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化学分析计量 2019年第6期28卷 94-97页

作者：贺舒文薛伟峰梁健健大连出入境检验检疫局检验检疫技术中心

建立流动注射在线分析法测定海水中氨氮的含量。于60℃的碱性条件下,海水中的氨氮与水杨酸钠和次氯酸盐在硝普钠的催化作用下反应生成蓝色化合物,在波长660 nm处检测,海水中的氨氮含量与吸光度成正比,线性相关系数为0.99997。方法的检... 详细信息

建立流动注射在线分析法测定海水中氨氮的含量。于60℃的碱性条件下,海水中的氨氮与水杨酸钠和次氯酸盐在硝普钠的催化作用下反应生成蓝色化合物,在波长660 nm处检测,海水中的氨氮含量与吸光度成正比,线性相关系数为0.99997。方法的检出限为0.003 mg/L,测定下限为0.020 mg/L,测定上限为5.00 mg/L。该方法应用于天然海水的测定,添加水平在0.020~5.00 mg/L时,平均加标回收率为88.5%~104.5%,测定结果的相对标准偏差为0.95%~9.64%。该方法具有运行成本低,操作方便,分析周期短,能够满足日常检测和海水监测的要求。

关键词：流动注射海水氨氮

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A thermally insulated solar evaporator coupled with a passive condenser for freshwater collection

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JOURNAL OF MATERIALS CheMISTRY A 2021年第39期9卷 22428-22439页

作者： Cheng, shuwen Sun, Zhehao Wu, Yang Gao, Peng he, Jiaxin Yin, Zongyou Liu, Liying Li, Gang Northeastern Univ Sch Met Shenyang 100819 Peoples R China Australian Natl Univ Res Sch Chem Canberra ACT 2601 Australia Univ Melbourne Dept Chem Engn Melbourne Vic 3010 Australia

Using solar energy to generate vapor and using passive freshwater collectors are sustainable and eco-friendly approaches to address the issue of clean water scarcity. The current challenge for solar evaporation is to develop facile manufacturing materials and scalable methods with high solar conversion efficiency by heat localization. In addition, a decrease in the solar evaporation rate due to humidity saturation in the evaporation chamber is also a reason for the lower freshwater collection rate. In this paper, we demonstrate a solar-driven, interfacial evaporation-based and passive electricity-independent desalination unisystem, which consists of an evaporation chamber that uses hydrophilic and low-cost carbonized biomass full of water transportation microchannels, for the first time, as a solar evaporator. Meanwhile, the designed external aluminum condenser of the condensation chamber realizes freshwater collection. With improved designs and repeated tests, such a desalination unisystem achieves a stable evaporation rate of 1.492 kg m(-2) h(-1) and solar-to-vapor conversion efficiency of similar to 90.8% under 1 sun. It also simultaneously generates freshwater with a collection efficiency of similar to 85.4% compared to the evaluated water evaporation rate in the open atmosphere. This portable, easily implemented, and nonenergy-consuming desalination unisystem has the potential to provide new inspiration for the realm of seawater desalination and wastewater treatment.

关键词： Desalination

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Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase

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BIOORGANIC & MEDICINAL CheMISTRY LETTERS 2019年第24期29卷 126104-126104页

作者： Liu, Hong Dai, Xing he, shuwen Brockunier, Linda Marcantonio, Karen Ludmerer, Steven W. Li, Fangbiao Feng, Kung-, I Nargund, Ravi P. Palani, Anandan Merck & Co Inc 2000 Galloping Hill Rd Kenilworth NJ 07033 USA

hepatitis C virus (HCV) NS5B polymerase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection. Several novel and potent HCV NS5B non-nucleoside inhibitors with unique tetracyclic bezonfuran-based structures were prepared and evaluated. Similar to clinical developmental compound MK-8876, N-linked (compounds 1 and 2) and C-linked (compounds 3 and 4) tetracyclic structures maintained broad spectrum anti-replicon potency profiles and demonstrated moderate to excellent oral bioavailability and pharmacokinetic parameters across the three preclinical animal species. To better understand the importance of tetracyclic structures related to pan genotypic potency profiles especially against clinically relevant GT1a variants, the teracycles with different ring size were prepared and in vitro evaluations suggested compounds with six number ring have better overall potency profiles.

关键词： hepatitis C virus NS5B polymerase Non-nucleoside inhibitors (NNI) MK-8876 Tetracyclic structure

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Characteristics of Moisture Transfer and Surface Crack Development of a Single Lignite Particle Driven by Humidity Difference

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ACS OMEGA 2021年第29期6卷 18702-18710页

作者： Gao, Mingqiang Xiao, Yawen Miao, Zhenyong Pel, Leo Wan, Keji he, Qiongqiong Xue, shuwen China Univ Min & Technol Sch Chem Engn & Technol Xuzhou 221116 Jiangsu Peoples R China Eindhoven Univ Technol Dept Appl Phys NL-5600 MB Eindhoven Netherlands China Univ Min & Technol Natl Engn Res Ctr Coal Preparat & Purificat Xuzhou 221116 Jiangsu Peoples R China

The research on moisture transfer characteristics and surface crack development of a single lignite particle (SLP) driven by humidity difference is helpful to achieve a better understanding of the fragmentation characteristics of lignite during the moisture transfer process. This is of great significance to the safe operation of a drying system. The characteristics of moisture transfer within SLP driven by humidity difference were studied in different stages. Six drying equations commonly used in the literature were selected to describe the moisture transfer behavior. The apparent diffusion coefficient (D-eff) of moisture in each stage was calculated to compare the driving forces of moisture transfer in different stages. The surface crack rate (CR) was used to quantitatively analyze the fragmentation characteristics of SLP caused by moisture transfer. The results showed that the moisture transfer process of SLP driven by humidity difference can be divided into three stages, and stage I is the main moisture removal stage. The larger the particle size, the longer the stage I, while less moisture is removed in this stage. A logarithmic drying equation best simulates the moisture transfer process of SLP. The larger the particle size, the larger the D-eff value in each stage. The driving force of moisture transfer in stage I is the largest, which is the opposite of a thermal drying process. CR for SLP has experienced a rapid increase - stable at the highest value - rapid decrease - stable during the moisture transfer process driven by the humidity difference.

关键词： Fragmentation Moisture Diffusion Particle size Humidity

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Enhancing Out-of-Distribution Generalization in VQA through Gini Impurity-guided Adaptive Margin Loss

Enhancing Out-of-Distribution Generalization in VQA through ...

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IEEE International Conference on Multimedia and Expo (ICME)

作者： shuwen Yang Tianyu Huai Anran Wu Xingjiao Wu Wenxin Hu Liang he East China Normal University Shanghai China Fudan University Shanghai China

ISBN: (数字)9798350390155

ISBN: (纸本)9798350390162

In the Visual Question Answering (VQA) task context, most methods are influenced by language bias, resulting in poor performance on out-of-distribution data. Recently, some works attempted to use the adaptive margin loss to address this bias issue. However, these works typically consider only the frequency of answer labels when designing margin loss, leading to some samples being overly emphasized or lacking sufficient attention during model training. To address this issue, we propose a novel margin loss guided by the Gini-impurity for VQA debiasing. By comprehensively considering label distribution and instance complexity, we use Gini impurity to adjust the margin values in margin loss, balancing the attention of the model to different samples. Importantly, our method is plug-and-play and can be directly applied to any baseline. In the VQA-CP v2 task, our evaluation results across various baselines surpass the current state-of-the-art methods.

关键词： Training Adaptation models Visualization Annotations Impurities Question answering (information retrieval) Complexity theory

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Low-Voltage and High-Gain Ultraviolet Detector Based on 4H-SiC n-p-n Bipolar Phototransistor

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IEEE TRANSACTIONS ON ELECTRON DEVICES 2021年第5期68卷 2342-2346页

作者： Guo, shuwen Zhao, Xiaolong he, Yongning Pan, Zijian Yang, Mingchao Cai, Yahui Fu, Xianghe Zhang, Liangliang Xi An Jiao Tong Univ Sch Microelect Xian 710049 Peoples R China Xi An Jiao Tong Univ State Key Lab Mfg Syst Engn Xian 710049 Peoples R China

A two-terminal 4H-SiC n-p-n bipolar phototransistor detector (PTD) with high gain is demonstrated. It was fabricated using the 4H-SiC epitaxial wafer grown by high-temperature chemical vapor deposition. The PTD shows a large photocurrent and responsivity enhancement over the conventional 4H-SiC p-i-n photodetector (PD). These enhancement effects are owing to the internal gain of the bipolar transistor. The detector shows a high optical gain of similar to 1450 at 360 nm and has a linear response to the ultraviolet (UV) light in the wide light intensity range of 0.7- 700 mu W/ cm 2 at a low operating voltage of 3 V. The PTD can respond to the UV light from 220 to 340 nm and the peak responsivity is similar to 125 A/W at 275 nm. This work is significant for developing high-performance SiC-based bipolar phototransistors.

关键词： 4H-SiC linear response optical gain phototransistor

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From Stress Resistance to Aroma Modification: The Role of the Ai-2/Luxs Quorum Sensing System in Lactiplantibacillus Plantarum During Wine Fermentation

SSRN

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SSRN 2025年

作者： Zhao, Yuzhu Liu, Doudou Gu, Huawei Liang, Yanying he, Ling Liu, shuwen Shi, Kan College of Enology College of Life Sciences College of Horticulture Shaanxi Engineering Research Center for Viti-Viniculture Viti-viniculture Engineering Technology Center of State Forestry and Grassland Administration Heyang Experimental and Demonstrational Stations for Grape Ningxia Helan Mountain’s East Foothill Wine Experiment and Demonstration Station Life Science Research Core Services Northwest A&F University Shaanxi Yangling China

Lactiplantibacillus plantarum is a promising malolactic fermentation (MLF) agent in winemaking, but its poor stress resistance compared to Oenococcus oeni restricts its widespread use. The AI-2/LuxS quorum sensing (QS) system’s role in L. plantarum’s adaptation to wine-related stresses during MLF has not been investigated, despite QS systems being known to be crucial for bacterial stress tolerance. To address this gap, this study investigated the function of the QS system in multiple stress response and enological performance of L. plantarum via luxS gene deletion and complementation. Deletion of luxS did not impact growth or acid production of L. plantarum XJ25 in optimal conditions but decreased AI-2 signal molecule activity. Under simulated wine stress conditions, including low pH and high ethanol concentrations, the wild-type strain exhibited significantly higher L-malic acid degradation rate and cell viability compared to the luxS deletion mutant. Transcriptome analysis revealed that the LuxS/AI-2 QS system regulates pathways associated with folic acid, methionine, and purine metabolism, as well as substance transport, enabling L. plantarum to adapt to wine-related stresses during the later stages of MLF. In Marselan wine, compared to the luxS deletion mutant, the wild-type strain with luxS gene showed superior MLF performance, including higher growth activity and L-malic acid degradation rate. Additionally, wines fermented with the wild-type strain exhibited a more stable color and higher concentrations of varietal aromas, which contributes to enhanced sensory quality. These results highlight the important role of LuxS/AI-2 QS system in improving the stress resistance and enological performance of L. plantarum. © 2025, The Authors. All rights reserved.

关键词： Wine

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N6-methyladenosine enhances the expression of TGF-β-SMAD signaling family to inhibit cell growth and promote cell metastasis

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CANCER LETTERS 2024年 603卷 217195-217195页

作者： Peng, Bo Cheng, shuwen Wang, he Liu, Tongfeng Gu, Yinmin Duan, Liqiang Cheng, Tianyou Wang, Xuetong Wang, Xiaodong Zhang, Qingqing Zhang, Yibi Zhao, Xueqing Yao, Xijuan Zhao, Xujie Song, Dalong Zeng, Jian Gao, Shan Univ Sci & Technol China Sch Biomed Engn Suzhou Div Life Sci & Med Hefei 230000 Peoples R China Chinese Acad Sci Suzhou Inst Biomed Engn & Technol Key Lab Biomed Diagnost Suzhou 215163 Peoples R China Southeast Univ Zhongda Hosp Adv Inst Life & Hlth Sch Life Sci & Technol Nanjing 210096 Peoples R China Nanjing Univ Med Sch Nanjing 210046 Peoples R China Shanghai Univ Coll Sci Dept Chem Shanghai 200444 Peoples R China Guizhou Univ Med Coll Guiyang 550025 Peoples R China Shanxi Acad Adv Res & Innovat Shanxi Prov Key Lab Prot Struct Determinat Taiyuan 030032 Peoples R China Guizhou Prov Peoples Hosp Dept Urol Guiyang Peoples R China Zhejiang Canc Hosp Dept Thorac Surg Zhejiang Key Lab Diag & Treatment Technol Thorac O Hangzhou Zhejiang Peoples R China Wenzhou Med Univ Wenzhou Peoples R China

TGF-beta-SMAD signaling pathway plays an important role in the progression of various cancers. However, posttranscriptional regulation such as N6-methyladenosine (m6A) of TGF-beta-SMAD signaling axis remains incompletely understood. here, we reveal that insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) is low expression as well as associated with poor prognosis in clear cell renal cell carcinoma (ccRCC) patients and inhibits proliferation as well as promotes metastasis of ccRCC cells. Mechanistically, IGF2BP2 systematically regulates TGF-beta-SMAD signaling family, including TGF-beta 1/2, TGF-beta R1/2 and SMAD2/3/4, through mediating their mRNA stability in an m6A-dependent manner. Furthermore, the functional effects of IGF2BP2 on ccRCC cells is mediated by TGF-beta-SMAD signaling downstream effector SMAD4, which is identified three m6A sites in 5 ' UTR and CDS. Our study establishes IGF2BP2-TGF-beta-SMAD axis as a new regulatory effector in ccRCC, providing new insights for developing novel therapeutic strategies.

关键词： IGF2BP2 TGF-beta SMAD m 6 A ccRCC

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New Combination of Semilate Rice: Yuanliangyou 1000

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Agricultural Biotechnology 2018年第6期7卷 74-77,80页

作者： Jinhe HU Guoxiang LIU Qiyun DENG Xiaojing WU shuwen he Fei ZHU Institute of Grain and Oil Crops Nanchang Academy of Agricultural Science Yuanshi Seed Industry High Tech Co. Ltd. Jiangxi Pusheng Agricultural Development Co. Ltd.

Yuanliangyou 1000 is new combination of semilate rice bred by Yuan S and R900 by Institute of Grain and Oil Crops of Nanchang Academy of Agricultural Science,Yuanshi Seed Industry High Tech Co.,*** Jiangxi Pusheng Agricultural Development Co.,*** passed through new variety certification of Jiangxi Province in 2017,and approval number was Ganshendao 20170020,which was suitable for plantation of semilate rice in *** this paper,breeding process,combination characteristic,main cultivation technique and seed production technology of Yuanliangyou 1000 were introduced.

关键词： Semilate rice New combination Yuanliangyou 1000 Breeding process

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Supplementation of Alhagi honey polysaccharides contributes to the improvement of the intestinal immunity regulating the structure of intestinal flora in mice

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FOOD & FUNCTION 2021年第20期12卷 9693-9707页

作者： Cai, Gaofeng Wusiman, Adelijiang Gu, Pengfei Mao, Ningning Xu, shuwen Zhu, Tianyu he, Jin Liu, Zhenguang Wang, Deyun Nanjing Agr Univ Coll Vet Med Inst Tradit Chinese Vet Med Nanjing 210095 Peoples R China Nanjing Agr Univ Coll Vet Med MOE Joint Int Res Lab Anim Hlth & Food Safety Nanjing 210095 Peoples R China Xinjiang Agr Univ Coll Vet Med Urumqi 830000 Peoples R China

Alhagi honey polysaccharides (AH), a main active component of Alhagi honey, are known to possess excellent pharmacological activities and have been widely used as dietary supplements in traditional Chinese medicine for thousands of years. This study is aimed to investigate the heath effect of AH on murine intestinal mucosal immune function and composition of the gut microbiome. ICR mice received daily intragastric administration of AH (three dosages, 200 mg kg(-1), 400 mg kg(-1), and 800 mg kg(-1)) or saline for 7 consecutive days. Results indicated an improvement in the intestinal barrier function through increases in secretory immunoglobulin A (sIgA) and beta-defensins. Simultaneously, AH also significantly stimulated IL-2, IL-4, IL-6, IL-10, IL-17, IFN-gamma, and TNF-alpha cytokine secretion as compared to the control samples. Moreover, hematoxylin and eosin staining showed that AH enhanced the number of intraepithelial lymphocytes (IELs) in the small intestine. An obvious increase in the ratio of IgA(+) cells of AH-treatment samples in the lamina propria was also detected by immunohistochemical staining. In addition, the CD3(+), CD4(+) and CD8(+) T-cell ratio in mesenteric lymph nodes and Peyer's patches in the AH-treatment was significantly higher than that in the control group. Furthermore, 16S rDNA gene sequencing was used to monitor the dynamic changes in the gut microbiota. The result revealed that AH significantly increased the indexes of Shannon and obviously decreased the indexes of Simpson, suggesting the enhancement of the diversity and richness of the intestinal microbiome. Moreover, AH modulated the gut microbiome via increasing the abundance of probiotics and decreasing the levels of pathogenic bacteria. In summary, these results indicated that AH could be used as a prebiotic to enhance murine intestinal mucosal immunity and to modulate the gut microbiome.

关键词： Polysaccharides

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