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Extended Abstracts of the 2023 CHI Conference on Human Factors in Computing Systems, CHI EA 2023

作者： Wang, shuwen Zhang, Lishan Zhang, Sixv lin, Bocheng Liu, Lili Xv, Min Central China Normal University Faculty of Artificial Intelligence in Education Wuhan China Central China Normal University School of Chinese Language and Literature Wuhan China

ISBN: (纸本)9781450394222

Social annotation is an effective tool to cultivate learners' literacy skills. Besides the learners themselves, their peers and teachers are also involved in the annotating process. To facilitate effective interactions among the different types of subjects, we redesigned the social annotation activity into a four-step learning mode and developed a collaborative reading system to support this learning mode. In this system, learners can not only annotate on specific content but also interact with their peers to exchange ideas. Specifically, before the class, learners annotate individually. In the meantime, they can see their peers' annotations and make replies. During the class, each group collaboratively reflects on the individuals' before-class annotations and completes an assigned group learning task on the system. At last, the teacher gives a summarization for the whole class. Through conducting three studies in different settings and data analysis, we found that individual annotation can positively influence the learners' understanding of learning materials and the following collaborative learning process. During the before-class annotation activity, making learners able to see peers' annotations encourages the learners to think deeply and constructively. Moreover, the detailed learning feedback on the group's annotation performance is helpful for individual and collaborative learning. Now that most of the feedbacks are crafted manually or by traditional machine learning algorithms, state-of-the-art natural language processing technology like pre-trained language model has been used to automatically detect learners' cognitive engagement and will be used to automatically generate feedback in the future. Finally, we put forward two recommendations for further design of social annotation tools: (1) Using annotation filtering mechanisms to hide low-quality comments;(2) Providing automatic learning feedback and interventions to encourage learners to interact with thei

关键词： Learning algorithms

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Impact of 3D Printing Technology on Comprehension of Surgical Anatomy of Retroperitoneal Tumor

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WORLD JOURNAL OF SURGERY 2018年第8期42卷 2339-2343页

作者： Yang, Tianyou lin, shuwen Tan, Tianbao Yang, Jiliang Pan, Jing Hu, Chao Li, Jiahao Zou, Yan Guangzhou Med Univ Guangzhou Women & Childrens Med Ctr Dept Pediat Surg 9 Jinsui Rd Guangzhou 510623 Guangdong Peoples R China Fifth Peoples Hosp Dongguan City Dongguan Peoples R China

To investigate the impact of 3D printed model on understanding of surgical anatomy of retroperitoneal tumor. Three-dimensional model was printed, based on multi-detectors computed tomography (MDCT) of a retroperitoneal tumor. Participants (10 students, 10 residents and 10 surgeons) were asked to identify vasculatures which were important in resection of the tumor, after viewing MDCT images, 3D visualization model and 3D printed model, respectively. Regarding this tumor, left renal vein (LRV), right renal pedicles (RRP) and inferior vena cava (IVC) were chosen as indicators to assess participants' performances. Identification of vasculatures was evaluated and a score was given (1 point = success;0 point = failure). The total number and percentage of correct identification were used to measure how these three types of anatomic presentation were able to transfer in terms of anatomical recognition. Recorded data were analyzed both pooling together data from three groups of participants and separately for each group. In analysis of overall comparison among 3D printing, 3D visualization and MDCT, recognition of all three vasculatures simultaneously was 83.33, 73.33 and 46.67%, respectively (P = 0.007);recognition of LRV was 90, 80 and 63.33% (P = 0.043), respectively;recognition of RRP was 96.67, 83.33 and 73.33% (P = 0.035), respectively;recognition of IVC was 93.33, 90 and 80% (P = 0.366), respectively. In subgroup analysis of performances of three groups of participants, no significant differences regarding anatomic recognition were observed among MDCT, 3D visualization and 3D printed model for each group of participants. Three-dimensional printed model improved the understanding of surgical anatomy of retroperitoneal tumor.

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EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes

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BMC CARDIOVASCULAR DISORDERS 2022年第1期22卷 1-11页

作者： Bo, Zhixiang Huang, shuwen Li, Li Chen, lin Chen, Ping Luo, Xiaoyi Shi, Fang Zhu, Bing Shen, lin Chongqing Med Univ Affiliated Hosp 2 Dept Thorac & Cardiovasc Surg 76 Linjiang Rd Chongqing 400010 Peoples R China Fujian Univ Tradit Chinese Med Res Base Tradit Chinese Med Syndrome Fuzhou 350122 Peoples R China Wushan Cty Hosp Tradit Chinese Med Dept Surg Chongqing 400010 Peoples R China Fifth Peoples Hosp Chongqing Dept Gastroenterol Chongqing 400010 Peoples R China

Background Myocardial infarction (MI) is characterized by coronary artery occlusion, ischemia and hypoxia of myocardial cells, leading to irreversible myocardial damage. Therefore, it is urgent to explore the potential mechanism of myocardial injury during the MI process to develop effective therapies for myocardial cell rescue. Methods We downloaded the GSE71906 dataset from GEO DataSets, and the R software was used to identify the differentially expressed genes (DEGs) in mouse heart tissues of MI and sham controls. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed to understand the significantly activated signaling pathways in MI. Protein-protein interaction (PPI) network was constructed to highlight the hub genes in DEGs. The Western Blot, qRT-PCR and TUNEL staining were used to explore the function of hub gene in hypoxia-induced cardiomyocytes in vitro. Results A total of 235 DEGs were identified in GSE71906 dataset. Functional enrichment analysis revealed that the upregulated genes were primarily associated with the inflammatory response and apoptosis. 20 hub genes were identified in PPI network, and the early growth response 2 (EGR2) was highlighted. In vitro. We confirmed the EGR2 was upregulated induced by hypoxia and revealed the upregulated EGR2 aggravates pro-inflammation and pro-apoptotic genes expression. In addition, EGR2 knockout mitigates hypoxia-induced inflammation and apoptosis in cardiomyocytes. Conclusion The present study identified the EGR2 was a hub gene in myocardial damage during MI process, the excessive EGR2 aggravates hypoxia-induced myocardial damage by accelerating inflammation and apoptosis in vitro. Therefore, targeting EGR2 offers a potential pharmacological strategy for myocardial cell rescue in MI.

关键词： Myocardial infarction (MI) Cardiomyocytes Hub-gene Hypoxia EGR2

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Near-Infrared Light-Responsive Nanofibrous Membranes for Treatment of Bacterial Wound Infections

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ACS APPLIED NANO MATERIALS 2023年第21期6卷 20298-20309页

作者： lin, Wenbo Sun, shuwen Zhang, Dongxue Liu, Yaling Yu, Jing Liu, Rongji Wang, Kaixuan Kan, Hong Dong, Kai Xu, Chen Jilin Agr Univ Coll Chinese Med Mat Changchun 130118 Peoples R China Ctr Ginseng Breeding & Dev Natl & Local Joint Engn Res Changchun 130118 Peoples R China

Bacterial wound infections pose a significant challenge for both patients and healthcare providers. To effectively treat bacterial wound infections, it is critical to develop functional wound dressings that can eradicate bacteria and promote wound healing. Herein, we report a facile and eco-friendly route for preparing a near-infrared (NIR) light-responsive bifunctional botanicals nanofibrous membrane as a wound dressing for the synergistic treatment of bacterial wound infections. The as-prepared nanofibrous membrane consisted of poly(vinyl alcohol) as a support matrix, tannic acid-Fe(III) nanoparticles as NIR laser-activated photothermal nanoagents, and berberine hydrochloride as the active botanicals. The bifunctional nanofibrous membrane exhibited high porosity, hydrophilicity, breathability, and biocompatibility, rendering it an optimal wound dressing. More importantly, the bifunctional nanofibrous membrane exhibited a synergistic sterilization performance under NIR laser irradiation to produce sufficient hyperthermia and on-demand release of botanicals. In vivo experiments demonstrated that the nanofibrous membrane could effectively kill bacteria in the early stages of infected wounds, promote collagen deposition, and accelerate wound healing. In summary, our bifunctional nanofibrous membrane presents immense potential for clinical applications in preventing bacterial infections and promoting skin repair.

关键词： electrospinning nanofibrous membrane photothermal-responsive botanicals synergistic sterilization woundhealing

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CAS FGOALS-f3-L Model Datasets for CMIP6 DCPP Experiment

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Advances in Atmospheric Sciences 2023年第10期40卷 1911-1922页

作者： Shuai HU Bo WU Yiming WANG Tianjun ZHOU Yongqiang YU Bian HE Pengfei lin Qing BAO Hailong LIU Kangjun CHEN shuwen ZHAO State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of the Chinese Academy of Sciences Beijing 100864China

The outputs of the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System(FGOALSf3-L)model for the decadal climate prediction project(DCPP)of the Coupled Model Intercomparison Project Phase 6(CMIP6)are described in this *** FGOALS-f3-L was initialized through the upgraded,weakly coupled data assimilation scheme,referred to as EnOI-IAU,which assimilates observational anomalies of sea surface temperature(SST)and upper-level(0–1000-m)ocean temperature and salinity profiles into the coupled ***,nine ensemble members of 10-year hindcast/forecast experiments were conducted for each initial year over the period of 1960–2021,based on initial conditions produced by three initialization *** hindcast and forecast experiments follow the experiment designs of the Component-A and Component-B of the DCPP,*** decadal prediction output datasets contain a total of 44 monthly mean atmospheric and oceanic *** preliminary evaluation indicates that the hindcast experiments show significant predictive skill for the interannual variations of SST in the north Pacific and multi-year variations of SST in the subtropical Pacific and the southern Indian Ocean.

关键词： CMIP6 DCPP FGOALS-f3-L decadal prediction model initialization

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Demonstration of Near-Size-Independent External Quantum Efficiency for 368 nm UV Micro-LEDs

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PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS 2024年第11期18卷

作者： Wang, Guangying Xie, shuwen Li, Yuting Zhang, Wentao Vigen, Jonathan Shih, Timothy lin, Qinchen Gong, Jiarui Ma, Zhenqiang Pasayat, Shubhra S. Gupta, Chirag Univ Wisconsin Dept Elect & Comp Engn Madison WI 53706 USA Univ Wisconsin Dept Mat Sci & Engn Madison WI 53706 USA

UV-ranged micro-LEDs are being explored for numerous applications due to their high stability and power efficiency. However, previous reports have shown reduced external quantum efficiency (EQE) and increased leakage current due to the increase in surface-to-volume ratio with a decrease in the micro-LED size. Herein, the size-related performance for UV-A micro-LEDs, ranging from 8 x 8 to 100 x 100 mu m(2), is studied. These devices exhibit reduced leakage current with the implementation of atomic layer deposition-based sidewall passivation. A systematic EQE comparison is performed with minimal leakage current and a size-independent on-wafer EQE of around 5.5% is obtained. Smaller sized devices experimentally show enhanced EQE at high current density due to their improved heat dissipation capabilities. To the best of authors' knowledge, this is the highest reported on-wafer EQE demonstrated in <10 mu m dimensioned 368 nm UV LEDs.

关键词： EQE Gallium nitride Microfabrication Micro-LEDs UV LEDs

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Ebola Virus Glycoprotein Impairs Human Retinal Pigment Epithelial Barrier Function via the PI3K/Akt-Nrf2 Pathway

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ACS INFECTIOUS DISEASES 2025年第5期11卷 1203-1215页

作者： Chen, Shaoying Wu, Dingzhou Deng, Xiujiao Zhan, Qingping Pan, Zhizhi Chen, Zhuo Liu, Zijia Chen, Chuqing Chen, Yuliu Li, lin Liu, shuwen Tan, Suiyi Southern Med Univ Sch Pharmaceut Sci NMPA Key Lab Res & Evaluat Drug Metab Guangdong Prov Key Lab New Drug Screening Guangzhou 510515 Peoples R China Southern Med Univ Key Lab Infect Dis Res South China Minist Educ Guangzhou 510515 Peoples R China

Ebola virus (EBOV) causes deadly Ebola virus disease (EVD), and EVD survivors are at high risk of developing blinding ocular complications, which associate with the breakdown of human retinal pigment epithelial (RPE) barrier. Here, we demonstrated EBOV glycoprotein (GP) could directly impair RPE barrier function. EBOV GP significantly decreased expression of tight junction (TJ) proteins in RPE monolayers, resulting in an increase of monolayer permeability. EBOV GP activated PI3K/Akt pathway and induced oxidative stress in RPE cells as evidenced by an increase in the production of reactive oxygen species (ROS), decreased expression of an antioxidant factor, nuclear factor erythroid 2-related factor 2 (Nrf2), and its downstream proteins heme oxygenase 1 (HO-1) and NAD(P)H dehydrogenase (quinone) 1 (NQO1). We found activating Nrf2 could counteract EBOV GP-induced RPE barrier injury. Furthermore, GP2 subunit is the key region in the GP that impairs RPE barrier function. Destruction of RPE barrier function by EBOV GP leads to translocation of bacteria and HIV-1. We confirmed EBOV GP-mediated impairment of RPE barrier function in mice. As an Nrf2 activator, resveratrol displays protective effects on the RPE barrier function. Collectively, our study demonstrates EBOV GP impairs the RPE barrier function through PI3K/Akt-Nrf2 pathway and resveratrol is a promising therapeutic agent for EVD-associated retinal complications.

关键词： EBOV glycoprotein retinal pigment epithelial PI3K/Akt Nrf2 resveratrol

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斗杆结构尺寸表达形式对智能优化进程的影响

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机械制造与自动化 2019年第4期48卷 93-96页

作者：罗承旭林述温林航福州大学机械工程及自动化学院

现有挖掘机斗杆结构使用的尺寸表达形式使优化过程中几何形状约束处理耗时长,直接影响了智能优化过程的效率和质量。针对上述问题,研究不同斗杆结构尺寸表达形式对几何形状约束及优化目标对应力约束的灵敏度,提出了新的尺寸表达形式,经... 详细信息

现有挖掘机斗杆结构使用的尺寸表达形式使优化过程中几何形状约束处理耗时长,直接影响了智能优化过程的效率和质量。针对上述问题,研究不同斗杆结构尺寸表达形式对几何形状约束及优化目标对应力约束的灵敏度,提出了新的尺寸表达形式,经分析得出:在新尺寸表达形式下优化过程几何形状约束处理得到简化,极大提高了智能优化过程的效率和质量。

关键词：尺寸表达形式几何形状约束灵敏度参数化建模

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Poplar glutathione S-transferase PtrGSTF8 contributes to reactive oxygen species scavenging and salt tolerance

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PLANT PHYSIOLOGY AND BIOCHEMISTRY 2024年 212卷 108766页

作者： Song, Yushuang Yu, Keji Zhang, shuwen Li, Yi Xu, Changwen Qian, Hongping Guo, Yayu Zhang, Xi Li, Ruili Dixon, Richard A. lin, Jinxing Beijing Forestry Univ Coll Biol Sci & Biotechnol Beijing 100083 Peoples R China Beijing Forestry Univ Inst Tree Dev & Genome Editing Beijing 100083 Peoples R China Univ North Texas BioDiscovery Inst Denton TX 76203 USA Univ North Texas Dept Biol Sci Denton TX 76203 USA

Glutathione S-transferases (GSTs) constitute a protein superfamily encoded by a large gene family and play a crucial role in plant growth and development. However, their precise functions in wood plant responses to abiotic stress are not fully understood. In this study, we isolated a Phi class glutathione S-transferase-encoding gene, PtrGSTF8, from poplar (Populus alba x P. glandulosa), which is significantly up-regulated under salt stress. Moreover, compared with wild-type (WT) plants, transgenic tobacco plants exhibited significant salt stress tolerance. Under salt stress, PtrGSTF8-overexpressing tobacco plants showed a significant increase in plant height and root length, and less accumulation of reactive oxygen species. In addition, these transgenic tobacco plants exhibited higher superoxide dismutase, peroxidase, and catalase activities and reduced malondialdehyde content compared with WT plants. Quantitative real-time PCR experiments showed that the overexpression of PtrGSTF8 increased the expression of numerous genes related to salt stress. Furthermore, PtrMYB108, a MYB transcription factor involved in salt resistance in poplar, was found to directly activate the promoter of PtrGSTF8, as demonstrated by yeast one-hybrid assays and luciferase complementation assays. Taken together, these findings suggest that poplar PtrGSTF8 contributes to enhanced salt tolerance and confers multiple growth advantages when overexpressed in tobacco.

关键词： Glutathione S-Transferase Poplar PtrGSTF8 PtrMYB108 Salt tolerance Transgenic tobacco

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In situ synchrotron X-ray diffraction for actuation in sodium bismuth titanate relaxor ferroelectrics

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MATERIALS HORIZONS 2025年 2025 Apr 30页

作者： Jia, Yuxin Fan, Yongbo Lei, lin Su, Yao Zhu, shuwen Dong, Guangzhi Hinterstein, Manuel Li, Qiang Wang, Weijia Fan, Huiqing Northwestern Polytech Univ Sch Elect & Informat Xian 710072 Peoples R China Hong Kong Polytech Univ Dept Appl Phys Kowloon 11 Yucai Rd Hong Kong Peoples R China Northwestern Polytech Univ Sch Mat Sci & Engn State Key Lab Solidificat Proc Xian 710072 Peoples R China Xidian Univ Sch Adv Mat & Nanotechnol Xian 710071 Peoples R China Fraunhofer Inst Mat Mech Freiburg Germany

Sodium bismuth titanate-based (NBT-based) ergodic relaxor ferroelectrics have garnered significant attention for actuator applications due to their fully reversible electrostrain behavior. In general, it is believed that the electrostain originates from three main aspects: electric field-induced phase transitions with volume changes, non-180 degrees domain switching, and lattice stretching without volume changes. However, the individual contribution remains to be quantitatively understood. In this work, in situ synchrotron X-ray diffraction in different integration directions is performed to quantify the contributions of electric field-induced phase transition and non-180 degrees domain switching to electrostrain for NBT-based ergodic relaxor ferroelectrics under external electric field. The calculated total strain is 0.41%, in which 0.038% results from volume strain related to the electric field-induced phase transition, while 0.127% is due to induced ferroelastic domain structures. The rest 0.245% is attributed to lattice stretching. The volume change caused directly by phase transition has a very limited effect on electrostrain, while the indirect effect of phase transition on strain (the domain switching of the ferroelectric phase) has a relatively large effect on electrostrain. This innovative work offers theoretical insights for optimizing NBT-based relaxor ferroelectric materials for actuator applications, contributing to better control of electrostrain.

关键词： Ferroelectric materials

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