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Patients' postures during migraine attacks

Journal of Headache and Pain 2003年第2期4卷 83-87页

作者： selekler, H. macit Can, Hafize Budak, Faik Department of Neurology Faculty of Medicine Kocaeli University Kocaeli Turkey

The aim of this study was to determine postures adopted by patients during migraine attack. A total of 199 migraine patients were questioned about their postures during the migraine attack. Of these, 92 patients did not choose a specific lying position, 22 could not lie down during the attack because of the increase in pain, while 6 avoided lying due to scalp tenderness. During the attack, 19 patients preferred holding their heads up (compared to painless period) with a few pillows and 41 applied pressure on the aching side;15 lay with their necks extended and 15 lay face downward. Various combinations of these postures were also reported. Pain may arise from extracranial muscles as well as vessels during a migraine attack. The posture chosen during attack is a reflection of vascular and muscle pains that provoke symptoms. The postures that patients chose were aimed to lessen the severity of symptoms of their migraine attacks. Patients know the position they adopt and do not need to be told by a doctor, but they come to consultations to be understood, to learn that others behave in the same way, and in some, to obtain reasons for their posture. The existence of a specific lying posture can be an advantage for the physician in terms of approaching the patient and selecting an appropriate therapy.

关键词： Attack Migraine Posture

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A non-traumatic interhemispheric subdural haematoma: Presented with headache as the sole complaint

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Journal of Headache and Pain 2005年第1期6卷 48-50页

作者： Alemdar, Murat selekler, Hamit macit Efendi, Husnu Department of Neurology Faculty of Medicine University of Kocaeli Derince 41900 Kocaeli Turkey

Due to their localisations and symptoms, interhemispheric subdural haematomas (ISH) compose a distinct category. Altered level of consciousness and hemiparesis are the most frequent symptoms. We report a case of ISH who presented with headache as the sole complaint. Left cerebellar haematoma and ISH were found incranial MRI and cranial computed tomography Cranial MR angiogram was normal. Haemogram and coagulation parameters were within normal limits. ISH should be considered among the diagnostic possibilities in elderly patients who present with headache as the sole symptom without other clinical features such as meningeal irritation signs, focal neurological symptoms and alteration of consciousness. Cranial imaging studies should be done in such cases. © Springer-Verlag Italia 2005.

关键词： Interhemispheric subdural haematoma Secondary headache

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Productivity losses attributable to headache, and their attempted recovery, in a heavy-manufacturing workforce in Turkey: implications for employers and politicians

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JOURNAL OF HEADACHE AND PAIN 2015年第1期16卷 1-8页

作者： selekler, H. macit Gokmen, Gursel Alvur, T. Muge Steiner, Timothy J. Norwegian Univ Sci & Technol Dept Neurosci N-7034 Trondheim Norway Univ London Imperial Coll Sci Technol & Med Div Brain Sci London England Kocaeli Univ Fac Med Dept Neurol Izmit Kocaeli Turkey Ford Otomotiv Sanayi AS Co Hlth Serv Golcuk Kocaeli Turkey Kocaeli Univ Fac Med Dept Family Med Izmit Kocaeli Turkey

Background: Headache disorders cause substantial productivity losses through absenteeism and impaired effectiveness at work (presenteeism). We had previously found these losses to be high in a mostly male, heavy-manufacturing workforce at Ford Otomotiv Sanayi AS (FO), in north-western Turkey. Here we aimed to confirm this finding in a year-long study to eliminate any effect of seasonal variation. The question then was how much of this lost productivity could be recovered by the effective provision of headache care. Methods: We used the HALT-30 Index to estimate productivity losses, surveying FO's entire workforce (N = 7,200) during annual health-checks provided by the company's on-site health clinic. Then we established, and widely advertised, a headache clinic within the same health clinic, providing specialist care free for 15 months. Outcome measures were HALT-30, company sickness records and the HURT questionnaire. Results: Usable data were collected from 5,916 employees (82.2 %;5,485 males [92.7 %], 431 females [7.3 %];mean age 32.5 +/- 5.4 years). One-month headache prevalence was 45.4 % (n = 2,688). Productivity losses were reported by 968 employees (16.4 %) and, per affected employee, increased from 0.23 to 7.56 days/month as headache frequency increased (P < 0005). Employees reporting headache on = 15 days/month (n = 64;1.1 %) accounted for 21.1 % of productivity losses, those with headache on 10-14 days (n = 104;1.8 %) another 18.5 %. With increasing headache frequency, absenteeism/presenteeism ratio (overall 1: 16) declined from about 1: 4 to about 1: 25 in those with headache on = 10 days/month. Headache frequency and lost productivity were higher in females than males (P < 0.0005). Both absenteeism and presenteeism rates declined after age 34 years (P < 0.0005). Only 344 employees with headache (12.8 %) requested appointments, and only 211 (7.8 %) actually consulted. Attendance was related to headache frequency (P < 0.0005). Too few returned for follow-

关键词： Headache disorders Burden Cost Lost productivity Work impact Health care Global campaign against headache

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Influence of the long term use of a computer on median, ulnar and radial sensory nerves in the wrist region

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INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH 2014年第6期27卷 1026-1035页

作者： Bamac, Belgin Colak, Serap Dundar, Gulmine selekler, Hamit macit Taskiran, Yavuz Colak, Tuncay Balci, Emin Kocaeli Univ Fac Med Dept Anat Kocaeli Turkey Kocaeli Univ Sch Phys Educ & Sports Kocaeli Turkey Kocaeli Univ Fac Med Dept Neurol Kocaeli Turkey

Repetitive microtrauma or overuse injuries may often affect upper extremities of the long term computer users. The aim of this study was to compare sensory nerve conduction velocities (SNCV) for median, radial and ulnar nerves in the wrist of computer users with the same parameters in controls who do not use computers regularly. Twenty one male computer users (age: mean (M) = 28.3 years +/- standard deviation (SD) = 7.5 years) and 21 male control subjects (age: M +/- SD = 24.1 +/- 4.6 years) were recruited for the study. Limb length and the perimeters of the dominant arm and forearm were measured for each subject. The neurophysiological study consisted of measuring sensory nerve conduction of the median, ulnar and radial nerves. The sensory conduction velocities of both median and ulnar nerves were significantly delayed in the dominant arm of the computer users compared to the controls. In addition, sensory conduction velocity of the median nerve was significantly delayed in the dominant extremity of the computer users compared to their non-dominant extremity. This study shows that computer users have a tendency toward developing median and ulnar sensory nerve damage in the wrist region. Mechanism of delayed SNCV in the median and ulnar nerves may be due to sustained extension and ulnar deviation of the wrist during computer mouse use and typing. Reduced SNCV changes were more apparent on the dominant side of the median nerve. This may indicate the increased neural deficits related to an increased use of the dominant side. Further investigation is needed to determine how to reduce potential risk factors at this stage in order to prevent development of median or ulnar neuropathy in the long term computer users.

关键词： Computer users Ulnar Median Radial Nerve

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Isolated Abducens Nerve Palsy Associated with Retinoic Acid Therapy: A Case Report

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STRABISMUS 2005年第3期13卷 129-132页

作者： Alemdar, Murat Iseri, Pervin selekler, Hamit macit Serbest, Alev Selek Komsuoglu, Sezer Sener Kocaeli Univ Fac Med Dept Neurol Izmit Kocaeli Turkey Kocaeli Univ Fac Med Dept Int Med Izmit Kocaeli Turkey

Isolated abducens nerve palsy is a rare complication of treatment with various drugs. Here, the authors report the case of a 23-year-old female with isolated left abducens nerve palsy after long-term retinoic acid therapy. The association is based on the temporal relationship and the exclusion of other possible etiologic factors following extensive laboratory and imaging diagnostics. The authors suggest that isolated abducens nerve palsy may be a presenting sign of a toxic neuropathy associated with retinoic acid therapy. After the exclusion of other organic lesions, especially idiopathic intracranial hypertension, and an assessment of the risk-benefit ratio, discontinuation of treatment must be considered in such cases.

关键词： Abducens nerve palsy cranial nerve paresis retinoic acid adverse drug reactions

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Corneal confocal microscopy identifies corneal nerve fiber loss in patients with migraine

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CEPHALALGIA 2023年第5期43卷

作者： Guldiken, Yigit Can Petropoulos, Ioannis N. Malik, Ayesha Malik, Rayaz A. Yuksel, Refref Budak, Faik selekler, Hamit macit Kocaeli Univ Res & Applicat Hosp Dept Neurol Baki Komsuoglu St TR-41380 Izmit Kocaeli Turkiye Weill Cornell Med Qatar Qatar Fdn Doha Qatar Kocaeli Univ Res & Applicat Hosp Dept Ophthalmol Izmit Kocaeli Turkiye

Background/HypothesisMigraine affects >1 billion people but its pathophysiology remains poorly understood. Alterations in the trigeminovascular system play an important role. We have compared corneal nerve morphology in patients with migraine to healthy controls. MethodsSixty patients with episodic (n = 32) or chronic (n = 28) migraine and 20 age-matched healthy control subjects were studied cross-sectionally. Their migraine characteristics and signs and symptoms of dry eyes were assessed. Manual and automated quantification of corneal nerves was undertaken by corneal confocal microscopy. ResultsIn patients with migraine compared to controls, manual corneal nerve fiber density (P < 0.001), branch density (P = 0.015) and length (P < 0.001);and automated corneal nerve fiber density (P < 0.001), branch density (P < 0.001), length (P < 0.001), total branch density (P < 0.001), nerve fiber area (P < 0.001), nerve fiber width (P = 0.045) and fractal dimension (P < 0.001) were lower. Automated corneal nerve fiber density was higher in patients with episodic migraine and aura (P = 0.010);and fractal dimension (P = 0.029) was lower in patients with more headache days in the last three months. Automated corneal nerve fiber density predicted a significant amount of the observed variance in pain intensity (adjusted r(2) = 0.14, partial r = -0.37, P = 0.004) in patients with migraine. ConclusionsCorneal confocal microscopy reveals corneal nerve loss in patients with migraine. It may serve as an objective imaging biomarker of neurodegeneration in migraine.

关键词： Migraine biomarker neurodegeneration corneal confocal microscopy

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Poster presentations

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Surgical and radiologic anatomy : SRA 2009年第1期31 Suppl 1卷 95-229页

作者： Funda Aksu Hakan Topacoglu Candan Arman Aytul Atac Suleyman Tetik Aida Hasanovic Amela Kulenovic Zakira Mornjakovic Branko Pikula Aida Sarac-Hadzihalilovic Alma Voljevica Belgin Bamac Tuncay Colak Murat Alemdar Gulmine Dundar macit selekler Ozgur Dincer Enis Colak Aydin Ozbek Cenk Kilic Kivanc Kamburoglu Tuncer Ozen Vatan Kavak Yalcin Kirici Emin Oztas Handan Altinkaya Soysal Erdogan Unur Nihat Ekinci Omur Karaca Olga Malakhova Murat Kocaoglu Serdar Toker Figen Taser Volkan Kilincoglu Mustafa Fahri Yurtgun Cannur Dalcik Ali Zeybek Marc Baroncini Johann Peltier Patrice Jissendi Jean-Pierre Pruvo Jean-Paul Francke Vincent Prevot Rengin Kosif Yasin Arifoglu Murat Diramali Mustafa Sarsilmaz Evren Kose Murat Ogeturk Burhan Akpinar Ilter Kus Sedat Meydan Alev Kara Zeliha Kurtoglu Ibrahim Tekdemir Alaittin Elhan Orhan Bas Ersan Odaci Hakan Mollaoglu Kagan Ucok Suleyman Kaplan Mehmet Senoglu Vedat Nacitarhan Ergul Belge Kurutas Nimet Senoglu Idris Altun Yalcin Atli Davut Ozbag Sacide Karakas M Dincer Bilgin Ayfer Metin Tellioglu Sercin Ozlem Betul Akcanal Yuksel Yildiz Hakki Gunes Hayrullah Kose Ibrahim Uzum Umit Naci Gundogmus Cigdem Caglayan Velichka Pavlova Mashenka Dimitrova Lilia Georgieva Elena Nikolova Deniz Uzmansel Nail Can Ozturk Canan Yurttas Saylam Erkin Ozgiray Mustafa Orhan Sedat Cagli Mehmet Zileli Derya Ozkan Taylan Akkaya Ayhan Comert Nilgun Balikci Esra Ozdemir Haluk Gumus Zafer Ergul Oskay Kaya Serdar Altun R Erkin Unlu Hakan Orbay Deog-Im Kim Seung-Ho Han Yi-Suk Kim Ho-Jeong Kim Kyu-Seok Lee Omur Elcioglu Hilmi Ozden Gul Guven Nurcan Imre Bulent Yalcin Hasan Ozan Pinar Akyer Mustafa Guvencer Vasfi Karatosun Mandeep Gill Sagoo Rachel Claire Aland Derya Ustuner M Cengiz Ustuner Jafar Ai Seyed Reza Ghazi Seyed Hadi Mansouri Mehmet Cudi Tuncer Mehmet Ufuk Aluclu Ozlen Karabulut Eyup Savas Hatipoglu Hasan Nazaroglu Cigdem Icke Emrah Akbay Turkan Gunay Suleyman Icke Selda Yildiz Fatih Yazar Barcin Orhan Barlas Delia Elena Zahoi Ahmet Kavakli Ufuk Tas Durrin Ozlem Dabak Hilal Irmak Sapmaz Necdet Kocabiyik Ce Department of Anatomy Dokuz Eylul University Izmir Turkey. funda.tastekin@deu.edu.tr. Department of Emergency Medicine Dokuz Eylul University Izmir Turkey. Department of Anatomy Dokuz Eylul University Izmir Turkey. Department of Anatomy Dokuz Eylul University Medical Faculty Izmir Turkey. Department of Histology and Embryology Mustafa Kemal University Faculty of Medicine Antakya-Hatay Turkey. Department of Anatomy Institute of Anatomy Sarajevo Bosnia and Herzegovina. Department of Anatomy The University of Sarajevo Medical Faculty Sarajevo Bosnia and Herzegovina. Department of Histology and Embriology Institute of Histology and Embriology Sarajevo Bosnia and Herzegovina. Department of Clinical Pathology Institute of Clinical Pathology Sarajevo Bosnia and Herzegovina. Department of Anatomy Kocaeli University Kocaeli Turkey. Department of Anatomy Kocaeli University Medical Faculty Kocaeli Turkey. Department of Neurology Kocaeli University Kocaeli Turkey. Department of Physical Education and Sport Kocaeli University Kocaeli Turkey. Department of Anatomy Gulhane Military Medical Academy Ankara Turkey. Department of Anatomy Faculty of Medicine Gulhane Military Medical Academy Ankara Turkey. Department of Anatomy Gulhane Military Medical Academy Faculty of Medicine Ankara Turkey. Department of Oral Diagnosis and Radiology Faculty of Dentistry Ankara University Ankara Turkey. Department of Oral Diagnosis and Radiology Ankara University Faculty of Dentistry Ankara Turkey. Department of Oral Diagnosis and Radiology Gulhane Military Medical Academy Ankara Turkey. Department of Oral Diagnosis and Radiology Gulhane Military Medical Academy Dental Science Center Ankara Turkey. Department of Anatomy Dicle University Diyarbakir Turkey. Department of Anatomy Dicle University Medical Faculty Diyarbakir Turkey. Department of Histology-Embriyology Faculty of Medicine Gulhane Military Medical Academy Ankara Turkey. Department of Anatomy Inonu University Sch

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