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Recent membrane separation technology for noble gas recovery

JOURNAL OF MATERIALS CHEMISTRY A 2024年第23期12卷 13605-13622页

作者： Yu, shuwen lin, Rijia Xie, Zixi Chai, Milton Chen, Ruiqi Li, Shichun Shi, Hongwei Zhang, Keying Shi, Zhiqiang Hou, Jingwei Univ Queensland Sch Chem Engn St Lucia Qld 4072 Australia Suzhou Univ Sch Chem & Chem Engn Suzhou 234000 Peoples R China China Acad Engn Phys Inst Chem Mat Mianyang 621900 Peoples R China

Due to their unique properties, noble gases are significant in various disciplines despite their relative scarcity in the Earth's atmosphere. However, capturing and purifying noble gases from gas mixtures remain challenging in gas processing and separation. Cryogenic distillation has been the most common technique for separating gases, including noble gases, from gas mixtures in industrial applications. Although this process effectively achieves high-purity separations, it is highly energy-intensive due to the extreme cooling requirements. Membrane technology is a promising alternative solution for achieving low-cost and energy-efficient separations. It enables industries to improve their sustainability, reduce operating costs, and enhance product quality. Future membrane separation methods for noble gas recovery, including helium (He), neon (Ne), argon (Ar), krypton (Kr), and xenon (Xe), will become a more prominent and sustainable alternative to traditional cryogenic distillation. This review examines the most recent progress in the development of membrane materials designed to separate noble gases over recent years, encompassing polymers, zeolites, metal-organic frameworks (MOFs), porous organic cages (POCs), and 2D nanosheet membranes. This review also highlights that future developments in membrane material design and simulation, coupled with innovative process engineering, can address the existing challenges in this field and unlock the potential of membrane-based noble gas separation technologies. This review summarizes the membrane separation for the recovery of noble gases, which are significant in various disciplines due to their unique properties.

关键词： Inert gases

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Prognostic and immune predictive roles of a novel tricarboxylic acid cycle-based model in hepatocellular carcinoma

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SCIENTIFIC REPORTS 2024年第1期14卷 1-15页

作者： Zeng, Yifan Yu, Tao Jiang, shuwen Wang, Jinzhi Chen, lin Lou, Zhuoqi Pan, Liya Zhang, Yongtao Ruan, Bing Zhejiang Univ Affiliated Hosp 1 Collaborat Innovat Ctr Diag & Treatment Infect Dis Sch MedNatl Clin Res Ctr Infect DisNatl Med Ctr 79 Qingchun Rd Hangzhou 310003 Peoples R China

Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer. Since the tricarboxylic acid cycle is widely involved in tumor metabolic reprogramming and cuproptosis, investigating related genes may help to identify prognostic signature of patients with HCC. Data on patients with HCC were sourced from public datasets, and were divided into train, test, and single-cell cohorts. A variety of machine learning algorithms were used to identify different molecular subtypes and determine the prognostic risk model. Our findings revealed that the risk score (TRscore), based on the genes OGDHL, CFHR4, and SPP1, showed excellent predictive performance in different datasets. Pathways related to cell cycle and immune inflammation were enriched in the high-risk group, whereas metabolism-related pathways were significantly enriched in the low-risk group. The high-risk group was associated with a greater number of mutations of detrimental biological behavior and higher levels of immune infiltration, immune checkpoint expression, and anti-cancer immunotherapy response. Low-risk patients demonstrated greater sensitivity to erlotinib and phenformin. SPP1 was mainly involved in the interaction among tumor-associated macrophages, T cells, and malignant cells via SPP1-CD44 and SPP1-(ITGA5 + ITGB1) ligand-receptor pairs. In summary, our study established a prognostic model, which may contribute to individualized treatment and clinical management of patients with HCC.

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Green synthesis of epigallocatechin gallate-ferric complex nanoparticles for photothermal enhanced antibacterial and wound healing

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BIOMEDICINE & PHARMACOTHERAPY 2024年 171卷 116175-116175页

作者： Wang, Cheng Xiao, Ru Yang, Qingbo Pan, Jiaoyang Cui, Pengfei Zhou, shuwen Qiu, lin Zhang, Yajing Wang, Jianhao Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Hebei Univ Chinese Med Coll Pharm Shijiazhuang 050200 Peoples R China Hebei Univ Chinese Med Hebei Higher Educ Appl Technol Res Ctr TCM Dev & I Shijiazhuang 050200 Peoples R China

Bacterial infections are a significant global health concern, particularly in the context of skin infections and chronic wounds, which was further exacerbated by the emerging of antibiotic resistance. Therefore, there are urgent needs to develop alternative antibacterial strategies without inducing significant resistance. Photothermal therapy (PTT) is a promising alternative approach but usually faces limitations such as the need for stable and environmental-friendly PTT agents and ensuring biocompatibility with living tissues, necessitating ongoing research for its clinical advancement. Herein, in this study, with the aim to develop a green synthesized PTT agent for photothermal enhanced antibacterial and wound healing, we proposed a facile one-pot method to prepare epigallocatechin gallate-ferric (EGCG-Fe) complex nanoparticles. The obtained nanoparticles showed improved good size distribution and stability with high reproducibility. More importantly, EGCG-Fe complex nanoparticles have additional photothermal conversion ability which can give photothermal enhanced antibacterial effect on various pathogens, including Gram-positive Staphylococcus aureus (S. aureus) and Gramnegative Escherichia coli (E. coli) strains. EGCG-Fe complex nanoparticles also showed powerful biofilm prevention and destruction effects with promoted antibacterial and wound healing on mice model. In conclusion, EGCG-Fe complex nanoparticles can be a robust green material with effective and novel light controllable antibacterial properties for photothermal enhanced antibacterial and wound healing applications.

关键词： EGCG Photothermal Stability Antibacterial Wound healing

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Multi-Granularity Relational Attention Network for Audio-Visual Question Answering

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IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY 2024年第8期34卷 7080-7094页

作者： Li, linjun Jin, Tao lin, Wang Jiang, Hao Pan, Wenwen Wang, Jian Xiao, shuwen Xia, Yan Jiang, Weihao Zhao, Zhou Zhejiang Univ Sch Software Technol Hangzhou 310063 Peoples R China Xidian Univ State Key Lab Integrated Serv Networks Xian 710071 Peoples R China Zhejiang Univ Coll Comp Sci & Technol Hangzhou 310063 Peoples R China Alibaba Inc Hangzhou 310023 Peoples R China

Recent methods for video question answering (VideoQA), aiming to generate answers based on given questions and video content, have made significant progress in cross-modal interaction. From the perspective of video understating, these existing frameworks concentrate on the various levels of visual content, partially assisted by subtitles. However, audio information is also instrumental in helping get correct answers, especially in videos with real-life scenarios. Indeed, in some cases, both audio and visual contents are required and complement each other to answer questions, which is defined as audio-visual question answering (AVQA). In this paper, we focus on importing raw audio for AVQA and contribute in three ways. Firstly, due to no dataset annotating QA pairs for raw audio, we introduce E-AVQA, a manually annotated and large-scale dataset involving multiple modalities. E-AVQA consists of 34,033 QA pairs on 33,340 clips of 18,786 videos from the e-commerce scenarios. Secondly, we propose a multi-granularity relational attention method with contrastive constraints between audio and visual features after the interaction, named MGN, which captures local sequential representation by leveraging the pairwise potential attention mechanism and obtains global multi-modal representation via designing the novel ternary potential attention mechanism. Thirdly, our proposed MGN outperforms the baseline on dataset E-AVQA, achieving 20.73% on WUPS@0.0 and 19.81% on BLEU@1, demonstrating its superiority with at least 1.02 improvement on WUPS@0.0 and about 10% on timing complexity over the baseline.

关键词： Visualization Question answering (information retrieval) Labeling Manuals Electronic commerce Task analysis Cognition Audio-visual question answering multi-granularity relational attention network e-commerce dataset

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Multi-view Coherence for Outdoor Reflective Surfaces 19th

Multi-view Coherence for Outdoor Reflective Surfaces

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19th International Conference on Advanced Intelligent Computing Technology and Applications (ICIC)

作者： Niu, shuwen Tang, Jingjing lin, Xingyao Lv, Haoyang Song, Liang Jian, Zihao Xiamen Univ Sch Informat Xiamen 361005 Peoples R China

ISBN: (纸本)9789819947546;9789819947553

In this work, we address the deficiency that traditional multi-view matching algorithms cannot be applied to outdoor reflective surfaces. Since glass reflects different scenes under different viewpoints, which violates the multi-view coherence, it leads to the traditional 3Dreconstruction algorithm to produce wrong estimation of camera poses, which eventually leads to the failure of reconstruction of outdoor buildings with glass surfaces. This paper proposes a pipeline that can improve the accuracy of reconstructing outdoor reflective surface. Firstly, we use a drone path planning algorithm that enables the dataset captured by the drone to have the maximum 3D reconstruction capability. Then, we propose a multi-view matching algorithm based on control points, which largely improves the accuracy and robustness of the current 3D reconstruction system. Finally, in order to restore the texture details of the 3D model, we replace the inaccurate texture mapping automatically generated by the modeling software with a new texture mapping through texture coordinate remapping. These three works together constitute a novel system that can reconstruct outdoor scenes with reflections in high quality. Finally, we apply our method to a variety of outdoor scenes with reflective surfaces, such as teaching buildings, libraries, and shopping malls, and we find that our method can produce the most excellent 3D reconstruction results.

关键词： Multi-view Coherence Control Points Outdoor Reconstruction Reflective Surfaces

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Imaged capillary isoelectric focusing method development for charge variants of high DAR ADCs

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ANALYTICA CHIMICA ACTA 2024年 1328卷 343176页

作者： Leng, Chuan Sun, shuwen lin, Wei Pavon, Jorge Alexander Gennaro, Lynn Gunawan, Rico C. Bu, Xiaodong Yang, Tong Li, Senwu Merck & Co Inc 126 East Lincoln Ave Rahway NJ 07065 USA Sichuan Kelun Biotech Biopharmaceut Co Ltd 666 Xinhua AveChengdu Cross Strait Sci & Technol Chengdu Sichuan Peoples R China

Background: Charge heterogeneity is a critical quality attribute for therapeutic biologics including antibody-drug conjugates (ADCs). Developing an ion exchange chromatography (IEX) or an imaged capillary isoelectric focusing (icIEF) method for ADCs with high drug-to-antibody ratio (DAR) is challenging because of the increased hydrophobicity from the payload-linker, DAR heterogeneity, and payload-linker instability. A sub-optimal method can be poorly stability-indicating due to the inability to discern contributions from charge and size variants conjugated with different number of drugs/payloads. Systematic strategy and guidance on charge variant method development is highly desired for high DAR ADCs with various complex structures. Results: This work encompasses the development and optimization of icIEF methods for high DAR ADCs of various DAR values (4-8) and payload linker chemistry. Method optimization focuses on improving resolution and stability indicating capabilities and differentiating contributions from the protein and payload-linker. Types, proportion, and combination of solubilizers and carrier ampholytes, as well as focusing parameters were interrogated. Our findings show that the structural units of the linker, the DAR, and the payload chemistry prescribe the selection of buffer, solubilizer, and ampholyte. We demonstrate that a stronger denaturant or solubilizer is needed for high DAR ADCs with polyethylene glycol (PEG)-containing linker structure compared to peptide linker. For unstable payload-linker, buffer system enhances sample stability which is vital to method robustness. In addition, a longer isoelectric focusing time is necessary for an ADC than its corresponding antibody to reach optimal focusing. Significance: To the best of our knowledge, this is the first comprehensive study on icIEF method development for charge variant determination of high DAR ADCs with unique physicochemical properties.

关键词： Imaged capillary isoelectric focusing (icIEF) Antibody-drug conjugate (ADC) Drug-to-antibody ratio (DAR) Monoclonal antibody (mAb) Charge variant Method development

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Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway

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ATHEROSCLEROSIS 2025年 402卷 119109-119109页

作者： Wen, Liming lin, Xiangjie Hu, Dongtu Li, Juncong Xie, Kaiji Li, Shunyi Su, shuwen Duan, Xiaolin Zhong, Guoheng lin, Yingwen Chen, Yangchao Xu, Tianyu Zeng, Qingchun Southern Med Univ Nanfang Hosp Dept Cardiol State Key Lab Organ Failure Res Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Key Lab Cardiac Funct & Microcircul Guangzhou 510515 Peoples R China Guangzhou Regenerat Med & Hlth Guangdong Lab Bioland Lab Guangzhou 510005 Peoples R China Chinese Univ Hong Kong Fac Med Sch Biomed Sci Shatin Hong Kong Peoples R China Sun Yat Sen Univ Dept Cardiol NHC Key Lab Assisted Circulat Affiliated Hosp 1 Guangzhou 510080 Peoples R China

Background: Trimethylamine N-oxide (TMAO) is a gut microbial metabolite that promotes calcified aortic valve disease (CAVD), but the underlying mechanism remains obscure. Herein, we aim to test the hypothesis that TMAO regulated the inflammatory process in aortic valves via N6-methyladenosine (m6A) RNA methylationmediated macrophage polarization. Methods: In vitro, we stimulated macrophages (Phorbol-12-Myristate-13-Acetate-induced THP-1) with TMAO and assessed the expression of methyltransferase-like 3 (Mettl3), IL-1 receptor associated kinase M (IRAK-M) and polarization markers. The interaction between YTH domain family protein 2 (YTHDF2) and IRAK-M mRNA was explored by RNA-IP and RNA decay assay. Functionally, the effects of macrophages on human aortic valve interstitial cells (AVICs) were measured via macrophage adhesion assay and co-culture system. In vivo, the influence of IRAK-M on CAVD development was verified using Irak-m- /- mice. Result: Mettl3 was highly expressed while IRAK-M was decreased in human calcified aortic valves. In vitro, TMAO upregulated the expression of Mettl3, while the expression of IRAK-M, an important negative regulator of the NF kappa B pathway, was remarkably decreased in macrophages. TMAO also induced classical macrophage activation (M1 polarization). Mechanistically, IRAK-M was identified as a target of Mettl3-mediated m6A modification, indicating the involvement of m6A methylation in the regulation of NF-kappa B activation. Moreover, RIP assay revealed the direct interaction between YTHDF2 and IRAK-M mRNA and this process was dependent on Mettl3. TMAO-treated macrophage conditioned medium induced inflammatory responses in human aortic valve interstitial cells (AVICs). In vivo experiments showed that the deletion of IRAK-M significantly accelerated the progression of aortic valve lesion in mice administrated with high-fat and choline diet (HFCD). Conclusion: TMAO induces the expression of Mettl3 in macrophages. Mettl3 promotes M1 po

关键词： Calcified aortic valve disease Trimethylamine N -Oxide Macrophage polarization N6-methyladenosine IRAK-M

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Rice cultivation in saline-alkaline soil shifts the coupling of phosphorus functional genes and salt tolerance genes based on metagenomic analysis

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APPLIED SOIL ECOLOGY 2025年 211卷

作者： Lv, Qilin Fan, Jingbiao Zhou, Tairan Pan, Xiaocheng Li, Huixian Ren, Xueqin Zhang, lin Hu, shuwen China Agr Univ Coll Resources & Environm Sci Dept Environm Sci & Engn Beijing 100193 Peoples R China China Agr Univ Coll Resources & Environm Sci State Key Lab Nutrient Use & Management Key Lab Plant Soil InteractMinist Educ Beijing 100193 Peoples R China China RongTong Agr Dev Grp Corp Ltd Beijing 100020 Peoples R China China Agr Univ Coll Resources & Environm Sci 2 Yuanmingyuan West Rd Beijing 100193 Peoples R China 14 Dongdaqiao Rd Beijing 100020 Peoples R China

Rice cultivation in saline-alkali soil can improve soil fertility and microbial activity. How this impacts the relative abundance of salt tolerance genes and phosphorus (P) cycling genes in soil, and their relationship, remains unclear. We studied the physicochemical and microbial properties of barren saline-alkali wasteland soil (WL) and saline-alkali wasteland cultivated with rice for 10, 21, or 30 years, in the Sognen Plain of northeastern China. Our results exhibited that rice cultivation in saline-alkaline soil reduced the saline-alkali properties of soil and mitigated osmotic stress to microorganisms. Rice planted in saline-alkaline soil reduced the abundance of microbial salt tolerance genes and the network interactions between salt tolerance and P cycling genes. Compared to 10-year and 21-year rice-planted saline-alkaline soils, rice planted 30 years ago had increased content of labile P, moderately labile P and organic P, resulting the decreases of the relative abundance of genes for organic P mineralization (phoD) and inorganic P solubilization (gcd) and the increase in the relative abundance of genes for low-affinity inorganic phosphate transporters (pit). Additionally, long-term rice cultivation decreased soil pH, leading to a decrease of abundance of inorganic P solubilization genes. The increase of soil P availability mitigated P limitation, resulting in the complexity of the P cycling gene network in 21-year and 30-year cultivated plots lower than in 10-year plot. These results suggest that reclamation of saline land for rice alleviates the effects of soil salinity on microbial activities, enhances soil P availability, and reduces the interaction of P cycling and salt tolerance genes, promoting the microbial P assimilation in soil.

关键词： Saline-alkali soil Rice cultivation Phosphorus Metagenomics cycling genes Salt-tolerance genes Co-occurrence network

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Preparation of Liposome Gel by Calcium Cross-linking Induces the Long-Term Release of DOX to Improve the Antitumor Effect

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MOLECULAR PHARMACEUTICS 2024年第5期21卷 2394-2405页

作者： Wang, Long Wang, Yi Ye, Zixuan Yu, Yitong Wang, Cheng Qiu, lin Du, Xuancheng Zhou, shuwen Wang, Jianhao Jiang, Pengju Changzhou Univ Sch Pharm Changzhou 213164 Peoples R China Shandong Univ Sch Phys Jinan 250100 Peoples R China

Doxorubicin (DOX) is one of the most commonly used anticancer drugs;however, its clinical application is greatly limited due to its toxicity and chemotherapy resistance. The delivery of DOX by liposomes (Lipos) can improve the blood circulation time in vivo and reduce toxic side effects, but the drug's accumulation in the tumor is often insufficient for effective treatment. In this study, we present a calcium cross-linked liposome gel for the encapsulation of DOX, demonstrating its superior long-term release capabilities compared to conventional Lipos. By leveraging this enhanced long-term release, we can enhance drug accumulation within tumors, ultimately leading to improved antitumor efficacy. Lipos were prepared using the thin-film dispersion method in this study. We utilized the ion-responsiveness of glutathione-gelatin (GSH-GG) to form the gel outside the Lipos and named the nanoparticles coated with GSH-GG on the outside of Lipos as Lipos@GSH-GG. The average size of Lipos@GSH-GG was around 342.9 nm, with a negative charge of -25.6 mV. The in vitro experiments revealed that Lipos@GSH-GG exhibited excellent biocompatibility and slower drug release compared to conventional Lipos. Further analysis of cellular uptake and cytotoxicity demonstrated that Lipos@GSH-GG loading DOX (DOX&Lipos@GSH-GG) exhibited superior long-term release effects and lower toxic side effects compared to Lipos loading DOX (DOX&Lipos). Additionally, the findings regarding the long-term release effect in vivo and the tumor accumulation within tumor-bearing mice of Lipos@GSH-GG suggested that, compared to Lipos, it demonstrated superior long-term release capabilities and achieved greater drug accumulation within tumors. In vivo antitumor efficacy experiments showed that DOX&Lipos@GSH-GG demonstrated superior antitumor efficacy to DOX&Lipos. Our study highlights Lipos@GSH-GG as a promising nanocarrier with the potential to enhance efficacy and safety by means of long-term release effects and ma

关键词： doxorubicin liposomes gel calcium-cross-linked ion response long-term release

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Optimization of p-type contact for electrical injection and light extraction for 365 nm UV-A LEDs

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SEMICONDUCTOR SCIENCE AND TECHNOLOGY 2024年第6期39卷 065004-065004页

作者： Li, Yuting Wang, Guangying lin, Qinchen Xie, shuwen Zhang, Wentao Shih, Timothy Vigen, Jonathan Mukhopadhyay, Swarnav Pasayat, Shubhra S. Gupta, Chirag Univ Wisconsin Madison Dept Elect & Comp Engn Madison WI 53706 USA Univ Wisconsin Madison Mat Sci & Engn Madison WI 53706 USA

This paper demonstrates low-resistance and high-transparency p-type contact materials for ultraviolet (UV) micro-light-emitting diodes (LEDs) at 365 nm. As a commonly used p-type LED contact, indium tin oxide (ITO) and nickel/ITO (Ni/ITO) contacts were studied before and after rapid thermal annealing (RTA) treatments. The transmittance at 365 nm wavelength of 200 nm thick ITO films increased from approximately 57%-90% after RTA at a temperature exceeding 400 degrees C, while the Ni/ITO film had a transmittance of about 73% after annealing. Micron-sized UV-LEDs with Ni/ITO p-contact were fabricated. Electrical characterization shows that Ni/ITO films annealed at 600 degrees C demonstrated good ohmic contact behavior and the highest on-wafer external quantum efficiency, despite slightly lower transmittance. This paper shows the potential of annealed Ni/ITO films as promising p-contact materials for high-performance 365 nm UV-LEDs.

关键词： Ni/ITO III-nitrides p-type contact LED annealing micro-fabrication UV-A

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