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材料导报 2025年第9期39卷 242-249页

作者：张龙姚旭文车春霞秦智李国洲韩迎红杨博兰州理工大学材料科学与工程学院兰州730050 兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050 中国石油石油化工研究院兰州化工研究中心兰州730060

聚丙烯(PP)/聚甲基丙烯酸甲酯(PMMA)复合材料具有良好的力学性能和耐热性,但PP与PMMA相容性较差,导致材料力学性能和热稳定性受限。本工作采用乳液聚合法制备了尺寸约118 nm的聚苯乙烯共聚甲基丙烯酸甲酯/聚苯乙烯(P(St-co-MMA)/PS)Janu... 详细信息

聚丙烯(PP)/聚甲基丙烯酸甲酯(PMMA)复合材料具有良好的力学性能和耐热性,但PP与PMMA相容性较差,导致材料力学性能和热稳定性受限。本工作采用乳液聚合法制备了尺寸约118 nm的聚苯乙烯共聚甲基丙烯酸甲酯/聚苯乙烯(P(St-co-MMA)/PS)Janus不对称乳胶纳米粒子(P(St-co-MMA)Janus NPs),将其以不同比例添加到PP/10%PMMA和PP/30%PMMA体系中,经熔融共混、注塑成型技术得到PP/PMMA/P-(St-co-MMA)Janus NPs复合材料,并进行了相关表征分析。结果表明,引入的P(St-co-MMA)Janus NPs分散在PP/PMMA复合材料中的两相界面处,其可显著改善复合材料的力学性能和热稳定性能。PP/10%PMMA/0.9%P(St-co-MMA)Janus NPs相比PP/10%PMMA,冲击强度和拉伸强度分别提高15.53%和14.03%;PP/30%PMMA/0.9%P(St-co-MMA)Janus NPs相比PP/30%PMMA,冲击强度和拉伸强度分别提高37.09%和32.35%,且热失重5%和50%对应的温度(T_(5)和T_(50))分别升高39.51%和33.37%。P(St-co-MMA)Janus纳米粒子对PP/PMMA复合材料的增强作用归因于其能够阻碍相分离、增强界面结合等。

关键词： Janus纳米粒子聚合物共混增容剂相界面

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Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis

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JOURNAL OF CONTROLLED RELEASE 2022年 349卷 520-532页

作者： Zhao, Zhenhao Zhang, Yujie Li, Chao Li, xuwen Chu, Yongchao Guo, qin Zhang, Yiwen Xia, Weiyi Liu, Peixin Chen, Hongyi Wang, Yu Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Breast-to-brain metastatic cells can interact with the surrounding cells, including astrocytes and microglia, to generate a pro-tumorigenic niche. Breast-to-brain metastasis can be treated using a dual strategy of eliminating metastatic tumor cells and normalizing their localized microenvironment. The effective accumulation of drugs at the action site of metastasis is crucial to realizing the above strategy, especially when dealing with the bloodbrain barrier (BBB)-penetrating and tumor-targeting tactics. Here, we establish an in-situ microenvironmenttailored micelle (T-M/siRNA) to co-deliver therapeutic siRNA and paclitaxel (PTX) into the breast-to-brain metastasis. Anchored with a D-type cyclic peptide, T-M/siRNA can penetrate the BBB and subsequently target the brain metastases. Upon internalization by metastatic tumor cells, T-M/siRNA can release PTX in the highlevel glutathione (GSH), resulting in killing cancer cells. Meanwhile, the micellar structure is dissociated, resulting in lowering the charge density to release the loaded siRNA that can targeted downregulate the expression of protocadherin 7 (PCDH7). Treatment of model mice revealed that T-M/siRNA can inhibit the abnormal activation of astrocytes and immunosuppressive activation of microglia, resulting in significantly enhanced synergistic anti-tumor efficacy. This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.

关键词： Breast -to -brain metastasis Micelle Microenvironment Protocadherin 7 Paclitaxel

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Fe-Mn-Cu-Ce/Al2O3 as an efficient catalyst for catalytic ozonation of bio-treated coking wastewater: Characteristics, efficiency, and mechanism

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ARABIAN JOURNAL OF CHEMISTRY 2023年第1期16卷

作者： Yuan, Run qin, Yihe He, Can Wang, Zichen Bai, Lu Zhao, Hong Jiang, Zijian Meng, Lingyao He, xuwen China Univ Min & Technol Beijing Dept Chem & Environm Engn Beijing 100083 Peoples R China Beijing Acad Sci & Technol Inst Resources & Environm Beijing 100089 Peoples R China

It is important to develop a catalyst that has high catalytic activity and can improve the degradation efficiency of refractory organic pollutants in the catalytic ozonation process. In this study, Fe-Mn-Cu-Ce/Al2O3 was synthesised via impregnation calcination for catalytic ozonation of bio-treated coking wastewater. The physical and chemical characteristics of the catalysts were analysed using X-ray diffraction (XRD), X-ray fluorescence spectrometry (XRF), X-ray photoelec-tron spectroscopy (XPS), scanning electron microscopy (SEM), and Brunauer-Emmett-Teller nitrogen adsorption-desorption methods. The effects of catalyst dosage, pH, and reflux ratio on the degradation efficiency of wastewater were examined in laboratory-scale experiments. The chem-ical oxygen demand (COD) removal rate of bio-treated coking wastewater was estimated to be 52.76 % under optimal conditions. The experiments on the catalytic mechanism demonstrated that the surface hydroxyl formed by the Lewis acid sites on the surface of the catalyst can react with ozone as the active site forming the active oxygen (center dot OH, .O2-, and 1O2), thereby efficiently degrading the organic pollutants in coking wastewater. Furthermore, a pilot-scale experiment on the catalytic ozonation of bio-treated coking wastewater was carried out using an Fe-Mn-Cu-Ce/Al2O3 catalyst, while the effects of the initial pollutant concentration, ozone concentration, and gas flow on the COD removal rate were studied on a pilot scale. It was found that the COD removal rate of the wastewater was ti 60 % under optimal parameters. After the treatment, the wastewater steadily reached the coking wastewater discharge standard (COD < 80 mg/L), while the operating cost of catalytic ozonation reached ti 0.032$/m3, thereby paving the way toward economic engineering applications. The COD degradation kinetics in the bio-treated coking wastewater followed pseudo -second-order kinetics. Three-dimensional fluorescence and gas chromatography-

关键词： Fe-Mn-Cu-Ce Catalytic ozonation Coking wastewater Catalytic mechanism Pilot-scale study

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Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models

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SAUDI JOURNAL OF BIOLOGICAL SCIENCES 2020年第9期27卷 2485-2490页

作者： qin, Zhenlong Wang, Lei Li, Guoyan Qian, xuwen Zhang, Jie Guo, Ying Liu, Guokai Beijing Univ Chinese Med Affiliated Hosp 3 Dept Anesthesiol Beijing 100029 Peoples R China Beijing Univ Chinese Med Dongzhimen Hosp Dept Anesthesiol 5 Haiyuncang Hutong Beijing 100700 Peoples R China

Objective: To investigate the analgesic effect of amitriptyline on neuropathic pain model rats, diabetic neuropathic pain model rats and fibromyalgia model rats. Methods: The healthy male Sprague wrote - Dawley (SD) rats were taken as the research object, and they were randomly divided into model group (group A), beside the sciatic nerve and injection of 5 mm amitriptyline group (group B), beside the sciatic nerve and injection of 10 mm amitriptyline group (group C), beside the sciatic nerve and injection of 15 mm amitriptyline group (group D), intraperitoneal injection of amitriptyline group (group E). Pain induced by selective injury of sciatic nerve branches in rats, pain induced by chronic compression of sciatic nerve, diabetic neuropathic pain and fibromyalgia were conducted to determine the pain threshold of mechanical stimulation in rats after drug administration. Results: The pain threshold of mechanical stimulation in the local amitriptyline group (group B, C, D) was significantly higher than that in the group A and group E at each time point after drug treatment, and the pain threshold of mechanical stimulation gradually increased with the increase of concentration. There was no statistically significant difference in mechanical stimulation pain threshold between group A and group E at each time point after drug treatment. Conclusion: Para-sciatic injection of amitriptyline at different concentrations has analgesic effects on neuropathic pain, diabetic neuropathic pain and fibromyalgia in rat models, and amitriptyline directly ACTS on the local sciatic nerve. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

关键词： Tricyclic antidepressants Rat model Neuropathic pain Diabetic neuropathic pain Fibromyalgia

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Data Report: Molecular and Isotopic Compositions of the Extracted Gas from China's First Offshore Natural Gas Hydrate Production Test in South China Sea

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ENERGIES 2018年第10期11卷 2793-2793页

作者： Ye, Jianliang qin, xuwen Qiu, Haijun Xie, Wenwei Lu, Hongfeng Lu, Cheng Zhou, Jianhou Liu, Jiyong Yang, Tianbang Cao, Jun Sa, Rina China Geol Survey Guangzhou Marine Geol Survey Guangzhou 510760 Guangdong Peoples R China

Three hundred gas samples recovered from SHSC-4 during China's first gas hydrate production test in the South China Sea were examined for gas component and isotopic composition. According to the gas chromatography analysis, all the gas samples from SHSC-4 are predominated by CH4, with minor N-2 + O-2, as well as trace amounts of CO2, C2H6, and C3H8. No H2S was detected. The molecular and isotopic data of the gas samples fall into the region of mixed origin on the plot of C-1/(C-2 + C-3) - C-13(1), which is close to the microbial origin. The discrimination diagram of C-13(1) - D-CH4 shows that the methane in all of the samples is of microbial origin, and is derived from the CO2 reduction.

关键词： isotopic composition methane gas hydrate South China Sea

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Identification of the Metabolites in Rat Urine after Oral Administration and Elucidation of the Metabolic Process of Naozhenning Granule Using LC-MS

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JOURNAL OF CHROMATOGRAPHIC SCIENCE 2020年第9期58卷 804-813页

作者： Li, Rongrong Liu, Yanzhi Liu, Haixia Wei, Chunhong Wang, Jiang qin, Xuemei Wang, xuwen Li, Zhenyu Shanxi Univ Modern Res Ctr Tradit Chinese Med Taiyuan 030006 Peoples R China Shanxi Zhendong Ante Biol Pharmaceut Co Ltd Jinzhong 030600 Peoples R China

Naozhenning (NZN) granule, a Chinese herbal formula, is widely used to treat craniocerebral trauma and promote functional recovery. In our previous study, the chemical components, as well as the serum metabolites in the male Sprague-Dawley rats of the NZN granule after oral administration were characterized. In this study, the urine metabolites in the male Sprague-Dawley rats were further investigated by ultrahigh-performance liquid chromatography-Q Exactive hybrid quadrupole-Orbitrap high-resolution accurate mass spectrometry. In order to identify the urine metabolites comprehensively, three sample preparation methods were used, including solid-phase extraction, protein precipitation method and solvent partition. Based on the accurate molecular weight and the fragmentation information from the MS spectra, a total of 76 urine metabolites were identified, which including 17 prototypes and 59 metabolites. The results showed that the detected urine metabolites were different for the different pretreatment methods, as some metabolites could only be detected in the particular pretreatment method. In addition, the metabolic processes of the components from NZN granule to the serum and urine were also elucidated and discussed. The results will provide useful information for further studying the relationship between the chemical components and pharmacological activity of NZN granule.

关键词： Metabolites

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Efficient advanced treatment of coking wastewater using O3/H2O2/Fe-shavings process

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JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING 2022年第2期10卷

作者： Yuan, Run Xia, Yu Wu, Xu He, Can qin, Yihe He, Changjun Zhang, Xuewei Li, Na He, xuwen China Univ Min & Technol Beijing Dept Chem & Environm Engn Beijing 100083 Peoples R China Beijing Acad Sci & Technol Inst Resources & Environm Beijing 100089 Peoples R China

Catalytic oxidation is widely used in the treatment of refractory wastewater. However, catalytic oxidation has some problems such as high cost and limited production of radicals. To improve these, in this study, a new process of O-3/H2O2/Fe-shavings which coupled catalytic ozonation and Fenton-like oxidation with Fe-shaving wastes reused, was used in the treatment of coking wastewater secondary biochemical effluent (CWSBE). The effects of the environmental conditions on the degradation of CWSBE were studied and the response surface method was used to optimise the parameters. The performances in organic pollutant removal from CWSBE were systematically analysed by a couple of methods such as gas chromatography mass spectrometry and threedimensional fluorescence. The results showed that macromolecular organics were degraded into small molecules pollutants after treatment by the O-3/H2O2/Fe-shavings process. At an ozone concentration of 27.5 mg/L, with the hydrogen peroxide concentration being 10.7 mmol/L, the reaction time 60 min, the initial pH value 3.6, and the pump speed 150 rpm, the COD removal degradation efficiency was 77.5%, and the effluent COD met relevant wastewater discharge standards in China (GB 16171-2012). The mechanism research showed *** plays an important role in the degradation of organic pollutants.

关键词： Advanced oxidation Coking wastewater Response surface method Water quality analysis Degradation mechanism

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Advanced treatment of phosphorus-containing tail water by Fe-Mg-Zr layered double hydroxide beads: Performance and mechanism

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JOURNAL OF ENVIRONMENTAL MANAGEMENT 2021年 296卷 113203-113203页

作者： Zhang, Yangzhong qin, Jiafu Wang, Xiaojun Chen, Zhenguo Zheng, xuwen Chen, Yongxing South China Univ Technol Sch Environm & Energy Guangzhou 510006 Peoples R China South China Univ Technol Sch Chem & Chem Engn Guangzhou 510006 Peoples R China

The adsorption process for low concentration phosphorus wastewater treatment has advantages of simple convenience, stable performance and less sludge, while most of current adsorbents fail to be separated for reuse. Meanwhile, few people pay attention to the removal of low concentration phosphorus from tail water by adsorbents. In this study, a newly efficient Fe-Mg-Zr layered double hydroxide beads were prepared by simple insitu crosslinking method and applied for low concentration phosphorus adsorption from real tail water. The maximum adsorption capacity of Fe-Mg-Zr beads was 21.61 mg/g, showing more practical application value for phosphorus removal. Fixed bed experiments showed that 5.0 g adsorbent could removed 2.12 mg phosphorus from tail wastewater containing 1.03 mg/L phosphorus. The beads adsorbent can be reused with excellent adsorption performance even after five cycles of adsorption-desorption operation. After detailed analyses, it was found that ligand exchange and ion exchange were the dominant mechanisms for phosphorus adsorption by this beads. Overall, the material has the advantages of simple preparation, good adsorption performance, easy separation and recycle, indicating a great potential for low concentration phosphorus wastewater treatment.

关键词： Fe-Mg-Zr beads Adsorption Phosphorus-containing tail water Recycling

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Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga

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JOURNAL OF BIOLOGICAL CHEMISTRY 2023年第8期299卷 105017页

作者： Zhou, Jujun Horton, John R. Kaur, Gundeep Chen, qin Li, xuwen Mendoza, Fabian Wu, Tao Blumenthal, Robert M. Zhang, Xing Cheng, Xiaodong Univ Texas MD Anderson Canc Ctr Dept Epigenet & Mol Carcinogenesis Houston TX 77030 USA Baylor Coll Med Dept Mol & Human Genet Houston TX USA Univ Toledo Coll Med & Life Sci Dept Med Microbiol & Immunol Program Bioinformat Toledo OH 43614 USA

Much is known about the generation, removal, and roles of 5-methylcytosine (5mC) in eukaryote DNA, and there is a growing body of evidence regarding N6-methyladenine, but very little is known about N4-methylcytosine (4mC) in the DNA of eukaryotes. The gene for the first metazoan DNA methyltransferase generating 4mC (N4CMT) was reported and characterized recently by others, in tiny freshwater invertebrates called bdelloid rotifers. Bdelloid rotifers are ancient, apparently asexual animals, and lack canonical 5mC DNA methyltransferases. Here, we characterize the kinetic properties and structural features of the catalytic domain of the N4CMT protein from the bdelloid rotifer Adineta vaga. We find that N4CMT generates high-level methylation at preferred sites, (A/C)CG(T/C/A), and low-level methylation at disfavored sites, exemplified by ACGG. Like the mammalian de novo 5mC DNA methyltransferase 3A/3B (DNMT3A/3B), N4CMT methylates CpG dinucleotides on both DNA strands, generating hemimethylated intermediates and eventually fully methylated CpG sites, particularly in the context of favored symmetric sites. In addition, like DNMT3A/3B, N4CMT methylates non-CpG sites, mainly CpA/TpG, though at a lower rate. Both N4CMT and DNMT3A/3B even prefer similar CpGflanking sequences. Structurally, the catalytic domain of N4CMT closely resembles the Caulobacter crescentus cell cycle-regulated DNA methyltransferase. The symmetric methylation of CpG, and similarity to a cell cycle-regulated DNA methyltransferase, together suggest that N4CMT might also carry out DNA synthesis-dependent methylation following DNA replication.

关键词： DNA methylation N4-methylcytosine metazoan cytosine-N4 DNA methyltransferase bdelloid rotifer Adineta vaga

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Efficient Removal and Recovery of Phosphorus from Industrial Wastewater in the Form of Vivianite

SSRN

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SSRN 2022年

作者： Zhang, Yangzhong qin, Jiafu Chen, Zhenguo Chen, Yongxing Zheng, xuwen Guo, Lu Wang, Xiaojun School of Environment and Energy South China University of Technology Guangzhou510006 China School of Environment South China Normal University Guangzhou510006 China

With the shortage of phosphorus resources, the concept of phosphorus recovery from wastewater is generally proposed. Recently, phosphorus recovery from wastewater in the form of vivianite has been widely reported, which could be used as a slow-release fertilizer as well as the production of lithium iron phosphate for Li-ion batteries. In this study, chemical precipitation thermodynamic modeling was applied to evaluate the effect of solution factors on vivianite crystallization with actual phosphorus containing industrial wastewater. The modeling results showed that the solution pH influences the concentration of diverse ions, and the initial Fe2+ concentration affects the formation area of vivianite. The saturation index (SI) of vivianite increased with the initial Fe2+ concentration and Fe:P molar ratio. pH 7.0, initial Fe2+ concentration 500 mg/L and Fe:P molar ratio 1.50 were the optimal conditions for phosphorus recovery. Mineral Liberation Analyzer (MLA) accurately determined the purity of vivianite was 24.13%, indicating the feasibility of recovering vivianite from industrial wastewater. In addition, the cost analysis showed that the cost of recovering phosphorus by the vivianite process was 0.925 USD/kg P, which can produce high-value vivianite products and realize "turn waste into treasure". © 2022, The Authors. All rights reserved.

关键词： Phosphorus

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