CIAPIN1, a newly identified antiapoptotic molecule, is a downstream effector of the receptor tyrosine kinase-Ras signaling pathway in the mouse Ba/F3 pro-B cell line. Neither CIAPIN1 expression nor its clinical signif...
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CIAPIN1, a newly identified antiapoptotic molecule, is a downstream effector of the receptor tyrosine kinase-Ras signaling pathway in the mouse Ba/F3 pro-B cell line. Neither CIAPIN1 expression nor its clinical significance has been previously examined in esophageal squamous cell carcinoma (ESCC), and the present immunohistochemical analysis is the first study on CIAPIN1 distribution in ESCC. To investigate the relationships between the expression of CIAPIN1 and clinicopathological characteristics of ESCC, and evaluate the relationship between the expression of this gene and prognosis in ESCC patients. The expression of CIAPIN1 was investigated in 112 surgically resected specimens of ESCC by immunohistochemistry using a specific monoclonal antibody. The relations of CIAPIN1 expression with clinicopathological characteristics and the postoperative survival rate were statistically analyzed. We found that the expression of CIAPIN1 was statistically correlated with the degree of differentiation, depth of invasion, and lymph node metastasis of ESCC. Consistently, the survival rates of patients with CIAPIN1-negative tumors tended to be statistically lower than those with CIAPIN1-positive tumors. However, no significant difference was observed between CIAPIN1 expression and the patient age, sex, tumor location, and distant metastasis. Furthermore, multivariate analysis was performed by using Cox's proportional hazards model, and the results showed that lymph node metastases and CIAPIN1 expression were two independent prognostic factors. CIAPIN1 might play an important role in esophageal carcinogenesis, and it could be considered as a valuable prognostic indicator in ESCC. Finally, functional enhancement of CIAPIN1 might lead to a novel strategy for the treatment of SCC in the esophagus.
Background: Insulin Resistance (IR) is associated with stroke. This study aimed to investigate the correlation between metabolic score for insulin resistance (METS-IR) level, a new biomarker for assessing IR, and stro...
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Background: Insulin Resistance (IR) is associated with stroke. This study aimed to investigate the correlation between metabolic score for insulin resistance (METS-IR) level, a new biomarker for assessing IR, and stroke. Methods: This is a cross-sectional study based on data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020 and included participants aged >= 20 years. All participants provided complete stroke and METS-IR related data. The study employed statistical techniques, including multivariate logistic regression analysis, restricted cubic splines (RCS), and stratified analyses to evaluate the relationship between the amounts of METS-IR and the risk of stroke. Results: The study included 14,029 participants aged 20 years or older. The fully adjusted model revealed a statistically significant correlation between METS-IR and stroke (OR=1.21, =1.21, 95% CI: 1.00, 1.46;P <0.05). Specifically, for every 10-unit increase in METS-IR, there was a 21% increase in the prevalence of stroke. The prevalence of stroke was 60% higher in the Q4 group compared to the Q1 group, as indicated by a significant association with METS-IR (OR=1.60, =1.60, 95% CI: 1.01, 2.54;P <0.05). The RCS analysis revealed a strong linear correlation between METS-IR and the incidence of stroke (P<0.05). P <0.05). Subgroup analyses showed that gender, age, race, alcohol consumption, smoking, diabetes, and hypertension exhibited correlation with this positive association, and a significant interaction was observed in age (P P for interaction < 0.05). Conclusions: The findings of this study indicate that elevated METS-IR levels are strongly linked to a greater risk of stroke in adults.
随着多微电网系统运行环境的不断变化,各子微电网将会动态地退出或加入多微电网系统中,导致多微电网系统的物理和信息链接发生动态变化,是影响多微电网协同优化的重大因素之一。针对多微电网动态链接行为下的协同优化问题,该文在引入体系(system of systems,SoS)方法构建多微电网So S架构以及动态交易链接矩阵的基础上,建立多微电网能量管理与贡献度评估模型,提出多微电网动态链接行为分析方法,定量分析不同动态链接行为对多微电网协同优化运行的影响。最后结合交替方向乘子法求解模型,通过仿真分析验证所建模型和分析方法的有效性。
The development of biosensing platforms has been impressively accelerated by advancements in liquid crystal (LC) technology. High response rate, easy operation, and good stability of the LC droplet-based biosensors ar...
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The development of biosensing platforms has been impressively accelerated by advancements in liquid crystal (LC) technology. High response rate, easy operation, and good stability of the LC droplet-based biosensors are all benefits of the long-range order of LC molecules. Bioprobes emerged when LC droplets were combined with biotechnology, and these bioprobes are used extensively for disease diagnosis, food safety, and environmental monitoring. The LC droplet biosensors have high sensitivity and excellent selectivity, making them an attractive tool for the label-free, economical, and real-time detection of different targets. Portable devices work well as the accessory kits for LC droplet-based biosensors to make them easier to use by anyone for on-site monitoring of targets. Herein, we offer a review of the latest developments in the design of LC droplet-based biosensors for qualitative target monitoring and quantitative target analysis.
作者：
Duan, XuekeChen, HaoxiangMa, YunQian, Zhiyuanzhang, QiLai, YunPeng, ruwenGong, QihuangGu, YingPeking Univ
Dept Phys State Key Lab Mesoscop Phys Beijing 100871 Peoples R China Peking Univ
Frontiers Sci Ctr Nanooptoelect Beijing 100871 Peoples R China Peking Univ
Collaborat Innovat Ctr Quantum Matter Beijing 100871 Peoples R China Peking Univ
Beijing Acad Quantum Informat Sci Beijing 100871 Peoples R China Shanxi Univ
Collaborat Innovat Ctr Extreme Opt Taiyuan 030006 Shanxi Peoples R China Peking Univ
Yangtze Delta Inst Optoelect Nantong 226010 Peoples R China Nanjing Univ
Natl Lab Solid State Microstruct Sch Phys Nanjing 210093 Peoples R China Nanjing Univ
Collaborat Innovat Ctr Adv Microstruct Nanjing 210093 Peoples R China
Resonances in optical cavities are used to manipulate light propagation, enhance light-matter interaction, modulate quantum states, and so on. However, the index contrast between the traditional cavities and the host ...
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Resonances in optical cavities are used to manipulate light propagation, enhance light-matter interaction, modulate quantum states, and so on. However, the index contrast between the traditional cavities and the host is generally not high, which to some extent limited their performances. By putting dielectric cavities into a host of zero-index materials, index contrast in principle can approach infinity. Here, we analytically deduced Mie resonance conditions at this extreme circumstance. Interestingly, we discovered a so-called resonance nesting effect, in which a set of cavities with different radii can possess the same type of resonance at the same wavelength. We also revealed previously unknown degeneracy between the 2(l)-TM (2(l)-TE) and 2(l+1)-TE (2(l + 1) -TM) modes for epsilon approximate to 0 (mu approximate to 0) material, and the 2(l)-TM and 2(l)-TE for both epsilon approximate to 0 and mu approximate to 0. Such extraordinary resonance nesting and degeneracy provide additional principles to manipulate cavity behaviors.
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