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Association Between Clinical Manifestations and Prognosis in Patients with COVID-19

CLINICAL THERAPEUTICS 2020年第6期42卷 964-972页

作者： Yu, Tao Cai, Shaohang Zheng, Zhidan Cai, Xuejuan Liu, Yuanyuan Yin, Sichun peng, Jie Xu, xuwen Southern Med Univ Nanfang Hosp Dept Infect Dis 1838 Guangzhou Ave North Guangzhou 510515 Guangdong Peoples R China Southern Med Univ Dongguan Peoples Hosp Dept Infect Dis Dongguan Guangdong Peoples R China

Purpose: The purpose of this study was to determine the risk factors associated with pneumonia, acute respiratory distress syndrome (ARDS), and clinical outcome among patients with novel coronavirus disease 2019 (COVID-19). Methods: This was a cross-sectional multicenter clinical study. A total of 95 patients infected with COVID-19 were enrolled. The COVID-19 diagnostic standard was polymerase chain reaction detection of target genes of 2019 novel coronavirus (2019-nCoV). Clinical, laboratory, and radiologic results, as well as treatment outcome data, were obtained. ARDS was defined as an oxygenation index (arterial partial pressure of oxygen/fraction of inspired oxygen) <= 300 mm Hg. Findings: Multivariate analysis showed that older age (odds ratio [OR], 1.078;p = 0.008) and high body mass index (OR, 1.327;p = 0.024) were independent risk factors associated with patients with pneumonia. For patients with ARDS, multivariate analysis showed that only high systolic blood pressure (OR, 1.046;p = 0.025) and high lactate dehydrogenase level (OR, 1.010;p = 0.021) were independent risk factors associated with ARDS. A total of 70 patients underwent CT imaging repeatedly after treatment. Patients were divided in a disease exacerbation group (n = 19) and a disease relief group (n = 51). High body mass index (OR, 1.285;p = 0.017) and tobacco smoking (OR, 16.13;p = 0.032) were independent risk factors associated with disease exacerbation after treatment. (C) 2020 The Authors. Published by Elsevier Inc.

关键词： 2019-nCoV Acute respiratory distress syndrome COVID-19 Pneumonia Risk factors

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Intelligent generation method of 3D machining process based on process knowledge

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INTERNATIONAL JOURNAL OF COMPUTER INTEGRATED MANUFACTURING 2020年第1期33卷 38-61页

作者： Jing, xuwen Zhu, Yuping Liu, Jinfeng Zhou, Honggen Zhao, peng Liu, Xiaojun Tian, Guizhong Ye, Hua Li, Qun Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Jiangsu Peoples R China Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang Jiangsu Peoples R China Southeast Univ Sch Mech Engn Nanjing Jiangsu Peoples R China Hudong Heavy Machinery Co Ltd Inst Comprehens Technol Shanghai Peoples R China

Intelligent manufacturing has become the trend of global manufacturing industry, and the core of the new industrial revolution and the commanding point of Made in China 2025. Process planning is an important part of intelligent manufacturing. To improve the speed and accuracy of intelligent generation of machining process, a systematic intelligent generation method of machining process based on process knowledge is proposed. Firstly, a method of modelling and management of process knowledge is presented. Secondly, by combining case-based reasoning with rule-based reasoning, accurate process information of machining features is obtained. Then, the skeleton process is formed. Thirdly, through the analysis of the precedence constraints and the processing experience constraints, the precedence relation between machining features is determined. Moreover, the precedence between process operations is formulated by process constraint matrix. Finally, a genetic algorithm (GA) approach is presented to obtain the global optimal process route for the part based on working step with process information. Taking the connecting rod and piston of marine diesel engine and the spindle box shell as the research object, the feasibility of this method is verified.

关键词： Process knowledge skeleton process process constraint matrix genetic algorithm machining process

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Research on the intelligent generation method of MBD model 3D marking using predefined features

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CONCURRENT ENGINEERING-RESEARCH AND APPLICATIONS 2020年第3期28卷 222-238页

作者： Jing, xuwen Tang, Mingming Liu, Jinfeng Zhou, Honggen Zhao, peng Wang, Zhen Cao, Xuwu Sheng, Sushan Wei, Gang Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Jiangsu Peoples R China Jiangsu Univ Sci & Technol Jiangsu Prov Key Lab Adv Mfg Marine Mech Equipmen Zhenjiang Jiangsu Peoples R China Shanxi Diesel Engine Heavy Ind Co Ltd Xingping Shanxi Peoples R China

Model-based definition (MBD) carries out a technological innovation for global manufacturing, application of MBD technology plays an important supporting in process design, product manufacturing and other development activities, rapid creation of MBD models have become a key to reduce time and cost for enterprises. However, interactive dimensioning method has severely hampered the efficiency of MBD model creation. This paper mainly studies the dimensions intelligent marking method based on the predefined features to solve the rapid modeling problem of MBD model. Firstly, the expression model of dimensions metadata is established based on the feature identifier. Secondly, by establishing an association mechanism between the dimensions and the predefined feature, the "model-feature-dimensioning" association model is formed. Thirdly, through analysis of the dimensioning type, the intelligent dimensioning algorithm process is determined. Moreover, the completeness check of the dimensions is guaranteed during the marking process. Finally, taking the connecting rod and crankshaft of marine diesel as the research object, the effectiveness of this method is verified.

关键词： MBD dimension predefined features metadata intelligent marking

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Community structure of benthic macroinvertebrates in native and introduced mangroves of northern Beibu Gulf, China: Implication for restoring mangrove ecosystems

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MARINE POLLUTION BULLETIN 2022年 180卷 113796页

作者： Zhen, Wenquan Kwan, Kit Yue Wang, Chun-Chieh Wu, xuwen Guo, Guo Deng, Qiuxiang Huang, Xing Wang, Xueping Zhu, Junhua Xu, peng Beibu Gulf Univ Coll Marine Sci Beibu Gulf Ocean Dev Res Ctr Guangxi Key Lab Beibu Gulf Marine Biodivers Conse Qinzhou 535011 Peoples R China Guangxi Acad Sci Guangxi Beibu Gulf Marine Res Ctr Guangxi Key Lab Marine Environm Sci Nanning 530007 Peoples R China Chinese Acad Sci Inst Oceanol Qingdao 266071 Peoples R China Guangxi Beihai Coastal Natl Wetland Pk Beihai 536000 Peoples R China

Introduced mangroves are widely used to restore mangrove ecosystems in South China. Results of potential impacts on indicative benthic macroinvertebrates are divergent. We explored the community structure of benthic macroinvertebrates in the mangrove ecosystem of northern Beibu Gulf, China across four habitats: native Avicennia marina mangrove, introduced Laguncularia racemosa mangrove, native-introduced mixed mangrove, and unvegetated intertidal flat. Based on the Hill number, community structure was estimated from the dimensions of estimated species richness, diversity, evenness, and species composition similarity. Benthic macroinvertebrates in the unvegetated flat significantly differed from the other three assemblages in mangroves;introduced L. racemosa mangrove had relatively distinct benthic macroinvertebrate assemblage from the native A. marina and the mixed mangroves, with lower species richness and similarity but higher diversity and evenness. Considering the lack of unanimous conclusion of potential impact on benthic macroinvertebrates under complex species interactions, native mangroves should be of top priority in ecosystem restoration.

关键词： Taxonomic diversity Species composition similarity Hill number Tidal flat Avicennia marina Laguncularia racemosa

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Highly efficient synthesis of hydrogen-bonded aromatic tetramers as macrocyclic receptors for selective recognition of lithium ions

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ORGANIC CHEMISTRY FRONTIERS 2019年第15期6卷 2654-2661页

作者： Guo, xuwen Yang, Yizhou peng, Zhiyong Cai, Yimin Feng, Wen Yuan, Lihua Sichuan Univ Coll Chem Key Lab Radiat Phys & Technol Minist Educ Chengdu 610064 Sichuan Peoples R China

Persistently folded aromatic amide macrocycles comprising four monomeric units (biphenyl-cyclo[4]aramide) were synthesized with high efficiency via a one-step approach along with the larger cyclic oligomer, biphenyl-cyclo[8]aramide as a minor product. Such cyclic hydrogen-bonded aromatic tetramers feature four amide oxygens enclosing a cavity with small dimensions, enabling the selective complexation of alkali metal ions, particularly Li+, with high affinity. The cyclization efficiency and selectivity of smaller macrocycles was further improved using fragment coupling and Li+-based template approaches. In addition, the superior binding ability of biphenyl-cyclo[4]aramide towards Li+ over its acyclic analogues was observed, demonstrating a remarkable macrocyclic effect.

关键词： Amides

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Phytoplankton community changes in a coastal upwelling system during the last century

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Global and Planetary Change 2023年 224卷

作者： peng, peng Bi, Rong Sachs, Julian P. Shi, Jie Luo, Yifei Chen, Weifang Huh, Chih-An Yu, Meng Cao, Yali Wang, Yaoyao Cao, Zhong Bao, Xiaohan Guo, Xinyu Li, Huijuan Feng, xuwen Li, Hongchun Zhao, Meixun Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China Qingdao266100 China Laoshan Laboratory Qingdao266237 China School of Oceanography University of Washington Box 355351 SeattleWA98195 United States Key laboratory of Marine Environment and Ecology Ministry of Education Ocean University of China Qingdao266100 China State Key Laboratory of Marine Environmental Science and College of Ocean and Earth Sciences Xiamen University Xiamen361102 China Institute of Earth Sciences Academia Sinica Taipei11529 Taiwan Yantai Maritime Safety Administration Yantai264000 China Jinan250014 China Second Institute of Oceanography Ministry of Natural Resources of People's Republic of China Hangzhou310012 China Department of Geosciences National Taiwan University Taipei10617 Taiwan

Phytoplankton communities in coastal upwelling systems are influenced by the interplay between human-induced and natural climate forcing that vary regionally and the two factors have not been well quantified. Combining lipid biomarker analyses in 23 sediment cores from the Zhejiang coast of the East China Sea and a physical-ecological model, we found that during the 1960s–2000s there was a 42 ± 4% increase in diatom proportions and a 17 ± 8% decrease in dinoflagellate proportions within the core upwelling area that is attributed to changes in Kuroshio Current transport and coastal upwelling. During the 1950s–2000s there was a 16 ± 8% increase in dinoflagellate proportions and 12 ± 4% decrease in diatom proportions outside the core upwelling area which is attributed to anthropogenic nutrient inputs and climate warming. Our results provide a novel approach to quantify mechanisms of past and future changes in marine phytoplankton communities. © 2023 Elsevier B.V.

关键词： Ocean currents

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Investigation of fluoride and turbidity removal from coal mine water by combined micro-flocculation and membrane filtration: Lab to pilot scale

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Journal of Environmental Sciences 2025年

作者： Liping Zhang Weiwei Wang Yiyun An Huaran Sun Eryong Wu xuwen He Siwei peng Cun Zhang School of Chemical and Environmental Engineering China University of Mining and Technology-Beijing Beijing 100083 China Datang Environmental Industry Group Co. Ltd Beijing 100097 China School of Mines Key Laboratory of Deep Coal Resource Ministry of Education of China China University of Mining & Technology Xuzhou Jiangsu 221116 China

The concentration of turbidity and fluoride in mine drainage exceeding the discharge standard, which impede coal mine water broader application. In this study, micro-flocculation, which was based on the fluoride removal agent (CFYJ-L) developed by our research group, was combined with direct filtration membrane (MFDMF) to remove the high concentrations of turbidity and fluoride. Firstly, we investigated the impacts of factors on fluoride, turbidity removal by the CFYJ-L, explored the mechanisms of fluoride removal and screened cleaning agents for membrane fouling. Findings indicate that the optimal process parameters were a dosage of 1.16 g/L, pH 6.11, stirring time 10.90 min, which would let F − concentration from 20 to 0.453 mg/L. Suspended solids (SS), Cl − , SO 4 2− and CO 3 2- all seems not reduced fluoride removal efficiency. The fluoride removal mechanism is primarily through electrostatic adsorption, ion exchange, complexation and hydrogen bonding, resulting in the formation of precipitates that remove fluoride. Meanwhile, the optimal process parameters for treating simulated fluorinated coal mine water with MFDMF process was an operating pressure of 0.2 MPa. Membrane fouling was mainly characterized by cake filtration, accompanied by pore clogging. The best cleaning agent for membrane fouling was 0.2 % HCl, which can increase the membrane flux recovery rate from 70 % to 91 %. A 90-day pilot site continuous operation demonstrated the stability of the MFDMF process, with a treatment cost was reduced from over 3.36 RMB/m 3 to 2.60 RMB/m 3 and land area reduction exceeding 40 % compared to existing process.

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他莫昔芬辅助治疗的ER阳性乳腺癌患者miR-122、miR-449a检测的临床价值研究

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现代生物医学进展 2024年第23期24卷 4592-4594页

作者：范丽莉许文林彭金娟李丽陶凯江苏大学医学院江苏镇江212013 江苏大学第四附属医院乳腺科江苏镇江212050 江苏大学第四附属医院中心实验室江苏镇江212050

目的:分析他莫昔芬辅助治疗的雌激素受体(ER)阳性乳腺癌患者微小RNA(mi R)-122、mi R-449a检测的临床价值。方法:选择258例ER阳性乳腺癌患者,均接受他莫昔芬辅助治疗。分析血清外泌体mi R-122、mi R-449a表达与患者临床病理特征的关系... 详细信息

目的:分析他莫昔芬辅助治疗的雌激素受体(ER)阳性乳腺癌患者微小RNA(mi R)-122、mi R-449a检测的临床价值。方法:选择258例ER阳性乳腺癌患者,均接受他莫昔芬辅助治疗。分析血清外泌体mi R-122、mi R-449a表达与患者临床病理特征的关系。随访5年,绘制Kaplan-Meier曲线分析生存率,采用多因素Cox回归分析影响因素。结果:组织学分级3级、TNM分期Ⅲ期、腋窝淋巴结转移、Ki-67高表达的ER阳性乳腺癌患者治疗前血清外泌体mi R-122高于组织学分级1-2级、TNM分期Ⅰ/Ⅱ期、无腋窝淋巴结转移、Ki-67低表达,mi R-449a则更低(P<0.05)。mi R-122高表达组中位总生存期(OS)低于mi R-122低表达组(P<0.05);mi R-449a低表达组中位OS低于mi R-449a高表达组(P<0.05);Cox回归分析显示TNM分期为Ⅲ期、Ki-67高表达(≥14%)、mi R-122高表达、mi R-449a低表达是ER阳性乳腺癌患者他莫昔芬辅助治疗预后不良的独立危险因素(P<0.05)。结论:ER阳性乳腺癌患者血清外泌体mi R-122、mi R-449a表达水平与患者组织学分级、TNM分期、腋窝淋巴结转移情况、Ki-67表达等临床病理特征相关,mi R-122高表达、mi R-449a低表达是影响患者5年生存期的独立危险因素,有望成为预测他莫昔芬辅助治疗预后的重要标志物。

关键词： ER阳性乳腺癌他莫昔芬 miR-122 miR-449a 预后

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BIAS CIRCUIT OF POWER AMPLIFIER, AND APPARATUS AND DEVICE

BIAS CIRCUIT OF POWER AMPLIFIER, AND APPARATUS AND DEVICE

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作者： peng, Zhenfei 彭振飞 SU, Qiang 苏强 NI, xuwen 倪旭文

标准号: WO2022/170816(A1)

Disclosed are a bias circuit of a power amplifier, and an apparatus and a device. The circuit comprises a first-part circuit, a second-part circuit and a power source, wherein the power source is connected to a power source end of the first-part circuit;two ends of the first-part circuit are connected to two ends of the second-part circuit in parallel, and one end following parallel connection is connected to a gate electrode of a first transistor of the power amplifier;the gate electrode of the first transistor is provided with a first bias voltage and a second bias voltage by the first-part circuit and the second-part circuit respectively, the voltages are superposed, and then a stable bias voltage is provided;and the impedance of the bias circuit is within a preset impedance range. Therefore, a power amplifier is provided with a first bias voltage by a first-part circuit, the power amplifier is provided with a second bias voltage by a second-part circuit, and the second bias voltage can be used to adjust the first bias voltage, so as to provide the power amplifier with a stable bias voltage;and the impedance of a bias circuit is within a preset impedance range, thereby ensuring the linearity performance of the power amplifier, and reducing the memory effect of the power amplifier.

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Spectroscopic study on transformations of dissolved organic matter in coal-to-liquids wastewater under integrated chemical oxidation and biological treatment process

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Journal of Environmental Sciences 2018年第8期30卷 206-216页

作者： Siwei peng xuwen He Hongwei Pan Department of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou 450045China

A large amount of wastewater containing various toxic organic contaminants is produced during coal-to-liquids process. In this study, several spectroscopic methods were used to monitor the transformation of organic pollutants during an integrated chemical oxidation and biological process. The results showed that the hydrophobic acid fraction increased after Fenton oxidation, which was likely due to the production of small-molecule organic acids. Soluble microbial products were generated during biological treatment processes,which were degraded after ozonation; meanwhile, the hydrophilic base and acid components increased. Ultraviolet-visible spectroscopic analysis indicated that peaks at the absorption wavelengths of 280 and 254 nm, which are associated with aromatic substances, were detected in the raw water. The aromatic substances were gradually removed, becoming undetectable after biological aeration filter（BAF） treatment. Fourier transform infrared spectroscopy analysis revealed that the functional groups of phenols;benzene, toluene, ethylbenzene, and xylene（BTEX）; aromatic hydrocarbons; aliphatic acids;aldehydes; and esters were present in raw wastewater. The organic substances were oxidized into small molecules after Fenton treatment. Aromatic hydrocarbons were effectively removed through bioadsorption and biodegradation after BAF *** organic matter was reduced and finally became undetectable after anoxic–oxic treatment in combination with a membrane bioreactor. Four fluorescent components were fractionated and obtained via excitation–emission matrix parallel factor analysis（EEM-PARAFAC）. Dissolved organic matter fractionation in conjunction with EEM-PARAFAC was able to monitor more precisely the evolution of characteristic organic contaminants.

关键词： Coal-to-liquids wastewater Spectroscopic analysis Dissolved organic matter fractionation UV–visible spectrum Excitation–emission matrix parallel factor analysis （EEM-PARAFAC）

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