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Hydroxyapatite microspheres encapsulated within hybrid hydrogel promote skin regeneration through the activation of Calcium Signaling and Motor Protein pathway

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BIOACTIVE MATERIALS 2025年 50卷 287-304页

作者： Liu, Shuo Song, Lu Huang, shuwen Liu, Zhanhong Xu, Yang Wang, Zhiyuan Qiu, He Wang, Jing Chen, Zhiru Xiao, Yumei Wang, Hang Zhu, Xiangdong Zhang, Kai Zhang, Xingdong lin, Hai Sichuan Univ Coll Biomed Engn Natl Engn Res Ctr Biomat Chengdu 610064 Peoples R China Sichuan Univ Inst Regulatory Sci Med Devices Chengdu 610064 Peoples R China Sichuan Univ Res Ctr Mat Genome Engn Chengdu 610064 Peoples R China Sichuan Univ Hlth & West China Hosp 4 West China Sch Publ Dept Cosmet & Plast Surg Chengdu Sichuan Peoples R China Sichuan Univ West China Hosp Stomatol Natl Clin Res Ctr Dept Cosmet & Plast Surg Oral & Maxillofacial Surg Chengdu 610041 Peoples R China Sichuan Univ Key Lab Leather Chem & Engn Minist Educ Chengdu 610065 Peoples R China

Hydroxyapatite (HAp), traditionally recognized for its efficacy in bone regeneration, has rarely been explored for skin regeneration applications. This investigation explored HAp microspheres with distinct physicochemical properties tailored away from conventional bone regeneration parameters, and the capacity promoting skin regeneration and mitigating the aging process were investigated when encapsulated in hyaluronate hydrogels. By benchmarking against well-established dermal fillers like PMMA and PLLA, it was revealed the specific attributes of HAp that were conducive to skin regeneration, providing initial insights into the underlying mechanism. HAp enhanced the fibroblast functionality by triggering minimal adaptive immune responses and enhancing the Calcium Signaling and Motor Protein Signaling pathways. This modulation supported the production of normal collagen fibers, essential for ECM maturation and skin structural integrity. The significant ECM regeneration and remodeling capabilities exhibited by the HAp-encapsulated hybrid hydrogels suggested promising application in facial rejuvenation procedures, potentially making a breakthrough in aesthetic and reconstructive surgery.

关键词： Hydroxyapatite Regeneration Calcium signaling Motor protein

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Millisecond self-heating and quenching synthesis of Fe/carbon nanocomposite for superior reductive remediation

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APPLIED CATALYSIS B-ENVIRONMENT AND ENERGY 2024年 342卷

作者： Sun, Liming Wu, Xuan Jiao, Yubing Jia, Chao Teng, Tao lin, Litao Yu, Fengbo He, Zhelin Gao, Jie Yan, shuwen Shi, Guosheng Ren, Zhiyong Jason Yang, Jinguang Zhang, Shicheng Zhu, Xiangdong Fudan Univ Dept Environm Sci & Engn Shanghai Tech Serv Platform Pollut Control & Resou Shanghai Key Lab Atmospher Particle Pollut & Preve Shanghai 200092 Peoples R China Chinese Acad Agr Sci Tobacco Res Inst Qingdao 266000 Peoples R China Shanghai Univ Shanghai Appl Radiat Inst State Key Lab Adv Special Steel Shanghai 200444 Peoples R China Princeton Univ Dept Civil & Environm Engn Princeton NJ 08544 USA Princeton Univ Andlinger Ctr Energy & Environm Princeton NJ 08544 USA Shanghai Inst Pollut Control & Ecol Secur Shanghai 200092 Peoples R China Shanghai Acad Environm Sci State Environm Protect Engn Ctr Urban Soil Contami Shanghai 200233 Peoples R China

Fe-0-based nanomaterials are extensively applied in environmental remediation, but their passivated oxide shell restricts deep application. However, efforts aimed at revitalizing Fe-oxide shells have shown limited success. Here, we report a "faster win fast" approach by preferential carbon layer deposition in milliseconds to block Feoxide shell growth via carbon-assisted flash Joule heating (C-FJH) reaction. C-FJH induced ultra-high temperature and electric shock promoted reductive Fe formation and subsequently melted to a phase-fusional heterostructure (Fe-0/FeCl2). Therefore, theoretical calculation confirmed that electron delocalization effect of derived heterostructure promoted electron transfer. Synchronously, rapid self-heating/quenching rate (similar to 10(2) K/ms) realized a thin aromatic-carbon layer deposition to sustain both high stability and activity of reductive Fe. The channels of thin aromatic-carbon layer favored inward diffusion of pollutants, which facilitated the subsequent reduction. Accordingly, derived heterostructure and carbon layer jointly contributed to the boosted removal of multiple pollutants (including metal oxyanions, perfluorinated compounds, and disinfection by-products).

关键词： Fe-0 -based nanomaterials Flash Joule heating Reduction Oxide shell-free Environmental remediation

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Constructing Robust 3D Ionomer Networks in the Catalyst Layer to Achieve Stable Water Electrolysis for Green Hydrogen Production

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ACS APPLIED MATERIALS & INTERFACES 2024年第13期16卷 16408-16417页

作者： Liu, Han Yang, Yang Liu, Jiawei Huang, Meiquan Lao, Kejie Pan, Yaping Wang, Xinhui Hu, Tian Wen, linrui Xu, shuwen Li, Shuirong Fang, Xiaoliang lin, Wen-Feng Zheng, Nanfeng Tao, Hua Bing Xiamen Univ Collaborat Innovat Ctr Chem Energy Mat State Key Lab Phys Chem Solid Surfaces Xiamen 361005 Peoples R China Xiamen Univ Coll Chem & Chem Engn Xiamen 361005 Peoples R China IKKEM Innovat Lab Sci & Technol Energy Mat Fujian Prov Xiamen 361005 Peoples R China Xiamen Univ Coll Energy Xiamen 361005 Peoples R China Loughborough Univ Dept Chem Engn Loughborough LE11 3TU England

The widespread application of proton exchange membrane water electrolyzers (PEMWEs) is hampered by insufficient lifetime caused by degradation of the anode catalyst layer (ACL). Here, an important degradation mechanism has been identified, attributed to poor mechanical stability causing the mass transfer channels to be blocked by ionomers under operating conditions. By using liquid-phase atomic force microscopy, we directly observed that the ionomers were randomly distributed (RD) in the ACL, which occupied the mass transfer channels due to swelling, creeping, and migration properties. Interestingly, we found that alternating treatments of the ACL in different water/temperature environments resulted in forming three-dimensional ionomer networks (3D INs) in the ACL, which increased the mechanical strength of microstructures by 3 times. Benefitting from the efficient and stable mass transfer channels, the lifetime was improved by 19 times. A low degradation rate of approximately 3.0 mu V/h at 80 C-degrees and a high current density of 2.0 A/cm(2) was achieved on a 50 cm(2) electrolyzer. These data demonstrated a forecasted lifetime of 80 000 h, approaching the 2026 DOE lifetime target. This work emphasizes the importance of the mechanical stability of the ACL and offers a general strategy for designing and developing a durable PEMWE.

关键词： PEM water electrolysis stability in hydrogen production anode catalyst layer three-dimensional ionomer networks thermal and water cycles

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Gelatinase-Responsive Photothermal Nanotherapy Based on Au Nanostars Functionalized with Antimicrobial Peptides for Treating Staphylococcus aureus Infections

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ACS APPLIED NANO MATERIALS 2022年第6期5卷 8324-8333页

作者： Wang, Xuan Wang, Jiawei Qiu, lin Wang, Cheng Lei, Xiaoling Cui, Pengfei Zhou, shuwen Zhao, Donghui Ni, Xinye Jiang, Pengju Wang, Jianhao Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Huazhong Univ Sci & Technol Britton Chance Ctr Biomed Photon Wuhan Natl Lab OptoelectColl Life Sci & Technol Hubei Bioinformat & Mol Imaging Key LabDept Biom Wuhan 430074 Hubei Peoples R China Nanjing Med Univ Affiliated Changzhou 2 Peoples Hosp Changzhou 213003 Jiangsu Peoples R China

As a pathogenic worldwide pathogen, Staphylococcus aurcus (S. aureus) has brought great challenges to the prevention and treatment of diseases in the community. Although antimicrobial peptides show potent antibacterial activity because of their unique bactericidal mechanism, their inherent cationic toxicity cannot be ignored. Utilizing the related characteristics of S. aureus to achieve targeted therapy can reduce the toxicity to host cells to a great extent. Herein, we designed Cy7-labeled antimicrobial peptide (GLFVDK(-Cy7)GKRWWKWWRRGPLGVRGC) with S. aurcus targeting recognition peptide (GLFVD) and gelatinase cleavage site (PLGVR), which together with SH-PEG was anchored to gold nanostars (AuNS) by the Authiol bond to form a photothermal nanoprobe (APA) targeting S. two's. The size of the generated APA nanoprobe was 201 +/- 3.7 nm, and it was nonfluorescent in the physiological environment due to the fluorescence resonance energy transfer between the AuNS core and Cy7. In ritro results showed that in the gelatinase environment secreted by S. aureus, antimicrobial peptides were released from AuNS and restored the fluorescence of Cy7 in situ, targeting and priority killing of S. aureus. In the mouse wound model of double bacterial infection, APA effectively removed S. aureus from the infected site and promoted the rapid healing of infected wounds through gelatinase-responsive drug release and photothermal synergistic antibacterial treatment.

关键词： gold nanostars gelatinase responsive targeted antimicrobial peptide photothermal therapy bacterial infection wound healing

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Polymerized Tannic Acid Offers a Nanosized Platform to Combat Bacterial Infection

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ACS BIOMATERIALS SCIENCE & ENGINEERING 2022年第11期8卷 5008-5017页

作者： Xiao, Ru Liu, Yadong Li, Yuting Shen, Yaoyan Zhou, shuwen Cui, Pengfei Hu, Huaanzi Jiang, Pengju Qiu, lin Wang, Cheng Wang, Jianhao Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Nanjing Med Univ Peoples Hosp Changzhou 2 Changzhou 213003 Peoples R China

Worldwide antibiotic abuse accelerates the evolu-tion of drug-resistant super bacteria, which goes against the war toward bacterial infection. Antibiotic-loaded nanoparticles as a typical form of nanomedicine hold great promise in combating bacterial infection, which requires the development of a suitable carrier. Tannic acid (TA) showed an inhibition effect on both Gram-positive and-negative strains;however, there are no reports on the development of antibacterial nanoformulations based on TA itself. We could get PTA NPs using a one-pot method, and their size and zeta-potential were characterized. Herein, we carefully tuned the polymerization of TA to give well-dispersed polytannic acid nanoparticles (PTA NPs) with a size of 100 nm. Moreover, our results demonstrated that PTA NPs showed enhanced antibacterial effects on both Gram-positive and-negative strains as compared to free TA. Especially, PTA NPs can preferably accelerate the healing of Staphylococcus-infected wounds. Based on its structure, we suggested that PTA NPs may have a similar property to polydopamine nanoparticles to offer high drug loading for potential combination therapy for extended application in bacterial infection management.

关键词： polymerized tannic acid bacterial infection nanomedicine

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Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction

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CELL COMMUNICATION AND SIGNAlinG 2025年第1期23卷 1-25页

作者： Qian, shuwen Su, Zehua lin, Jiaqi Hou, Qianhao Wang, Xiaomei Li, Yuling Wang, Jieying Huang, Changchun Wang, Zetian Cubero, Francisco Javier Wang, Xiangrui Liao, Lijun Tongji Univ Yangpu Hosp Sch Med Dept Anesthesiol & Pain Management Shanghai 200090 Peoples R China Tongji Univ Shanghai East Hosp Sch Med Dept Pain Management Shanghai 200120 Peoples R China Tongji Univ Jian Hosp Shanghai East Hosp Sch Med Nanchang 343006 Jiangxi Peoples R China Shanghai Jiao Tong Univ Renji Hosp Clin Ctr Invest Sch Med Shanghai 200127 Peoples R China Ningbo First Hosp Dept Anesthesiol Ningbo 315010 Zhejiang Peoples R China Univ Complutense Madrid Sch Med Dept Immunol Ophthalmol & ENT Madrid Spain Tongji Univ Shanghai East Hosp Inst Pain Med Sch Med Shanghai 200120 Peoples R China

Background and aimsBacterial translocation and intestinal dysbiosis due to gut barrier dysfunction are widely recognized as major causes of the initiation and development of intra-abdominal sepsis. Systemic bacterial translocation and hepatic activation of the myeloid differentiation primary response gene 88 (Myd88) can disturb bile acids (BAs) metabolism, further exacerbating intestinal dysbiosis. The farnesoid X receptor (FXR) and fibroblast growth factor (FGF) 15/19 are well known to be involved in the control of BAs synthesis and enterohepatic circulation. However, the influence of intestinal microbiota on intestinal Myd88 signaling, the FXR/FGF15 axis, as well as gut-liver crosstalk during sepsis remains unclear. The present study aims to decipher the role of intestinal Myd88 in abdominal sepsis, its impact on intestinal FXR signaling and FGF15-mediated gut-liver *** levels of FXR and FGF15 in the liver and intestines, alongside assessments of gut barrier function, were evaluated in septic wild-type (WT) mice 24 h post-cecal ligation and puncture (CLP) surgery. Subsequently, the FXR agonist INT-747 was administered to explore the relationship between FXR activation and gut barrier function. Further investigations involved Myd88-deficient mice with specific deletion of Myd88 in intestinal epithelial cells (Myd88 triangle IEC), subjected to CLP to examine the interplay among intestinal Myd88, FXR, gut barrier function, microbiota, and BA composition. Additionally, fecal microbiota transplantation (FMT) from septic mice to Myd88 triangle IEC mice was conducted to study the impact of dysbiosis on intestinal Myd88 expression during sepsis, using floxed (Myd88fl/fl) mice as controls. Finally, the effects of the probiotic intervention on gut barrier function and sepsis outcomes in CLP mice were *** of sepsis via CLP led to hepatic cholestasis, suppressed FXR-FGF15 signaling, altered gut microbiota composition, and comp

关键词： Sepsis Gut microbiota Myd88 FXR FGF15 Probiotics Bile acids

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Reconfigurable Glass Scintillation Screen for Conformal X-Ray Imaging of Shape-Changeable Objects

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LASER & PHOTONICS REVIEWS 2025年第11期

作者： Jiang, Jinke Mao, Xingchu Zheng, Xiaoxin Ye, Xin Li, Cuicui Li, Huimin Ge, Chao Chen, Jiashuai Wang, shuwen Zhang, Leilei Cui, Shuangyue lin, Qinglian Guo, Qing Han, Quanxiang Zhang, Yuhai Tao, Xutang Liu, Yang Shandong Univ Inst Crystal Mat State Key Lab Crystal Mat Jinan 250100 Peoples R China Univ Jinan Inst Adv Interdisciplinary Res iAIR Sch Chem & Chem Engn Jinan 250022 Peoples R China Beijing Univ Technol Inst Laser Engn Sch Phys & Optoelect Engn Beijing 100124 Peoples R China State Key Lab NBC Protect Civilian Beijing 102205 Peoples R China Naval Aeronaut Univ Aviat Operat Serv Coll Yantai 264000 Peoples R China Qilu Inst Technol Coll Biol & Chem Engn Jinan 250200 Peoples R China

As the kernel component of X-ray imaging systems, the mainstream flat-panel detectors suffer from image distortion and blurring when applied to irregular shaped objects, because of the non-conformal collocation between the detector and the object. Herein, by taking advantage of the robust glass-forming capability and versatile processability of (TPT)(2)MnBr4 (TPT = propyltriphenylphosphonium) scintillator, reconfigurable scintillation screen for conformal X-ray imaging is explored. Compared to the flexible polymer screens doped with micro-/nanoparticles, the melt-casted large-area (20 x 20 cm(2)) scintillation screens are homogeneous and immune to light scattering, thus manifesting optical transmittance of above 80% in the 525-800 nm range and high spatial resolution of 25.5 lp mm(-1). More impressively, the screen can be reconfigured in shape near its glass transition temperature, realizing continuous conformance with irregular or changeable objects. Exemplified by conformal X-ray imaging of a flexed elbow joint and a flexible circuit with variational shapes, the reconfigurable screens demonstrate superiorities in both image clarity (15 lp mm(-1) versus 3 lp mm(-1) for the conformal imaging versus non-conformal imaging) and reduction of radiation dosage. That, plus the scalable fabrication process and cost-effective raw materials, will promise reconfigurable glass scintillation screens great potential in customized medical diagnostics and industrial inspection.

关键词： conformal X-ray imaging glass reconfigurability scintillation screen

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异态转译:行动者网络视角下的乡村政策传播——以山东A镇征地补偿政策传播为例

传播创新研究

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传播创新研究 2025年第1期 58-80+229-230页

作者：王舒雯林婕北京大学新媒体研究院武汉大学新闻与传播学院

本研究以山东省A镇征地补偿政策传播为例,通过田野调查以及对23位行动者的深度访谈发现,政府人员、村干部、村民等人类行动者和信息渠道、熟人关系、情感倾向等非人类行动者交织,形成了错综复杂的信息转译网络。人类行动者驱动着非人类... 详细信息

本研究以山东省A镇征地补偿政策传播为例,通过田野调查以及对23位行动者的深度访谈发现,政府人员、村干部、村民等人类行动者和信息渠道、熟人关系、情感倾向等非人类行动者交织,形成了错综复杂的信息转译网络。人类行动者驱动着非人类行动者的“行动”。该网络信息传播异化,体现了信息不对称和不对等,这种信息不对称和不对等造成异议频频发生。这项研究不仅有助于理解中国乡村政策传播中异化的转译机制,还有助于推动乡村治理的现代化。

关键词：政策传播乡村传播行动者网络理论征地补偿政策

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Two-level fault diagnosis RBF networks for auto-transformer rectifier units using multi-source features

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JOURNAL OF POWER ELECTRONICS 2020年第3期20卷 754-763页

作者： lin, Yi Ge, Hongjuan Chen, shuwen Pecht, Michael Nanjing Univ Aeronaut & Astronaut Coll Civil Aviat Nanjing Peoples R China Univ Maryland Ctr Adv Life Cycle Engn College Pk MD 20742 USA

The auto-transformer rectifier unit (ATRU) is one of the most widely used avionic secondary power supplies. Timely fault identification and location of the ATRU is significant in terms of system reliability. A two-level fault diagnosis method for the ATRU using multi-source features (MSF) is proposed in this paper. Based on the topology of the ATRU, three key electrical signals are selected and analyzed to extract appropriate features for fault diagnosis. Mathematic expressions and simulation results of the feature signals under different fault modes are presented in the paper. Therefore, a unique MSF system is developed and a two-level fault diagnosis method based on radial basis function network groups is proposed. On the first level, the overall fault set is classified into three subsets and then on the second level, three radial basis function neural networks are constructed and trained to realize accurate fault localization. To verify the diagnosis performance of the proposed method, several comparative tests are implemented on a 12-pulse ATRU system, which shows that this method has a lower computational cost, better diagnostic accuracy and increased stability when compared with alternative methods.

关键词： Auto-transformer rectifier unit Fault diagnosis Multi-source features Radial basis function neural networks

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Bioinspired Macrocyclic Molecule Supported Two-Dimensional Lamellar Membrane with Robust Interlayer Structure for High-Efficiency Nanofiltration

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ADVANCED SCIENCE 2023年第5期10卷 e2206516页

作者： Zhang, Pengcheng Zhang, Yujuan Wang, lin Qiu, Kaikai Tang, Xiaoyi Gibson, John K. Liu, Xue Mei, Lei An, shuwen Huang, Zhiwei Ren, Peng Wang, Yi Chai, Zhifang Shi, Weiqun Chinese Acad Sci Inst High Energy Phys Lab Nucl Energy Chem Beijing 100049 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Radiochem Lab Lanzhou 730000 Peoples R China Chinese Acad Sci Ningbo Inst Mat Technol & Engn Engn Lab Adv Energy Mat Ningbo 315201 Peoples R China Univ Sci & Technol Beijing Sch Mat Sci & Engn Beijing 100083 Peoples R China Lawrence Berkeley Natl Lab Chem Sci Div Berkeley CA 94720 USA Xi An Jiao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China East China Univ Technol Sch Nucl Sci & Engn Nanchang 330013 Peoples R China State Key Lab NBC Protect Civilian Beijing 102205 Peoples R China

2D lamellar membranes (2DLMs) are used for efficient desalination and nanofiltration. However, weak interactions between adjacent stacked nanosheets result in susceptibility to swelling that limits practical applicability. Inspired by the super adhesion of multi-point suction cups on octopus tentacles, a 2DLM is constructed from Ti3C2Tx MXene supported by the macrocyclic "multi-point" molecule cucurbit[5]uril (CB5) and demonstrated for nanofiltration of methyl blue (MB) and enrichment of uranyl carbonate. Experimental results and density functional theory calculations indicate that CB5 rivets to the surface of the nanoflakes through strong stable interactions between its multiple binding sites and surface hydroxyl functional groups on MXene nanosheets. This novel 2DLM exhibits excellent nanofiltration performance (69 L m(-2)h(-1)bar(-1) permeance with 93.6% rejection for MB) and can be recycled at least 30 times without significant degradation. The 2DLM exhibits excellent swelling resistance at high salinity, with a demonstration of selective enrichment of uranyl carbonate from artificial water and natural seawater. The results provide a new strategy for constructing highly stable 2DLMs with interlayer spacing controllable from sub-nano to nanometer scales, for size-selective sieving of molecules and ions, high-efficiency nanofiltration, and other applications.

关键词： membrane separation MXene nanofiltration size sieving uranium enrichment

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