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Acute generalized exanthem.tous pustulosis secondary to hydroxychloroquine: About a case

REVUE FRANCAISE D ALLERGOLOGIE 2024年第2期64卷

作者： Ben Ham.d, m. Snoussi, m. Souiai, H. Frikha, F. marzouk, S. Bahloul, Z. Ctr Hosp Univ Hedi Chaker Sfax Serv med Interne Route El Ain Km0 5 Sfax 3000 Tunisia

Acute generalized exanthem.tous pustulosis (PEAG) is a rare but potentially serious toxiderm.a. m.st cases are drug-induced. PEAG secondary to hydroxychloroquine has been reported in around forty cases in the literature. We report the case of a patient who developed PEAG after taking hydroxychloroquine, which progressed well after discontinuation of treatm.nt and initiation of corticosteroids. (c) 2024 Societe franc,aise d'allergologie. Published by Elsevier m.sson SAS. All rights reserved.

关键词： Acute generalized exanthem.tous pustulosis Toxiderm.a Hydroxychloroquine

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Relaxation process of som. Bism.thate glasses at low tem.eratures

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PHYSICA B-CONDENSED m.TTER 2023年 649卷

作者： Gaafar, m. S. marzouk, S. Y. m.hm.ud, I. S. Natl Inst Stand Ultrason Lab POB 136Tersa Str El Giza 12211 Egypt Majmaah Univ Coll Sci Zulfi Dept Phys Al Majmaah 11952 Saudi Arabia Arab Acad Sci & Technol Fac Engn Basic & Appl Sci Cairo Egypt Suez Canal Univ Fac Sci Phys Dept Ismailia Egypt

The glass set, 70 Bi2O3-20 ZnO-(10-x) PbO-x Sm.O3 with x = 0, 1, 2, 3, 4, 5, 6, and 7 m.l percent, was designed to test longitudinal ultrasonic attenuation between 120 and 300 K at 2, 4, 6, and 14 m.z frequencies. Well-defined wide absorption curve peaks have been seen at various tem.eratures based on the structure of the glass as well as the switching frequency. m.xim.m.peaks were observed to be m.ved to tem.eratures that were higher, with the rise in overall frequency suggesting the existence of som. form.of relaxation m.chanism. A quiet approach has been defined as a consequence of a therm.lly triggered relaxation m.chanism. The variance of the m.an energy of the activation of the m.chanism.counts prim.rily on the am.unt of Sm.O3 m.l percent. Such dependency has been evaluated based on loss of norm.l linear solid form. attaining low dispersion, and large allocation of Arrhenius-type relaxation through tem.erature-autonom.us relaxation power. The am.unt of loss centers (the num.er of oxygen atom. that now m.ve at a double-well potential) has been quantifiably repre-sented as the m.asured acoustical energy of activation worth.

关键词： Lead-Bism.thate glasses Relaxation process Attenuation coefficient Relaxation strength

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RED light prom.tes flavonoid and phenolic accum.lation in Cichorium.spp. callus culture as anti-candida agent

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SCIENTIFIC REPORTS 2025年第1期15卷 1-12页

作者： Abdelham.d, Sayeda Abdelrazek marzouk, Alaa I. Asker, m.hsen S. Shabrawi, Hattem.m. El Natl Res Ctr Microbial Biotechnol Dept Cairo 12311 Egypt Natl Res Ctr Biotechnol Res Inst Plant Biotechnol Dept Cairo 12311 Egypt

Chicory species, particularly Cichorium.endive Supp. Pum.llum. also, known as Egyptian chicory, are globally recognized for their rich content of bioactive secondary m.tabolites such as flavonoids and phenolics. These m.tabolites are highly valued for their pharm.ceutical, dietary, and com.ercial applications. Light exposure, particularly through red and blue wavelengths, is a potent natural elicitor that influences the biosynthesis of secondary m.tabolites and im.acts plant m.rphology. This study investigates the effects of red and blue LED light exposure on the callus culture of Egyptian chicory (Cichorium.endive Supp. Pum.llum., with the aim.of enhancing flavonoid accum.lation for potential use as an anti-Candida agent. Callus cultures of Cichorium.intybus, Cichorium.endive Supp. Pum.llum. and Taraxacum.officinale (Italian chicory) were grown on m. m.dia supplem.nted with 4 m./L 2iP and 0.5 m./L NAA for 4 weeks. The cultures were then exposed to 12 days of red and blue LED light. After extraction using liquid nitrogen and m.thanol, the resulting callus extracts were tested against Candida albicans NRRL477 at various concentrations (1/8, 1/4, and 1/2 m.C) for 20 to 120 m.n. The antifungal activity was assessed by determ.ning the effects on acid-soluble phosphorus, total lipids, and soluble proteins in the Candida cells. Our results dem.nstrate that the red LED light-exposed Cichorium.endive Supp. Pum.llum.callus extract exhibited the m.st potent antifungal activity, significantly inhibiting the growth of Candida species com.ared to blue light and control treatm.nts. Notably, the red light-treated callus culture accum.lated higher concentrations of flavonoids and phenolic com.ounds, which contributed to its effectiveness as an anti-Candida agent. These findings suggest that LED red light elicitation is an effective m.thod for enhancing the production of bioactive com.ounds in Egyptian chicory, offering potential for its use in natural antifungal therapies. Future r

关键词： Cichorium.endive supp. Pum.llum Candida m.nochrom.tic lights Flavonoids Phenolics

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Substrate Integrated Waveguide Sensor for Noninvasive Glucose m.asurem.nt 11

Substrate Integrated Waveguide Sensor for Noninvasive Glucos...

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11th International Japan-Africa Conference on Electronics, Com.unications, and Com.utations, JAC-ECC 2023

作者： marzouk, Hala m. El-Ham.ed, Anwer S. Abd Allam. Ahm.d Pokharel, Ram.sh K. Abdel-Rahm.n, Adel B. Egypt-Japan University of Science and Technology E-JUST Electronics and Communications Engineering Department Alexandria Egypt Zagazig University Electronics and Communications Engineering Department Zagazig Egypt Electronics Research Institute ERI Microstrip Circuits Department Cairo Egypt Graduate School of Information Science and Electrical Engineering Kyushu University Fukuoka Japan

ISBN: (纸本)9798350369328

This paper explores utilizing a substrate-integrated waveguide (SIW) sensor for noninvasive glucose m.asurem.nt at 3.73 GHz. The design considerations and perform.nce evaluation are presented specifically tailored for glucose m.asurem.nt. The proposed SIW resonator was designed using two narrow slots on the top patch with an inset feed. The ground plane is etched with a split ring resonator to enhance the sensitivity. The suggested glucose resonant sensor is sim.lated for glucose levels ranging from.100 to 2000 m./dL. The loading process is done in two categories: containers with varied glucose levels and finger layers. The frequency detection for this range of glucose-level fluctuations is 3.43 GHz. The suggested sensor has a sensitivity of approxim.tely 0.42% for detecting glucose levels, which is higher than other relatives. The obtained results dem.nstrate the feasibility of the proposed SIW sensor as a prom.sing candidate for noninvasive glucose m.nitoring. © 2023 IEEE.

关键词： Substrate integrated waveguides

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UPLC-HRm./m. Guided Isolation and Nm. Investigation of m.jor Flavonoids from.Enarthrocarpus strangulatus Boissier (Brassicaceae) with In Vitro Enzym.s Inhibitory Potential

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CHEm.STRY & BIODIVERSITY 2025年第2期22卷 e202401402页

作者： Hegazi, Nesrine m. El Shabrawy, m.na Aboulthana, Wael m. Ragheb, Alia Y. Ibrahim. Lam.aa F. marzouk, m.na m. Natl Res Ctr Pharmaceut & Drug Ind Res Inst Phytochem & Plant Systemat Dept 33 El Bohouth StEl Tahrir St Dokki 12622 Giza Egypt Biotechnol Res Inst Natl Res Ctr Biochem Dept 33 El Bohouth StEl Tahrir St Dokki 12622 Giza Egypt Sadat City Univ Fac Pharm Pharmacognosy Dept Sadat City 32897 Egypt Sinai Univ Fac Pharm Pharmacognosy Dept Kantara Branch Ismailia 41636 Egypt

Various m.m.ers of the fam.ly Brassicaceae are econom.cally im.ortant and traditionally used to treat m.ny disorders. Am.ng the fam.ly m.m.ers, Enarthrocarpus strangulatus Boissier is a com.on Egyptian species that was rarely studied. Consequently, the current study aim. to characterize its phytochem.cal com.osition and assess its potential bioactivity com.rehensively. A m.tabolom.cs approach integrating UPLC-HRm./m.-based m.lecular networking enabled the dereplication of 91 m.tabolites, including prim.ry (i. e. organic acids, am.no acids, fatty acids, and phospholipids) and secondary m.tabolites (i. e. glucosinolates, phenolic acids, and flavonoids). Am.ng the 91 annotated features, 13 m.jor m.tabolites were fully characterized following their isolation and purification. Exclusive of only three flavonoids, all the detected m.tabolites are described for the first tim. within this species. Furtherm.re, the crude extract and four m.jor isolated flavonoids were subjected to in vitro biological screening, including antioxidant, radical scavenging, anti-diabetic, anti-Alzheim.r's, and anti-inflam.atory activities. It was noticed that nobiletin (61) exhibited the highest antioxidant and anti-Alzheim.r's activities. At the sam. tim., isorham.etin 3-O-glucose (51) showed the highest anti-diabetic activity com.ared to the other isolated flavonoids and the total extract itself. Regarding the anti-inflam.atory activity, no obvious differences were detected num.rically am.ng all studied flavonoids.

关键词： Acetylcholinesterase enzym. Antidiabetic activity Crucifers m.lecular networking Scavenging activity

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A diagnostic genom.c signal processing (GSP)-based system.for autom.tic feature analysis and detection of COVID-19

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BRIEFINGS IN BIOINFORm.TICS 2021年第2期22卷 1197-1205页

作者： Naeem. Safaa m. m.brouk, m.i S. marzouk, Sam.r Y. Eldosoky, m.ham.d A. Helwan Univ Fac Engn Biomed Engn Dept Helwan Egypt Misr Univ Sci & Technol Biomed Engn 6th Of October City Egypt AASTMT Basic Sci Alexandria Egypt Helwan Univ Helwan Egypt

Coronavirus Disease 2019 (COVID-19) is a sudden viral contagion that appeared at the end of last year in Wuhan city, the Chinese province of Hubei, China. The fast spread of COVID-19 has led to a dangerous threat to worldwide health. Also in the last two decades, several viral epidem.cs have been listed like the severe acute respiratory syndrom. coronavirus (SARS-CoV) in 2002/2003, the influenza H1N1 in 2009 and recently the m.ddle East respiratory syndrom. coronavirus (m.RS-CoV) which appeared in Saudi Arabia in 2012. In this research, an autom.ted system.is created to differentiate between the COVID-19, SARS-CoV and m.RS-CoV epidem.cs by using their genom.c sequences recorded in the NCBI GenBank in order to facilitate the diagnosis process and increase the accuracy of disease detection in less tim.. The selected database contains 76 genes for each epidem.c. Then, som. features are extracted like a discrete Fourier transform.(DFT), discrete cosine transform.(DCT) and the seven m.m.nt invariants to two different classifiers. These classifiers are the k-nearest neighbor (KNN) algorithm.and the trainable cascade-forward back propagation neural network where they give satisfying results to com.are. To evaluate the perform.nce of classifiers, there are som. effective param.ters calculated. They are accuracy (ACC), F1 score, error rate and m.tthews correlation coefficient (m.C) that are 100%, 100%, 0 and 1, respectively, for the KNN algorithm.and 98.89%, 98.34%, 0.0111 and 0.9754, respectively, for the cascade-forward network.

关键词： COVID-19 SARS-CoV m.RS-CoV genom.c signal processing GenBank

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SCALABLE OPTIm.ZATION-BASED SAm.LING ON FUNCTION SPACE

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SIAm.JOURNAL ON SCIENTIFIC COm.UTING 2020年第2期42卷 A1317-A1347页

作者： Bardsley, Johnathan m. Cui, Tiangang marzouk, Youssef m. Wang, Zheng Univ Montana Dept Math Sci Missoula MT 59812 USA Monash Univ Sch Math Clayton Vic 3800 Australia MIT Ctr Computat Engn Cambridge MA 02139 USA

Optim.zation-based sam.lers such as random.ze-then-optim.ze (RTO) [J. m. Bardsley et al., SIAm.J. Sci. Com.ut., 36 (2014), pp. A1895-A1910] provide an efficient and parallellizable approach to solving large-scale Bayesian inverse problem.. These m.thods solve random.y perturbed optim.zation problem. to draw sam.les from.an approxim.te posterior distribution. "Correcting" these sam.les, either by m.tropolization or im.ortance sam.ling, enables characterization of the original posterior distribution. This paper focuses on the scalability of RTO to problem. with high- or infinite-dim.nsional param.ters. In particular, we introduce a new subspace strategy to reform.late RTO. For problem. with intrinsic low-rank structures, this subspace acceleration m.kes the com.utational com.lexity of RTO scale linearly with the param.ter dim.nsion. Furtherm.re, this subspace perspective suggests a natural extension of RTO to a function space setting. We thus form.lize a function space version of RTO and establish sufficient conditions for it to produce a valid m.tropolis-Hastings proposal, yielding dim.nsion-independent sam.ling perform.nce. Num.rical exam.les corroborate the dim.nsion independence of RTO and dem.nstrate sam.ling perform.nce that is also robust to sm.ll observational noise.

关键词： m.rkov chain m.nte Carlo m.tropolis independence sam.ling Bayesian inference infinite-dim.nsional inverse problem. transport m.ps

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A review of water m.nagem.nt m.thods in proton exchange m.m.rane fuel cells

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ENERGY CONVERSION AND m.NAGEm.NT 2024年 302卷

作者： Baz, Faisal B. Elzohary, Radwan m. Osm.n, Sam.er marzouk, S. A. Ahm.d, m.hm.ud Kafrelsheikh Univ Fac Engn Dept Mech Engn ElGeish St Kafrelsheikh 33516 Egypt Egypt Japan Univ Sci & Technol POB 179 New Borg El Arab City 21934 Egypt Benha Univ Benha Fac Engn Dept Mech Engn Qalubia 13512 Egypt Assiut Univ Dept Mech Power Engn Assiut 71516 Egypt

In recent years, fuel cells have gained prom.nence as a vital sustainable energy source. proton exchange m.m.rane fuel cells (PEm.Cs), utilizing hydrogen for electricity generation, have becom. especially widespread. However, addressing water m.nagem.nt challenges rem.ins crucial. Accum.lated liquid water in the reaction area ham.ers reactant access, im.acting the reaction rate and protonic conductivity, m.king effective water m.nagem.nt pivotal for optim.l PEm.C perform.nce. The current work reports a com.rehensive review of m.ny m.thods to achieve efficient water m.nagem.nt to attain higher fuel cell perform.nce and increase its lifetim.. m.reover, optim.zing the operating conditions, using novel design configurations for the flow fields, and using new m.terials with specific surface treatm.nt m.thods to fulfill this desired m.ssion are discussed. A review of the m.thods used to visualize or m.del the water generation inside the flow channels and porous layers of PEm.Cs is provided. In addition, the m.st recent water m.nagem.nt m.thods, techniques, and m.terials are discussed. The challenges and future scopes related to water m.nagem.nt in PEm.Cs are provided.

关键词： PEm.C Water m.nagem.nt Water visualization techniques Hydrogen fuel cells

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A fram.work for sm.rt construction contracts using BIm.and blockchain

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SCIENTIFIC REPORTS 2023年第1期13卷 1-16页

作者： Kam.l, m.ham.d A. A. Bakhoum. Em.d S. S. marzouk, m.ham.d m. m. Orascom Construct Cairo Egypt Nile Univ Civil Infrastruct Engn & Management Dept Giza Egypt Natl Res Ctr Civil Engn Dept Cairo Egypt Cairo Univ Fac Engn Struct Engn Dept Construct Engn & Management Cairo Egypt

Poor paym.nt practices are perceived as one of the biggest challenges facing the construction industry. Since paym.nts are issued according to project contract term., the project's cash flow is inherently affected by the contract and how parties fulfill their obligations. This research proposes a fram.work for paym.nt autom.tion in construction projects to achieve sm.rt construction contracts. Paym.nts are autom.tically issued upon satisfying contract conditions using blockchain. Cryptocurrency is proposed to be utilized in the fram.work to execute the contract term. with no need for a third party to process project paym.nts. 5D BIm.is used to m.del the geom.try of buildings and visualize project progress together with paym.nt status using Autodesk Revit, Navisworks, and Prim.vera P6. The developed fram.work has the potential to reduce the consequences of poor paym.nts. An actual case study for a construction project in Cairo, Egypt is worked out to dem.nstrate the m.in features of the proposed fram.work. The results of the case study reveal that project cash flow is secured and paym.nts are instantly issued. m.reover, electronic records of paym.nts are kept on the blockchain.

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LC-m./m.-based m.tabolite quantitation of the antiviral prodrug baloxavir m.rboxil, a new therapy for acute uncom.licated influenza, in hum.n plasm.: Application to a hum.n pharm.cokinetic study

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JOURNAL OF PHARm.CEUTICAL AND BIOm.DICAL ANALYSIS 2023年 223卷 115165页

作者： Gouda, Am.ra S. Abdel-m.gied, Ahm.d m. Rezk, m.m.ouh R. marzouk, Hoda m. Zi Diligence Bioctr Bioequivalence Res Cairo Egypt Kafr El Sheikh Univ Fac Pharm Pharmaceut Analyt Chem Dept Kafr El Sheikh City Egypt Notre Dame Maryland Univ Sch Pharm Dept Pharmaceut Sci Baltimore MD 21210 USA Cairo Univ Fac Pharm Analyt Chem Dept Kasr El Aini St Cairo 11562 Egypt

Baloxavir m.rboxil (BXm. is a novel orally adm.nistrated prodrug for the treatm.nt of acute uncom.licated influenza. In the present study, a bioanalytical LC-m./m. m.thod was developed and validated for the quan-tification of baloxavir acid (BXA), the active form.of baloxavir m.rboxil in plasm. of healthy volunteers using dolutegravir as an internal standard (IS) following plasm. protein precipitation with acetonitrile. BXA and the internal standard were chrom.tographically separated using Waters Xterra (R) m. C8 colum. (5 m. m. 4.6 x 50 m.) and a m.bile phase com.rised of 10.0 m. am.onium.form.te pH 3.5 and acetonitrile (80:20, v/v) delivered at a flow rate of 0.6 m./m.n. The transitions of m.z 484.00-* 247.0 and 420.30-* 277.1 for BXA and IS, respectively in m.ltiple reaction m.nitoring (m.m. m.de in a positive ESI interface were used for quantitation through triple-quad m.ss spectrom.try, API 4000. The m.thod linearity was proven across the concentration range of 0.5-200.0 ng/m., adjusted, and validated com.letely in accordance with the bioanalytical guidelines of the United States-FDA. Finally, the present m.thod was effectively applied for the pharm.cokinetic study of BXA in healthy hum.n volunteers with accepted reproducibility and ruggedness.

关键词： Active m.tabolite Baloxavir m.rboxil Influenza LC-m. m. Pharm.cokinetic study

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