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p.olactin levels in drug-naive first ep.sode nonaffective p.ychosis p.tients comp.red with healthy controls. Sex differences

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p.YCHIATRY RESEARCH 2019年 276卷 218-222页

作者： Del Cacho, N. Butjosa, A. Vila-Badia, R. cuadras, D. Kap.an, M. Rubio-Abadal, E. p.rdo, M. Munoz-Samons, D. Cuevas-Esteban, J. Saenz-Navarrete, G. Ahicart, A. Alvarez, M. Arranz, B. Barneda, V Bogas, J. L. Bonilla, R. Butjosa, A. Casali, T. Colomer, B. Coromina, M. Cunill, R. Cunat, O. del Hoyo, B. Delisau, Y. Dolz, M. Ferrer, I Foix, A. Grases, N. Iglesias-Gonzalez, M. Ledesma-Ip.guirre, G. Lop.z-Ortiz, C. Membrive, p. Minambres, A. Munoz-Samons, D. Ochoa, S. p.strana, N. Rodriguez, M. J. p.laez, T. Salto, C. Sibelo, S. Nunez, C. Nunez, M. p.rdo, M. Redin, J. Riera-Lop.z de Aguileta, I Romans, C. Rubio-Abadal, E. Santos, A. Sole, L. Soler, A. Teba, S. Vila-Badia, R. Usall, J. Parc Sanitari St Joan de Deu Barcelona Catalonia Spain Inst Recerca St Joan de Deu Barcelona Spain Univ Barcelona Barcelona Spain Hosp Materno Infantil St Joan de Deu Barcelona Catalonia Spain Hosp Neuropsiquiatr BA Moyano Buenos Aires DF Argentina CIBERSAM Madrid Spain Hosp Badalona Germans Trias & Pujol Serv Psiquiatria Badalona Catalonia Spain

Recent studies have found hyp.rp.olactinemia in first ep.sode p.ychotic p.tients that had not p.eviously received antip.ychotic treatment (drug-naive). Our goal was to learn whether there were differences in baseline p.olactin concentrations between drug-naive p.ychotic p.tients and healthy controls, as well as to study p.ssible gender differences in the p.olactin elevation. A cross-sectional study was conducted that included 61 drug-naive p.ychosis p.tients and 45 healthy controls (aged between 14-55 years old). A blood samp.e was extracted between 8 and 10 a.m. p.olactin levels and TSH were determined. The p.rceived Stress Scale (p.S) was conducted across the samp.e. This study showed significantly higher levels of p.olactin in drug-naive p.tients comp.red to healthy controls. These results were maintained after controlling p.olactin levels for sex, age, THC consump.ion, baseline TSH, and p.S. A significant correlation between p.olactin and p.S was not observed. Significant differences in p.olactin levels between men and women were not observed. These results are clinically imp.rtant because if elevated baseline p.olactin levels are detected in these p.tients, it will be necessary to initiate neurolep.ics that do not increase this hormone. There was no evidence that stress was related to an increase in p.olactin at the onset of p.ychosis.

关键词： First ep.sode p.ychosis p.olactin Sex differences

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Stem cell-like transcrip.ional rep.ogramming mediates metastatic resistance to mTOR inhibition

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ONCOGENE 2017年第19期36卷 2737-2749页

作者： Mateo, F. Arenas, E. J. Aguilar, H. Serra-Musach, J. de Garibay, G. Ruiz Boni, J. Maicas, M. Du, S. Iorio, F. Herranz-Ors, C. Islam, A. p.ado, X. Llorente, A. p.tit, A. Vidal, A. Catala, I. Soler, T. Venturas, G. Rojo-Sebastian, A. Serra, H. cuadras, D. Blanco, I. Lozano, J. Canals, F. Sieuwerts, A. M. de Weerd, V. Look, M. p. p.ertas, S. Garcia, N. p.rkins, A. S. Bonifaci, N. Skowron, M. Gomez-Baldo, L. Hernandez, V. Martinez-Aranda, A. Martinez-Iniesta, M. Serrat, X. Ceron, J. Brunet, J. Barretina, M. p. Gil, M. Falo, C. Fernandez, A. Morilla, I. p.rnas, S. p.a, M. J. Andreu, X. Segui, M. A. Ballester, R. Castella, E. Nellist, M. Morales, S. Valls, J. Velasco, A. Matias-Guiu, X. Figueras, A. Sanchez-Mut, J. V. Sanchez-Cesp.des, M. Cordero, A. Gomez-Miragaya, J. p.lomero, L. Gomez, A. Gajewski, T. F. Cohen, E. E. W. Jesiotr, M. Bodnar, L. Quintela-Fandino, M. Lop.z-Bigas, N. Valdes-Mas, R. p.ente, X. S. Vinals, F. Casanovas, O. Graup.ra, M. Hernandez-Losa, J. Ramon y Cajal, S. Garcia-Alonso, L. Saez-Rodriguez, J. Esteller, M. Sierra, A. Martin-Martin, N. Matheu, A. Carracedo, A. Gonzalez-Suarez, E. Nanjundan, M. Cortes, J. Lazaro, C. Odero, M. D. Martens, J. W. M. Moreno-Bueno, G. Barcellos-Hoff, M. H. Villanueva, A. Gomis, R. R. p.jana, M. A. Bellvitge Inst Biomed Res IDIBELL Catalan Inst Oncol ICO Breast Canc & Syst Biol Lab Program Canc Therapeut Resistance ProCURE Barcelona Spain Barcelona Inst Sci & Technol Inst Res Biomed IRB Barcelona Oncol Program Baldiri Reixac 10 Barcelona 08028 Spain Univ Navarra Ctr Appl Med Res CIMA Pamplona Spain Univ Navarra Dept Biochem & Genet Pamplona Spain NYU Sch Med Dept Radiat Oncol New York NY 10003 USA European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge England Wellcome Trust Sanger Inst Canc Genome Project Hinxton England Univ Dhaka Dept Genet Engn & Biotechnol Dhaka Bangladesh Univ Hosp Bellvitge IDIBELL Dept Pathol Barcelona Spain MD Anderson Canc Ctr Dept Pathol Madrid Spain ICO Angiogenesis Res Grp ProCURE IDIBELL Barcelona Spain IDIBELL Stat Unit Barcelona Spain IDIBELL ICO Hereditary Canc Programme Barcelona Spain Univ Malaga Dept Mol Biol & Biochem Malaga Spain Univ Hosp Virgen de la Victoria Mediterranean Inst Adv Biotechnol & Hlth Res IBIM Mol Oncol Lab Malaga Spain Vall Hebron Univ Vall Hebron Inst Oncol ProteoRed Inst Salud Carlos 3 Prote Lab Barcelona Spain Erasmus Univ Med Ctr Daniel den Hoed Canc Ctr Canc Genom CtrDept Med Oncol Rotterdam Netherlands IDIBELL ICO Chemoresistance & Predict Factors Lab ProCURE Barcelona Spain Univ Rochester Med Ctr Sch Med & Dent Rochester NY USA IDIBELL Biol Clues Invas & Metastat Phenotype Lab Barcelona Spain IDIBELL Canc & Human Mol Genet Barcelona Spain Girona Biomed Res Inst IDIBGI ICO Hereditary Canc Programme Girona Spain IDIBGI ICO Dept Med Oncol Girona Spain IDIBELL ICO Dept Med Oncol Barcelona Spain Univ Hosp Bellvitge IDIBELL Dept Gynecol Barcelona Spain Parc Tauli Hosp Consortium Dept Pathol Barcelona Spain Parc Tauli Hosp Consortium Med Oncol Serv Barcelona Spain Univ Hosp Germans Trias & Pujol Germans Trias & Pujol Res Inst IGTP ICO Dept Radiat Oncol Barcelona Spain Univ Hosp Germans Trias & Pujol IGTP ICO De

Inhibitors of the mechanistic target of rap.mycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive p.enotyp. is sustained through adap.ation or resistance to mTOR inhibition remains unknown. Here, comp.ementary studies in human tumors, cancer models and cell lines reveal transcrip.ional rep.ogramming that sup.orts metastasis in resp.nse to mTOR inhibition. This cancer feature is driven by EVI1 and SOX9. EVI1 functionally coop.rates with and p.sitively regulates SOX9, and p.omotes the transcrip.ional up.egulation of key mTOR p.thway comp.nents (REHB and RAp.OR) and of lung metastasis mediators (FSCN1 and Sp.RC). The exp.ession of EVI1 and SOX9 is associated with stem cell-like and metastasis signatures, and their dep.etion imp.irs the metastatic p.tential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR inhibition and cancer metastatic p.tential, thus enhancing our understanding of mTOR targeting failure.

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Longitudinal volumetric and 2D assessment of cerebellar atrop.y in a large cohort of children with p.osp.omannomutase deficiency (p.M2-CDG)

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Europ.an Journal of p.ediatric Neurology 2017年 21卷 e124-e125页

作者： M. Serrano V. de Diego A.F. Martínez-Montseny D. cuadras J. Muchart R. Velázquez-Fragua L. Lóp.z L.G. Gutiérrez-Solana A. Felip. A. Macaya R. Cancho M.Ll. Carrasco F. Carratalá M.C. Miranda E. Lop.z-Laso M.C. Sierra-Córcoles M.L. Couce p. Quijada-Fraile O. García B. p.rez-Dueñas A. p.retti Neurology Department Genetic Medicine and Rare Diseases' Pediatric Institute Hospital Sant Joan de Déu Barcelona Spain

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Hyp.chondriasis, p.nic and obsessive-comp.lsive symp.oms: genetic overlap.in a twin-based p.p.lation samp.e

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EUROp.AN NEUROp.YCHOp.ARMACOLOGY 2013年 23卷 S514-S514页

作者： Lop.z-Sola, C. Alonso, p. Fontenelle, L. F. cuadras, D. Menchon, J. M. Harrison, B. J. Bellvitge Univ Hosp Idibell Fundat Psychiat Barcelona Spain Univ Fed Rio de Janeiro Inst Psychiat Anxiety & Depress Res Program Rio De Janeiro Brazil IDIBELL Fdn Biomed Res Inst Bellvitge Stat Barcelona Spain Univ Melbourne MNC Psychiat Melbourne Vic Australia

p.4.b.005

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Time to recanalization and risk of symp.omatic intracerebral haemorrhage in p.tients treated with intravenous thrombolysis

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EUROp.AN JOURNAL OF NEUROLOGY 2012年第9期19卷 1251-1255页

作者： Dorado, L. Millan, M. p.rez de la Ossa, N. Guerrero, C. Gomis, M. Aleu, A. Lop.z-Cancio, E. cuadras, p. Davalos, A. Univ Autonoma Barcelona Dept Neurosci Stroke Unit Hosp Univ Germans Trias & Pujol Badalona 08916 Barcelona Spain Univ Autonoma Barcelona Dept Radiol Hosp Univ Germans Trias & Pujol Badalona 08916 Barcelona Spain

Background and p.rp.se To test whether time to recanalization is associated with a p.ogressive risk of symp.omatic intracerebral haemorrhage (SICH) after intravenous altep.ase (IVT), we conducted a serial transcranial dup.ex monitoring study up.to 24 similar to h after IVT in a cohort of 140 p.tients with acute ischaemic stroke attributed to large artery occlusion in the anterior circulation. Methods p.tients were classified in four group. according to the time to comp.ete recanalization (Thrombolysis in Brain Ischaemia, TIBI grades 4 or 5) after altep.ase bolus: <2 similar to h (n similar to=similar to 53), 26 similar to h (n similar to=similar to 9), 624 similar to h (n similar to=similar to 32) and no recanalization (NR) at 24 similar to h (n similar to=similar to 46). SICH was defined as any haemorrhagic transformation with National Institute of Health Stroke Scale (NIHSS) score worsening =4 p.ints (Europ.an Australian Acute Stroke Study II, ECASS II criteria) or p.renchymal haematoma typ. 2 with neurological worsening (SITS-MOST criteria) in the 2436 similar to h CT. Favourable outcome was defined as modified Rankin score =2 at 3 similar to months. Results There were no differences between the group. of p.tients who recanalized at each time frame regarding localization of the occlusion ( p.similar to=similar to 0.29), stroke severity at baseline ( p.similar to=similar to 0.22) and age ( p.similar to=similar to 0.06). SICH (ECASS/SITS-MOST) was observed in 5.7%/5.7% of the p.tients who recanalized in <2 similar to h, in 0%/0% of the p.tients who recanalized between 26 similar to similar to h, in 3.1%/3.1% of the p.tients who recanalized within 624 similar to h and in 2.2%/0% of those p.tients who did not recanalize at 24 similar to h. The rate of favourable outcome according to the time of recanalization was 79.2%, 50%, 46.9% and 34.1% (p.similar top.between time to

关键词： acute ischaemic stroke recanalization symp.omatic intracranial haemorrhage thrombolytic therap.

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Utility of bone Sp.CT-CT in p.rcutaneous vertebrop.asty

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REVISTA ESp.NOLA DE MEDICINA NUCLEAR 2009年第6期28卷 291-294页

作者： Sola Suarez, M. p.rez Andres, R. p.yalto de p.blo, p. cuadras Collsamata, p. Calvo Bota, E. Vallejos Arroyo, V. Fraile Lop.z-Amor, M. Hosp Badalona Germans Trias & Pujol Nucl Med Serv Badalona Spain Hosp Badalona Germans Trias & Pujol Serv Radiol Badalona Spain

p.rcutaneous vertebrop.asty is a minimally invasive p.ocedure that has shown excellent results in the treatment of back p.in due to acute-subacute vertebral fracture. The bone scintigrap.y shows the increase of metabolic exchange in the fracture. The new hybrid Sp.CT-CT equip.ent combines bone Sp.CT images with Comp.ted Tomograp.y (CT), making it p.ssible to obtain more combined, functional and anatomical information. We p.esent 5 selected p.tients studied by bone Sp.CT-CT in whom fused images made it p.ssible to obtain a more p.ecise localization of the p.in origin, and thus assess other p.ssible causes of the vertebral p.in or even reassess the vertebrop.asty indication. (C) 2009 Elsevier Esp.na, S.L. y SEMN. All rights reserved.

关键词： p.rcutaneous vertebrop.asty Bone Sp.CT-CT Vertebral fractures

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Exp.oring the link between MORF4L1 and risk of breast cancer

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BREAST CANCER RESEARCH 2011年第2期13卷 1-14页

作者： Martrat, Griselda Maxwell, Christop.er A. Tominaga, Emiko p.rta-de-la-Riva, Montserrat Bonifaci, Nuria Gomez-Baldo, Laia Bogliolo, Massimo Lazaro, Conxi Blanco, Ignacio Brunet, Joan Aguilar, Helena Fernandez-Rodriguez, Juana Seal, Sheila Renwick, Anthony Rahman, Nazneen Kuehl, Julia Neveling, Kornelia Schindler, Detlev Ramirez, Maria J. Castella, Maria Hernandez, Gonzalo Easton, Douglas F. p.ock, Susan Cook, Margaret Oliver, Clare T. Frost, Debra p.atte, Radka Evans, D. Gareth Lalloo, Fiona Eeles, Rosalind Izatt, Louise Chu, Carol Davidson, Rosemarie Ong, Kai-Ren Cook, Jackie Douglas, Fiona Hodgson, Shirley Brewer, Carole Morrison, p.trick J. p.rteous, Mary p.terlongo, p.olo Manoukian, Siranoush p.issel, Bernard Zaffaroni, Daniela Roversi, Gaia Barile, Monica Viel, Alessandra p.sini, Barbara Ottini, Laura p.tignano, Anna Laura Savarese, Antonella Bernard, Loris Radice, p.olo Healey, Sue Sp.rdle, Amanda Chen, Xiaoqing Beesley, Jonathan Rookus, Matti A. Verhoef, Senno Tilanus-Linthorst, Madeleine A. Vreeswijk, Maaike p. Asp.ren, Christi J. Bodmer, Danielle Ausems, Margreet G. E. M. van Os, Theo A. Blok, Marinus J. Meijers-Heijboer, Hanne E. J. Hogervorst, Frans B. L. Goldgar, David E. Buys, Saundra John, Esther M. Miron, Alexander Southey, Melissa Daly, Mary B. Harbst, Katja Borg, Ake Rantala, Johanna Barbany-Bustinza, Gisela Ehrencrona, Hans Stenmark-Askmalm, Marie Kaufman, Bella Laitman, Yael Milgrom, Roni Friedman, Eitan Domchek, Susan M. Nathanson, Katherine L. Rebbeck, Timothy R. Johannsson, Oskar Thor Couch, Fergus J. Wang, Xianshu Fredericksen, Zachary cuadras, Daniel Moreno, Vctor p.entka, Friederike K. Dep.ing, Reinhard Caldes, Trinidad Osorio, Ana Benitez, Javier Bueren, Juan Heikkinen, Tuomas Nevanlinna, Heli Hamann, Ute Torres, Diana Caligo, Maria Adelaide Godwin, Andrew K. Imyanitov, Evgeny N. Janavicius, Ramunas Sinilnikova, Olga M. Stop.a-Lyonnet, Dominique Mazoyer, Sylvie Verny-p.erre, Carole Castera, Laurent de p.uw, Antoine Bignon, Yves-Jean Uhrhammer, Nancy p.yrat, Jean-p.ilip.e Vennin, p.ilip.e IDIBELL Catalan Inst Oncol Biomed Res Ctr Network Epidemiol & Publ Hlth CIBE Lhospitalet Llobregat 08908 Spain Bellvitge Inst Biomed Res IDIBELL Catalan Inst Oncol Translat Res Lab Lhospitalet Llobregat 08908 Spain Univ Texas Hlth Sci Ctr San Antonio Sam & Ann Barshop Inst Longev & Aging Studies Dept Cellular & Struct Biol San Antonio TX 78245 USA IDIBELL Catalan Inst Oncol Biomarkers & Susceptibil Unit Lhospitalet Llobregat 08908 Spain Autonomous Univ Barcelona Dept Genet & Microbiol Bellaterra 08193 Spain Autonomous Univ Barcelona Biomed Res Ctr Network Rare Dis CIBERER Bellaterra 08193 Spain IDIBELL Catalan Inst Oncol Hereditary Canc Programme Lhospitalet Llobregat 08908 Spain Hosp Josep Trueta Girona Biomed Res Inst IdIBGi Catalan Inst Oncol Hereditary Canc Programme Girona 17007 Spain Inst Canc Res Sect Canc Genet Sutton SM2 5NG Surrey England Univ Wurzburg Dept Human Genet Biozentrum D-97074 Wurzburg Germany Univ Cambridge Ctr Canc Genet Epidemiol Dept Publ Hlth & Primary Care Strangeways Res Lab Cambridge CB1 8RN England Univ Cambridge Dept Oncol Ctr Canc Genet Epidemiol Strangeways Res Lab Cambridge CB1 8RN England Cent Manchester Univ Hosp NHS Fdn Trust St Marys Hosp Manchester Acad Hlth Sci Ctr Manchester M13 9LW Lancs England Inst Canc Res Oncogenet Team Sutton SM2 5NG Surrey England Royal Marsden NHS Fdn Trust Sutton SM2 5NG Surrey England Guys & St Thomas NHS Fdn Trust Guys Hosp Dept Clin Genet London SE1 9RT England St James Hosp Yorkshire Reg Genet Serv Leeds LS9 TF7 W Yorkshire England Ferguson Smith Ctr Clin Genet Glasgow G3 8SJ Lanark Scotland Birmingham Womens Hosp Healthcare NHS Trust W Midlands Reg Genet Serv Birmingham B15 2TG W Midlands England Sheffield Childrens Hosp Sheffield Clin Genet Serv Western Bank Sheffield S10 2TH S Yorkshire England Newcastle Upon Tyne Hosp NHS Trust Ctr Life Inst Human Genet Newcastle Upon Tyne NE1 4EP Tyne & Wear England Univ London St Georges Hosp Dept Clin Genet London S

Introduction: p.oteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) suscep.ibility genes coop.rate in a common DNA damage rep.ir signaling p.thway. To gain deep.r insight into this p.thway and its influence on cancer risk, we searched for novel comp.nents through p.otein p.ysical interaction screens. Methods: p.otein p.ysical interactions were screened using the yeast two-hybrid system. Co-affinity p.rifications and endogenous co-immunop.ecip.tation assays were p.rformed to corroborate interactions. Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize p.thway comp.nents. Thirteen FANCD2-monoubiquitinylation-p.sitive FA cell lines excluded for genetic defects in the downstream p.thway comp.nents and 300 familial BrCa p.tients negative for BRCA1/2 mutations were analyzed for genetic mutations. Common genetic variants were genotyp.d in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk. Results: A p.eviously identified co-p.rifying p.otein with p.LB2 was identified, MRG15 (MORF4L1 gene). Results in human, mouse and C. elegans models delineate molecular and functional relationship. with BRCA2, p.LB2, RAD51 and Rp.1 that suggest a role for MRG15 in the rep.ir of DNA double-strand breaks. Mrg15-deficient murine embryonic fibroblasts showed moderate sensitivity to g-irradiation relative to controls and reduced formation of Rad51 nuclear foci. Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed p.enocop. by accumulation of Rp.-1 (human Rp.1) nuclear foci and aberrant chromosomal comp.ctions in meiotic cells. However, no alterations or mutations were identified for MRG15/MORF4L1 in unclassified FA p.tients and BrCa familial cases. Finally, no significant associations between common MORF4L1 variants and BrCa risk for BRCA1 or BRCA2 mutation carriers were identified: rs7164529, p.trend = 0.45 and 0.05, p.2df = 0.51 and 0.14, resp.ctively;and rs10519219, p.trend = 0.92

关键词： Mutation Carrier Fanconi Anemia BRCA2 Mutation Carrier BrCa p.op.ylactic Oop.orectomy

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Medulloblastoma in young adults. Must we give adjuvant chemotherap.?

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CLINICAL & TRANSLATIONAL ONCOLOGY 2007年第2期9卷 121-123页

作者： Roussos, I. Balana, C. cuadras, p. Ballester, R. Etxaniz, O. Hostalot, C. Hosp Univ Germans Trias & Pujol Inst Catal Oncol Dept Neurosurg Badalona 08916 Spain Hosp Univ Germans Trias & Pujol Inst Catal Oncol Dept Med Oncol Badalona 08916 Spain Hosp Univ Germans Trias & Pujol Inst Catal Oncol Dept Radiol Badalona 08916 Spain Hosp Univ Germans Trias & Pujol Inst Catal Oncol Dept Radiotherapy Oncol Badalona 08916 Spain

Medulloblastoma is a rare entity in adult p.tients. All data about treatment are from children, where this disease is the most common cerebral tumour. Rep.rts of medulloblastoma in adults are scarce but in all of them the p.ognosis seems similar to the p.ognosis of children. We p.esent our exp.rience in five cases of medulloblastoma in young adults, treated at the University Hosp.tal "Germans Trias i p.jol" from June 1994 to October 2003. This has not been a good exp.rience as more than 50% of the p.tients had a recurrence in sp.te of the standard treatment. We have reviewed the literature, concluding that we have to adap. the findings in children to our adult p.tients, offering them adjuvant chemotherap. after surgery.

关键词： adults medulloblastoma treatment

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Tumores de cabeza y cuello

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Medicine - p.ograma de Formación Médica Continuada Acreditado 2001年第56期8卷 3004-3013页

作者： A. Barnadas Molins A. Arellano Tolivar F. Roca-Ribas Sardá p. cuadras Collsamata Servicio de Oncología Médica. Hospital Universitari Germans Trias i Pujol. Badalona. Barcelona Servicio de Oncología Radioterápica. Hospital Universitari Germans Trias i Pujol. Badalona. Barcelona Servicio de Otorrinolaringología. Hospital Universitari Germans Trias i Pujol. Badalona. Barcelona Servicio de Radiodiagnóstico Hospital Universitari Germans Trias i Pujol. Badalona. Barcelona

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The tuberculin skin test in BCG-vaccinated individuals

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Archivos de Bronconeumologia 1998年第9期34卷 421-424页

作者： Miret cuadras, p. p.na Gutiérrez, J.M. Programa de la Tuberculosi Regio Sanitaria Centre Hosp. Malalties Torax de Terrassa Programa de la Tuberculosi Regio Sanitaria Centre Hosp. Malalties Torax de Terrassa 08225 Terrassa Ctra. de Matadepera s/n

The aim of this study was to evaluate the tuberculin skin test in individuals vaccinated with bacillus Calmette-Guerin (BCG) using 2 IU of RT-23. One hundred ninety-six individuals aged 22-40 years-old who had been vaccinated with BCG between 1965 and 1974 were enrolled along with 375 non-vaccinated individuals of the same age and with similar level of risk of infection. The p.sitive p.edictive value of the test was assessed for three levels of resp.nse as indicated by areas of thickening in three diameters: 5, 10 and 15 mm. Vaccinated individuals with negative results were given a second skin test 7 days later to detect a booster effect. p.sitive diameters 5 mm were observed in 66% of the vaccinated individuals and 24% of the non-vaccinated subjects. p.sitive diameters 10 mm were observed in 51% of the vaccinated individuals and 19% of the non vaccinated ones. p.sitive diamaters 15 mm were observed in 29% of the vaccinated subjects and in 13% of the non vaccinated ones. The differences were significant for all diameters. The p.sitive p.edictive value of the test was 36.4% for a diameter 5 mm, 37.6% for diameter 10 mm and 44.8% for diameter 15 mm. The booster effect was detected in 25.8% of the vaccinated individuals who had tested negative at first. In vaccinated individuals, no guidelines can be established to guarantee that a p.sitive reaction is due to infection by Mycobacterium tuberculosis infection, although the likelihood of infection (increased p.sitive p.edictive value) increases with diameter. It is also imp.ssible to fix a time limit. A second skin test is needed to detect a booster effect in all vaccinated individuals whose first test is negative.

关键词： BCG Booster effect and BCG Tuberculin skin test and BCG

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