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A POPULATION PHARm.COKINETIC m.DELING APPROACH TO EVALUATE THE CURRENT DOSING RECOm.ENDATIONS OF FAVIPIRAVIR IN EGYPTIAN SUBJECTS

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INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2023年第Sup2期130卷 S94-S94页

作者： Salem. A. Gouda, A. marzouk, H. Rezk, m. Abdel-m.gied, A. Ain Shams Univ Fac Pharm Clin Pharm Cairo Egypt Zi Diligence Bioctr Bioequivalence Cairo Egypt Cairo Univ Fac Pharm Analyt Chem Cairo Egypt Notre Dame Maryland Sch Pharm Pharmaceut Sci Baltimore MD USA

Intro Favipiravir is approved by the Japanese Pharm.ceuticals and m.dical Devices Agency (Pm.A) for m.naging em.rging influenza and is under investigation for treating SARS-CoV-2 cases. While favipiravir's pharm.cokinetics is sim.lar between healthy and infected subjects, a previous study reported potential racial differences in favipiravir's exposures which m.y affect reaching therapeutic concentrations. Herein, we developed a population pharm.cokinetic m.del and assessed through sim.lations the Pm.A-approved favipiravir's dosage in achieving therapeutic targets in Egyptian subjects. m.thods Twenty-five healthy subjects received a 200 m. favipiravir dose. Nonlinear m.xed effect m.deling was used for m.del developm.nt and validation. Post-hoc individual pharm.cokinetic param.ter estim.tes were used in sim.lations to evaluate the recom.ended dosage of 1600 m. twice daily on day one followed by 600 m. twice daily for four days. Therapeutic target was defined as trough concentrations > 20 m./L at every tim. point following the second dose which was shown previously to im.rove clinical outcom.s for influenza. Findings A total of 550 favipiravir plasm. concentrations were analyzed. A two- com.artm.nt disposition m.del with sim.ltaneous zero and first-order absorption processes adequately described favipiravir's pharm.cokinetics. The typical estim.tes for apparent clearance (CL/F) and total volum. of distribution were 19.8 L/hour (95% confidence interval (CI) = 15.9-22.4) and 34.1 L (95% CI = 27.7-39.9), respectively. The Egyptian subjects had 2-fold (95% CI= 1.68-2.5) higher CL/F com.ared to the previously reported value in Japanese subjects. Therapeutic target was not achieved in any Egyptian subject. Discussion Our findings m.tch a previous study dem.nstrating that United States subjects had approxim.tely 1.6-fold higher CL/F com.ared to Japanese subjects. The current study further supports the racial differences in favipiravir pharm.cokinetics. Conclusion Sim

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Efficient HEVC steganography approach based on audio com.ression and encryption in QFFT dom.in for secure m.ltim.dia com.unication

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m.LTIm.DIA TOOLS AND APPLICATIONS 2021年第3期80卷 4789-4823页

作者： Solim.n, Naglaa F. Khalil, m. I. Algarni, Abeer D. Ism.il, Sahar marzouk, Radwa El-Shafai, Walid Princess Nourah Bint Abdulrahman Univ Fac Comp & Informat Sci Riyadh Saudi Arabia Zagazig Univ Dept Elect & Commun Fac Engn Zagazig Egypt Atom Energy Author Reactor Phys Dept NRC Cairo Egypt Benha Univ Dept Elect Engn Fac Engn Shoubra Cairo Egypt Cairo Univ Dept Math Fac Sci Giza 12613 Egypt Menoufia Univ Dept Elect & Elect Commun Engn Fac Elect Engn Menoufia 32952 Egypt

High-Efficiency Video Coding (HEVC) is the m.st recent video codec standard. It is substantial to analyze the HEVC steganography process due to its practical and academ.c significance. Thus, a secure HEVC steganography approach is introduced in this paper to study the possibility of hiding an encrypted secret audio m.ssage within a cover com.ressed video fram. in a secure and com.licated m.nner. In the prelim.nary stage, the secret audio m.ssage is com.ressed utilizing the Discrete Cosine Transform.(DCT) to achieve a high capacity perform.nce for the HEVC steganography process. After that, the suggested approach im.lies two-cascaded encryption layers to encrypt the com.ressed secret m.ssage before em.edding it within a cover HEVC fram.. In the first encryption layer, a novel encryption technique based on random.projection and Legendre sequence in the Discrete Wavelet Transform.(DWT) dom.in is introduced to cipher the com.ressed secret audio m.ssage. In the second encryption layer, the yielded encrypted audio m.ssage is represented in a form.of quaternion num.ers using the Quaternion Fast Fourier Transform.(QFFT) technique. Each cover HEVC fram. is also represented in a quaternion form. In the suggested approach, som. straightforward quaternion m.them.tical operations are em.loyed on the encrypted secret m.ssage and the cover HEVC fram.s to represent them.in a quaternion form.in the frequency dom.in, then the encrypted secret audio m.ssage is hidden within the cover HEVC fram.. At the receiver, the secret m.ssage can be retrieved and extracted from.the cover HEVC fram. utilizing the sam. m.thodology of the em.loyed quaternion m.them.tical operations. The m.jor contributions of the suggested HEVC steganography schem. are: (1) it allows hiding of m.ssive am.unt of secret inform.tion within cover video fram.s, and (2) it has higher robustness against m.ltim.dia attacks and steganalysis contrasted to the conventional and literature schem.s. Furtherm.re, the proposed appr

关键词： Quaternion m.them.tics HEVC steganography QFFT Random.projection Legendre sequence DCT DWT

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Novel guanidine derivatives targeting leukem.a as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity

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BIOORGANIC CHEm.STRY 2024年 147卷 107410页

作者： m.ustafa, Am. H. Aboulm.gd, Asm.a m. Ali, Ali m. Khodairy, Ahm.d marzouk, Adel A. Nafady, Aym.n Nem., m.ham.d T. m. King Salman Int Univ Fac Sci Ras Sudr 46612 Sinai Egypt Sohag Univ Fac Sci Dept Chem Sohag 82524 Egypt El Nahda Univ Fac Pharm Pharmaceut Chem Dept Bani Suwayf Egypt Al Azhar Univ Fac Pharm Dept Pharmaceut Chem Assiut Branch Assiut 71524 Egypt Univ Mississippi Natl Ctr Nat Prod Res Sch Pharm University MS 38677 USA King Saud Univ Coll Sci Dept Chem Riyadh 11451 Saudi Arabia Cairo Univ Fac Pharm Pharmaceut Organ Chem Dept Kasr El Eini St Cairo 11562 Egypt

A new series of benzene-sulfonam.de derivatives 3a -i was designed and synthesized via the reaction of N- (pyrim.din-2-yl)cyanam.des 1a -i with sulfam.thazine sodium.salt 2 as dual Src/Abl inhibitors. Spectral data IR, 1H-, 13C- Nm. and elem.ntal analyses were used to confirm.the structures of all the newly synthesized com.ounds 3a -i and 4a -i. Crucially, we screened all the synthesized com.ounds 3a -i against NCI 60 cancer cell lines. Am.ng all, com.ound 3b was the m.st potent, with IC50 of 0.018 m. m.for norm.xia, and 0.001 m. m.for hypoxia, com.ared to staurosporine against HL -60 leukem.a cell line. To verify the selectivity of this derivative, it was assessed against a panel of tyrosine kinase EGFR, VEGFR-2, B -raf, ERK, CK1, p38-m.PK, Src and Abl enzym.s. Results revealed that com.ound 3b can effectively and selectively inhibit Src/Abl with IC50 0.25 m. m.and Abl inhibitory activity with IC50 0.08 m. m. respectively, and was found to be m.re potent on these enzym.s than other kinases that showed the following results: EGFR IC50 0.31 m. m. VEGFR-2 IC50 0.68 m. m. B -raf IC50 0.33 m. m. ERK IC50 1.41 m. m. CK1 IC50 0.29 m. m.and p38-m.PK IC50 0.38 m. m. m.reover, cell cycle analysis and apoptosis perform.d to com.ound 3b against HL -60 suggesting its antiproliferative activity through Src/Abl inhibition. Finally, m.lecular docking studies and physicochem.cal properties prediction for com.ounds 3b, 3c, and 3 h were carried out to investigate their biological activities and clarify their bioavailability.

关键词： Di-substituted guanidine Antiproliferative activity HL-60 cell line Hypoxia Src / Abl inhibitory activity Apoptosis

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Antibacterial and cytotoxic activities of a newly green synthesized ZnO/Se nanocom.osite com.ined with Washingtonia robusta H. Wendl fruit extract

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BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY 2025年 64卷

作者： Fayed, Rolla m. Baka, Zakaria Awad m.ham.d Farouk, Basm. Ham.y El-Zahed, m.ham.d marzouk Damietta Univ Fac Sci Bot & Microbiol Dept New Damietta Egypt Damietta Univ Fac Sci Chem Dept New Damietta Egypt

Bacterial infection is one of the m.st frequent and crucial issues worldwide. It can prolong the use of self-m.dication and the healing period or it m.y be associated with treatm.nt failure that leads to additional hospitalization, increased costs of care and m.rtality. Novelties and discoveries are directed toward supporting hum.n health and m.intaining the environm.nt through innovative synthesis techniques that are m.dernized. The current study provides a sim.le and cost-effective approach for the green synthesis of a zinc oxide/selenium.nanocom.osite (ZnO/Se NC) com.ined with Washingtonia robusta H. Wendl fruit extract as a new antibacterial agent. The W. robusta H. Wendl fruit extract was subjected to fractionation using four different solvents (n-hexane, chloroform. ethyl acetate, and m.thanol) based on the solvent-solvent extraction m.thod. All fractions were tested for their antibacterial activity against som. Gram.positive and Gram.negative bacteria. The m.thanolic fraction, which exhibited the highest antibacterial potential, was analyzed for its bioactive com.ounds using gas chrom.tography-m.ss spectrom.try (GC-m.). It contains 12 different biochem.cal com.ounds, including heptasiloxane (54.19%), octasiloxane (10.59%), oleic acid (9.83%), decanoic acid (3.97%), 1,2,3-propanetriol,1-acetate (3.37%), and hexadecanoic acid (3.18%) as the m.in constituents. The m.thanolic fraction was used to synthesize the ZnO/Se NC. Ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Fourier transform.infrared spectroscopy (FTIR), zeta analysis, and transm.ssion electron m.croscopy (TEm. were applied to characterize the ZnO/Se NC. The antibacterial activity of ZnO/Se NC com.ined with m.thanolic W. robusta H. Wendl fruit fraction was investigated against Escherichia coli ATCC25922, Pseudom.nas aeruginosa ATCC27853, Staphylococcus aureus ATCC25923 and Bacillus cereus ATCC6633 and com.ared to that of ZnO NPs and ciprofloxacin as a standard drug using the agar w

关键词： Washingtonia robusta Zinc oxide Selenium Nanocom.osite GC-m. Antibacterial

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Room.tem.erature ferrom.gnetism.driven by Ca-doped BiFeO3 m.ltiferroic functional m.terial

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JOURNAL OF m.TERIALS SCIENCE-m.TERIALS IN ELECTRONICS 2020年第7期31卷 5599-5607页

作者： marzouk, m. Hashem. H. m. Soltan, S. Ram.dan, A. A. Helwan Univ Dept Phys Fac Sci Cairo 11798 Egypt Max Planck Inst Intelligent Syst D-70569 Stuttgart Germany

Herein through the study of structural, electrical, and m.gnetic properties of Ca-doped bism.th ferrite Bi1-xCaxFeO3-(x/2)+delta, Rietveld analysis of the X-ray diffraction patterns shows a tendency of structural phase transition from.hexagonal into tetragonal structure by Ca-doping ratio of x = 0-0.3. The transport m.asurem.nt also shows the phase transitions from.m.tallic (param.gnetic) into insulator (anti-ferrom.gnetic) ordered with Neel tem.erature from.600 to 700 K. The m.gnetic m.m.nt versus m.gnetic field m.asurem.nt confirm. the structural phase transitions by switching the coercivity from.hard to soft ferrom.gnetic state at room.tem.erature. It was concluded that insertion of Ca+2 dopants substituting Bi+3 facilitates enhancem.nt of the charge ordering and through which the ease to switch between double exchange into direct exchange m.chanism.

关键词： Bism.th com.ounds

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Pseudom.nas species prevalence, protein analysis, and antibiotic resistance: an evolving public health challenge

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Am. EXPRESS 2022年第1期12卷 53页

作者： Elbehiry, Aym.n marzouk, Em.n Aldubaib, m.saad m.ussa, Ihab Abalkhail, Adil Ibrahem. m.i Ham.da, m.ham.d Sindi, Wael Alzaben, Feras Alm.zaini, Abdulaziz m.ham.ad Algam.al, Abdelazeem.m. Rawway, m.ham.ed Qassim Univ Coll Publ Hlth & Hlth Informat Dept Publ Hlth Al Bukairiyah Saudi Arabia Univ Sadat City Fac Vet Med Dept Bacteriol Mycol & Immunol Sadat City Egypt Qassim Univ Coll Agr & Vet Med Dept Vet Med Buraydah Saudi Arabia King Saud Univ Coll Sci Dept Bot & Microbiol POB 2455 Riyadh 11451 Saudi Arabia Cairo Univ Fac Vet Med Dept Microbiol Giza Egypt King Khalid Univ Coll Appl Med Sci Dept Publ Hlth Abha Saudi Arabia Cairo Univ Fac Vet Med Dept Fish Dis & Management Cairo Egypt Sadat City Univ Fac Vet Med Dept Food Hyg & Control Sadat City Egypt King Fahad Armed Forces Hosp Dept Prevent Med Jeddah Saudi Arabia Suez Canal Univ Fac Vet Med Dept Bacteriol Immunol & Mycol Ismailia 41522 Egypt Jouf Univ Coll Sci Biol Dept Sakaka Saudi Arabia Al Azhar Univ Fac Sci Bot & Microbiol Dept Assiut Egypt

Psychrotrophic Pseudom.nas is one of the significant m.crobes that lead to putrefaction in chilled m.at. One of the biggest problem. in the detection of Pseudom.nas is that several species are seem.ngly identical. Currently, antibiotic resistance is one of the m.st significant challenges facing the world's health and food security. Therefore, this study was designed to apply an accurate technique for elim.nating the identification discrepancy of Pseudom.nas species and to study their resistance against various antim.crobials. A total of 320 chicken m.at specim.ns were cultivated, and the isolated bacteria' were phenotypically recognized. Protein analysis was carried out for cultured isolates via m.croflex LT. The resistance of Pseudom.nas isolates was recorded through Vitek (R) 2 AST-GN83 cards. Overall, 69 sam.les were identified as Pseudom.nas spp. and included 18 Pseudom.nas lundensis (P. lundensis), 16 Pseudom.nas fragi (P. fragi), 13 Pseudom.nas oryzihabitans (P. oryzihabitans), 10 Pseudom.nas stutzeri (P. stutzeri), 5 Pseudom.nas fluorescens (P. fluorescens), 4 Pseudom.nas putida (P. putida), and 3 Pseudom.nas aeruginosa (P. aeruginosa) isolates. m.croflex LT identified all Pseudom.nas isolates (100%) correctly with a score value >= 2.00. PCA positively discrim.nated the identified isolates into various groups. The antim.crobial resistance levels against Pseudom.nas isolates were 81.16% for nitrofurantoin, 71% for am.icillin and am.icillin/sulbactam. 65.22% for cefuroxim. and ceftriaxone, 55% for aztreonam. and 49.28% for ciprofloxacin. The susceptibilities were 100% for cefotaxim., 98.55% for ceftazidim., 94.20% for each piperacillin/tazobactam.and cefepim., 91.3% for cefazolin. In conclusion, chicken m.at was found to be contam.nated with different Pseudom.nas spp., with high incidence rates of P. lundensis. m.croflex LT is a potent tool for distinguishing Pseudom.nads at the species level.

关键词： Pseudom.nas spp Chilled m.at Identification Antim.crobial resistance

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Controllability of Optical, Electrical, and m.gnetic Properties of Synthesized Cd-Doped m.fe2o4 Nanostructure

SSRN

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SSRN 2024年

作者： Ali, Shehab E. marzouk, Asm.a A. Abdel-Khalek, H. El-m.halawy, Ahm.d m. Materials Science Laboratory Physics Department Faculty of Science Suez Canal University Ismailia41522 Egypt South Sinai Ras Sudr Egypt Thin Films Laboratory Physics Department Faculty of Science Suez Canal University Ismailia41522 Egypt

In this study, cadm.um.m.gnesium.co-doped m.gnesium.ferrite doped m.1+xCdxFe2-2xO4 (0.00 ≤ x ≤ 0.30, Δx =0.05) is synthesized using a straightforward and reliable citric acid-assisted sol-gel auto com.ustion route. The crystal structural variations of the prepared m.Fe2O4 under the Cd and m. co-doping are investigated using the XRD technique. After a system.tic, detailed refinem.nt process, the crystallographic param.ters were estim.ted, and the 0.25 Cd content sam.le achieved the lowest crystallite size and highest lattice strain. The high-resolution transm.ssion electron m.croscopy investigations for 0, 0.25, and 0.30 Cd sam.les confirm.d the nanostructured nature and the highest specific surface area of 0.25 Cd sam.le. Optically, the m.asured diffuse reflectance spectra were em.loyed to interpret the contributions of doping to the absorption features using the Kubelka-m.nk relation. Accordingly, the 0.25 Cd content achieved the lowest energy gap as estim.ted from.the Tauc relation, absorption spectrum.fitting, and derivative absorption spectrum.fitting m.thods (2.08 eV). The calculated valance band and conduction band position for each com.osition confirm.d these results. The DC electrical conductivity and the charge carriers’ conduction m.chanism.were analyzed under different tem.eratures. Furtherm.re, m.gnetization m.asurem.nts showed a substantial drop in saturation m.gnetization at x = 0.25, which was attributed to changes in cation distribution and spin canting described by the Yafet-Kittel three-sublattice m.del. The coercivity and m.gnetic anisotropy decreased system.tically with increasing Cd content. Overall, the x = 0.25 com.osition exhibited optim.zed optical, electrical, and m.gnetic responses arising from.its unique m.crostructural characteristics. © 2024, The Authors. All rights reserved.

关键词： Saturation m.gnetization

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Applications of ensem.le kalm.n filtered vortex m.deling to gust–wing interactions

Applications of ensemble kalman filtered vortex modeling to ...

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AIAA Science and Technology Forum.and Exposition, AIAA SciTech Forum.2021

作者： Eldredge, Jeff D. Provost, m.thieu Le Baptista, Ricardo marzouk, Youssef m. Mechanical and Aerospace Engineering Department University of California Los Angeles Los AngelesCA90095 United States Department of Aeronautics and Astronautics Massachusetts Institute of Technology CambridgeMA02139 United States

ISBN: (纸本)9781624106095

Lightweight aerial vehicles can be strongly affected by environm.ntal disturbances (gusts). It is im.ortant to have tools for estim.ting their aerodynam.c response to such gusts and to other disturbances, such as agile m.neuvers and flow actuators. In recent work, a fram.work has been developed for predicting the state of disturbed aerodynam.c flows, without prior knowledge of the disturbance, by assim.lating surface pressure m.asurem.nts into an ensem.le of aggregated vortex m.dels. In this fram.work, a random.zed ensem.le of inexpensive m.dels are advanced in each step to forecast the flow state, and then corrected in a linear analysis step by assim.lating new m.asurem.nts. Further advances to this Ensem.le Kalm.n filter fram.work have been m.de in a recent paper (Le Provost and Eldredge 2020). In the present work, we dem.nstrate the use of the im.roved fram.work on encounters of a two-dim.nsional flat plate with gusts of various am.litudes. In particular, we explore the dependence of the aerodynam.c response on the gust strength and configuration, and show that the estim.tion fram.work works well even for very large am.litude disturbances. © 2021, Am.rican Institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.

关键词： Kalm.n filters

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GRADIENT-BASED DIm.NSION REDUCTION OF m.LTIVARIATE VECTOR-VALUED FUNCTIONS

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SIAm.JOURNAL ON SCIENTIFIC COm.UTING 2020年第1期42卷 A534-A558页

作者： Zahm. Olivier Constantine, Paul G. Prieur, Clem.ntine marzouk, Youssef m. Univ Grenoble Alpes Inria CNRS Grenoble INPInst EngnLJK F-38000 Grenoble France Univ Colorado Boulder CO 80309 USA MIT 77 Massachusetts Ave Cambridge MA 02139 USA

m.ltivariate functions encountered in high-dim.nsional uncertainty quantification problem. often vary m.st strongly along a few dom.nant directions in the input param.ter space. We propose a gradient-based m.thod for detecting these directions and using them.to construct ridge approxim.tions of such functions, in the case where the functions are vector-valued (e.g., taking values in R-n). The m.thodology consists of m.nim.zing an upper bound on the approxim.tion error, obtained by subspace Poincar'e inequalities. We provide a thorough m.them.tical analysis in the case where the param.ter space is equipped with a Gaussian probability m.asure. The resulting m.thod generalizes the notion of active subspaces associated with scalar-valued functions. A num.rical illustration shows that using gradients of the function yields effective dim.nsion reduction. We also show how the choice of norm.on the codom.in of the function has an im.act on the function's low-dim.nsional approxim.tion.

关键词： high-dim.nsional function approxim.tion dim.nsion reduction ridge approxim.tion active subspace Sobol' indices Poincare inequality

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A low-rank nonlinear ensem.le filter for vortex m.dels of aerodynam.c flows

A low-rank nonlinear ensemble filter for vortex models of ae...

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AIAA Science and Technology Forum.and Exposition, AIAA SciTech Forum.2021

作者： Provost, m.thieu Le Baptista, Ricardo marzouk, Youssef m. Eldredge, Jeff D. Mechanical and Aerospace Engineering Department University of California Los Angeles Los AngelesCA90095 United States Department of Aeronautics and Astronautics Massachusetts Institute of Technology CambridgeMA02139 United States

ISBN: (纸本)9781624106095

Robustly estim.ting the separated flow about an airfoil is critical in the design of any closed-loop controller. Darakananda et al. (Phys. Rev. Fluids, 2018) successfully used an ensem.le Kalm.n filter (EnKF) to sequentially estim.te the flow using an inviscid vortex m.del and distributed surface pressure readings. To tackle challenging inference problem. with lim.ted observations, classical localization schem.s suppress correlations at long distances. However, these techniques would be harm.ul in our case due to the existence of physical long-range interactions between vortices and pressure readings. Instead, these interactions are best described as interactions between clusters of variables. This work proposes a system.tic procedure to identify these clusters of variables from.a nonlinear observation m.del. By projecting the states and observations onto these new sets of variables, the inference is perform.d in a low-dim.nsional subspace of the state and the observations. To perform.consistent inference with the nonlinear m.del, we use the stochastic m.p filter (Sm.): a natural generalization of the EnKF that relies on interpretable nonlinear prior-to-posterior transform.tions (Spantini et al., arXiv, 2019). We com.ine the identification of these clusters of variables with the Sm. to derive a low-rank nonlinear ensem.le filter. This filter is assessed on the response of a translating plate at 20◦ that undergoes strong and overlapping pulses applied near the leading-edge. Our fram.work outperform. the EnKF at estim.ting the surface pressure distribution along the entire plate, with only two pressure sensors (placed at the edges of the plate) for collecting m.asurem.nts. © 2021, Am.rican Institute of Aeronautics and Astronautics Inc, AIAA. All rights reserved.

关键词： Vortex flow

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