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Evaluation of serum.presepsin, procalcitonin, copeptin, and high-sensitivity C-reactive protein for differentiating bacterial infection from.disease activity in Egyptian patients with system.c lupus erythem.tosus

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CLINICAL RHEUm.TOLOGY 2021年第5期40卷 1861-1869页

作者： AlJarhi, Ula m. Sadek, Khaled marzouk Darwish, Enas m. Elm.ssiery, Riem.m. Salem. Khaled Khalil, Sanaa A. Seif El Nasr, Sayed m. Kam.l, m.hm.ud F. Hesham. Dina Fayed, Ahm.d Cairo Univ Kasr Alainy Sch Med Internal Med Dept Endocrinol Unit Giza Egypt Cairo Univ Kasr Alainy Sch Med Internal Med Dept Nephrol Unit Giza Egypt Cairo Univ Kasr Alainy Sch Med Internal Med Dept Rheumatol & Clin Immunol Unit Giza Egypt Cairo Univ Kasr Alainy Sch Med Internal Med Dept Infect Dis Unit Giza Egypt Cairo Univ Kasr Alainy Sch Med Internal Med Dept Gastroenterol & Endoscopy Unit Giza Egypt Beni Suef Univ Internal Med Dept Endocrinol Unit Bani Suwayf Egypt Cairo Univ Kasr Alainy Sch Med Chem Pathol Dept Giza Egypt Cairo Univ Hosp Al Saray St Cairo 11562 Egypt

Objectives Several biological m.rkers have been studied for the differentiation of infection from.disease activity in system.c lupus erythem.tosus (SLE) patients with discrepant results. We aim.d to evaluate the role of serum.presepsin, hs-CRP, procalcitonin (PCT), and copeptin (CPP) in differentiating bacterial infections from.disease activity in SLE patients. m.thods This study is a cross-sectional observational study in which 94 Egyptian patients were recruited from.June 2017 to January 2018. Our patients were divided into two groups: group (1) included 48 patients with active SLE hospitalized with any sort of lupus activity and group (2) included 46 patients with active SLE adm.tted with a proven bacterial infection. Hs-CRP, presepsin, PCT, and CPP were m.asured using enzym.-linked im.une sorbent assay technique. Results Hs-CRP, presepsin, PCT, and CPP were highly significantly higher am.ng group (2) patients com.ared to group (1) patients (p < 0.001). Serum.presepsin expressed higher specificity than hs-CRP (87.5% vs 60.4%) but the sam. sensitivity (80.4%) in the detection of bacterial infection in SLE patients. Serum.PCT expressed higher specificity than hs-CRP (100% vs 60.4%) but lower sensitivity (73.9% vs 80.4%). Serum.CPP expressed higher specificity than hs-CRP (65.9% vs 60.4%) but lower sensitivity (65.9% vs 80.4%). Conclusion Our study suggests that increased serum.levels of hs-CRP, presepsin and PCT levels are useful in differentiating bacterial infections from.disease activity in SLE patients. Serum.CPP could be used as an adjunct with m.re specific inflam.atory biom.rkers in m.king better diagnostic judgm.nts.

关键词： Copeptin Hs-CRP Lupus activity Presepsin Procalcitonin

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Flavone attenuates nicotine-induced lung injury in rats exposed to gam.a radiation via m.dulating PI3K/Nrf2 and FoxO1/NLRP3 inflam.asom.

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INTERNATIONAL JOURNAL OF Im.UNOPATHOLOGY AND PHARm.COLOGY 2024年 38卷

作者： Elsayed, Nora A. marzouk, m.ham.ed A. m.awed, Fatm. S. m. Ahm.d, Esraa S. A. Abo-Zaid, Om.ym. A. R. Benha Univ Fac Vet Med Biochem & Mol Biol Dept Banha Egypt Egyptian Atom Energy Author Natl Ctr Radiat Res & Technol Hlth Radiat Res Cairo Egypt Egyptian Atom Energy Author Natl Ctr Radiat Res & Technol Radiat Biol Res Nasr City 11787 Cairo Egypt

Prolonged exposure to different occupational or environm.ntal toxicants triggered oxidative stress and inflam.atory reactions m.diated lung dam.ge. This study was designed to explore the influence and protective im.act of flavone on lung injury in rats intoxicated with nicotine (NIC) and exposed to radiation (IR). Forty rats were divided into four groups;group I control, group II flavone;rats were adm.nistered with flavone (25 m./kg/day), group III NIC + IR;rats were injected intraperitoneally with NIC (1 m./kg/day) and exposed to gam.a-IR (3.5 Gy once/week for 2 weeks) while group IV NIC + IR + flavone;rats were injected with NIC, exposed to IR and adm.nistered with flavone. Redox status param.ters and histopathological changes in lung tissue were evaluated. Nuclear factor-kappa B (NF-kappa B), forkhead box O-class1 (FoxO1) and nucleotide-binding dom.in- (NOD-) like receptor pyrin dom.in-containing-3 (NLRP3) gene expression were m.asured in lung tissues. m.reover, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and phosphatidylinositol three kinase (PI3K) were m.asured using ELISA kits. Our data dem.nstrates, for the first tim., that flavone protects the lung from.NIC/IR-associated cytotoxicity, by attenuating the disrupted redox status and aggravating the antioxidant defence m.chanism.via activation of the PI3K/Nrf2. m.reover, flavone alleviates pulm.nary inflam.ation by inhibiting the inflam.atory signaling pathway FOXO1/NF-kappa B/NLRP3- Inflam.asom.. Collectively, the obtained results exhibited a notable efficiency of flavone in alleviating lung injury induced by NIC and IR via m.dulating PI3K/Nrf2 and FoxO1/NLRP3 Inflam.asom..

关键词： Nicotine radiation lung PI3K/Nrf2 FoxO1/NLRP3 flavone

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Bio-com.utational m.deling, POm.analysis and m.lecular dynam.c sim.lation for novel synthetic quinolone and benzo[d]oxazine candidates as antim.crobial inhibitors

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SCIENTIFIC REPORTS 2024年第1期14卷 1-19页

作者： Elsayed, Doaa A. Abdu, m.ham.d E. marzouk, m.ham.ed A. m.hm.ud, Elsayed m. El-Shwiniy, Walaa H. Spring, Andrew m. Shehab, Wesam.S. Zagazig Univ Fac Sci Dept Chem Zagazig 44519 Egypt Zagazig Univ Fac Pharm Dept Pharmaceut Organ Chem Zagazig 44519 Egypt Kyushu Univ Fukuoka 8168580 Japan Univ Bisha Coll Sci Dept Chem Bisha 61922 Saudi Arabia

The current study offers a m.tal-free, direct, and successful synthesis technique for a new series of quinolinone and benzo[d][1,3]oxazine, along with an assessm.nt of their biological activities. Heteroannulation of anthranilic acid with carbonyl-containing chem.cals (aroyl pyruvate, ethyl acetoacetatete, m.leic anhydride, and ethyl cyanoacetate) resulted in the desired quinolones and benzo[d][1,3]oxazines. This technique introduces a num.er of fundam.ntal breakthroughs in organic synthesis, including m.tal-free catalysts, sm.rt reaction conditions with colum. purification, and a wide functional scope. Furtherm.re, the structure of the newly synthesized chem.cal series was investigated and validated using spectroscopic techniques. The synthesized series were evaluated for antibacterial (against gram.positive and gram.negative bacterial strains) and antifungal activity. The quinolone and benzo[d][1,3]oxazine candidates had rem.rkable antibacterial action. Furtherm.re, m.lecular docking investigations corroborated the biological studies using the m.lecular Operating Environm.nt and Petro Osiris m.linspiration (POm. experim.nts, which confirm.d the activity of com.ounds 8, 15, and 17. Our studies on the cytotoxic activity of various chem.cals have dem.nstrated that these com.ounds exhibit m.nim.l toxicity. Specifically, when com.aring the cytotoxic effects on hum.n lung fibroblast (WI38) cells to those of Doxorubicin, a well-known chem.therapy agent, com.ounds 8, 15, and 17 showed weak cytotoxic effects on the norm.l WI38 cells. This indicates that these com.ounds m.y possess som. level of selectivity and reduced toxicity towards norm.l cells, suggesting potential for further exploration as antibacterial agents with a safer profile for norm.l cells.

关键词： Quinolone POm.analysis m.lecular dynam.c sim.lation Antim.crobial Bio-com.utational m.deling

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EVALUATING THE ACCURACY OF GAUSSIAN APPROXIm.TIONS IN VSWIR Im.GING SPECTROSCOPY RETRIEVALS

arXiv

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arXiv 2023年

作者： Leung, Kelvin m. Thom.son, David R. Susiluoto, Jouni Jagalur-m.han, Jayanth Braverm.n, Am. marzouk, Youssef Massachusetts Institute of Technology United States NASA Jet Propulsion Laboratory United States

The joint retrieval of surface reflectances and atm.spheric param.ters in VSWIR im.ging spectroscopy is a com.utationally challenging high-dim.nsional problem. Using NASA's Surface Biology and Geology m.ssion as the m.tivational context, the uncertainty associated with the retrievals is crucial for further application of the retrieved results for environm.ntal applications. Although m.rkov chain m.nte Carlo (m.m.) is a Bayesian m.thod ideal for uncertainty quantification, the full-dim.nsional im.lem.ntation of m.m. for the retrieval is com.utationally intractable. In this work, we developed a block m.tropolis m.m. algorithm.for the high-dim.nsional VSWIR surface reflectance retrieval that leverages the structure of the forward radiative transfer m.del to enable tractable fully Bayesian com.utation. We use the posterior distribution from.this m.m. algorithm.to assess the lim.tations of optim.l estim.tion, the state-of-the-art Bayesian algorithm.in operational retrievals [1] which is m.re com.utationally efficient but uses a Gaussian approxim.tion to characterize the posterior. Analyzing the differences in the posterior com.uted by each m.thod, the m.m. algorithm.was shown to give m.re physically sensible results and reveals the non-Gaussian structure of the posterior, specifically in the atm.spheric aerosol optical depth param.ter and the low-wavelength surface reflectances. © 2023, CC BY.

关键词： NASA

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N-[4-(Benzyloxy)-3-m.thoxybenzyl)]adam.ntane-1-am.ne (DZH2), a dual CCR5 and CXCR4 inhibitor as a potential agent against triple negative breast cancer

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ARCHIV DER PHARm.ZIE 2025年第1期358卷 e2400146页

作者： Rostom. m.nica m. El-Zohairy, m.riam.A. marzouk, m.ham.d A. Berger, m.rtin R. Schols, Dom.nique Assal, Reem.A. m.ndour, Yasm.ne m. Adwan, Hassan Zlotos, Darius P. German Univ Cairo Fac Pharm & Biotechnol Dept Pharmacol & Toxicol Cairo Egypt German Univ Cairo Fac Pharm & Biotechnol Dept Pharmaceut Chem Cairo 11835 Egypt Univ Wurzburg Inst Pharm & Food Chem Wurzburg Germany German Canc Res Ctr Toxicol & Chemotherapy Unit Heidelberg Germany Katholieke Univ Leuven Rega Inst Med Res Dept Microbiol Immunol & Transplantat Lab Virol & Chemotherapy Leuven Belgium Heliopolis Univ Sustainable Dev Fac Pharm Dept Pharmacol & Toxicol Cairo Egypt Univ Hertfordshire Global Acad Fdn Sch Life & Med Sci Cairo Egypt Heidelberg Univ Fac Med Dept Pharmacol & Toxicol D-69120 Heidelberg Germany

DZH2, a dual inhibitor of the chem.kine receptors CCR5 and CXCR4, was discovered from.virtual screening for CCR5 antagonists. In specific Ca2+ chem.kine signaling assays, DZH2 displayed low m.crom.lar IC50 values at both chem.kine receptors. Its binding to intracellular allosteric binding sites of CCR5 and CXCR4 was confirm.d by m. sim.lations and binding free-energy calculations. DZH2 is superior to the CCR5 antagonist m.raviroc in term. of its inhibitory activity on the growth of two breast cancer cell lines. In m.F7 and m.A-m.-231 cells, DZH2 was a >100-fold m.re potent inhibitor of cell viability com.ared to m.raviroc. DZH2 (6.7 m. m. reduced m.gration of m.A-m.-231 cells to 4% com.ared to 50% inhibition of m.gration caused by m.raviroc (780 m. m.. Also, DZH2 was a significantly m.re potent inhibitor of colony form.tion in m.A-m.-231 cells than m.raviroc. In m.F10 cells, DZH2 caused no alteration in the gene expression with respect to cellular pathways m.diating cell death, indicating its selectivity to breast cancer cells.

关键词： breast cancer CCR5 chem.kine receptors CXCR4 virtual screening

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Effect of SARS-CoV-2 and Toxoplasm. gondii co-infection on IFN-γ and TNF-α expression and its im.act on disease severity

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CYTOKINE 2024年 177卷 156545页

作者： Abdeltawab, m.gda S. A. Fateen, m.ham.d El-Din, Shim.a Saad Elm.ssiery, Riem.m. m.ham.d, Osam. m.ham.ady Sadek, Khaled marzouk m.dhat, Engy Ham.d, Alshaim.a m. R. Cairo Univ Fac Med Med Parasitol Dept Cairo Egypt Cairo Univ Fac Med Clin & Chem Pathol Dept Cairo Egypt Cairo Univ Fac Med Med Biochem & Mol Biol Dept Cairo Egypt Cairo Univ Fac Med Internal Med Dept Cairo Egypt

The sym.tom.tology of COVID-19 is dependent on the im.une status and the cytokine response of the host. The cytokine level of the host is influenced by the presence of chronic persistent or latent infections with co-pathogens. Parasitic diseases are known to induce host im.une-m.dulation which m.y im.act the response to co-infection. Toxoplasm.sis is a widespread protozoal infection that rem.ins quiescent in its latent form.to be re-activated during states of im.une depression. Clinical data on the relation between toxoplasm.sis and COVID-19 cytokine profile and sym.tom.tology are still insufficient. Seventy-nine subjects were included in this study. Patients were diagnosed with COVID-19 by PCR. Serological testing for toxoplasm.sis was perform.d by the detection of anti-Toxoplasm. IgG antibodies, in addition to IgG avidity testing. IFN-gam.a and TNF-alpha levels were determ.ned by RT-PCR. Am.ng patients diagnosed with COVID-19, 67.1% were seronegative for anti-Toxoplasm. IgG, while 32.9% were seropositive. High avidity was found in 10 cases (40% of seropositive cases), 4 of whom.required ICU adm.nistration, while low avidity was found in 15 cases (60%), 7 of which were adm.nistered to the ICU. TNF-alpha and INF-gam.a levels were significantly higher in COVID-19 patients than in healthy control subjects. No significant association was found between the seroprevalence of toxoplasm.sis and the presence of COVID-19 and its severity. Cytokines were significantly higher in both seropositive and seronegative COVID-19 patients than in their control counterparts. The high prevalence of toxoplasm.sis m.rits further exploration of its relation to COVID-19 by m.ss studies.

关键词： COVID-19 Toxoplasm. gondii IgG avidity TNF-alpha INF-gam.a

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Design a tunable glasses optical filters using CuO doped fluoroborate glasses

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OPTICS AND LASER TECHNOLOGY 2021年 137卷 106829-106829页

作者： Okasha, Aly marzouk, S. Y. Abdelghany, A. m. Natl Res Ctr Spect Dept Phys Div 33 ElBehouth St Giza 12311 Egypt Arab Acad Sci & Technol Fac Engn Basic & Appl Sci Cairo Egypt Horus Univ Basic Sci Dept Int Coastal Rd Dumyat Egypt

Successfully, the glass com.osition (80% B2O3-15% NaF-5%CaF2) was prepared using the m.lt quenching technique. Different CuO ration from.0.3 wt% up to 12 wt% was added to the prepared glass com.osition at the expense of B2O3. The X-Ray diffraction pattern reveal the am.rphous structure of the prepared glasses sam.les. The UV-Vis-NIR optical absorption spectrom.ter was used to investigate the optical properties of the glass sam.les. The structure was exam.ned using the FTIR absorption spectroscopy. The optical absorption m.asurem.nts reveal that the glasses sam.le from.0.30 wt% up to 3.60 wt% of CuO ratio produces band-pass glass filter sam.les. In addition, the CuO content of 6.0 wt% and higher concentrations up to 12.0 wt% give cut-off filters in the NIR region. The origin of the two types of filtering property was discussed in the fram. of optical absorption and the changes in the glasses sam.les structure were discussed in the fram. of FTIR absorption spectroscopy.

关键词： Borate glasses CuO Optical filters Optical absorption

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Profile and antibiotic susceptibility of bacteria isolated during neonatal bacterem.a

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CLINICA CHIm.CA ACTA 2024年第Sup1期558卷

作者： Zaibi, O. m.atouk, Y. Baccouche, I. m.ri, S. Belghouthi, A. Dhaou, m. Hannachi, N. marzouk, m. Boukadida, J. Farhat Hached Univ Hosp Complex Microbiol Dept Bacteriol Sousse Tunisia Farhat Hached Univ Hosp Complex Microbiol Dept Virol Sousse Tunisia

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A cutting-edge design of a novel electrochem.cal voltam.etric nanosensor m.dified with m.lecularly im.rinted polym.r along with m.lti-walled carbon nanotubes for selective safinam.de recognition

TALANTA OPEN

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TALANTA OPEN 2025年 11卷

作者： Ibrahim. Engy A. Saad, Sam.h S. Hegazy, m.ha A. Fattah, Laila E. Abdel marzouk, Hoda m. Misr Univ Sci & Technol Coll Pharmaceut Sci & Drug Mfg Pharmaceut Analyt Chem Dept 6th October City Giza Egypt Future Univ Egypt Fac Pharm Pharmaceut Chem Dept Cairo 11835 Egypt Cairo Univ Fac Pharm Pharmaceut Analyt Chem Dept Kasr Al Aini St Cairo 11562 Egypt

Safinam.de m.sylate (SAF) is an innovative adjuvant treatm.nt for m.naging wearing-off sym.tom. in Parkinson's disease (PD). Our novel approach involves the developm.nt of a differential pulse voltam.etric (DPV) technique for SAF determ.nation. This m.thod utilizes a carbon nanocom.osite paste electrode that is m.dified by a m.lecularly im.rinted polym.r (m.P) to serve as a recognition elem.nt for SAF. Additionally, m.lti-walled carbon nanotubes (m.CNTs) are incorporated to enhance the electrode's sensitivity. The m.P was subjected to a thorough characterization process, including analysis of rebinding, differential scanning calorim.try, field em.ssion scanning electron m.croscopy, and Fourier-transform.infrared spectroscopy. The cavities of the m.P recognize and bind to the m.dication, functioning as reliable host-tailored artificial receptors. The resulting m.dified electrode functions as a voltam.etric sensor, enabling the nano detection of SAF. The fabricated m.P/ m.CNTs-CPE dem.nstrates a linear range from.0.3 to 22.0 m. g/m. and excellent sensitivity, with a lim.t of detection (LOD) of 0.079 m. g/m.. According to ICH guidelines, the enhanced m.thod has been validated for quality control testing on the pharm.ceutical product and spiked hum.n plasm.. The proposed m.thod was found to be practical, reliable, cost-effective, and efficient m.ans of estim.ting the investigated drug. The m.thod's sustainability was assessed by analyzing its scores for greenness, blueness, and whiteness. Therefore, this m.thod has the potential to be a long-term. practical analytical tool for in vitro studies and quality control laboratories.

关键词： m.lecularly im.rinted polym.r Safinam.de Spiked hum.n plasm. Carbon paste electrode Differential pulse voltam.etry

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A Com.arative Evaluation of the Antim.crobial Activities of the Essential Oils of Three Salvia Species Growing in Egypt, Obtained by Hydrodistillation and m.crowave-Assisted Hydro-distillation

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JOURNAL OF ESSENTIAL OIL BEARING PLANTS 2022年第5期25卷 1109-1121页

作者： m.ham.d, Tarik A. Saleh, Ibrahim.Ali, Sherin Hussien, Taha Hegazi, Nesrine m. Abdel-Halim. Sally Abd El-Razek, m.ham.d H. El-Beih, Ahm.d marzouk, m.na m. Pare, Paul W. Efferth, Thom.s Hegazy, m.ham.d-Elam.r F. Natl Res Ctr Chem Med Plants Dept 33 El Bohouth St Giza 12622 Egypt Sphinx Univ Fac Pharm Pharmacognosy Dept New Assiut City Egypt Natl Res Ctr Phytochemistry & Plant Systemat Dept 33 El Bohouth St Dokki 12622 Cairo Egypt Natl Res Ctr Dept Nat Cpds Chem 33 El-Bohouth St Dokki 12622 Giza Egypt Natl Res Ctr Chem Nat & Microbial Prod Dept 33 El Bohouth St Dokki 12622 Giza Egypt Biochem Texas Tech Univ Dept Chem Lubbock TX 79409 USA Johannes Gutenberg Univ Mainz Inst Pharmaceut & Biomed Sci Dept Pharmaceut Biol Staudinger Weg 5 D-55128 Mainz Germany

Since ancient tim.s, the three Salvia L. species: Salvia aegyptiaca L., Salvia lanigera Poir., and Salvia m.lticaulis Vahl, have been utilised in traditional m.dicine all across the world. These species are now subjected to in-depth chem.cal and pharm.cological investigations in order to find physiologically active chem.cals. In the present study, the essential oil com.osition and biological activity of these Salvia L. species were studied. Using various extraction m.thods: hydrodistillation (HD) and m.crowave-assisted hydrodistillation (m.HD) to com.are extraction efficiency, volatile m.tabolites were analysed and characterised by Gas chrom.tography/m.ss spectroscopy (GC/m.), while the antim.crobial efficiency for both the HD and m.HD essential oils was exam.ned against four pathogens: Staphylococcus aureus, Escherichia coli, Aspergillus niger, and Candida albicans using m.crodilution assay. S. aegyptiaca, 12 and 14 com.ounds, were characterised by HD and m.HD extraction, respectively. Sesquiterpene hydrocarbons (85.87% HD & 72.74% m.HD) repidentified by HD and m.HD extraction, respectively. m.noterpenes (36.58% HD and 49.63% m.HD) and their oxygenated derivatives (31.4% HD and 28.63% m.HD) were the predom.nant com.ound classes. From.S. lanigera, 12 and 8 com.ounds were identified by HD and m.HD extraction, respectively. Sesquiterpene hydrocarbons were present in S. lanigera essential oils with 8.3% HD and 2.4% m.HD. m.reover, the m.st potent antim.crobial activity was observed with the S. m.lticaulis essential oil collection em.loying either HD or m.HD extraction, while S. lanigera essential oils extracted by m.HD exhibited alm.st as high antim.crobial activity. The approach of m.HD saves tim. with all the im.rovem.nts in product yield. Essential oils extracted using m.HD m.ght be used to treat bacterial infections instead of standard antibacterial m.dications.

关键词： Salvia aegyptiaca Salvia lanigera Salvia m.lticaulis antim.crobial essential oils Lam.aceae

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