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Transient Outward K⁺ Current Underlies Heterogeneity of Action Potential Duration and Early Afterdepolarization from Right Ventricle in Transgenic Rabbit Model of Long QT Type 1

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BIOPHYSICAL JOURNAL 2015年第2期108卷 113A-113A页

作者： Choi, Bum-Rak Li, Weiyan Terentyev, Dmitry Rees, Colin Terentieva, Radmila Kim, Taeyun peng, xuwen Qu, Zhilin Karma, Alain Koren, Gideon RIH Dept Med Providence RI USA Brown Med Sch Providence RI USA Northeastern Univ Dept Phys Boston MA 02115 USA Penn State Univ Dept Comparat Med Hershey PA USA Univ Calif Los Angeles Dept Med Los Angeles CA 90024 USA

565-Pos

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Studies on Triterpenoid Glycosides from Rhizomes ofPanacis majoris and Their Antiplatelet Aggregation Activity

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Chemical Research in Chinese Universities 2016年第6期32卷 943-946页

作者： LI Min JIN Yongri WANG Xiaozhong WU Qian LIU Ying LI peng LI xuwen College of Chemistry Jilin University Changchun 130021 P. R. China

A new triterpenoid glycoside（l） and seven known triterpenoid glycosides, pseudoginsenoside RT2（2）,yesanchinoside R2（3）, vinaginsenoside R13（4）, vinaginsenoside R8（5）, notoginsenoside E（6）, 6＂＇-O-acetylginsenosideRe（7）, 6＂-O-acetylginsenoside Rbl（8）, were isolated from the rhizomes of Panaeis maforis. The new triterpenoidglycoside was elucidated as 3-O-[β-D-glucopyranosyl-（l→2）-fl-D-（6＇-O-ethyl）-glucuronopyranosyl]-oleanolicacid-28-O-β-D-glucopyranoside by extensive spectroscopic and phytochemical methods. Compounds 2-8 wereobtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate（ADP）-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibitedmoderate antiplatelet aggregation activity induced by arachidonic acid（AA）.

关键词： Panacis majoris Rhizome Triterpenoid glycoside Antiplatelet aggregation

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Sensitive determination of three aconitum alkaloids and their metabolites in human plasma by matrix solid-phase dispersion with vortex-assisted dispersive liquid-liquid microextraction and HPLC with diode array detection

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JOURNAL OF SEPARATION SCIENCE 2016年第10期39卷 1971-1978页

作者： Wang, Xiaozhong Li, xuwen Li, Lanjie Li, Min Liu, Ying Wu, Qian Li, peng Jin, Yongri Jilin Univ Coll Chem Changchun 130012 Peoples R China Ningxia Univ Sch Chem & Chem Engn Yinchuan Peoples R China

A simple and sensitive method for determination of three aconitum alkaloids and their metabolites in human plasma was developed using matrix solid-phase dispersion combined with vortex-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography with diode array detection. The plasma sample was directly purified by matrix solid-phase dispersion and the eluate obtained was concentrated and further clarified by vortex-assisted dispersive liquid-liquid microextraction. Some important parameters affecting the extraction efficiency, such as type and amount of dispersing sorbent, type and volume of elution solvent, type and volume of extraction solvent, salt concentration as well as sample solution pH, were investigated in detail. Under optimal conditions, the proposed method has good repeatability and reproducibility with intraday and interday relative standard deviations lower than 5.44 and 5.75%, respectively. The recoveries of the aconitum alkaloids ranged from 73.81 to 101.82%, and the detection limits were achieved within the range of 1.6-2.1 ng/mL. The proposed method offered the advantages of good applicability, sensitivity, simplicity, and feasibility, which makes it suitable for the determination of trace amounts of aconitum alkaloids in human plasma samples.

关键词： Aconitum alkaloids Dispersive liquid-liquid microextraction Human plasma Matrix solid-phase dispersion

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Modulation of Action Potential Alternans by IKs in Myocardial Infarction

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BIOPHYSICAL JOURNAL 2015年第2期108卷 273A-273A页

作者： Choi, Bum-Rak Kim, Tae Yun Grizotte-Lake, Mayara Daley, Jean Schofield, Lorraine Bist, Kamana Yammine, Joseph Kunitomo, Yukiko Lu, Yichun peng, xuwen Qu, Zhilin Koren, Gideon Rhode Isl Hosp Cardiovasc Res Ctr Providence RI USA Brown Med Sch Providence RI USA Penn State Univ Dept Comparat Med Coll Med Hershey PA USA Univ Calif Los Angeles Dept Med Los Angeles CA 90024 USA

1374-Pos

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Long-peptide therapeutic vaccination against CRPV-induced papillomas in HLA-A2.1 transgenic rabbits

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Trials in Vaccinology 2014年第1期3卷 134-142页

作者： Hu, Jiafen Budgeon, Lynn R. Balogh, Karla K. peng, xuwen Cladel, Nancy M. Christensen, Neil D. Jake Gittlen Cancer Research Foundation Pennsylvania State University College of Medicine Hershey PA 17033 United States Department of Pathology Pennsylvania State University College of Medicine Hershey PA 17033 United States Department of Comparative Medicine Pennsylvania State University College of Medicine Hershey PA 17033 United States Microbiology and Immunology Pennsylvania State University College of Medicine Hershey PA 17033 United States

Long peptide immunization is a promising strategy to clear established tumors. In the current study, we investigated the therapeutic effect of a naturally existing long peptide that contained two HLA-A2.1 restricted epitopes (CRPVE1/149-157 and CRPVE1/161-169) from cottontail rabbit papillomavirus (CRPV) E1 using our CRPV/HLA-A2.1 transgenic rabbit model. A universal Tetanus Toxin helper motif (TT helper) was tagged at either the N-terminus or the carboxyl-terminus of this long peptide and designated as TT-E1 peptide and E1 peptide-TT, respectively. Four groups of HLA-A2.1 transgenic rabbits were infected with wild type CRPV DNA. Three weeks post-infection, the rabbits were immunized four times with TT-E1 peptide, E1 peptide only, E1 peptide-TT or TT-control peptide with two-week intervals between immunizations. Tumor outgrowth was monitored and recorded weekly. After the third booster immunization, tumors on two of the four E1 peptide-TT immunized rabbits began to shrink. One animal from this group was free of tumors at the termination of the study. The mean papilloma size of E1 peptide-TT immunized rabbits was significantly smaller when compared with that of the three other groups (P < 0.05, one way ANOVA analysis). It is interesting that E1 peptide-TT vaccination not only stimulated stronger T cell mediated immune responses but also stronger antibody generations. We conclude that the location of a TT helper motif tagged at the long peptide vaccine is critical for the outcome of therapeutic responses to persistent tumors in our HLA-A2.1 transgenic rabbit model. © 2014 The Authors. Published by Elsevier Ltd.

关键词： CRPV HLA-A2.1 Long peptide T-cell mediated immune response Therapeutic vaccine Transgenic rabbit

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Bipolaris oryzae, a novel fungal opportunist causing keratitis

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DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 2016年第1期85卷 61-65页

作者： Wang, Luxia Al-Hatmi, Abdullah M. S. Lai, xuwen peng, Lianghong Yang, Chuanhong Lai, Huangwen Li, Jianxun Meis, Jacques F. de Hoog, G. Sybren Zhuo, Chao Chen, Min Guangzhou Gen Hosp Guangzhou Mil Command Dept Lab Guangzhou Guangdong Peoples R China CBS KNAW Fungal Biodivers Ctr Utrecht Netherlands Univ Amsterdam Inst Biodivers & Ecosyst Dynam Amsterdam Netherlands Ibri Hosp Minist Hlth Directorate Gen Hlth Serv Ibri Oman Guangzhou Mil Command Guangzhou Gen Hosp Dept Pathol Guangzhou Guangdong Peoples R China Guangzhou Gen Hosp Guangzhou Mil Command Dept Ophthalmol Guangzhou Guangdong Peoples R China Canisius Wilhelmina Hosp Dept Med Microbiol & Infect Dis Nijmegen Netherlands Radboud Univ Nijmegen Med Ctr Dept Med Microbiol NL-6525 ED Nijmegen Netherlands Univ Fed Parana Basic Pathol Dept Curitiba Parana Brazil King Abdulaziz Univ Jeddah 21413 Saudi Arabia Guangzhou Med Univ Affiliated Hosp 1 State Key Lab Resp Dis Guangzhou Guangdong Peoples R China Second Mil Med Univ Shanghai Changzheng Hosp Shanghai Inst Med Mycol Dept DermatolShanghai Key Lab Mol Med Mycol Shanghai Peoples R China

We report a case of mycotic keratitis caused by Bipolaris oryzae with predisposing trauma from a foreign body. The fungus was identified by sequencing the internal transcribed spacer region, translation elongation factor 1 alpha (TEFL) gene, and partial glyceraldehyde-3-phosphate dehydrogenase (GPDH) gene, and the species identity was confirmed on the basis of its characteristic conidial phenotype. The patient was treated with surgical intervention and antifungal agents, including intravenous fluconazole (FLC), oral itraconazole, topical 0.15% amphotericin B eye drops, and 0.5% FLC eye drops. To our knowledge, this is the first report of mycotic keratitis caused by B. oryzae worldwide. (C) 2016 Elsevier Inc. All rights reserved.

关键词： Mycotic keratitis Bipolaris oryzae Amphotericin B

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Hyperphosphorylation of RyRs Underlies Triggered Activity in Transgenic Rabbit Model of LQT2 Syndrome

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BIOPHYSICAL JOURNAL 2014年第2期106卷 431A-432A页

作者： Terentyev, Dmitry Li, Weyian Terentyeva, Radmila Cooper, Leroy L. Lu, YiChun Jindal, Hitesh peng, xuwen Koren, Gideon Brown Univ Providence RI 02912 USA Rhode Isl Hosp Providence RI USA Penn State Univ Coll Med Hershey HI USA

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Correction: CEPC Technical Design Report: Accelerator

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Radiation Detection Technology and Methods 2024年第1期9卷 184-192页

作者： Abdallah, Waleed de Freitas, Tiago CarlosAdorno Afanaciev, Konstantin Ahmad, Shakeel Ahmed, Ijaz Ai, Xiaocong Aleem, Abid Altmannshofer, Wolfgang Alves, Fabio An, Weiming An, Rui Anderle, Daniele Paolo Antusch, Stefan Arai, Yasuo Arbuzov, Andrej Arhrib, Abdesslam Ashry, Mustafa Bai, Sha Bai, Yu Bai, Yang Bairathi, Vipul Balazs, Csaba Bambade, Philip Ban, Yong Bandyopadhyay, Triparno Bao, Shou-Shan Barber, Desmond P. Bat, Ays¸e Batozskaya, Varvara Behera, Subash Chandra Belyaev, Alexander Bertucci, Michele Bi, Xiao-Jun Bi, Yuanjie Bian, Tianjian Bianchi, Fabrizio Bieko¨tter, Thomas Biglietti, Michela Bilanishvili, Shalva Binglin, Deng Bodrov, Denis Bogomyagkov, Anton Bondarenko, Serge Boogert, Stewart Boonekamp, Maarten Borri, Marcello Bosotti, Angelo Boudry, Vincent Boukidi, Mohammed Boyko, Igor Bozovic, Ivanka Bozzi, Giuseppe Brient, Jean-Claude Budzinskaya, Anastasiia Bukhari, Masroor Bytev, Vladimir Cacciapaglia, Giacomo Cai, Hua Cai, Wenyong Cai, Wujun Cai, Yijian Cai, Yizhou Cai, Yuchen Cai, Haiying Cai, Huacheng Calibbi, Lorenzo Cang, Junsong Cao, Guofu Cao, Jianshe Chance, Antoine Chang, Xuejun Chang, Yue Chang, Zhe Chang, Xinyuan Chao, Wei Chatrabhuti, Auttakit Che, Yimin Che, Yuzhi Chen, Bin Chen, Danping Chen, Fuqing Chen, Fusan Chen, Gang Chen, Guoming Chen, Hua-Xing Chen, Huirun Chen, Jinhui Chen, Ji-Yuan Chen, Kai Chen, Mali Chen, Mingjun Chen, Mingshui Chen, Ning Chen, Shanhong Chen, Shanzhen Chen, Shao-Long Chen, Shaomin Chen, Shiqiang Chen, Tianlu Chen, Wei Chen, Xiang Chen, Xiaoyu Chen, Xin Chen, Xun Chen, Xurong Chen, Ye Chen, Ying Chen, Yukai Chen, Zelin Chen, Zilin Chen, Boping Chen, Chunhui Cheng, Hok Chuen Cheng, Huajie Cheng, Shan Cheng, Tongguang Chi, Yunlong Chimenti, Pietro Chiu, Wen Han Cho, Guk Chu, Ming-Chung Chu, Xiaotong Chu, Ziliang Coloretti, Guglielmo Crivellin, Andreas Cui, Hanhua Cui, Xiaohao Cui, Zhaoyuan D’Anzi, Brunella Dai, Ling-Yun Dai, Xinchen Dai, xuwen De Maria, Antonio De Filippis, Nicola De La Taille, Christophe De Mori, Francesca De Sio, Chiara Del Core, Elisa Deng, Cairo University Giza Egypt Xi’an Jiaotong-Liverpool University Suzhou China Institute of Power Engineering of National Academy of Sciences of Belarus Minsk Belarus Pakistan Institute of Nuclear Science and Technology (PINSTECH) Islamabad Pakistan Applied Physics Department Science and Technology Federal Urdu University of Arts Islamabad Pakistan Zhengzhou University Zhengzhou China Institute of High Energy Physics Chinese Academy of Sciences Beijing China University of California Santa Cruz Santa Cruz USA Nanjing University Nanjing China Beijing Normal University Beijing China Harvard University Cambridge USA South China Normal University Guangzhou China University of Basel Basel Switzerland High Energy Accelerator Research Organization (KEK) Tsukuba Japan Joint Institute for Nuclear Research Dubna Russia Faculty of Sciences and Techniques Université Abdelmalek Essaadi Tangier Morocco Southeast University Nanjing China Department of Physics University of Wisconsin–Madison Madison USA Instituto de Alta Investigación Universidad de Tarapacá Arica Chile Monash University Melbourne Australia Laboratoire de Physique des 2 infinis Irène Joliot-Curie – IJCLab Orsay France Peking University Beijing China Department of Physics and Nanotechnology SRM Institute of Science and Technology Kattankulathur India Shandong University Jinan China University of New Mexico Albuquerque USA Bandirma Onyedi Eylul University Bandırma Turkey National Centre for Nuclear Research Warsaw Poland Indian Institute of Technology Madras (IN) Chennai India University of Southampton Southampton UK INFN Milano - LASA Segrate Italy Sun Yat-Sen University Guangzhou China China Institute of Atomic Energy Beijing China INFN-University of Torino Turin Italy Karlsruhe Institute of Technology Institute for Theoretical Physics Karlsruhe Germany INFN-Sezione di Roma Tre Rome Italy Kutaisi International University Kutaisi Georgia Soochow University Suzhou China Budker Institute

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城镇化进程中土地生态安全动态评价——以衡阳市为例

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衡阳师范学院学报 2016年第3期37卷 81-86页

作者：王鹏徐文娣邓育武田亚平衡阳师范学院城市与旅游学院湖南衡阳421002 江西师范大学地理与环境学院江西南昌330022

基于国内已有的相关研究成果,结合区域经济与生态发展特点,以城镇化为驱动力,利用PSR模型,构建城镇化率、城市生活垃圾无害化处理率、建成区绿化覆盖率等土地生态安全评价指标体系。运用熵权法确定各项指标权重,根据归一化指标数值和权... 详细信息

基于国内已有的相关研究成果,结合区域经济与生态发展特点,以城镇化为驱动力,利用PSR模型,构建城镇化率、城市生活垃圾无害化处理率、建成区绿化覆盖率等土地生态安全评价指标体系。运用熵权法确定各项指标权重,根据归一化指标数值和权重,计算衡阳市2004—2013年的土地生态安全综合值并对其进行动态分析。结果表明:衡阳市土地生态安全综合值由2004年的0.129 704提高到到2013年的0.853 102,总体呈上升趋势,土地资源生态安全状况有好转趋势,但仍处于风险级和敏感级。研究认为,控制人口增长;加强环境以及土地生态安全保护意识的宣传和教育力度;统筹城乡发展,保护耕地,调整产业结构,发展循环低碳经济;建立生态安全补偿机制;使生态建设适应城镇化进程的脚步,是协调衡阳市生态、经济、社会可持续发展的关键。

关键词： PSR模型熵权法城镇化土地生态安全衡阳市

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