection and transmission. Liposomes contain cobalt-porphyrin phospholipid (CoPoP), monophosphoryl lipid A and QS-21, and rapidly bind His-tagged CSP and Pfs230D1+ upon admixture to form bivalent particles that maintain reactivity with conformational monoclonal antibodies. Use of multicolor fluorophore-labeled antigens reveals liposome binding upon admixture, stability in serum and enhanced uptake in murine macrophages in vitro. Bivalent liposomes induce humoral and cellular responses against both CSP and Pfs230D1+. Vaccine-induced antibodies reduce parasite numbers in mosquito midguts in a standard membrane feeding assay. Mice immunized with liposome-displayed antigens or that passively receive antibodies from immunized rabbits have reduced parasite liver burden following challenge with transgenic sporozoites expressing P. falciparum CSP.

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Reply to 'Early shaping of a leaf'

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NATURE PLANTS 2018年第9期4卷 620-621页

作者： Feng, Shiliang zhou, luwen Lu, Shouqin Long, Mian Jiao, Yuling Ningbo Univ Fac Mech Engn & Mech Ningbo Zhejiang Peoples R China Chinese Acad Sci Inst Mech Key Lab Micrograv Natl Micrograv LabCtr Biomech & Bioengn Beijing Peoples R China Chinese Acad Sci Inst Mech Beijing Key Lab Engn Construct & Mechanobiol Beijing Peoples R China Chinese Acad Sci Inst Genet & Dev Biol State Key Lab Plant Genom Beijing Peoples R China

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