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临床心身疾病杂志 2024年第6期30卷 1-5页

作者：何堂礼周健张露文商丘市第二人民医院河南商丘476000 新乡医学院第二附属医院河南新乡453000

目的探讨双相情感障碍(BD)抑郁发作患者血清微小核糖核酸(miRNA)-318-3p(miR-381-3p)表达水平及其临床意义。方法选取2020年1月~2022年3月商丘市第二人民医院收治的BD抑郁发作患者(抑郁发作组)和BD躁狂发作患者(躁狂发作组)各140例,另招... 详细信息

目的探讨双相情感障碍(BD)抑郁发作患者血清微小核糖核酸(miRNA)-318-3p(miR-381-3p)表达水平及其临床意义。方法选取2020年1月~2022年3月商丘市第二人民医院收治的BD抑郁发作患者(抑郁发作组)和BD躁狂发作患者(躁狂发作组)各140例,另招募140名健康志愿者设为健康组。检测三组受试者血清miR-381-3p表达水平,并比较不同临床特征BD抑郁发作患者血清miR-381-3p表达水平。采用汉密顿抑郁量表(HAMD-17)、杨氏躁狂评定量表(YMRS)及简易智能精神状态检查量表(MMSE)评定三组受试者抑郁、躁狂和认知功能状况。采用Pearson法分析BD抑郁发作患者血清miR-381-3p表达水平与HAMD-17、YMRS及MMSE评分的相关性。结果抑郁发作组、躁狂发作组患者的血清miR-381-3p表达水平均高于健康组,且抑郁发作组高于躁狂发作组(P<0.01)。病程≥3 a、发作次数≥5次、本次抑郁发作持续时间≥6个月、HAMD-17评分>24分的抑郁发作组患者血清miR-381-3p表达水平分别高于病程<3 a、发作次数<5次、本次抑郁发作持续时间<6个月、HAMD-17评分≤24分的患者(P<0.01)。抑郁发作组患者的HAMD-17评分高于躁狂发作组与健康组,YMRS评分低于躁狂发作组,MMSE评分低于躁狂发作组和健康组;躁狂发作组患者YMRS评分高于健康组,MMSE评分低于健康组(P<0.01)。Pearson相关性分析结果显示,抑郁发作组患者血清miR-381-3p表达水平与HAMD-17、YMRS评分均呈正相关,与MMSE评分呈负相关(P<0.01)。结论miR-381-3p在BD抑郁发作患者血清中呈高表达,表达水平与患者抑郁程度呈正相关,且损害患者的认知功能。miR-381-3p有望成为评估BD抑郁发作患者疾病进展及治疗效果的参考指标。

关键词：双相情感障碍抑郁发作微小核糖核酸-318-3p 认知功能

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Secular trend analysis of antibiotic utilisation in China's hospitals 2011-2018, a retrospective analysis of procurement data

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ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL 2020年第1期9卷 53-53页

作者： Wushouer, Haishaerjiang zhou, Yue Zhang, Xi Fu, Mengyuan Fan, Daiming Shi, luwen Guan, Xiaodong Chinese Acad Engn Ctr Strateg Studies 2 Bingjiaokou HuTong Beijing 100088 Peoples R China Tsinghua Univ Sch Med 30 Shuangqing Rd Beijing 100084 Peoples R China Peking Univ IRCMA 38 Xueyuan Rd Beijing 100191 Peoples R China Peking Univ Sch Pharmaceut Sci Dept Pharm Adm & Clin Pharm 38 Xueyuan Rd Beijing 100191 Peoples R China Air Force Mil Med Univ Xijing Hosp Digest Dis Natl Clin Res Ctr Digest Dis State Key Lab Canc Biol 15 Changlexi Rd Xian 710032 Peoples R China Harvard Med Sch Dept Populat Med 133 Brookline Ave Boston MA 02215 USA Harvard Pilgr Hlth Care Inst 133 Brookline Ave Boston MA 02215 USA

Background This study was aimed to explore the secular trends of antibiotic utilisation in China's hospitals over an 8-year period. Methods We retrospectively analysed aggregated monthly antibiotic procurement data of 586 hospitals from 28 provinces in China from January 2011 to December 2018. Information including generic name, procurement amount, dosage form, strength, the route of administration, and geographical data were collected. Population weighted antibiotic utilisation were expressed in DDD per 1000 inhabitants per day (DID). WHO's 'Access, Watch, Reserve' categorization was also adopted to analyse antibiotic utilisation. Results Between 2011 and 2018, total antibiotic utlisation in China's hospitals increased by 39.6% (from 4.8 DID in 2010 to 6.7 DID in 2018). Antibiotic utilisation was stable or had moderately decreased in 13 provinces, while in the other 15 provinces they had substantially increased. Cephalosporins were the most consumed antibiotics, accounting for 26.9% of the total antibiotic utilisation (1.8 DID/6.7 DID). In 2018, antibiotics in the Access category comprised 19.4% of the total utilisation (1.3 DID/6.7 DID), where antibiotics in the Watch category comprised the largest proportion of 71.6% (4.8 DID/6.7 DID). Population-weighted antibiotic utlisation was greater in secondary hospitals than in tertiary hospitals (7.3 DID vs 6.6 DID). The utilisation of oral forms was almost two times the amount of parenteral forms in secondary hospitals, whereas in tertiary hospitals the amounts were about the same. Conclusions Despite efforts have been made towards restricting antibiotic use by the Chinese government, antibiotic utilisation demonstrated an upward trend after the medical reform. The increase of last-resort antibiotics raises serious concern for public health. Current patterns of antibiotic utilisation demonstrated that gaps are existed towards the global target set up by the WHO. To better facilitate proper antibiotic use, more efforts a

关键词： Trend Antibiotic Utilisation Hospitals China

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Dissipative particle dynamics simulation of flow through periodic arrays of circular micropillar

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Applied Mathematics and Mechanics(English Edition) 2016年第11期37卷 1431-1440页

作者： luwen zhou Yuqian ZHANG Xiaolong DENG Moubin LIU Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Cancer Institute and Hospital Chinese Academy of Medical SciencesBeiiing 100021China Beijing Computational Science Research Center Beijing 100084China College of Engineering Peking UaiversityBeijing 100871China

Flow through arrays of micropillar embedded inside microfluidic chip systems is important for various microfluidic devices. It is critical to accurately predict the mass flow rate through pillar arrays based on the pillar design. This work presents a dissipative particle dynamics （DPD） model to simulate a problem of flow across periodic arrays of circular micropillar and investigates the permeability of two types of micropillar arrays. The flow fields including horizontal and vertical velocity fields, the number density field, and the streamline of the flow are analyzed. The predicted solid volumes by the presented DPD simulation of both types of arrays are quite close to the actual counterparts. These quantitative agreements show usefulness and effectiveness of the DPD model in simulating arrays of micropillar. By comparing two types of micropillar arrangement patterns, we find that the arrangement pattern of micropillar does not have significant influence on the permeability of the array.

关键词： array of micropillar permeability dissipative particle dynamics （DPD）

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Mechanical remodeling of normally sized mammalian cells under a gravity vector

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FASEB JOURNAL 2017年第2期31卷 802-813页

作者： Zhang, Chen zhou, luwen Zhang, Fan Lu, Dongyuan Li, Ning Zheng, Lu Xu, Yanhong Li, Zhan Sun, Shujin Long, Mian Chinese Acad Sci Ctr Biomech & Bioengn Key Lab Micrograv Natl Micrograv Lab Beijing Peoples R China Chinese Acad Sci Inst Mech Beijing Key Lab Engn Construct & Mechanobiol Beijing Peoples R China Chinese Acad Sci Inst Mech 15 North 4th Ring Rd Beijing 100190 Peoples R China

Translocation of the dense nucleus along a gravity vector initiates mechanical remodeling of a cell, but the underlying mechanisms of cytoskeletal network and focal adhesion complex (FAC) reorganization in a mammalian cell remain unclear. We quantified the remodeling of an MC3T3-E1 cell placed in upward-, downward-, or edge-on-orientated substrate. Nucleus longitudinal translocation presents a high value in downward orientation at 24 h or in edge-on orientation at 72 h, which is consistent with orientation-dependent distribution of perinuclear actin stress fibers and vimentin cords. Redistribution of total FAC area and fractionized super mature adhesion number coordinates this dependence at short duration. This orientation-dependent remodeling is associated with nucleus flattering and lamin A/C phosphorylation. Actin depolymerization or Rho-associated protein kinase signaling inhibition abolishes the orientation dependence of nucleus translocation, whereas tubulin polymerization inhibition or vimentin disruption reserves the dependence. A biomechanical model is therefore proposed for integrating the mechanosensing of nucleus translocation with cytoskeletal remodeling and FAC reorganization induced by a gravity vector.

关键词： gravity-directed mechanosensing nucleus translocation cytoskeletal remodeling FAC reorganization

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The Fractional CO2 Laser for the Treatment of Genitourinary Syndrome of Menopause: A Prospective Multicenter Cohort Study

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LASERS IN SURGERY AND MEDICINE 2021年第5期53卷 647-653页

作者： Li, Jingran Li, Huan zhou, Yanfei Xie, Meiqing Miao, Yali Wang, luwen Zhao, Yan Ying, Ting Hu, Yan Chen, Yu Chen, Yaxiao Sun, Xiuli Wang, Jianliu Peking Univ Dept Obstet & Gynecol Peoples Hosp South St Beijing 100044 Peoples R China Peking Univ Dept Obstet & Gynecol Shenzhen Hosp Lianhua Rd Shenzhen 518036 Guangdong Peoples R China Changsha Hosp Matern & Child Healthcare Dept Obstet & Gynecol Chengnan East Rd Changsha 410007 Hunan Peoples R China Sun Yat Sen Univ Dept Obstet & Gynecol Sun Yat Sen Mem Hosp Yanjiang West Rd Guangzhou 510120 Guangdong Peoples R China West China Second Univ Hosp Dept Obstet & Gynecol Renmin South Rd Chengdu 610041 Sichuan Peoples R China Zhengzhou Univ Dept Obstet & Gynecol Affiliated Hosp 3 Kangfuqian St Zhengzhou 450008 Henan Peoples R China Puyang Oilfield Gen Hosp Dept Obstet & Gynecol Daqing Rd Puyang 457000 Henan Peoples R China Liuzhou Matern & Child Healthcare Dept Obstet & Gynecol Sanzhong Rd Liuzhou 545001 Guangxi Peoples R China

Background and Objectives Genitourinary syndrome of menopause (GSM) is a common condition affecting of most postmenopausal women, which greatly impacks the quality of life,and need to treat. This prospective multicenter cohort study aimed to compare the efficacy and safety of the fractional carbon dioxide (CO2) laser with that of topical estrogen for vaginal treatment and relieving symptoms of genitourinary syndrome of menopause (GSM). Study Design/Materials and Methods This study included 162 postmenopausal patients who received vaginal laser or topical Estriol cream therapy between January 2017 and May 2019 at eight study centers in China. The degree of GSM-related symptoms (vaginal burning, dryness, and dyspareunia) was evaluated using the Vaginal Health Index score (VHIS) and Visual Analog Scale (VAS) at baseline, 1, 3, 6, and 12 months posttreatment. The primary endpoint was the improvement in vaginal burning, dryness, and dyspareunia at 6 months after treatment. Multivariate logistic regression was used to compare the rate of improvement in the two groups. Results At baseline, the laser and control groups showed no significant difference in the mean age, time after menopause, and the VHIS (all P > 0.05). In the laser group, compared with baseline, significant differences were seen in the VHIS after the first or second treatment session and at 1, 3, 6, and 12 months posttreatment (P < 0.01). In the control group, compared with baseline, the VHIS showed significant differences after 1, 3, and 6 months of treatment (P < 0.05). However, there was no significant difference after 3 and 6 months of follow-up between the two groups (P > 0.05). The VHIS scores were significantly higher after 1 month (16.63 +/- 2.79 vs. 15.57 +/- 2.43) and 12 months (15.72 +/- 2.59 vs. 12.12 +/- 4.08) of treatment in both the groups (P < 0.05). At 6 months after treatment, both groups showed improvement in vaginal burning, vaginal dryness, and dyspareunia (P > 0.05). The VAS findings at

关键词： genitourinary syndrome of menopause vulvovaginal atrophy vaginal burning fractional CO2 laser vaginal laser treatment

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水箱进口结构对热泵热水器释能性能的影响

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中南大学学报（自然科学版） 2022年第2期53卷 688-695页

作者：杜明浩李舒宏胡明月秦露雯许成城周润发东南大学能源与环境学院江苏南京210096

为提高空气源热泵热水器系统性能,针对蓄热水箱进口,设计弧形挡板型水箱进口结构,建立热泵系统与水箱系统耦合模型,并搭建空气源热泵热水器实验台。选取热水输出率、系统性能系数η两项评价指标,对采用弧形挡板型、上冲型和侧进型进口... 详细信息

为提高空气源热泵热水器系统性能,针对蓄热水箱进口,设计弧形挡板型水箱进口结构,建立热泵系统与水箱系统耦合模型,并搭建空气源热泵热水器实验台。选取热水输出率、系统性能系数η两项评价指标,对采用弧形挡板型、上冲型和侧进型进口结构的热泵热水器的释能性能进行比较,研究结果表明:模拟与实验出口水温误差在±0.5℃以内,释能20 min内系统性能系数η误差小于5.3%。热泵热水器采用弧形挡板型进口结构时,在进口流量10 L/min、进口水温15℃的工况下,热水输出率和系统性能系数η较上冲型分别提升了47.6%和19.5%,较侧进型分别提升了14.8%和6.9%;在进口流量为5~15 L/min、进口水温为5~25℃的变工况下,热水输出率和系统性能系数η也均有提升,最大分别可达62.1%和22.0%。

关键词：进口结构弧形挡板双高效

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数实产业技术融合对我国企业全球价值链稳定性的影响研究

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国际经贸探索 2025年第2期41卷 36-53页

作者：张兵张露文周宏伟南开大学经济学院

文章基于专利引用网络构建企业层面数实产业技术融合指标,从理论和实证两个方面深入探讨了数实产业技术融合对我国企业全球价值链稳定性的影响及其作用机制。研究结果表明,企业进行数实产业技术融合能显著提升其全球价值链的稳定性。融... 详细信息

文章基于专利引用网络构建企业层面数实产业技术融合指标,从理论和实证两个方面深入探讨了数实产业技术融合对我国企业全球价值链稳定性的影响及其作用机制。研究结果表明,企业进行数实产业技术融合能显著提升其全球价值链的稳定性。融合垂直深度越深、水平广度越广,这一“稳链”作用越明显。机制分析表明,企业通过数实产业技术融合能够扩大出口产品范围、优化进口中间品布局策略及拓展专利知识宽度,从而提升我国企业全球价值链的稳定性。在异质性分析层面,数实产业技术融合对企业全球价值链稳定性的影响在具有不同内部特征和外部环境的企业中存在明显差异。文章为新时代促进数字新质生产力与实体产业的深度融合、提升企业全球价值链稳定性提供了实证支持与政策指引。

关键词：数实产业技术融合专利引用网络全球价值链稳定性贸易策略优化

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Content-Dependent Fine-Grained Speaker Embedding for Zero-Shot Speaker Adaptation in Text-to-Speech Synthesis

arXiv

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arXiv 2022年

作者： zhou, Yixuan Song, Changhe Li, Xiang Zhang, luwen Wu, Zhiyong Bian, Yanyao Su, Dan Meng, Helen Shenzhen International Graduate School Tsinghua University Shenzhen China The Chinese University of Hong Kong Hong Kong Tencent AI Lab Tencent Shenzhen China

Zero-shot speaker adaptation aims to clone an unseen speaker's voice without any adaptation time and parameters. Previous researches usually use a speaker encoder to extract a global fixed speaker embedding from reference speech, and several attempts have tried variable-length speaker embedding. However, they neglect to transfer the personal pronunciation characteristics related to phoneme content, leading to poor speaker similarity in terms of detailed speaking styles and pronunciation habits. To improve the ability of the speaker encoder to model personal pronunciation characteristics, we propose content-dependent fine-grained speaker embedding for zero-shot speaker adaptation. The corresponding local content embeddings and speaker embeddings are extracted from a reference speech, respectively. Instead of modeling the temporal relations, a reference attention module is introduced to model the content relevance between the reference speech and the input text, and to generate the fine-grained speaker embedding for each phoneme encoder output. The experimental results show that our proposed method can improve speaker similarity of synthesized speeches, especially for unseen speakers. Copyright © 2022, The Authors. All rights reserved.

关键词： Embeddings

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四物汤的药理作用研究进展

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中医药信息 2024年第5期41卷 69-75页

作者：周大果沈子芯牟春燕朱路文黑龙江中医药大学黑龙江哈尔滨150040

四物汤是补血调血的基础方,具有补血不滞血、行血不伤血的特点,常用于治疗临床多种疾病,具有较高的临床价值。笔者通过综述相关研究文献发现,四物汤具有补充血容量、活血抗凝、雌激素样作用、子宫双向调节、改善卵巢功能、降血脂、提高... 详细信息

四物汤是补血调血的基础方,具有补血不滞血、行血不伤血的特点,常用于治疗临床多种疾病,具有较高的临床价值。笔者通过综述相关研究文献发现,四物汤具有补充血容量、活血抗凝、雌激素样作用、子宫双向调节、改善卵巢功能、降血脂、提高学习记忆能力、抗氧化损伤、抗炎抗菌、提高免疫功能、抗衰老、保肝和抗辐射、药物损伤及抗突变等药理作用,主要作用在血液系统、女性生殖系统与心脑血管系统,主要通过磷脂酰肌醇-3-激酶/蛋白激酶B(PI3K/Akt)信号通路、表皮生长因子受体/磷脂酰肌醇3-激酶(EGFR/PI3K)信号通路、肝激酶B1/腺苷酸活化蛋白激酶(LKB1/AMPK)信号通路等发挥治疗作用。

关键词：四物汤药理作用研究进展

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Enhanced dielectric and energy -storage performance of nanocomposites using interface -modified anti-ferroelectric fillers

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JOURNAL OF ALLOYS AND COMPOUNDS 2020年 831卷 154770-154770页

作者： Li, Lili zhou, Bing Ye, Jianfei Wu, Wei Wen, Fei Xie, Yunchuan Bass, Patrick Xu, Zhuo Wang, luwen Wang, Gaofeng Zhang, Zhicheng Hangzhou Dianzi Univ Coll Elect & Informat Minist Educ Engn Res Ctr Smart Microsensors & Microsyst Hangzhou 310018 Peoples R China Xi An Jiao Tong Univ Dept Chem Mat Xian Key Lab Sustainable Energy Mat Chem Xian 710049 Peoples R China Xi An Jiao Tong Univ Minist Educ Key Lab Elect Mat Res Lab Xian 710049 Peoples R China Xi An Jiao Tong Univ Int Ctr Dielectr Res Xian 710049 Peoples R China The Citadel Dept Mech Engn Charleston SC 29409 USA

Polymer-based 0-3 composites filled with ferroelectric ceramic particles have exhibited prominent dielectric responses and energy-storage performance, and are expected to be promising materials for high-performance, energy-storage capacitors in advanced electric systems. Unfortunately, low discharging efficiency hampers their practical application due to the high remnant polarization and interface related dielectric loss. In the present work, an anti-ferroelectric ceramic (Pb_0.97La_0.02)[Zr_0.63(Sn_0.3Ti_0.07)O₃] (PLZST) was prepared as the filler due to their intrinsic ultra-low dielectric loss and remnant polarization. Meanwhile, 3-aminopropyltriethoxysilane (KH550) was used to modify the surface of PLZST to enhance the interfacial compatibility between the PLZST filler and the polymer matrix. Enhanced dielectric permittivity, lowered loss, increased breakdown strength, and energy density were obtained at a relatively low loading content of the modified fillers (m-PLZST). Specifically, a considerably high energy density of 12.8 J/cm³ was achieved in a thin film with 8.0 wt% m-PLZST fillers. In comparing the properties of the composites filled with surface modified PLZST (m-PLZST) and pristine PLZST, the significant performance enhancement is well addressed with the accompanying reduction in loss, lowered remnant polarization, and depressed interfacial polarization. This result correlates to the anti-ferroelectric characteristics of the filler and enhanced compatibility from the surface modification.

关键词： Anti-ferroelectric Composites Surface treatment Dielectric response High energy density

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