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Seabed erosion and deposition formulas applied to a 2D hydrodynamic harbor engineering simulation

ARABIAN JOURNAL OF GEOSCIENCES 2022年第6期15卷 1-19页

作者： Li, Yuting Fang, xuwen Li, Ruijie Song, Zhiyao peng, Guoqiang Chen, peng Nanjing Normal Univ Key Lab Virtual Geog Environm Minist Educ PRC Nanjing 210023 Peoples R China Nanjing Normal Univ State Key Lab Cultivat Base Geog Environm Evolut Nanjing 210023 Peoples R China Nanjing Normal Univ Jiangsu Ctr Collaborat Innovat Geog Informat Reso Nanjing 210023 Peoples R China Xiamen Univ Coll Ocean & Earth Sci Xiamen 361102 Peoples R China Hohai Univ Key Lab Coastal Disaster & Def Minist Educ Nanjing 210098 Peoples R China Hohai Univ Coll Oceanog Nanjing 210098 Peoples R China Hohai Univ Coll Harbour Coastal & Offshore Engn Nanjing 210098 Peoples R China Shaanxi Normal Univ Sch Geog & Tourism Xian 710062 Peoples R China

In coastal engineering, predicting seabed erosion and deposition can help understand hydrodynamic changes of the coastal area. The present work aims to address the prevalent challenge that there is often a shortage of measured data in coastal areas. In this paper, a new seabed erosion and deposition formula with four forms is proposed and combined with 2D hydrodynamic harbor engineering simulation of Daishan Island situated in Zhejiang province, China. The simulation shows that (1) in the open channel, the proposed new formula considers the friction coefficient before and after trenching, thus providing a more accurate prediction result;(2) in the sheltered channels, the proposed new formula can roughly estimate the deposition intensity;(3) in the basin entrance, the proposed new formula provides an estimation better aligned with reality than existing formulae. Meanwhile, the recovery saturation coefficient is not a constant;it can be set at 0.31 in the obtained formulas for calculations during the back silting, and at 0.11 during scouring. Therefore, the proposed new formula provides an improved solution to prediction of seabed erosion and deposition and is applicable to Daishan coastal area in different situations.

关键词： Tidal current and sediment Channel deposition Seabed erosion and deposition Erosion and deposition formula

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Studies on New Steroidal Saponins from Allii macrostemonis Bulbus and Their Antitumor Activities

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Chemical Research in Chinese Universities 2018年第1期34卷 61-66页

作者： YAO Hua WANG Tong WU Qian LIU Ying LI peng LI xuwen JIN Yongri Scienttfic Research Center China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China College of Chemistry Jilin University Changchun 130012 P. R. China

Two new steroidal saponms（2, 3） and two known compounds（1, 4） were isolated from 75% ethanol extract ofAllii macrostemonis bulbus by various spectral methods. The two new steroidal saponins were respectively elucidated as （25S）-26-O-β-D-glucopyranosyl-5α-furostanol-2α,3β,22,26-tetrol-3-O-β-D-glucopyranosyl（1→2）-[β-D- glucopyranosyl（1→3）]-β-D-glucopyranosyl（1→4 ）-β-D-galactopyranoside（2 ） and 26-O-β-D-glucopyranosyl-5α- furostanol-25（ 27）-ene-3β,22,26-tetrol-3-O-β-D-glucopyranosyl（ 1→2 ）-[β-D-glucopyranosyl（ 1→3 ）] -β-D-glucopyranosyl- （1→4）-β-D-galactopyranoside（3）. Compound 4 was obtained from this medical plant for the first time. The activity experiments of proliferation inhibition on tumor cells were performed by cell counting kit-8（CCK-8） method for compound 2（25S-configuration） and its isomer（compound 1, 25R-configttration）. The results show that compounds 1 and 2 have weak inhibition on lung cancer A549 cells, melanoma A375 cells and breast cancer MCF-7 cells as well as certain inhibitory effect on liver cancer HepG2 cells, and the inhibitory effect of compound 1 is stronger than that of compound 2.

关键词： Allii macrostemonis bulbus Steroidal saponin Structure identification Proliferation inhibition Cell counting kit-8（CCK-8） method

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Association between hypertension and prognosis of patients with COVID-19: A systematic review and meta-analysis

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CLINICAL AND EXPERIMENTAL HYPERTENSION 2022年第5期44卷 451-458页

作者： Qian, Zhe Li, Zhuohong peng, Jie Gao, Qiqing Cai, Shaohang Xu, xuwen Southern Med Univ Nanfang Hosp Dept Infect Dis 1838 Guangzhou Ave North Guangdong Kguangzhou GD Peoples R China

Background To investigate the association between hypertension and clinical outcomes, including in-hospital mortality, intensive care unit (ICU) admission, and invasive ventilation in patients with coronavirus disease 2019 (COVID-19) pneumonia. Methods We implemented a systematic search of PubMed for articles that assessed clinical outcomes of hypertensive patients infected with SARS-CoV-2. The primary outcomes evaluated included: in-hospital mortality, ICU admission, and the use of invasive ventilation. Results A total of 18 studies were included, involving 13,293 patients and covering from January 25, 2020, to April 20, 2020. The relationship between hypertension and prognosis in COVID-19 patients was evaluated. Results showed that hypertension was a risk factor for in-hospital mortality in COVID-19 patients (RR: 2.20, 95% CI, 1.83-2.65, P < .001). Moreover, patients with hypertension were more likely to be admitted to ICU (RR: 1.86, 95% CI, 1.13-3.07, P = .001) and to use invasive ventilation (RR: 2.99, 95% CI, 1.73-5.17, P < .001). Conclusions Among COVID-19 patients, those combined with hypertension had a significantly higher risk of in-hospital deaths, admission to ICU, and need for invasive ventilation.

关键词： COVID-19 epidemiology hypertension respiratory infections virology

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The Modeling and Using Strategy for the Digital Twin in Process Planning

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IEEE ACCESS 2020年 8卷 41229-41245页

作者： Zhao, peng Liu, Jinfeng Jing, xuwen Tang, Mingming Sheng, Sushan Zhou, Honggen Liu, Xiaojun Jiangsu Univ Sci & Technol Dept Mech Engn Zhenjiang 212013 Jiangsu Peoples R China Southeast Univ Dept Mech Engn Nanjing Peoples R China

Process planning is the core of guiding process production and one of the most critical parts to realize intelligent manufacturing of products. In order to realize the monitoring, simulation, prediction and control of the physical space in the intelligent manufacturing mode, the digital twin technology is used to guide the process planning. This research describes a modeling method of digital twin process model (DTPM) for manufacturing process and the contents of DT data, discusses the acquisition method of real-time data and the management method of simulation data. Aiming at the data fusion between physical space and virtual space, a hierarchical model and mapping strategy for multi-source heterogeneous data in machining process are proposed to generate the DT data. Finally, the guidance and the visualization function in process planning of DTPM is analyzed, and the effectiveness of this method is verified by choosing the design process of a key component in a marine diesel engine.

关键词： Manufacturing Solid modeling Process planning Data models Three-dimensional displays Process design Digital twin DTPM process planning data perception simulation optimization

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Studies on Triterpenoid Glycosides from Rhizomes ofPanacis majoris and Their Antiplatelet Aggregation Activity

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Chemical Research in Chinese Universities 2016年第6期32卷 943-946页

作者： LI Min JIN Yongri WANG Xiaozhong WU Qian LIU Ying LI peng LI xuwen College of Chemistry Jilin University Changchun 130021 P. R. China

A new triterpenoid glycoside（l） and seven known triterpenoid glycosides, pseudoginsenoside RT2（2）,yesanchinoside R2（3）, vinaginsenoside R13（4）, vinaginsenoside R8（5）, notoginsenoside E（6）, 6＂＇-O-acetylginsenosideRe（7）, 6＂-O-acetylginsenoside Rbl（8）, were isolated from the rhizomes of Panaeis maforis. The new triterpenoidglycoside was elucidated as 3-O-[β-D-glucopyranosyl-（l→2）-fl-D-（6＇-O-ethyl）-glucuronopyranosyl]-oleanolicacid-28-O-β-D-glucopyranoside by extensive spectroscopic and phytochemical methods. Compounds 2-8 wereobtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate（ADP）-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibitedmoderate antiplatelet aggregation activity induced by arachidonic acid（AA）.

关键词： Panacis majoris Rhizome Triterpenoid glycoside Antiplatelet aggregation

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The wide utility of rabbits as models of human diseases

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EXPERIMENTAL AND MOLECULAR MEDICINE 2018年第5期50卷 66-66页

作者： Esteves, Pedro J. Abrantes, Joana Baldauf, Hanna-Mari BenMohamed, Lbachir Chen, Yuxing Christensen, Neil Gonzalez-Gallego, Javier Giacani, Lorenzo Hu, Jiafen Kaplan, Gilla Keppler, Oliver T. Knight, Katherine L. Kong, Xiang-peng Lanning, Dennis K. Le Pendu, Jacques de Matos, Ana Lemos Liu, Jia Liu, Shuying Lopes, Ana M. Lu, Shan Lukehart, Sheila Manabe, Yukari C. Neves, Fabiana McFadden, Grant Pan, Ruimin peng, xuwen de Sousa-Pereira, Patricia Pinheiro, Ana Rahman, Masmudur Ruvoen-Clouet, Natalie Subbian, Selvakumar Tunon, Maria Jesus van der Loo, Wessel Vaine, Michael Via, Laura E. Wang, Shixia Mage, Rose Univ Porto CIBIO InBIO Res Network Biodivers & Evolutionary Biol Campus VairaoRua Padre Armando Quintas P-4485661 Vairao Portugal Univ Porto Dept Biol Fac Ciencias Rua Campo Alegre S-N P-4169007 Porto Portugal Inst Invest & Formacao Avancada Ciencias & Tecnol Gandra Portugal LMU Munchen Max von Pettenkofer Inst Fac Med Natl Reference Ctr Retroviruses D-81377 Munich Germany LMU Munchen Gene Ctr Fac Med VirolNatl Reference Ctr Retroviruses D-81377 Munich Germany Univ Calif Irvine Gavin Herbert Eye Inst Lab Cellular & Mol Immunol Sch Med Irvine CA 92697 USA Univ Calif Irvine Sch Med Dept Mol Biol & Biochem Irvine CA 92697 USA Univ Calif Irvine Inst Immunol Sch Med Sch Irvine Irvine CA 92697 USA Univ Massachusetts Med Sch Dept Med Worcester MA 01605 USA Penn State Univ Dept Pathol Hershey PA USA Penn State Univ Dept Microbiol & Immunol Hershey PA USA Penn State Univ Dept Comparat Med Hershey PA USA Univ Leon Inst Biomed IBIOMED Leon 24071 Spain Univ Leon CIBERehd Leon 24071 Spain Univ Washington Dept Med Seattle WA USA Univ Washington Dept Global Hlth Seattle WA 98195 USA Bill & Melinda Gates Fdn Seattle WA USA Loyola Univ Chicago Dept Microbiol & Immunol Maywood IL 60153 USA NYU Sch Med Dept Biochem & Mol Pharmacol New York NY 10016 USA Univ Nantes Univ Angers CRCINA INSERM Nantes France Arizona State Univ Biodesign Inst Ctr Immunotherapy Vaccines & Virotherapy Tempe AZ 85287 USA Univ Arkansas Med Sci Dept Microbiol & Immunol Little Rock AR 72205 USA Univ Porto Inst Biomed Sci Abel Salazar ICBAS Dept Anat Porto Portugal Univ Porto Inst Biomed Sci Abel Salazar ICBAS Unit Multidisciplinary Res Biomed UMIB Porto Portugal Johns Hopkins Univ Sch Med Dept Med Div Infect Dis Baltimore MD 21205 USA Rutgers State Univ PHRI New Jersey Med Sch RBHS Newark NJ USA NIAID Tubercolosis Res Sect Lab Clin Infect Dis Div Intramural ResNIH 9000 Rockville Pike Bethesda MD 20892 USA Univ Cape Town Dept Clin Lab Sci Inst Infect

Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur's rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens.

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Dynamic design method of digital twin process model driven by knowledge-evolution machining features

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INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH 2022年第7期60卷 2312-2330页

作者： Liu, Jinfeng Zhao, peng Jing, xuwen Cao, Xuwu Sheng, Sushan Zhou, Honggen Liu, Xiaojun Feng, Feng Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Jiangsu Peoples R China Southeast Univ Sch Mech Engn Nanjing Peoples R China Shaanxi Diesel Engine Heavy Ind Co Ltd Xingping Peoples R China

Machining plan is the core of guiding manufacturing production and is regarded as one of the keys to ensure the quality of product processing. Existing process design methods are inefficient to quickly handle the machining plan changed induced by the unpredictable events in real-time production. It inevitably causes time and economic losses for the enterprise. In order to express the evolutionary characteristics of product processing, the construction method of digital twin process model (DTPM) is proposed based on the knowledge-evolution machining features. Three key technologies include correlation structure of process knowledge, expression method of the evolution geometric features and the association mechanism between two are solved. On this basis, the construction framework of DTPM is illustrated. Then, the organisation and management mechanism of multi-source heterogeneous data is discussed in detail. At last, a case study of the complex machined part is researched, the results show that the processing time reduced by about 7% and the processing stability improved by 40%. Meanwhile, the implementation scheme, application process and effect of this case are described in detail to provide reference for enterprises.

关键词： Digital twin process knowledge machining features dynamic evolution

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A study on genotype x environment interactions for the multiple traits of maize hybrids in China

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AGRONOMY JOURNAL 2021年第6期113卷 4889-4899页

作者： Yue, Haiwang Jiang, xuwen Wei, Jianwei Xie, Junliang Chen, Shuping peng, Haicheng Bu, Junzhou Hebei Acad Agr & Forestry Sci Dryland Farming Inst Hebei Prov Key Lab Crops Drought Resistance Res Hengshui 053000 Hebei Peoples R China Qingdao Agr Univ Maize Res Inst Coll Agron Qingdao 266109 Shandong Peoples R China

The correct interpretation of the adaptability and stability of maize (Zea mays L.) hybrids in different ecological environments is very important for plant breeders. Additive main effect and multiplicative interaction model and genotype main effects and genotype x environment interaction biplot are the two most popular methods in the analysis of genotype x environment interaction in multienvironment trials. We conducted an experiment designed to examine and evaluate the adaptability and stability of four agronomic traits of 19 tested maize genotypes in two consecutive growth cycles across seven provinces including 37 locations using a randomized completely block design with three replicates. The combined ANOVA for all traits showed that the effect of genotype, environment, and genotype x environment interaction were significant at 0.1% probability levels. In order to evaluate multiple agronomic traits more accurately, multitrait stability index (MTSI) as an emerging selection method based on mean performance and stability was adopted. Agronomic trait grain yield (GY) was positively correlated with grain weight per ear and growth period. In addition, it was also found that GY and bar tip length showed obvious negative correlation. The MTSI is very helpful for breeders who hope to select mean performance and stability based on a variety of agronomic traits because it provides a convenient selection process while taking into account the relevant results of the traits.

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A Novel Flavone from the Leaves of Murraya paniculata

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CHEMISTRY OF NATURAL COMPOUNDS 2018年第6期54卷 1061-1063页

作者： Li, peng Zhang, Yue Wang, Ziqi Chen, Honghui Li, xuwen Jin, Yongri Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China

A phytochemical investigation of the leaves of Murraya paniculata (L.) Jack resulted in a novel compound, 3,5-dihydroxy-5,7,4-trimethoxyflavone, together with 13 known compounds. The structure of the novel compound wa... 详细信息

关键词： Murraya paniculata (L.) Jack leaves flavonoids

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Sensitive determination of three aconitum alkaloids and their metabolites in human plasma by matrix solid-phase dispersion with vortex-assisted dispersive liquid-liquid microextraction and HPLC with diode array detection

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JOURNAL OF SEPARATION SCIENCE 2016年第10期39卷 1971-1978页

作者： Wang, Xiaozhong Li, xuwen Li, Lanjie Li, Min Liu, Ying Wu, Qian Li, peng Jin, Yongri Jilin Univ Coll Chem Changchun 130012 Peoples R China Ningxia Univ Sch Chem & Chem Engn Yinchuan Peoples R China

A simple and sensitive method for determination of three aconitum alkaloids and their metabolites in human plasma was developed using matrix solid-phase dispersion combined with vortex-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography with diode array detection. The plasma sample was directly purified by matrix solid-phase dispersion and the eluate obtained was concentrated and further clarified by vortex-assisted dispersive liquid-liquid microextraction. Some important parameters affecting the extraction efficiency, such as type and amount of dispersing sorbent, type and volume of elution solvent, type and volume of extraction solvent, salt concentration as well as sample solution pH, were investigated in detail. Under optimal conditions, the proposed method has good repeatability and reproducibility with intraday and interday relative standard deviations lower than 5.44 and 5.75%, respectively. The recoveries of the aconitum alkaloids ranged from 73.81 to 101.82%, and the detection limits were achieved within the range of 1.6-2.1 ng/mL. The proposed method offered the advantages of good applicability, sensitivity, simplicity, and feasibility, which makes it suitable for the determination of trace amounts of aconitum alkaloids in human plasma samples.

关键词： Aconitum alkaloids Dispersive liquid-liquid microextraction Human plasma Matrix solid-phase dispersion

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