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Multifunctional ORF3 protein of hepatitis E virus

JOURNAL OF MEDICAL VIROLOGY 2024年第6期96卷 e29691-e29691页

作者： Li, Xiaoxuan Sun, xuwen Pinpin, Ji Zhao, qin Sun, Yani Northwest Agr & Forestry Univ Coll Vet Med Dept Prevent Vet Med Yangling Shaanxi Peoples R China

Hepatitis E virus (HEV) is an emerging zoonotic pathogen that is transmitted primarily through the fecal-oral route and can cause acute hepatitis in humans. Since HEV was identified as a zoonotic pathogen, different species of HEV strains have been globally identified from various hosts, leading to an expanding range of hosts. The HEV genome consists of a 5' noncoding region, three open reading frames (ORFs), and a 3' noncoding region. The ORF3 protein is the smallest but has many functions in HEV release and pathogenesis. In this review, we systematically summarize recent progress in understanding the functions of the HEV ORF3 protein in virion release, biogenesis of quasi-enveloped viruses, antigenicity, and host environmental regulation. This review will help us to understand HEV replication and pathogenesis mechanisms better.

关键词： hepatitis E innate immunity ORF3 protein quasi-enveloped virion

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Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis

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JOURNAL OF CONTROLLED RELEASE 2022年 349卷 520-532页

作者： Zhao, Zhenhao Zhang, Yujie Li, Chao Li, xuwen Chu, Yongchao Guo, qin Zhang, Yiwen Xia, Weiyi Liu, Peixin Chen, Hongyi Wang, Yu Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Breast-to-brain metastatic cells can interact with the surrounding cells, including astrocytes and microglia, to generate a pro-tumorigenic niche. Breast-to-brain metastasis can be treated using a dual strategy of eliminating metastatic tumor cells and normalizing their localized microenvironment. The effective accumulation of drugs at the action site of metastasis is crucial to realizing the above strategy, especially when dealing with the bloodbrain barrier (BBB)-penetrating and tumor-targeting tactics. Here, we establish an in-situ microenvironmenttailored micelle (T-M/siRNA) to co-deliver therapeutic siRNA and paclitaxel (PTX) into the breast-to-brain metastasis. Anchored with a D-type cyclic peptide, T-M/siRNA can penetrate the BBB and subsequently target the brain metastases. Upon internalization by metastatic tumor cells, T-M/siRNA can release PTX in the highlevel glutathione (GSH), resulting in killing cancer cells. Meanwhile, the micellar structure is dissociated, resulting in lowering the charge density to release the loaded siRNA that can targeted downregulate the expression of protocadherin 7 (PCDH7). Treatment of model mice revealed that T-M/siRNA can inhibit the abnormal activation of astrocytes and immunosuppressive activation of microglia, resulting in significantly enhanced synergistic anti-tumor efficacy. This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.

关键词： Breast -to -brain metastasis Micelle Microenvironment Protocadherin 7 Paclitaxel

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中国南海天然气水合物第二次试采主要进展

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中国地质 2020年第3期47卷 557-568页

作者：叶建良秦绪文谢文卫卢海龙马宝金邱海峻梁金强陆敬安匡增桂陆程梁前勇魏士鹏于彦江刘春生李彬申凯翔史浩贤卢秋平李晶寇贝贝宋刚李博张贺恩陆红锋马超董一飞边航中国地质调查局北京100037 中国地质调查局广州海洋地质调查局广东广州510075 中国地质调查局勘探技术研究所河北廊坊065000 北京大学北京100871 中国石油集团海洋工程有限公司北京100102 中国地质调查局油气调查中心北京100083 南方海洋科学与工程广东省实验室(广州) 广东广州510000

泥质粉砂型天然气水合物被认为是储量最大开采难度亦最大的水合物储层,2017年南海天然气水合物试采,初步验证了此类水合物储层具备可开采性。在总结前次试采认识的基础上,对试采矿体进行优选、精细评价、数值与试验模拟和陆地试验,中国... 详细信息

泥质粉砂型天然气水合物被认为是储量最大开采难度亦最大的水合物储层,2017年南海天然气水合物试采,初步验证了此类水合物储层具备可开采性。在总结前次试采认识的基础上,对试采矿体进行优选、精细评价、数值与试验模拟和陆地试验,中国地质调查局于2019年10月-2020年4月在南海水深1225 m神狐海域进行了第二次天然气水合物试采。本次试采攻克了钻井井口稳定性、水平井定向钻进、储层增产改造与防砂、精准降压等一系列深水浅软地层水平井技术难题,实现连续产气30 d,总产气量86.14×104m3,日均产气2.87×104m3,是首次试采日产气量的5.57倍,大大提高了日产气量和产气总量。试采监测结果表明,整个试采过程海底、海水及大气甲烷含量无异常。本次成功试采进一步表明,泥质粉砂储层天然气水合物具备可安全高效开采的可行性。

关键词：南海天然气水合物第二次试采水平井储层改造环境影响油气资源工程神狐海域南海

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Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020年 192卷 112156-000页

作者： Tang, qin Fu, Weitao Zhang, Minkui Wang, Ercheng Shan, Lvhu Chai, Xin Pang, Jinping Wang, xuwen Xu, Xiaohong Xu, Lei Li, Dan Sheng, Rong Hou, Tingjun Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Chinese Acad Sci Univ Chinese Acad Sci Zhejiang Canc Hosp Inst Canc Res & Basic Med SciCanc Hosp Hangzhou 310022 Zhejiang Peoples R China Jiangsu Univ Technol Sch Elect & Informat Engn Inst Bioinformat & Med Engn Changzhou 213001 Jiangsu Peoples R China

Androgen receptor (AR) plays important roles in the development of prostate cancer (PCa), and therefore it has been regarded as the most important therapeutic target for both hormone-sensitive prostate cancer (HSPC) and advanced PCa. In this study, a novel hit (C18) with IC50 of 2.4 mu M against AR transcriptional activity in LNCaP cell was identified through structure-based virtual screening based on molecular docking and free energy calculations. The structure-activity relationship analysis and structural optimization of C18 resulted in the discovery of a structural analogue (AT2), a more potent AR antagonist with 16-fold improved anti-AR potency. Further assays indicated that AT2 was capable of effectively inhibiting the transcriptional function of AR and blocking the nuclear translocation of AR like the second-generation AR antagonists. The antagonists discovered in this study may be served as the promising lead compounds for the development of AR-driven PCa therapeutics. (c) 2020 Elsevier Masson SAS. All rights reserved.

关键词： Prostate cancer Androgen receptor Structure-based virtual screening Antagonist Molecular docking

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Efficient removal and recovery of phosphorus from industrial wastewater in the form of vivianite

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ENVIRONMENTAL RESEARCH 2023年第1期228卷 115848页

作者： Zhang, Yangzhong qin, Jiafu Chen, Zhenguo Chen, Yongxing Zheng, xuwen Guo, Lu Wang, Xiaojun South China Univ Technol Sch Environm & Energy Guangzhou 510006 Peoples R China South China Normal Univ Sch Environm Guangzhou 510006 Peoples R China Hua An Biotech Co Ltd Foshan 528300 Peoples R China

With the shortage of phosphorus resources, the concept of phosphorus recovery from wastewater is generally proposed. Recently, phosphorus recovery from wastewater in the form of vivianite has been widely reported, which could be used as a slow-release fertilizer as well as the production of lithium iron phosphate for Li-ion batteries. In this study, chemical precipitation thermodynamic modeling was applied to evaluate the effect of solution factors on vivianite crystallization with actual phosphorus containing industrial wastewater. The modeling results showed that the solution pH influences the concentration of diverse ions, and the initial Fe2+ concentration affects the formation area of vivianite. The saturation index (SI) of vivianite increased with the initial Fe2+ concentration and Fe:P molar ratio. pH 7.0, initial Fe2+ concentration 500 mg/L and Fe:P molar ratio 1.50 were the optimal conditions for phosphorus recovery. Mineral Liberation Analyzer (MLA) accurately determined the purity of vivianite was 24.13%, indicating the feasibility of recovering vivianite from industrial wastewater. In addition, the cost analysis showed that the cost of recovering phosphorus by the vivianite process was 0.925 USD/kg P, which can produce high-value vivianite products and realize "turn waste into treasure".

关键词： Phosphorus recovery Vivianite Crystallization zone Resource recycling

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Notice of Retraction: Advanced Treatment of Coking Wastewater in Relation to COD Using Three-Dimensional Electrodes

Notice of Retraction: Advanced Treatment of Coking Wastewate...

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International Conference on Bioinformatics and Biomedical Engineering (ICBBE)

作者： xuwen He Jingwen Gong Liyuan Liu Hao Wang Gong Zhang Qiang qin School of Chemical & Environmental Engineering China University of Mining and Technology Beijing China

This article has been retracted by the publisher.

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Comparative transcriptome analysis of gene expression patterns on B16F10 melanoma cells under Photobiomodulation of different light modes

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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 2021年第0期216卷 112127-112127页

作者： Chen, Zeqing qin, Haokuan Lin, Shangfei Lu, Zhicheng Fan, Xuewei Liu, xuwen Liu, Muqing Fudan Univ Acad Engn & Technol Inst Future Lighting 220th Handan Rd Shanghai 200433 Peoples R China Zhongshan Fudan Joint Innovat Ctr 6th Xiangxing Rd Zhongshan City 528403 Peoples R China Fudan Univ Inst Elect Light Sources 220th Handan Rd Shanghai 200433 Peoples R China

Cutaneous melanoma is one of the aggressive cancers. Recent studies have shown that Photobiomodulation (PBM) can inhibit the proliferation of melanoma cells. However, it is not clear that the effect of PBM light mode on the inhibition of melanoma cells. Herein, we investigated the difference of influence between continuous wave (CW) and Pulse PBM on B16F10 melanoma cells. Our results suggested that Pulse mode had a more sig-nificant inhibition on the viability of B16F10 melanoma cells than CW mode under the PBM light parameter of wavelength, dose, and average irradiance at 457 nm, 1.14 J/cm(2), and 0.19 mW/cm(2). Besides, we revealed the differentially expressed genes of B16F10 melanoma cells under the various treatments of PBM light mode (not PBM treatment, CW mode, and Pulse mode) by RNA sequencing. Together, our data suggested that Pulse-PBM can improve the effect of PBM on cells significantly and there may be different molecular mechanisms be-tween Pulse and CW mode including anti-proliferative and cell necrosis. The study shed new light on investi-gating the molecular mechanisms of various PBM light modes on B16F10 melanoma cells.

关键词： Photobiomodulation B16F10 melanoma cells Continuous wave Pulse light mode Transcriptomic study

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Notice of Retraction: Electrochemical Treatment of Contaminants in Coking Wastewater with Ti/RuO2-IrO2 Electrodes

Notice of Retraction: Electrochemical Treatment of Contamina...

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International Conference on Bioinformatics and Biomedical Engineering (ICBBE)

作者： xuwen He Liyuan Liu Hao Wang Jingwen Gong Qiang qin Jianbing Wang Chunhui Zhang School of Chemical and Environmental Engineering China University of Mining and Technology Beijing China

This article has been retracted by the publisher.

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Glucose Addition Enhanced the Advanced Treatment of Coking Wastewater

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WATER 2021年第23期13卷 3365页

作者： Li, Na Xia, Yu He, xuwen Li, Weijia Yuan, Lianhua Wu, Xu qin, Yihe Yuan, Run Gong, Xun China Univ Min & Technol Sch Chem & Environm Engn Beijing 100083 Peoples R China

Biological processes have high removal efficiencies and low operational costs, but the secondary effluent of coking wastewater (CWW), even at a low concentration, is difficult for microorganisms to degrade directly. In this study, glucose was used as a carbon source and co-metabolic substrate for microbial acclimation in order to enhance the advanced treatment of coking wastewater (CWW). The removal performance of the pollutants, especially recalcitrant compounds, was studied and the changes in the microbial community structure after activated sludge acclimation were analyzed. The effect of glucose addition on the secondary biochemical effluent of coking wastewater (SBECW) treatment by the acclimated sludge was further studied by a comparison between the performance of two parallel reactors seeded with the acclimated sludge. Our results showed that the concentrations of chemical oxygen demand (COD), total organic carbon (TOC), and UV absorption at 254 nm (UV254) of the wastewater decreased in the acclimation process. Refractory organic matter, such as polycyclic aromatic hydrocarbons and nitrogen-containing heterocyclics, in the SBECW was effectively degraded by the acclimated sludge. High-throughput sequencing revealed that microbes with a strong ability to degrade recalcitrant compounds were enriched after acclimation, such as Thauera (8.91%), Pseudomonas (3.35%), and Blastocatella (10.76%). Seeded with the acclimated sludge, the reactor with the glucose addition showed higher COD removal efficiencies than the control system without glucose addition (p < 0.05). Collectively, glucose addition enhanced the advanced treatment of coking wastewater (CWW).

关键词： microbial acclimation coking wastewater advanced treatment recalcitrant compounds microbial diversity

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Efficient advanced treatment of coking wastewater using O3/H2O2/Fe-shavings process

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JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING 2022年第2期10卷

作者： Yuan, Run Xia, Yu Wu, Xu He, Can qin, Yihe He, Changjun Zhang, Xuewei Li, Na He, xuwen China Univ Min & Technol Beijing Dept Chem & Environm Engn Beijing 100083 Peoples R China Beijing Acad Sci & Technol Inst Resources & Environm Beijing 100089 Peoples R China

Catalytic oxidation is widely used in the treatment of refractory wastewater. However, catalytic oxidation has some problems such as high cost and limited production of radicals. To improve these, in this study, a new process of O-3/H2O2/Fe-shavings which coupled catalytic ozonation and Fenton-like oxidation with Fe-shaving wastes reused, was used in the treatment of coking wastewater secondary biochemical effluent (CWSBE). The effects of the environmental conditions on the degradation of CWSBE were studied and the response surface method was used to optimise the parameters. The performances in organic pollutant removal from CWSBE were systematically analysed by a couple of methods such as gas chromatography mass spectrometry and threedimensional fluorescence. The results showed that macromolecular organics were degraded into small molecules pollutants after treatment by the O-3/H2O2/Fe-shavings process. At an ozone concentration of 27.5 mg/L, with the hydrogen peroxide concentration being 10.7 mmol/L, the reaction time 60 min, the initial pH value 3.6, and the pump speed 150 rpm, the COD removal degradation efficiency was 77.5%, and the effluent COD met relevant wastewater discharge standards in China (GB 16171-2012). The mechanism research showed *** plays an important role in the degradation of organic pollutants.

关键词： Advanced oxidation Coking wastewater Response surface method Water quality analysis Degradation mechanism

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