检索结果-内蒙古大学图书馆

Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization

引用

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2008年第6期295卷 H2264-H2272页

作者： Odening, Katja E. Hyder, Omar Chaves, Leonard Schofield, Lorraine Brunner, Michael Kirk, Malcolm Zehender, Manfred peng, xuwen Koren, Gideon Brown Univ Warren Alpert Med Sch Rhode Isl Hosp Cardiovasc Res CtrDiv Cardiol Providence RI 02903 USA Univ Freiburg Innere Med 3 D-7800 Freiburg Germany Penn State Univ Coll Med Dept Comparat Med Hershey PA USA

Odening KE, Hyder O, Chaves L, Schofield L, Brunner M, Kirk M, Zehender M, peng X, Koren G. Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization. Am J Physiol Heart Circ Physiol 295: H2264-H2272, 2008. First published October 3, 2008;doi: 10.1152/ajpheart. 00680.2008. Anesthetic agents prolong cardiac repolarization by blocking ion currents. However, the clinical relevance of this blockade in subjects with reduced repolarization reserve is unknown. We have generated transgenic long QT syndromes type 1 (LQT1) and type 2 (LQT2) rabbits that lack slow delayed rectifier K+ currents (I-Ks) or rapidly activating K+ currents (I-Kr) and used them as a model system to detect the channel-blocking properties of anesthetic agents. Therefore, LQT1, LQT2, and littermate control (LMC) rabbits were administered isoflurane, thiopental, midazolam, propofol, or ketamine, and surface ECGs were analyzed. Genotype-specific heart rate correction formulas were used to determine the expected QT interval at a given heart rate. The QT index (QTi) was calculated as percentage of the observed QT/expected QT. Isoflurane, a drug that blocks I-Ks, prolonged the QTi only in LQT2 and LMC but not in LQT1 rabbits. Midazolam, which blocks inward rectifier K+ current (I-Ks), prolonged the QTi in both LQT1 and LQT2 but not in LMC. Thiopental, which blocks both I-Ks and I-K1, increased the QTi in LQT2 and LMC more than in LQT1. By contrast, ketamine, which does not block I-Kr, I-Ks, or I-K1, did not alter the QTi in any group. Finally, anesthesia with isoflurane or propofol resulted in lethal polymorphic ventricular tachycardia (pVT) in three out of nine LQT2 rabbits. Transgenic LQT1 and LQT2 rabbits could serve as an in vivo model in which to examine the pharmacogenomics of drug-induced QT prolongation of anesthetic agents and their proarrhythmic potential. Transgenic LQT2 rabbits developed pVT under isoflurane an

关键词： repolarization reserve long QT syndrome types 1 and 2 sudden cardiac death ventricular fibrillation

来源：评论

学校读者我要写书评

暂无评论

Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo

引用

EUROPEAN JOURNAL OF PHARMACOLOGY 2011年第1期650卷 309-316页

作者： Biermann, Jurgen Wu, Kezhong Odening, Katja E. Asbach, Stefan Koren, Gideon peng, xuwen Zehender, Manfred Bode, Christoph Brunner, Michael Univ Hosp Freiburg Dept Cardiol & Angiol D-79106 Freiburg Germany Brown Univ Rhode Isl Hosp Warren Alpert Med Sch Cardiovasc Res Ctr Providence RI 02903 USA Penn State Univ Coll Med Dept Comparat Med Hershey PA USA

Transgenic rabbits expressing loss-of-function pore mutants of the human gene KCHQ1 (K(v)LQT1-Y315S) have a Long QT-Syndrome 1 (LQT1) phenotype We evaluated for the first time the effect of nicorandil an opener of ATP sensitive potassium channels and of isoproterenol on cardiac action potential duration and heart rate dependent dispersion of repolarisation in transgenic LQT1 rabbits In vivo LQT1 and littermate control were subjected to transvenous electrophysiological studies in vitro monophasic action potentials were recorded from explanted Langendorff-perfused hearts In vivo ventricular effective refractory periods (VERP) at the right ventricular base were significantly prolonged in LQT1 as compared to litterrnate control resulting in a more pronounced VERP dispersion in LQT1 This difference in VI RP dispersion between LQT1 and littermate control disappeared after infusion of nicorandil In vitro mean action potential durations (APD(75) and APD(90)) of LQT1 were significantly prolonged compared to littermate control at baseline Nicorandil decreased APD(75) and APD(90) in LQT1 and littermate control at all stimulated heart rates After adding nicorandil the APD90 it all hearts rates and the APD75 at high heart rates were no longer different Dispersion of repolarisation (AAPD(75) and Delta APD(90)) was heart rate dependently decreased after nicorandil at all tested stimulation cycle lengths only in LQT1 We demonstrated phenotypic differences of LQT1 and littermate control in vivo and in vitro Nicorandil 20 mu mol/1 improved repolarisation abnormalities and heterogeneities in transgenic LQT1 rabbits (C) 2010 Elsevier B V All rights reserved

关键词： Long QT Syndrome Polymorphic ventricular tachycardia Transgenic rabbit model Electrophysiological studies Nicorandil Dispersion of repolarisation

来源：评论

学校读者我要写书评

暂无评论

Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice

引用

PSYCHOPHARMACOLOGY 2025年第3期242卷 533-544页

作者： Li, Kaixi Xu, Deli Qiao, Yanling Kuai, Lixin Luo, xuwen Di, Bin Xu, peng China Pharmaceut Univ Sch Pharm Nanjing 210009 Peoples R China Off China Natl Narcot Control Commiss Pharmaceut Univ Joint Lab Key Technol Narcot Contr Beijing 100193 Peoples R China Minist Publ Secur Drug Intelligence & Forens Ctr Key Lab Drug Monitoring & Control Beijing 100193 Peoples R China

Rationale The newly emerging synthetic cannabinoids (SCs) 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 have been observed to produce effects by activating cannabinoid type 1 (CB1) receptors. Nevertheless, the pharmacological effects and potential for abuse of these three substances remain to be studied. These substances have yet to be regulated in many countries. Objectives We investigated the safety, pharmacological effects, rewarding effects, and cannabinoid withdrawal of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201. Methods This study evaluated the drug safety and the cannabinoid-specific pharmacological effects of the three substances through acute toxicity experiments (in which the LD50 of each substance was obtained) and tetrad experiments (comprising assessments of hypothermia, analgesia, locomotion inhibition, and catalepsy). Furthermore, the conditioned place preference (CPP) experiments and withdrawal experiments were conducted to evaluate the rewarding effect and cannabinoid withdrawal potential of the substances in question. Results The results demonstrated that all three drugs exhibited certain acute toxic effects and could potentially induce tetrad effects. The data were analyzed using non-linear regression, and the corresponding ED50 values and 95% confidence intervals (CI) were obtained. The rank order of potency was determined to be CUMYL-PEGACLONE > 5F-EDMB-PICA > NM-2201. In the CPP experiments, it was demonstrated that 5F-EDMB-PICA significantly induced an increase in CPP score at a dose of 0.3 mg/kg, while NM-2201 caused an increase in CPP score and a significant aversion effect at a dose of 2 and 3 mg/kg, respectively. It is noteworthy that all three types of SCs were observed to produce a significant biphasic effect, indicating that CPP scores were biphasic for all compounds. Following the administration of the CB1 receptor antagonist rimonabant, a notable increase in head twitches and paw tremors was observed, indicating that these three SCs indu

关键词： 5F-EDMB-PICA CUMYL-PEGACLONE NM-2201 Acute toxicity Tetrad effects CPP Withdrawal

来源：评论

学校读者我要写书评

暂无评论

Hydrogels for the removal of the methylene blue dye from wastewater: a review

引用

ENVIRONMENTAL CHEMISTRY LETTERS 2022年第4期20卷 2665-2685页

作者： Yang, Yinchuan Zhu, Qinlin peng, xuwen Sun, Jingjing Li, Cong Zhang, Xinmiao Zhang, Hao Chen, Jiabin Zhou, Xuefei Zeng, Hongbo Zhang, Yalei Tongji Univ Coll Environm Sci & Engn State Key Lab Pollut Control & Resources Reuse Shanghai 200092 Peoples R China Tongji Univ Shanghai Inst Pollut Control & Ecol Secur Shanghai 200092 Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G IH9 Canada Univ Shanghai Sci & Technol Coll Environm & Architecture Shanghai 200093 Peoples R China Sinopec Beijing Res Inst Chem Ind Environm Protect Res Inst Beijing 100013 Peoples R China

Water pollution is a major environmental issue with the rapid development of industry. Therefore, advanced technologies and materials are needed to remove pollutants from contaminated waters. The adsorption process displays many advantages such as high adaptability and removal efficiency for water sources of varying quality. Hydrogels have recently attracted attention due to their high adsorption capacity and structural stability, yet several issues remain to be explored, such as the number of reuse and engineering applications. Here, we review hydrogels for the removal of methylene blue from wastewater, with focus on hydrogel preparation and properties, adsorption performance and mechanisms, reusability and comparison with biological and chemical oxidation methods.

关键词： Hydrogel Methylene blue Adsorption Dye Wastewater treatment

来源：评论

学校读者我要写书评

暂无评论

Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome

引用

JOURNAL OF PHYSIOLOGY-LONDON 2009年第19期587卷 4661-4680页

作者： Ziv, Ohad Morales, Eduardo Song, Yoon-kyu peng, xuwen Odening, Katja E. Buxton, Alfred E. Karma, Alain Koren, Gideon Choi, Bum-Rak Brown Univ Warren Alpert Med Sch Rhode Isl Hosp Div CardiolCardiovasc Res Ctr Providence RI 02903 USA Brown Univ Div Engn Providence RI 02903 USA Penn State Univ Coll Med Dept Comparat Med Hershey PA USA Northeastern Univ Dept Phys Boston MA 02115 USA

Enhanced dispersion of repolarization has been proposed as an important mechanism in long QT related arrhythmias. Dispersion can be dynamic and can be augmented with the occurrence of spatially out-of-phase action potential duration (APD) alternans (discordant alternans;DA). We investigated the role of tissue heterogeneity in generating DA using a novel transgenic rabbit model of type 2 long QT syndrome (LQT2). Littermate control (LMC) and LQT2 rabbit hearts (n = 5 for each) were retrogradely perfused and action potentials were mapped from the epicardial surface using di-4-ANEPPS and a high speed CMOS camera. Spatial dispersion (delta APD and delta slope of APD restitution) were both increased in LQT2 compared to LMC (delta APD: 34 +/- 7 ms vs. 23 +/- 6 ms;delta slope:1.14 +/- 0.23 vs. 0.59 +/- 0.19). Onset of DA under a ramp stimulation protocol was seen at longer pacing cycle length (CL) in LQT2 compared to LMC hearts (206 +/- 24 ms vs. 156 +/- 5 ms). Nodal lines between regions with APD alternans out of phase from each other were correlated with conduction velocity (CV) alternation in LMC but not in LQT2 hearts. In LQT2 hearts, larger APD dispersion was associated with onset of DA at longer pacing CL. At shorter CLs, closer to ventricular fibrillation induction (VF), nodal lines in LQT2 (n = 2 out of 5) showed persistent complex beat-to-beat changes in nodal line formation of DA associated with competing contribution from CV restitution and tissue spatial heterogeneity, increasing vulnerability to conduction block. In conclusion, tissue heterogeneity plays a significant role in providing substrate for ventricular arrhythmia in LQT2 rabbits by facilitating DA onset and contributing to unstable nodal lines prone to reentry formation.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Comparative analysis of three heating methods for natural gas hydrate production: Electric heating, steam injection, and hot water injection

引用

APPLIED THERMAL ENGINEERING 2025年 269卷

作者： Zhang, Zhaobin Xu, Tao Li, Shouding Guo, peng Li, Xiao Lu, Cheng Sun, Yiming Wang, Pingkang Qin, xuwen Chinese Acad Sci Inst Geol & Geophys Key Lab Deep Petr Intelligent Explorat & Dev Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China China Geol Survey China Aero Geophys Survey & Remote Sensing Ctr Nat Beijing 100083 Peoples R China Minist Nat Resources China Geol Survey Oil & Gas Resources Survey Beijing 100083 Peoples R China Natl Engn Res Ctr Gas Hydrate Explorat & Dev Guangzhou 510075 Guangdong Peoples R China

Natural gas hydrates are a promising and environmentally sustainable energy resource, but their commercial production remains challenging. External heating is crucial for improving production efficiency. In this study, we employed a self-developed simulator (IGG-hydrate) to compare the thermal performance of three key heating methods: electric heating (EH), steam injection (SI), and hot water injection (WI). Quantitative indicators, including heating and depressurization thresholds, were introduced to assess the effectiveness of each method. The results demonstrate that external heating significantly facilitates hydrate dissociation, with electric heating and steam injection showing comparable gas production rates and early-stage efficiency. However, both electric heating and steam injection methods can cause localized overheating near injection wells, leading to energy inefficiency. In contrast, hot water injection achieves a more uniform temperature distribution and a broader heating range, while avoiding excessive temperature rise. However, it also reduces depressurization efficiency and increases subsidence near the wells. To optimize performance, we propose a steam-water alternating injection strategy: steam is injected initially for rapid dissociation near the wells, followed by hot water injection to extend the heating range and maintain thermal efficiency with the same equipment.

关键词： Heating method Electric heating Steam injection Hot water injection Hydrate

来源：评论

学校读者我要写书评

暂无评论

Long-peptide therapeutic vaccination against CRPV-induced papillomas in HLA-A2.1 transgenic rabbits

引用

Trials in Vaccinology 2014年第1期3卷 134-142页

作者： Hu, Jiafen Budgeon, Lynn R. Balogh, Karla K. peng, xuwen Cladel, Nancy M. Christensen, Neil D. Jake Gittlen Cancer Research Foundation Pennsylvania State University College of Medicine Hershey PA 17033 United States Department of Pathology Pennsylvania State University College of Medicine Hershey PA 17033 United States Department of Comparative Medicine Pennsylvania State University College of Medicine Hershey PA 17033 United States Microbiology and Immunology Pennsylvania State University College of Medicine Hershey PA 17033 United States

Long peptide immunization is a promising strategy to clear established tumors. In the current study, we investigated the therapeutic effect of a naturally existing long peptide that contained two HLA-A2.1 restricted epitopes (CRPVE1/149-157 and CRPVE1/161-169) from cottontail rabbit papillomavirus (CRPV) E1 using our CRPV/HLA-A2.1 transgenic rabbit model. A universal Tetanus Toxin helper motif (TT helper) was tagged at either the N-terminus or the carboxyl-terminus of this long peptide and designated as TT-E1 peptide and E1 peptide-TT, respectively. Four groups of HLA-A2.1 transgenic rabbits were infected with wild type CRPV DNA. Three weeks post-infection, the rabbits were immunized four times with TT-E1 peptide, E1 peptide only, E1 peptide-TT or TT-control peptide with two-week intervals between immunizations. Tumor outgrowth was monitored and recorded weekly. After the third booster immunization, tumors on two of the four E1 peptide-TT immunized rabbits began to shrink. One animal from this group was free of tumors at the termination of the study. The mean papilloma size of E1 peptide-TT immunized rabbits was significantly smaller when compared with that of the three other groups (P < 0.05, one way ANOVA analysis). It is interesting that E1 peptide-TT vaccination not only stimulated stronger T cell mediated immune responses but also stronger antibody generations. We conclude that the location of a TT helper motif tagged at the long peptide vaccine is critical for the outcome of therapeutic responses to persistent tumors in our HLA-A2.1 transgenic rabbit model. © 2014 The Authors. Published by Elsevier Ltd.

关键词： CRPV HLA-A2.1 Long peptide T-cell mediated immune response Therapeutic vaccine Transgenic rabbit

来源：评论

学校读者我要写书评

暂无评论

Strong and Specific Protective and Therapeutic Immunity Induced by Single HLA-A2.1 Restricted Epitope DNA Vaccine in Rabbits

引用

Procedia in Vaccinology 2009年第1期1卷 4-14页

作者： Hu, Jiafen Schell, Todd D. peng, xuwen Cladel, Nancy M. Balogh, Karla K. Christensen, Neil D. Jake Gittlen Cancer Research Foundation Pennsylvania State University College of Medicine Hershey PA 17033 United States Department of Pathology Pennsylvania State University College of Medicine Hershey PA 17033 United States Department of Microbiology and Immunology Pennsylvania State University College of Medicine Hershey PA 17033 United States Department of Comparative Medicine Pennsylvania State University College of Medicine Hershey PA 17033 United States

An HLA-A2.1 transgenic rabbit /Cottontail rabbit papillomavirus (CRPV) infection model has been reported previously. In this study, we incorporated online MHCI epitope prediction software and HLA-A2.1 transgenic mouse and rabbit systems together to demonstrate an efficient way to identify and test immunogenicity of two HLA-A2.1 restricted epitopes from CRPVE1 (161-169 LLFRQAHSV and 303-311 MLQEKPFQL). Both epitopes were able to induce specific cytotoxic CD8 T cells in HLA-A2.1 mice and rabbits after peptide and DNA immunization and in vitro stimulation respectively. Using an epitope DNA vaccination method, we achieved partial and complete protection against CRPV DNA challenge by CRPVE1/161-169 and CRPVE1/303-311 respectively in HLA-A2.1 transgenic outbred rabbits. CRPVE1/303-311 also showed strong and specific therapeutic effects in CRPV-infected HLA-A2.1 transgenic outbred rabbits. Interestingly, epitope CRPVE1/303-311 (but not E1/161-169) showed strong protective immunity in non-transgenic EIII/JC inbred (but not outbred) NZW rabbits. Our data demonstrates an efficient way to identify HLA-A2.1 restricted epitopes for the development of prophylactic and therapeutic vaccines. © 2009.

关键词： A2 CRPV Epitope DNA vaccine Transgenic mouse Transgenic rabbit

来源：评论

学校读者我要写书评

暂无评论

Pharmaco-toxicological effects of the synthetic cannabinoids 4F-ABUTINACA, SDB-005, and JWH-018 in mice. In vitro and in vivo studies

引用

EUROPEAN JOURNAL OF PHARMACOLOGY 2025年 996卷 177586页

作者： Luo, xuwen Kuai, Lixin Shi, Xuesong Qiao, Yanling Li, Kaixi Xu, Deli Di, Bin Yan, Fang Xu, peng China Pharmaceut Univ Sch Pharm Nanjing 210009 Peoples R China China Pharmaceut Univ Joint Lab Key Technol Narcot Control Off China Natl Narcot Control Commiss Beijing 100193 Peoples R China Minist Publ Secur Drug Intelligence & Forens Ctr Key Lab Drug Monitoring & Control Beijing 100193 Peoples R China

Background: Synthetic cannabinoids (SCs) are currently one of the most severely abused new psychoactive substances in the world. However, there remains a notable lack of pharmacological data on the newly emerged synthetic cannabinoids. In the present study, the in vitro and in vivo pharmacological effects of the fourth-generation synthetic cannabinoids 4F-ABUTINACA and SDB-005 are determined and compared to those of the first-generation synthetic cannabinoid JWH-018. Methods: In this study, the affinities of three SCs for CB1 receptors were evaluated using surface plasmon resonance (SPR) experiments. The acute toxicity of these three SCs was assessed through the up-and-down procedure, while their cannabinoid-specific pharmacological effects were determined through tetrad assays, which examined parameters such as temperature regulation, analgesia, locomotor activity, and catalepsy. Additionally, conditioned place preference (CPP) experiments and a precipitated withdrawal tests were conducted to assess the psychoactive effects and physical dependence of the SCs. Results: SPR experiments and acute toxicity tests demonstrated that in vitro KD values were positively correlated with in vivo ED50 potency estimates. All SCs were found to induce the classical "tetrad effects" in a dose-dependent manner. Notably, all SCs displayed significant biphasic effects in CPP experiments. Following the administration of the CB1 receptor antagonist rimonabant, a significant increase in head twitches and paw tremors was observed, indicating that the physical dependence manifested after the ingestion of SCs is mediated by the CB1 receptor. Conclusions: These findings suggest that these SCs have cannabinoid-specific pharmacological effects and abuse potential, providing robust experimental data to support future regulatory efforts.

关键词： 4F-ABUTINACA SDB-005 JWH-018 Tetrad CPP Precipitated withdrawal

来源：评论

学校读者我要写书评

暂无评论

Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective

引用

HEART RHYTHM 2012年第5期9卷 823-832页

作者： Odening, Katja E. Choi, Bum-Rak Liu, Gong Xin Hartmann, Kathryn Ziv, Ohad Chaves, Leonard Schofield, Lorraine Centracchio, Jason Zehender, Manfred peng, xuwen Brunner, Michael Koren, Gideon Brown Univ Rhode Isl Hosp Div Cardiol Cardiovasc Res CtrAlpert Med Sch Providence RI 02903 USA Univ Hosp Freiburg Dept Cardiol Freiburg Germany Penn State Univ Coll Med Dept Comparat Med Hershey PA USA

BACKGROUND Postpubertal women with inherited long QT syndrome type 2 (LQT2) are at increased risk for polymorphic ventricular tachycardia (pVT) and sudden cardiac death (SCD), particularly during the postpartum period. OBJECTIVE To investigate whether sex hormones directly modulate the arrhythmogenic risk in LQTS. METHODS Prepubertal ovariectomized transgenic LQT2 rabbits were treated with estradiol (EST), progesterone (PROG), dihydrotestosterone (DHT), or placebo (OVX). RESULTS During 8 weeks of treatment, major cardiac events-spontaneous pVT or SCD-occurred in 5 of the 7 EST rabbits and in 2 of the 9 OVX rabbits (P < .05);in contrast, no events occurred in 9 PROG rabbits and 6 DHT rabbits (P < .01 vs PROG;P < .05 vs DHT). Moreover, EST increased the incidence of pVT (P < .05 vs OVX), while PROG reduced premature ventricular contractions, bigeminy, couplets, triplets, and pVT (P < .01 vs OVX;P < .001 vs EST). In vivo electrocardiographic monitoring, in vivo electrophysiological studies, and ex vivo optical mapping studies revealed that EST promoted SCD by steepening the QT/RR slope (P < .05), by prolonging cardiac refractoriness (P < .05), and by altering the spatial pattern of action potential duration dispersion. Isoproterenol-induced Ca2+ oscillations resulted in early afterdepolarizations in EST-treated hearts (4 of 4), while PROG prevented SCD by eliminating this early afterdepolarization formation in 4 of the 7 hearts (P = .058 vs EST;P < .05 vs OVX). Analyses of ion currents demonstrated that EST increased the density of I-Ca,I-L as compared with OVX (P < .05) while PROG decreased it (P < .05). CONCLUSION This study reveals the proarrhythmic effect of EST and the antiarrhythmic effect of PROG in LQT2 in vivo, outlining a new potential antiarrhythmic therapy for LQTS. KEYWORDS Long QT syndrome;Sex hormones;Arrhythmogenesis;Sudden cardiac death;Transgenic LQT2 rabbit model;Cardiac ion currents;Early afterdepolarization;In vivo electrophysiological study

关键词： Long QT syndrome Sex hormones Arrhythmogenesis Sudden cardiac death Transgenic LQT2 rabbit model Cardiac ion currents Early afterdepolarization In vivo electrophysiological study

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：