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铸造Mg-3.0Nd-0.2Zn-Zr(wt.%)镁合金高周疲劳累积损伤行为

材料科学与工程学报 2020年第5期38卷 693-700页

作者：岳海燕付彭怀徐旭文彭立明沈冰峰中国商飞上海飞机制造有限公司上海200436 上海交通大学轻合金精密成型国家工程研究中心上海2002402 中冶宝钢技术服务有限公司上海201908

利用激光共聚焦显微镜和电子背散射衍射技术对铸造镁合金的室温高周疲劳累积损伤行为进行了研究。结果表明,疲劳累积损伤机制与晶粒取向和热处理有关。铸态合金的疲劳损伤方式有孪生和基面滑移两种,在载荷水平为疲劳极限条件下,基面滑... 详细信息

利用激光共聚焦显微镜和电子背散射衍射技术对铸造镁合金的室温高周疲劳累积损伤行为进行了研究。结果表明,疲劳累积损伤机制与晶粒取向和热处理有关。铸态合金的疲劳损伤方式有孪生和基面滑移两种,在载荷水平为疲劳极限条件下,基面滑移形成驻留滑移条纹是主要的损伤形貌。晶内驻留滑移条纹的数量随该晶粒的基面施密特因子增大而变多。铸态合金经固溶时效处理后,晶粒基面施密特因子对驻留滑移条纹的数量影响不明显。与铸态合金相比,具有相同施密特因子的晶粒内,时效态合金的驻留滑移条纹的数量较小。

关键词：镁合金高周疲劳损伤机制驻留滑移条带热处理取向因子

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Studies on New Steroidal Saponins from Allii macrostemonis Bulbus and Their Antitumor Activities

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Chemical Research in Chinese Universities 2018年第1期34卷 61-66页

作者： YAO Hua WANG Tong WU Qian LIU Ying LI peng LI xuwen JIN Yongri Scienttfic Research Center China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China College of Chemistry Jilin University Changchun 130012 P. R. China

Two new steroidal saponms（2, 3） and two known compounds（1, 4） were isolated from 75% ethanol extract ofAllii macrostemonis bulbus by various spectral methods. The two new steroidal saponins were respectively elucidated as （25S）-26-O-β-D-glucopyranosyl-5α-furostanol-2α,3β,22,26-tetrol-3-O-β-D-glucopyranosyl（1→2）-[β-D- glucopyranosyl（1→3）]-β-D-glucopyranosyl（1→4 ）-β-D-galactopyranoside（2 ） and 26-O-β-D-glucopyranosyl-5α- furostanol-25（ 27）-ene-3β,22,26-tetrol-3-O-β-D-glucopyranosyl（ 1→2 ）-[β-D-glucopyranosyl（ 1→3 ）] -β-D-glucopyranosyl- （1→4）-β-D-galactopyranoside（3）. Compound 4 was obtained from this medical plant for the first time. The activity experiments of proliferation inhibition on tumor cells were performed by cell counting kit-8（CCK-8） method for compound 2（25S-configuration） and its isomer（compound 1, 25R-configttration）. The results show that compounds 1 and 2 have weak inhibition on lung cancer A549 cells, melanoma A375 cells and breast cancer MCF-7 cells as well as certain inhibitory effect on liver cancer HepG2 cells, and the inhibitory effect of compound 1 is stronger than that of compound 2.

关键词： Allii macrostemonis bulbus Steroidal saponin Structure identification Proliferation inhibition Cell counting kit-8（CCK-8） method

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CSPG4和AQP1在脑胶质瘤中的表达及意义

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临床医学研究与实践 2022年第20期7卷 54-56页

作者：廖秋林赖续文吴晓莉韩丽芳彭大云庄洁娜廖月媛广东祈福医院病理科广东广州511495 南部战区总医院病理科广东广州510010

目的探讨硫酸软骨素蛋白聚糖4(CSPG4)和水通道蛋白1(AQP1)在脑胶质瘤中的表达及其对低级别脑胶质瘤和胚胎发育不良性神经上皮肿瘤(DNT)的鉴别诊断价值。方法选取于广东祈福医院和南部战区总医院确诊的160例脑胶质瘤初诊患者和20例DNT患... 详细信息

目的探讨硫酸软骨素蛋白聚糖4(CSPG4)和水通道蛋白1(AQP1)在脑胶质瘤中的表达及其对低级别脑胶质瘤和胚胎发育不良性神经上皮肿瘤(DNT)的鉴别诊断价值。方法选取于广东祈福医院和南部战区总医院确诊的160例脑胶质瘤初诊患者和20例DNT患者的病理标本。采用免疫组化(IHC)法检测患者肿瘤组织和正常脑组织中的CSPG4和AQP1表达水平。结果CSPG4和AQP1在脑胶质瘤组织中的阳性率均高于正常脑组织(P<0.05)。CSPG4和AQP1在不同WHO分级脑胶质瘤组织中的阳性率比较,差异具有统计学意义(P<0.05),且随着脑胶质瘤WHO分级的提高两者的阳性率逐渐升高。CSPG4和AQP1在低级别脑胶质瘤和DNT组织中的阳性率比较,差异均无统计学意义(P>0.05)。CSPG4和AQP1在脑胶质瘤组织中的表达无相关性。结论CSPG4和AQP1可用于脑胶质瘤的辅助诊断,且表达水平随着脑胶质瘤WHO分级的提高而升高。但CSPG4和AQP1不能用于低级别脑胶质瘤与DNT的鉴别诊断。

关键词：脑胶质瘤胚胎发育不良性神经上皮肿瘤硫酸软骨素蛋白聚糖4 水通道蛋白1 免疫组化

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Improved Local Maximal Occurrence Feature Representation for Person Re-identification 9

Improved Local Maximal Occurrence Feature Representation for...

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9th IEEE International Conference on Software Engineering and Service Science (ICSESS)

作者： Zhu, Yuanxin Yang, Zhao Yao, xuwen Zhao, Sai peng, Shaohu Guangzhou Univ Sch Mech & Elect Engn Guangzhou 510006 Guangdong Peoples R China

ISBN: (纸本)9781538665657

Person re-identification is a technique to automatically search the same people in diffe..ent camera views. It is a challenging task because of the huge variations caused by different illuminations and views in images. There is an effective method tackling the problem, which learns a useful feature representation for the pedestrian images, In recent research, a featu..e rep..esentation named Local Maximal Occurrence (LOMO) achieves outstanding performance, but LOMO has a disadvantage that its robustness to illumination is not excellent. In this pape.., we propose an imp..oved LOMO representation to further reduce the impact of light. The improved LOMO feature combines Color Name feature with LOMO, because Color Name feature has strong robustness to illumination. However, Color Name feature has the weakness that it loses graphical details. The..efore, the feature is unsuitable for traditional pooling method. To overcome the disadvantage, a specific pooling method called global Gaussian pooling for Color Name feature is designed, which is based on Gaussian distribution and can weigh the different regions of an image. The important regions gain mo..e attention in matching images. The experimental results on two public available datasets demonstrate the effectiveness of our proposed approach.

关键词： component Person re-identification feature representation

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A Novel Flavone from the Leaves of Murraya paniculata

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CHEMISTRY OF NATURAL COMPOUNDS 2018年第6期54卷 1061-1063页

作者： Li, peng Zhang, Yue Wang, Ziqi Chen, Honghui Li, xuwen Jin, Yongri Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China

A phytochemical investigation of the leaves of Murraya paniculata (L.) Jack resulted in a novel compound, 3,5-dihydroxy-5,7,4-trimethoxyflavone, together with 13 known compounds. The structure of the novel compound wa... 详细信息

关键词： Murraya paniculata (L.) Jack leaves flavonoids

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Improving identification ability of adulterants in powdered Panax notoginseng using particle swarm optimization and data fusion

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INFRARED PHYSICS & TECHNOLOGY 2019年 103卷 103101-000页

作者： Yang, Xiaodong Song, Jie peng, Lin Gao, Lutao Liu, xuwen Xie, Lin Li, Guanglin Southwest Univ Coll Engn & Technol Chongqing 400715 Peoples R China Yunnan Agr Univ Coll Big Data Kunming 650201 Yunnan Peoples R China

Panax notoginseng (P. notoginseng) is frequently targeted for adulteration with lower-grade P. notoginseng because of its high price. This paper presents a novel method to improve the identification ability of adulterants using spectroscopic techniques and chemometrics. P. notoginseng powder of different grades were blended at different percentages (0-100%), in which the minimum blend ratio was 0.5%. NIR (12,497-4000 cm(-1)) and FT-MIR (4000-400 cm(-1)) spectra of samples were acquired. The wavenumbers of 7099-4200 cm(-1), 3600-2750 cm(-1), and 1750-400 cm(-1) were selected manually as characteristic spectra, which included 3706 variables. Then principal component analysis (PCA) was used to further reduce the data dimension of characteristic spectra, and the first nine principal components (PCs) were applied to build classification models of 14 (the ratio of 0.5% excluded) and 15 kinds of blend ratios. Finally, Support vector machine (SVM) was built for classification of adulterants of different blend ratio. The accuracy of prediction set is 92.46% and 91.79%, respectively. On this basis, particle swarm optimization (PSO) was applied to optimize the parameters of SVM, and the accuracy of prediction set increased to 96.65% and 96.97%, respectively. The results demonstrate that the application of data fusion of NIR and FT-MIR spectra combined with SVM optimized by PSO can improve the identification ability of adulterants in powdered P. notoginseng.

关键词： Panax notoginseng Adulteration PCA PSO SVM

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Centrifugation free and air-assisted liquid-liquid microextraction based on deep eutectic solvent for determination of rare ginsenosides in Kang'ai injection

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MICROCHEMICAL JOURNAL 2018年 142卷 313-320页

作者： Li, peng Ye, Junfeng Zhang, Yue Wang, Ziqi Ren, Sujuan Li, xuwen Jin, Yongri Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China Jilin Univ Hosp 1 Changchun 130012 Jilin Peoples R China

A simple, effective and convenient enrichment method coupled with high performance liquid chromatography (HPLC) was established for the analysis of rare ginsenosides in Kang'ai (KA) injection. Air assisted liquid-liquid microextraction was used in this work for the first time to determine the rare ginsenosides in KA injection. Deep eutectic solvent (DES) and tetrahydrofuran (THF) were specially selected as a novel green extraction solvent and an emulsified solvent, respectively. To remove the DES droplets, Fe3O4 nanoparticles were used. Therefore, centrifugation was free in this work, which can increase the efficiency of analysis procedure. Moreover, Fe3O4 nanoparticles were reusable. To achieve better extraction efficiency and enrichment factor, the experimental conditions have been optimized, including type and volume of DES and emulsified solvent, amount of Fe3O4 nanoparticles and inorganic salt, and pH value. Under the optimum extraction condition, the validation parameters show the limits of detection (LODs) are in the range from 10.2 ng/mL to 137.8 ng/mL and the limits of quantity (LOQs) are in the range from 55.5 ng/mL to 428.5 ng/mL. The recoveries of analytes range from 91.3% to 106.7% with the relative standard deviations (RSDs) ranging from 1.2% to 4.5%. The recommended approach was utilized to acquire the information of constituents in KA injection. Moreover, the results in this research could provide a study basis for further study of KA injection.

关键词： Deep eutectic solvent Liquid-liquid microextraction Rare ginsenosides Kang'ai injection HPLC

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Determination of common ginsenosides in Kang'ai injection by aqueous two-phase extraction with deep eutectic solvents and HPLC-UV/DAD

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MICROCHEMICAL JOURNAL 2018年 137卷 302-308页

作者： Li, peng Zhao, pengyun Liu, Weijie Jiang, Yifu Wang, Wenjiao Bao, Longyue Jin, Yongri Li, xuwen Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China

In this work, four kinds of deep eutectic solvents (DESs), composed of choline chloride (ChCl) and several alcohols, were synthesized and characterized by H-1 NMR and FT-IR spectra. Based on DES ( ChCl and 1,4-butanediol) and inorganic salt solution (dipotassium phosphate, K2HPO4), aqueous two-phase system (ATPS) coupled with high-performance liquid chromatography has been developed and applied. This method was used for the efficient extraction and determination of eight common ginsenosides (including ginsenoside Rg(1), Re, Rf, Rg(2), Rc, Rb-2 and Rd) in the traditional Chinese medicine injection named Kang'ai injection. To achieve optimum extraction performance, the experimental conditions were optimized, including type and amount of DES and salt, ultrasound time, temperature and pH value. In the dynamic linearity range, experimental results showed satisfactory recoveries of analytes ranging from 92.7-110.8% with the relative standard deviations (RSDs) ranging from 1.2-3.9%. It has been proved that DES-ATPS has great potential for determination of active ingredients in traditional Chinese medicine injection as well as samples in other analytical science field. (C) 2017 Elsevier B.V. All rights reserved.

关键词： Aqueous two-phase system Ginsenosides High-performance liquid chromatography Kang'ai injection

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The wide utility of rabbits as models of human diseases

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EXPERIMENTAL AND MOLECULAR MEDICINE 2018年第5期50卷 66-66页

作者： Esteves, Pedro J. Abrantes, Joana Baldauf, Hanna-Mari BenMohamed, Lbachir Chen, Yuxing Christensen, Neil Gonzalez-Gallego, Javier Giacani, Lorenzo Hu, Jiafen Kaplan, Gilla Keppler, Oliver T. Knight, Katherine L. Kong, Xiang-peng Lanning, Dennis K. Le Pendu, Jacques de Matos, Ana Lemos Liu, Jia Liu, Shuying Lopes, Ana M. Lu, Shan Lukehart, Sheila Manabe, Yukari C. Neves, Fabiana McFadden, Grant Pan, Ruimin peng, xuwen de Sousa-Pereira, Patricia Pinheiro, Ana Rahman, Masmudur Ruvoen-Clouet, Natalie Subbian, Selvakumar Tunon, Maria Jesus van der Loo, Wessel Vaine, Michael Via, Laura E. Wang, Shixia Mage, Rose Univ Porto CIBIO InBIO Res Network Biodivers & Evolutionary Biol Campus VairaoRua Padre Armando Quintas P-4485661 Vairao Portugal Univ Porto Dept Biol Fac Ciencias Rua Campo Alegre S-N P-4169007 Porto Portugal Inst Invest & Formacao Avancada Ciencias & Tecnol Gandra Portugal LMU Munchen Max von Pettenkofer Inst Fac Med Natl Reference Ctr Retroviruses D-81377 Munich Germany LMU Munchen Gene Ctr Fac Med VirolNatl Reference Ctr Retroviruses D-81377 Munich Germany Univ Calif Irvine Gavin Herbert Eye Inst Lab Cellular & Mol Immunol Sch Med Irvine CA 92697 USA Univ Calif Irvine Sch Med Dept Mol Biol & Biochem Irvine CA 92697 USA Univ Calif Irvine Inst Immunol Sch Med Sch Irvine Irvine CA 92697 USA Univ Massachusetts Med Sch Dept Med Worcester MA 01605 USA Penn State Univ Dept Pathol Hershey PA USA Penn State Univ Dept Microbiol & Immunol Hershey PA USA Penn State Univ Dept Comparat Med Hershey PA USA Univ Leon Inst Biomed IBIOMED Leon 24071 Spain Univ Leon CIBERehd Leon 24071 Spain Univ Washington Dept Med Seattle WA USA Univ Washington Dept Global Hlth Seattle WA 98195 USA Bill & Melinda Gates Fdn Seattle WA USA Loyola Univ Chicago Dept Microbiol & Immunol Maywood IL 60153 USA NYU Sch Med Dept Biochem & Mol Pharmacol New York NY 10016 USA Univ Nantes Univ Angers CRCINA INSERM Nantes France Arizona State Univ Biodesign Inst Ctr Immunotherapy Vaccines & Virotherapy Tempe AZ 85287 USA Univ Arkansas Med Sci Dept Microbiol & Immunol Little Rock AR 72205 USA Univ Porto Inst Biomed Sci Abel Salazar ICBAS Dept Anat Porto Portugal Univ Porto Inst Biomed Sci Abel Salazar ICBAS Unit Multidisciplinary Res Biomed UMIB Porto Portugal Johns Hopkins Univ Sch Med Dept Med Div Infect Dis Baltimore MD 21205 USA Rutgers State Univ PHRI New Jersey Med Sch RBHS Newark NJ USA NIAID Tubercolosis Res Sect Lab Clin Infect Dis Div Intramural ResNIH 9000 Rockville Pike Bethesda MD 20892 USA Univ Cape Town Dept Clin Lab Sci Inst Infect

Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur's rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens.

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High Q and high gradient performance of the first medium-temperature baking 1.3 GHz cryomodule

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Physical Review Accelerators and Beams 2024年第9期27卷 092003页

作者： Weimin Pan Jiyuan Zhai Feisi He Rui Ge Zhenghui Mi peng Sha Song Jin Ruixiong Han Qunyao Wang Haiying Lin Guangwei Wang xuwen Dai Zhanjun Zhang Mei Li Minjing Sang Liangrui Sun Rui Ye Tongxian Zhao Shaopeng Li Keyu Zhu Baiqi Liu Xiaolong Wang Xiangchen Yang Xiaojuan Bian Xiangzhen Zhang Huizhou Ma Jianbing Zhao Liang Zhang Hui Zhao Runbing Guo Zhihui Mu Conglai Yang Xiaobing Zheng Chao Dong Hongjuan Zheng Zhengze Chang Xiaochen Yang Tongming Huang Qiang Ma Zihan Wang Ming Liu Wenzhong Zhou Senyu Chen Chinese Academy of Sciences Beijing 100049 China Beijing 100049 China

The world’s first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (rf) cavities treated by medium-temperature furnace baking (mid-T bake) was developed at the Institute of High Energy Physics, Chinese Academy of Sciences. The 9-cell cavities in the cryomodule achieved an unprecedented high average intrinsic quality factor (Q0) of 3.8×1010 at 16 MV/m and 3.6×1010 at 21 MV/m in the horizontal test. The cryomodule can operate stably up to a total continuous wave rf voltage greater than 193 MV, with an average cavity usable accelerating gradient of more than 23 MV/m. The results significantly exceed the specifications of Circular Electron Positron Collider and Dalian advanced light source and the other high repetition rate free electron laser facilities [Linac Coherent Light Source II (LCLS-II), LCLS-II-high energy, Shanghai High Repetition Rate X-ray FEL and Extreme Light Facility, Shenzhen Superconducting Soft X-Ray Free Electron Laser, etc.]. There is evidence that the mid-T bake cavity may not require fast cooldown or long processing time in the cryomodule. This paper reviews the cryomodule performance and discusses some important issues in cryomodule assembly and testing.

关键词： Radio frequency techniques Superconducting RF

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