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Multi-Connectivity Representation Learning Network for Major Depressive Disorder Diagnosis

IEEE TRANSACTIONS ON MEDICAL IMAGING 2023年第10期42卷 3012-3024页

作者： Kong, Youyong Wang, Wenhan Liu, Xiaoyun gao, shuwen Hou, Zhenghua Xie, Chunming Zhang, Zhijun Yuan, Yonggui Southeast Univ Sch Comp Sci & Engn Jiangsu Prov Joint Int Res Lab Med Informat Proc Nanjing 210096 Peoples R China Southeast Univ Key Lab Comp Network & Informat Integrat Minist Educ Nanjing 210096 Peoples R China Southeast Univ Sch Comp Sci & Engn Jiangsu Prov Joint Int Res Lab Med Informat Proc Nanjing 210096 Peoples R China Southeast Univ Zhongda Hosp Sch Med Dept Psychosomat & Psychiat Nanjing 210009 Peoples R China Southeast Univ Zhongda Hosp Sch Med Dept Neurol Nanjing 210009 Peoples R China

The pathophysiology of major depressive disorder (MDD) has been demonstrated to be highly associated with the dysfunctional integration of brain activity. Existing studies only fuse multi-connectivity information in a one-shot approach and ignore the temporal property of functional connectivity. A desired model should utilize the rich information in multiple connectivities to help improve the performance. In this study, we develop a multi-connectivity representation learning framework to integrate multi-connectivity topological representation from structural connectivity, functional connectivity and dynamic functional connectivities for automatic diagnosis of MDD. Briefly, structural graph, static functional graph and dynamic functional graphs are first computed from the diffusion magnetic resonance imaging (dMRI) and resting state functional magnetic resonance imaging (rsfMRI). Secondly, a novel Multi-Connectivity Representation Learning Network (MCRLN) approach is developed to integrate the multiple graphs with modules of structural-functional fusion and static-dynamic fusion. We innovatively design a Structural-Functional Fusion (SFF) module, which decouples graph convolution to capture modality-specific features and modality-shared features separately for an accurate brain region representation. To further integrate the static graphs and dynamic functional graphs, a novel Static-Dynamic Fusion (SDF) module is developed to pass the important connections from static graphs to dynamic graphs via attention values. Finally, the performance of the proposed approach is comprehensively examined with large cohorts of clinical data, which demonstrates its effectiveness in classifying MDD patients. The sound performance suggests the potential of the MCRLN approach for the clinical use in diagnosis. The code is available at https://***/LIST-KONG/MultiConnectivity-master.

关键词： Graph convolutional network major depressive disorder diagnosis functional connectivity structural connectivity dynamic functional connectivities

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Nanotechnology-driven strategies to enhance the treatment of drug-resistant bacterial infections

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WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY 2024年第3期16卷 e1968页

作者： Zhang, Junjie Liu, Ming Guo, Haiyang gao, shuwen Hu, Yanling Zeng, Guisheng Yang, Dongliang Bengbu Med Univ Sch Fundamental Sci Bengbu Peoples R China Nanjing Polytech Inst Coll Life & Hlth Nanjing 210048 Peoples R China ASTAR Infect Dis Labs ID Labs 8A Biomed Grove05-13 Immunos Singapore 138648 Singapore Nanjing Tech Univ NanjingTech Key Lab Flexible Elect KLOFE Nanjing 211816 Peoples R China Nanjing Tech Univ NanjingTech Inst Adv Mat IAM Sch Phys & Math Sci Nanjing 211816 Peoples R China

The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating bacterial infections, but its effectiveness against multidrug-resistant bacteria is diminishing due to the slow development of new antibiotics and the increase of bacterial drug resistance. Consequently, developing new a\ntimicrobial strategies and improving antibiotic efficacy to combat bacterial infection has become an urgent priority. The emergence of nanotechnology has revolutionized the traditional antibiotic treatment, presenting new opportunities for refractory bacterial infection. Here we comprehensively review the research progress in nanotechnology-based antimicrobial drug delivery and highlight diverse platforms designed to target different bacterial resistance mechanisms. We also outline the use of nanotechnology in combining antibiotic therapy with other therapeutic modalities to enhance the therapeutic effectiveness of drug-resistant bacterial infections. These innovative therapeutic strategies have the potential to enhance bacterial susceptibility and overcome bacterial resistance. Finally, the challenges and prospects for the application of nanomaterial-based antimicrobial strategies in combating bacterial resistance are discussed. This article is categorized under: Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

关键词： antimicrobial bacterial biofilm bacterial resistance combination therapy intracellular infection nanotechnology

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Spatio-temporal graph convolutional network for diagnosis and treatment response prediction of major depressive disorder from functional connectivity

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HUMAN BRAIN MAPPING 2021年第12期42卷 3922-3933页

作者： Kong, Youyong gao, shuwen Yue, Yingying Hou, Zhenhua Shu, Huazhong Xie, Chunming Zhang, Zhijun Yuan, Yonggui Southeast Univ Sch Comp Sci & Engn Lab Image Sci & Technol Nanjing Peoples R China Southeast Univ Minist Educ Key Lab Comp Network & Informat Integrat Nanjing Peoples R China Southeast Univ Sch Med Zhongda Hosp Dept Psychosomat & Psychiat Nanjing Peoples R China Southeast Univ Sch Med Zhongda Hosp Dept Neurol Nanjing Peoples R China

The pathophysiology of major depressive disorder (MDD) has been explored to be highly associated with the dysfunctional integration of brain networks. It is therefore imperative to explore neuroimaging biomarkers to aid diagnosis and treatment. In this study, we developed a spatiotemporal graph convolutional network (STGCN) framework to learn discriminative features from functional connectivity for automatic diagnosis and treatment response prediction of MDD. Briefly, dynamic functional networks were first obtained from the resting-state fMRI with the sliding temporal window method. Secondly, a novel STGCN approach was proposed by introducing the modules of spatial graph attention convolution (SGAC) and temporal fusion. A novel SGAC was proposed to improve the feature learning ability and special anatomy prior guided pooling was developed to enable the feature dimension reduction. A temporal fusion module was proposed to capture the dynamic features of functional connectivity between adjacent sliding windows. Finally, the STGCN proposed approach was utilized to the tasks of diagnosis and antidepressant treatment response prediction for MDD. Performances of the framework were comprehensively examined with large cohorts of clinical data, which demonstrated its effectiveness in classifying MDD patients and predicting the treatment response. The sound performance suggests the potential of the STGCN for the clinical use in diagnosis and treatment prediction.

关键词： functional connectivity graph convolutional network individual diagnosis major depressive disorder treatment response prediction

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新时代省属本科高校校园文化育人创新路径探究

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文化创新比较研究 2023年第30期7卷 147-150页

作者：高树文邵欣霞山东交通学院山东济南250357 山东管理学院山东济南250357

党中央历来高度重视大学生思想政治教育工作,高校文化育人在新时代大学生思想政治教育中起到十分重要的作用,“以文化人”“以文育人”是落实立德树人根本任务的内在要求,是高校思想政治教育的重要形式,也是落实“三全育人”工作的重要... 详细信息

党中央历来高度重视大学生思想政治教育工作,高校文化育人在新时代大学生思想政治教育中起到十分重要的作用,“以文化人”“以文育人”是落实立德树人根本任务的内在要求,是高校思想政治教育的重要形式,也是落实“三全育人”工作的重要举措。该文通过问卷调查发现,当前省属本科高校文化育人过程中存在文化育人功能不健全、文化育人感染力不足、文化育人形式缺乏创新等问题,针对以上问题提出了完善文化育人评价体系、挖掘文化育人元素、创新文化育人新路径等对策,以期不断加强校园文化建设,提升校园文化育人的实效。

关键词：校园文化文化育人内涵育人功能文化育人评价体系网络文化育人 “一站式”社区

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Global topology alteration of the brain functional network affects the 8-week antidepressant response in major depressive disorder

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JOURNAL OF AFFECTIVE DISORDERS 2021年第0期294卷 491-496页

作者： Zhang, Yanran Liu, Xiaoyun Hou, Zhenghua Yin, Yingying Xie, Chunming Zhang, Haisan Zhang, Hongxing Kong, Youyong gao, shuwen Zhang, Zhijun Yuan, Yonggui Southeast Univ Sch Med Zhongda Hosp Dept Psychosomat & Psychiat Nanjing Jiangsu Peoples R China Southeast Univ Sch Med ZhongDa Hosp Dept Neurol Nanjing Jiangsu Peoples R China Xinxiang Med Univ Affiliated Hosp 2 Dept Clin Magnet Resonance Imaging Xinxiang Henan Peoples R China Xinxiang Med Univ Affiliated Hosp 2 Dept Psychiat Xinxiang Henan Peoples R China Southeast Univ Sch Comp Sci & Engn Key Lab Comp Network & Informat Integrat Lab Image Sci & TechnolMinist Educ Nanjing Jiangsu Peoples R China

Purpose: Previous studies have indicated that the global topology of the brain functional network in patients with major depressive disorder (MDD) differs from that of those with normal controls (NCs). However, the relationship between an altered global topology and the response to antidepressants remains unclear. Here, we investigated whether differences in global topology affect the efficacy of antidepressants in MDD patients. Methods: 108 MDD patients and 61 NCs were recruited. A magnetic resonance imaging (MRI) scan was performed at the baseline, and the Hamilton Depression Scale-24 (HAMD 24) was assessed at baseline and after 2 and 8 weeks of antidepressant treatment. Seven global topological parameters of the brain functional network were measured and compared between groups. A correlation analysis was performed to identify the relationships between global topological parameters and antidepressant efficacy. Results: The brain networks of MDD patients and NCs were both small-world networks. The clustering coefficient (C-p) and local efficiency (E-loc) were significantly smaller in MDD patients compared with those in NCs. The characteristic path length (L-p) were negatively correlated with the 8-week reductive rate of HAMD 24 in the MDD group. Conclusion: The present research found that the brain functional network of MDD patients still had a small-world organization but with a lower C-p and E-l(oc), than the NCs. In addition, the brain network global topology might have an impact on the antidepressant response and thus had the potential to become a treatment predictor of MDD.

关键词： Major depressive disorder Global topology Small-world Efficacy

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发行绿色债券对企业绿色技术创新的影响

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管理科学与研究（中英文版） 2023年第7期12卷 14-25页

作者：高舒雯李佳邓歆乐上海理工大学管理学院上海200093

在双碳目标之下,绿色债券对于企业绿色转型起着关键作用,但是“漂绿”现象的存在使得实际效果有待进一步考量。本研究以“2016年绿色债券市场”的启动作为政策冲击点,基于2011-2020年中国上市企业数据构建双重差分模型,考察发行绿色债... 详细信息

在双碳目标之下,绿色债券对于企业绿色转型起着关键作用,但是“漂绿”现象的存在使得实际效果有待进一步考量。本研究以“2016年绿色债券市场”的启动作为政策冲击点,基于2011-2020年中国上市企业数据构建双重差分模型,考察发行绿色债券对上市企业绿色技术创新的影响。研究结果表明:企业发行绿色债券能够显著促进其绿色技术创新。异质性检验发现,非国有和制造业企业发行绿色债券对其绿色技术创新促进效果更为显著。调节效应检验发现,企业融资约束水平对传导机制具有正向调节作用。最后,从政府角度提出规范绿债市场、明确绿债投向和保障绿色信息披露质量等相关建议,落实发挥绿债市场对实体经济的提升效应。

关键词：绿色债券绿色技术创新融资约束双重差分法

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Ultrathin CuSe nanosheets as the anode for sodium ion battery with high rate performance and long cycle life

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ELECTROCHIMICA ACTA 2022年 404卷 139703-139703页

作者： Yu, Dengfeng Wei, Xinsong Zhao, Di gao, shuwen Zhao, Gongyuan Zhang, Hong Li, Zhuo Yu, Miao Sun, Ye Harbin Inst Technol Sch Instrumentat Sci & Engn Condensed Matter Sci & Technol Inst Harbin 150080 Peoples R China Harbin Inst Technol Sch Chem & Chem Engn State Key Lab Urban Water Resource & Environm Harbin 150001 Peoples R China

Sodium-ion batteries (SIBs) have quickly developed to be important alternative energy storage devices other than lithium-ion batteries in the explosively growing market of large-scale grid storage and low-speed electric vehicles, thanks to their low cost and the abundance of sodium resources. However, the sluggish sodiation kinetics remains major concerns in design of competent anode materials for SIBs. Herein, by using a one-step, facile hydrothermal synthesis, well-defined ultrathin CuSe nanosheets (thick-ness of similar to 5 nm) were fabricated, leading to a narrow bandgap, flexible Cu-Se bonding and abundant electrochemically active sites. As a result, the product presents high rate performance: a high capacity of 404 mAh g(-1) is achieved at a current density of 0.1 A g(-1) after 100 operation cycles, and the capacity can be maintained to 276 mAh g(-1) even at a high current density of 20 A g(-1) . According to kinetics analysis, surface capacitance contributes dominatly in the electrochemical process, facilitating fast sodiation. Moreover, coordinated the ultrathin thickness and two-dimensional morphology of the nanosheets with their three-dimensional open framework, the volume expansion-related issues during charge/discharge processes have been well addressed, resulting in ultrahigh cycling stability (with 100% capacity mainte-nance after 500 cycles at 0.5 A g(-1) ) together with ultralong cycle life (up to 10,0 0 0 working cycles) at 20 A g(-1) . (c) 2021 Elsevier Ltd. All rights reserved.

关键词： 2D nanosheets CuSe Sodium ion battery High rate Long cycle life

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国内《共产党宣言》翻译研究综述

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嘉兴学院学报 2022年第5期34卷 82-88,144页

作者：冯正斌高淑雯西安科技大学人文与外国语学院陕西西安710600

目前,国内学界对《共产党宣言》翻译研究主要从微观文本分析、译本传播历史、译介影响贡献等多维角度进行分析,且涌现了一批新的研究成果。从年度发文量、作者与发文单位、期刊来源、研究主题四个方面对新研究成果进行总结分析,揭示《... 详细信息

目前,国内学界对《共产党宣言》翻译研究主要从微观文本分析、译本传播历史、译介影响贡献等多维角度进行分析,且涌现了一批新的研究成果。从年度发文量、作者与发文单位、期刊来源、研究主题四个方面对新研究成果进行总结分析,揭示《共产党宣言》翻译研究概况、研究热点、发展趋势以及存在的问题,并针对研究不足提出相应建议,为后续相关领域研究提供借鉴。

关键词：《共产党宣言》翻译研究综述

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Rational design of geranylgeranyl diphosphate synthase enhances carotenoid production and improves photosynthetic efficiency in Nicotiana tabacum

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Science Bulletin 2022年第3期67卷 315-327页

作者： Chen Dong Ge Qu Jinggong Guo Fang Wei shuwen gao Zhoutong Sun Lifeng Jin Xuwu Sun Jean-David Rochaix Yuchen Miao Ran Wang Zhengzhou Tobacco Research Institute Zhengzhou 450001China Key Laboratory of Plant Stress Biology State Key Laboratory of Cotton BiologySchool of Life SciencesHenan UniversityKaifeng 475001China College of Biological Engineering Henan University of TechnologyZhengzhou 450001China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China School of Agricultural Sciences Zhengzhou UniversityZhengzhou 450001China Departments of Molecular Biology and Plant Biology University of GenevaGeneva 1211Switzerland

Restricted genetic diversity can supply only a limited number of elite genes for modern plant cultivation and *** this study,we demonstrate that rational design enables the engineering of geranyl-geranyl diphosphate synthase(NtGGPPS),an enzyme of the methylerythritol phosphate pathway(MEP)in the model plant Nicotiana *** the crucial bottleneck in carotenoid biosynthesis,NtGGPPS1 interacts with phytoene synthase(NtPSY1)to channel GGPP into the production of *** of this enzyme in the ntggpps1 mutant leads to decreased carotenoid *** the aim of enhanc-ing NtGGPPS1 activity,we undertook structure-guided rational redesign of its substrate binding pocket in combination with sequence *** activity of the designed NtGGPPS1(a pentuple mutant of five sites V154A/I161L/F218Y/I209S/V233E,d-NtGGPPS1)was measured by a high-throughput colorimetric assay.d-NtGGPPS1 exhibited significantly higher conversion of IPP and each co-substrate(DMAPP~1995.5-fold,GPP~25.9-fold,and FPP~16.7-fold)for GGPP synthesis compared with wild-type ***,the transient and stable expression of d-NtGGPPS1 in the ntggpps1 mutant increased carotenoid levels in leaves,improved photosynthetic efficiency,and increased biomass relative to *** findings provide a firm basis for the engineering of GGPPS and will facilitate the development of quality and yield *** results open the door for the structure-guided rational design of elite genes in higher plants。

关键词： Rational design Carotenoid Methylerythritol phosphate pathway(MEP) Geranylgeranyl diphosphate synthase(GGPPS) Nicotiana tabacum

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氧化钕暴露引起人胚肺成纤维细胞m6A修饰的改变及其机制

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环境与职业医学 2023年第9期40卷 1014-1023页

作者：赵钊郑婧婧杨茗琁王素华史雪敏杲淑雯赵宇航内蒙古科技大学包头医学院公共卫生学院内蒙古包头014040

[背景]职业和环境颗粒物可引起机体纤维化,并伴随RNA的m6A修饰改变,氧化钕(Nd2O3)可导致小鼠肺部发生纤维化,里面含有大量成纤维细胞。[目的]探讨Nd2O3引起人胚肺成纤维细胞(HELF细胞)纤维化过程中肿瘤坏死因子受体相关蛋白6/核因子-κB... 详细信息

[背景]职业和环境颗粒物可引起机体纤维化,并伴随RNA的m6A修饰改变,氧化钕(Nd2O3)可导致小鼠肺部发生纤维化,里面含有大量成纤维细胞。[目的]探讨Nd2O3引起人胚肺成纤维细胞(HELF细胞)纤维化过程中肿瘤坏死因子受体相关蛋白6/核因子-κB(TRAF6/NF-κB)信号通路的m6A修饰变化,并确定TRAF6的关键m6A修饰位点。[方法]不同浓度的Nd2O3(0、1.563、3.125、6.25、12.5、25、50、100、200 mg·L^(-1))染毒HELF细胞24、48 h,检测细胞活力,确定染毒时间及剂量。检测纤维化指标[羟脯氨酸(HYP)、转化生长因子-β1(TGF-β1)]、m6A甲基化水平、甲基化转移酶(METTL3和METTL14)、去甲基化酶(FTO和ALKBH5)、阅读蛋白(YTHDC2和YTHDF2)、纤维化相关基因[Ⅰ型胶原蛋白(collagen-Ⅰ)、波形蛋白(vimentin)、α平滑肌肌动蛋白(α-SMA)]、信号通路相关蛋白(TRAF6、NFKB1、P65、P-P65)等蛋白和基因表达情况。采用RNA甲基化免疫共沉淀-实时荧光定量PCR(MeRIPqPCR)法检测TRAF6 mRNA中m6A的富集情况。[结果]通过检测细胞活力,确定实验染毒剂量为6.25、12.5、25 mg·L^(-1),染毒时间为48 h。暴露48 h后,相较于对照组,25 mg·L^(-1)Nd2O3组HYP的含量升高,6.25、12.5、25 mg·L^(-1)Nd2O3组TGF-β1的含量均升高(P<0.05);HELF细胞12.5、25 mg·L^(-1)Nd2O3组总体m6A甲基化的含量升高(P<0.05);在m RNA水平上,甲基化转移酶METTL3、METTL14(6.25、12.5、25 mg·L^(-1)Nd2O3组)的m RNA表达升高(P<0.05);阅读蛋白YTHDF2(6.25、12.5、25 mg·L^(-1)Nd2O3组)的mRNA表达升高(P<0.05),而YTHDC2(25 mg·L^(-1)Nd2O3组)的mRNA表达降低(P<0.05);去甲基化酶FTO(12.5、25 mg·L^(-1)Nd2O3组)和ALKBH5(25 mg·L^(-1)Nd2O3组)的mRNA表达降低(P<0.05);纤维化相关基因vimentin、α-SMA、collagen-Ⅰ(6.25、12.5、25 mg·L^(-1)Nd2O3)的mRNA表达升高(P<0.05);通路相关基因TRAF6(25 mg·L^(-1)Nd2O3组)、NFKB1(12.5、25 mg·L^(-1)Nd2O3组)的mRNA表达升高(P<0.05);在蛋白水平上,相比于对照组,甲基化转移酶METTL3(25 mg·L^(-1)Nd2O3组)和METTL14(12.5、25 mg·L^(-1)Nd2O3组)升高(P<0.05);阅读蛋白YTHDF2(12.5、25 mg·L^(-1)Nd2O3组)升高,而YTHDC2(25 mg·L^(-1)Nd2O3组)降低(均P<0.05);去甲基化酶FTO(25 mg·L^(-1)Nd2O3组)降低(P<0.05);纤维化相关蛋白vimentin在Nd2O3浓度为25 mg·L^(-1)时升高,α-SMA、collagen-Ⅰ的蛋白相对表达量在Nd2O3浓度为12.5、25 mg·L^(-1)时升高(均P<0.05);TRAF6和P-P65在Nd2O3浓度为25 mg·L^(-1)时升高(均P<0.05)。MeRIP-qPCR结果显示,相较于对照组,Nd2O3暴露组的m6A富集比例明显增加(P<0.05)。[结论]HELF暴露于Nd2O3后,细胞发生纤维化相关指标改变,使得部分m6A甲基化酶表达上升,去甲基化酶表达下降,从而使m6A甲基化上升,并可能通过激活TRAF6/NF-κB信号通路,促进纤维化的进展。

关键词：氧化钕纤维化 N6-甲基腺苷修饰肺成纤维细胞肿瘤坏死因子受体相关蛋白6/核因子-κB

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