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living in a dynamic environment: The effects of multi-ways temperature variation on embryo and newborn juveniles of a shallow-water octopus ( Amphioctopus fangsiao )

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SCIENCE OF THE TOTAL ENVIRONMENT 2024年 923卷 171510页

作者： Zheng, Jian li, shuwen Zheng, Xiaodong Ocean Univ China Key Lab Mariculture Minist Educ Qingdao 266003 Peoples R China Ocean Univ China Inst Evolut & Marine Biodivers IEMB Qingdao 266003 Peoples R China Ocean Univ China Key Lab Evolut & Marine Biodivers Minist Educ Qingdao 266003 Peoples R China

Shallow waters are characterized by fluctuating environmental conditions, modulating marine life cycles and biological phenomena. Multiple variations in water temperature could affect eggs and embryos during spawning events of many marine invertebrate species, yet most of the findings on embryonic development in invertebrates come from experiments based on the constant temperature. In this study, to examine the effects of temperature variation on octopus embryos, Amphioctopus fangsiao , a common shallow-water octopus along the coast of China, was exposed to the constant temperature (18 degrees C, in situ temperature of the seawater in lianyungang), ramping temperatures (from 18 to 24 degrees C), diel oscillating temperatures (18 degrees C and 20 degrees C for 12 h each day), and acute increasing temperatures (the temperature increased sharply from 18 degrees C to 24 degrees C at embryonic development stage XIX) for 47 days (from embryogenesis to settlement). The results demonstrated that the temperature variations accelerated the development time of A. fangsiao embryos. Temperature fluctuations could cause embryonic oxidative damage and disorder of glycolipid metabolism, thereby affecting the growth performance of embryos and the survival rate of hatchings. Through transcriptome sequencing, the mechanistic adaption of the embryo to environmental temperature variations was revealed. The pathways involved in the TCA cycle, DNA replication and repair, protein synthesis, cell signaling, and nervous system damage repair were significantly enriched, indicating that the embryo could improve heat tolerance to thermal stress by regulating gene expression. Moreover, acute warming temperatures posed the most detrimental effects on A. fangsiao embryos, which could cause embryos to hatch prematurely from the vegetal pole, further reducing the survival of hatchings. Meanwhile, the diel oscillating temperature was observed to affect the normal morphology of the embryo, resulting i

关键词： Early life stages Temperature fluctuation Oxidative stress Survival Molecular mechanism Octopus

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Relationship Between Preoperative Nutritional Indicators and Postoperative Complications in Patients with Oesophageal Cancer: A Meta-Analysis

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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 2024年第7期76卷 563-572页

作者： li, Shaoxue Zhang, Haoran He, Jie li, shuwen Anhui Med Univ Sch Nursing 81 MeiShan Rd Hefei Anhui Peoples R China

Nutritional status is an essential factor in the occurrence of complications in patients with esophageal cancer. We sought to assess the relationship between malnutrition and complications using various nutritional assessment indicators. We conducted a comprehensive literature search of medical databases for articles published up to July 2023. The primary outcome indicator is the occurrence of complications, for which we combined 95% confidence intervals (CIs) and odds ratios (ORs) for postoperative complications and analyzed them using a random effects model. The analysis was carried out using STATA15.0 software. A total of 33 study groups from 22 publications with 5,675 subjects were included. Pooled results show that nutritional indicators are strongly correlated with the occurrence of postoperative complications (OR = 1.45, 95% CI: 1.30-1.62). In the subgroup analyses, comprehensive indicators and the skeletal muscle index were significantly associated with complications, whereas laboratory indicators were not associated with complications (comprehensive indicators OR = 2.68, 95% CI: 1.80-4.00;skeletal muscle index OR = 2.93, 95% CI: 1.44-5.99;laboratory indicators OR = 1.05, 95% CI: 0.96-1.16). Patients with normal body mass index and hospitalized patients were more likely to develop complications. Malnutrition is strongly associated with the development of complications. Nutritional indicators and patient characteristics influenced this relationship.

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Does All Social Support Work? Examining the Mechanisms of Patient-Reported Symptom Interference after Esophagectomy Affecting life Satisfaction

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PATIENT PREFERENCE AND ADHERENCE 2024年 18卷 1755-1766页

作者： Yuan, Mengmeng Wu, lijun li, Wen li, shuwen Anhui Med Univ Sch Nursing 15 Feicui RdEcon & Technol Dev Dist Hefei 230601 Anhui Peoples R China Anhui Med Univ Dept Oncol Affiliated Hosp 1 Hefei Anhui Peoples R China

Purpose: We intended to explore the chain mediation role of resilience and different sources of social support on the relationship between symptom interference and life satisfaction from the patient-reported perspective. Patients and Methods: Two hundred and twenty-six patients after esophagectomy were investigated using four validated scales to estimate the symptom interference, resilience, different sources of social support, and life satisfaction. The chain mediation analysis was conducted using SPSS PROCESS Macro Model 6. Results: Mediation analysis showed that symptom interference indirectly influenced life satisfaction through two significant mediating pathways: (i) resilience (B = -0.138, 95% CI: -0.194 to -0.091);(ii) the chain mediators involving in resilience and family support (B = -0.049, 95% CI: -0.073 to -0.026). Surprisingly, the mediating pathway of family support was not significant. Conclusion: Interventions for resilience and family support could mitigate the adverse effects of symptom interference in patients after esophagectomy, improving life satisfaction. Of these, resilience may be more critical in terms of the utilization of social resources than family support.

关键词： life satisfaction oesophageal cancer social support resilience symptom interference

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Drug repositioning based on residual attention network and free multiscale adversarial training

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BMC BIOINFORMATICS 2024年第1期25卷 1页

作者： li, Guanghui li, shuwen liang, Cheng Xiao, Qiu Luo, Jiawei East China Jiaotong Univ Sch Informat Engn Nanchang Peoples R China Shandong Normal Univ Sch Informat Sci & Engn Jinan Peoples R China Hunan Normal Univ Coll Informat Sci & Engn Changsha Peoples R China Hunan Univ Coll Comp Sci & Elect Engn Changsha Peoples R China

BackgroundConducting traditional wet experiments to guide drug development is an expensive, time-consuming and risky process. Analyzing drug function and repositioning plays a key role in identifying new therapeutic potential of approved drugs and discovering therapeutic approaches for untreated diseases. Exploring drug-disease associations has far-reaching implications for identifying disease pathogenesis and treatment. However, reliable detection of drug-disease relationships via traditional methods is costly and slow. Therefore, investigations into computational methods for predicting drug-disease associations are currently *** paper presents a novel drug-disease association prediction method, RAFGAE. First, RAFGAE integrates known associations between diseases and drugs into a bipartite network. Second, RAFGAE designs the Re_GAT framework, which includes multilayer graph attention networks (GATs) and two residual networks. The multilayer GATs are utilized for learning the node embeddings, which is achieved by aggregating information from multihop neighbors. The two residual networks are used to alleviate the deep network oversmoothing problem, and an attention mechanism is introduced to combine the node embeddings from different attention layers. Third, two graph autoencoders (GAEs) with collaborative training are constructed to simulate label propagation to predict potential associations. On this basis, free multiscale adversarial training (FMAT) is introduced. FMAT enhances node feature quality through small gradient adversarial perturbation iterations, improving the prediction performance. Finally, tenfold cross-validations on two benchmark datasets show that RAFGAE outperforms current methods. In addition, case studies have confirmed that RAFGAE can detect novel drug-disease *** comprehensive experimental results validate the utility and accuracy of RAFGAE. We believe that this method may serve as an excellent predictor

关键词： Graph attention network Residual network Graph autoencoder Adversarial training Drug-disease association

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Individualized symptom experience and predictors in cancer patients after oesophagectomy: A latent profile analysis

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EUROPEAN JOURNAL OF ONCOLOGY NURSING 2025年 74卷 102806-102806页

作者： Ma, Xuanxuan Ge, Yaping Zhang, Xue li, Shaoxue li, shuwen Anhui Med Univ Sch Nursing Hefei Peoples R China

Purpose: In the care for oesophageal cancer, symptom assessment was mainly carried out from the perspective of the total score using scales, which ignored individual differences in symptom experience among patients. To provide personalized symptom management, individual differences among patients with oesophageal cancer warranted further investigation. The objective was to identify the different symptom profiles of patients after oesophagectomy and examine the risk factors affecting the symptom profiles. Methods: It was a descriptive study with cross-sectional design. A total of 258 participants were recruited. Latent profile analysis was used to identify different profile of symptoms, and multiple logistic regression was used to identify risk factors. Results: Three distinct profiles were identified: the "complex symptoms group" (32.6%), the "throat symptoms group" (25.2%), and the "single fatigue group" (42.2%). Patients with higher prognostic nutritional index (OR = 0.797), higher resilience scale score (OR = 0.907), living in city or town (OR = 0.396), and stage II cancer (OR = 0.413) were more likely to be classified as "single fatigue group". Patients with higher prognostic nutritional index (OR = 1.233) and cervical anastomosis (OR = 4.586) tended to be classified as the "throat symptoms group". Unemployed patients (OR = 0.204) tended to belong to the "complex symptoms group," whereas patients with higher prognostic nutritional index were less likely to be in the "complex symptoms group." Conclusion: Individual differences existed in the symptom experience of patients undergoing surgery for oesophageal cancer. Precise symptom management programs should be designed and implemented according to the individualized characteristics of the patient's symptom experience to promote patients' recovery.

关键词： Oesophagectomy Symptoms Latent profile analysis Risk factors

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Boosting photocatalytic reduction over perylene-C3N5 driven by constructing donor-acceptor structure

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JOURNAL OF ALLOYS AND COMPOUNDS 2025年 1014卷

作者： liu, Zheng li, Mengjie Wu, Jie Zhao, Jinjuan li, shuwen Yang, Honglei Lanzhou Univ Coll Chem & Chem Engn State Key Lab Appl Organ Chem Gansu Prov Engn Lab Chem Catalysis Lanzhou 730000 Peoples R China

As a promising N-rich carbon nitride photocatalyst, the suboptimal carrier separation capability represents a significant obstacle to C3N5 practical application. Herein, this work presents a constructing donor-acceptor structure (D-A) strategy for incorporating the aromatic molecule Perylene 3,4,9,10-tetracarboxylic acid (PTA) into the backbone of C3N5 (PTA-C3N5). The incorporation of PTA can facilitate the delocalization of pi electrons, which enables the effective participation of photogenerated electrons in the reaction, thereby enhancing the photocatalytic capacity of the material. Moreover, the formation of the D-A structure also alters the band structure, and facilitates the migration of charge carriers. As a result, the synthesized PTA-C3N5 exhibits a markedly elevated efficiency for the photocatalytic reduction of Cr(VI), with a rate constant (k) of 15.65 x 10-3 min-1, which is approximately twice that of the original C3N5. Furthermore, the addition of PTA resulted in a notable enhancement in the crystallinity of the catalyst, effectively ameliorate the defects and suppressed the complexation of photogenerated carriers. This work presents a processing strategy for carbon nitride structural adjustment, which introduces a new paradigm for the design of organic materials at the D-A interface with the objective of achieving enhanced photocatalytic capabilities.

关键词： Donor-acceptor structure Photocatalysis Perylene 3,4,9,10-tetracarboxylic acid

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Gas-induced modulation of carbon nitride morphology through a green one-step calcination strategy

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GREEN CHEMISTRY 2025年第12期27卷 3293-3302页

作者： Wu, Jie liu, Zheng li, Mengjie Zhao, Jinjuan li, shuwen Yang, Honglei Lanzhou Univ Coll Chem & Chem Engn State Key Lab Appl Organ Chem Gansu Prov Engn Lab Chem Catalysis Lanzhou 730000 Peoples R China

Considering that graphitic carbon nitride (g-C3N4) has been employed as a photocatalytic material, multidimensional morphology modulation is of particular importance as the most effective method for increasing the specific surface area and enhancing the catalytic properties among all modifications. This work focuses on the development of a facile and green synthesis strategy for multidimensional carbon nitride, and the catalytic properties of the prepared materials were evaluated by utilizing Cr(vi) reduction as a model reaction. Ultimately, following the optimization of the preparation conditions such as calcination temperature and heating rate, the sample TCN-5, a conical tubular carbon nitride material with sea urchin-like stacking, was fabricated through the simple one-step calcination of melamine. The material exhibits the most optimal photocatalytic activity owing to its distinctive one-dimensional structure and exhibits enhanced light-sensing and mass transfer capabilities. Furthermore, the theory of gas-induced modulation in the morphology and structure of carbon nitride is further proposed. Briefly, the ammonia gas produced by precursor polymerisation affects the molecular structure at the microscopic level by altering the particle stacking density and exerts an influence on the morphology of the sample at the macroscopic level through the pushing and stripping effect of the gas. This work provides substantial evidence and theoretical guidance for the optimized modification of carbon nitride, presenting a new way for developing advanced carbon nitride materials and beyond.

关键词： Photocatalytic activity

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Changes in functional activities and volatile flavor compounds of fermented mung beans, cowpeas, and quinoa started with Bacillus amyloliquefaciens SY07

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FOOD RESEARCH INTERNATIONAL 2025年 201卷 115636页

作者： Ren, Dirong Ren, Chenghuan Ren, Jiamin li, shuwen Yang, Xiya li, Fengjuan Tianjin Univ Sci & Technol Coll Food Sci & Engn State Key Lab Food Nutr & Safety Tianjin 300457 Peoples R China

In this work, the functional activities including alpha-glucosidase, alpha-amylase, angiotensin converting enzyme (ACE) inhibitory activity, and antioxidant activity of mixed grains (mung beans, cowpeas, and quinoa) fermented with Bacillus amyloliquefaciens SY07 were investigated. The volatile flavor of the mixed grains collected every 12 h during 72 h-fermentation were further detected as well. The inhibition on alpha-glucosidase and alpha-amylase reached up to 89.34 % and 50.03 % with the sample concentration of 5.17 and 9.38 mg/mL, respectively. Moreover, the ACE inhibitory activity reached to 93.66 % with the sample concentration of 0.59 mg/mL. The antioxidant capacity of the mixed grains, evaluated by ABTS and DPPH radical scavenging capacities and ferric ion reducing power, was also significantly improved (p < 0.05) during fermentation. The maximum of ABTS and DPPH radical scavenging capacities increased to 8.64 and 3.21 mg TE/g DW, respectively, and the maximum ferric ion reducing power reached to 5.73 mg TE/g DW. Twenty-one volatile flavor compounds with odor activity values (OAVs) >= 1 were detected, and six key volatile flavor substances were identified by OPLS-DA analysis, namely, isovaleric acid, acetoin, phenylacetic acid, (Z)-2-nonenol, 1-hexanol, and 1-octen-3-ol, with overall strong creamy, sweet, baked-potato, and cocoa flavors upon fermentation. These findings revealed a favorable pathway for B. amyloliquefaciens SY07 to be used to improve the functional and flavor properties of fermented grains, which would also be of great value for further elucidating the mechanism of the formation of the volatile flavor differences and developing novel quality cereal-based products.

关键词： Bacillus amyloliquefaciens Grains Fermentation Functional activities Volatile flavor compounds

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Early postoperative core symptoms and their relationship with resilience in oesophageal cancer patients-A multicentre cross-sectional study

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JOURNAL OF ADVANCED NURSING 2024年第0期 2024 Aug 23页

作者： li, Shaoxue Wu, lijun He, Jie Ge, Yaping li, shuwen Anhui Med Univ Sch Nursing 15 Feicui Rd Hefei 230601 Anhui Peoples R China

Aim: To assess early postoperative core symptoms in oesophageal cancer patients and their relationship with resilience. Background: Patients with oesophageal cancer face a high number of severe symptoms in the early post-operative period and require the development of an effective symptom management programme. Identifying core symptoms through network analysis helps in accurate patient care. Design: A multicentre cross-sectional study. Methods: A cross-sectional survey was conducted from August 2022 to August 2023 at three hospitals in Anhui Province, China. A total of 469 patients were recruited for this study and 418 (89.1%) patients completed this investigation. Using network analysis to find early post-operative core symptoms in oesophageal cancer patients. Multiple linear regression was used to analyse resilience factors affecting core symptoms. Results: Sadness was the most core symptom in oesophageal cancer patients in the early post-operative period (r(s) = 1.41), followed by incision pain and difficulty breathing while resting (r(s) = 1.20, r(s) = 1.08). Resilience was significantly associated with patients' feelings of sadness, with optimism having the greatest impact on sadness (p < .01). Conclusion: Sadness is the most core symptom in patients in the early post-operative period and special attention should be paid to improving their level of resilience. Local symptoms and dysfunction in the early post-operative period should be treated in a synergistic manner. Impact: This study identifies core symptoms and their relationship to resilience in patients with oesophageal cancer in the early post-operative period. Symptoms as the main core symptom in patients in the early post-operative period, which was sadness and was significantly associated with resilience. Precise interventions can be made to target patients' core post-operative symptoms, which can help improve the effectiveness of symptom management. Reporting Method: We have complied with the relevant

关键词： core symptoms network analysis oesophageal cancer resilience

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HOW DOES AI CAPABIliTY ENABLE DIGITAL PRODUCT INNOVATION? A MIXED METHODS DESIGN

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INTERNATIONAL JOURNAL OF INNOVATION MANAGEMENT 2025年第3N04期29卷

作者： li, shuwen liu, Jiaxing Yang, Xiaotian Dalian Univ Technol Sch Management Dalian Peoples R China

Despite the fact that Artificial Intelligence (AI) in innovation management has been a topic of interest for several decades, little is known throughout the literature about how and why AI capability creates product value. In this work, we proposed a dual process model to explore the effects of AI capability on digital product innovation and tested it using quantitative and qualitative methods. In quantitative analysis, based on AI-Open Innovation matrix and dynamic capability theory, we tested the model using a total of 314 managers from 127 firms in the Chinese mainland. We found that AI capability enables digital product innovation by enhancing online value co-creation (a process of external asset) and digital resilience (a process of internal asset). Moreover, socio-cognitive sensemaking strengthens the mediation process of digital resilience but has no significant moderating effect on the mediation process of online value co-creation. The qualitative analysis enables us to better interpret the reasons why sensemaking plays different roles in mediation processes and suggests that it strengthens the effects of online value co-creation and digital resilience on digital product innovation through the external loop (time effect) and the internal loop (interactive effect), respectively. Our findings provide insights into how firms can scale digital product innovation using AI, with important implications for management.

关键词： AI capability online value co-creation digital resilience socio-cognitive sensemaking digital product innovation

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