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Sound Source Localization Based on SRP-PHAT Spatial Spectrum and Deep Neural Network

Computers, Materials & Continua 2020年第7期64卷 253-271页

作者： Xiaoyan Zhao shuwen Chen lin Zhou Ying Chen School of Information and Communication Engineering Nanjing Institute of TechnologyNanjing211167China School of Mathematics and Information Technology Jiangsu Second Normal UniversityNanjing210013China School of Information Science and Engineering Southeast UniversityNanjing210096China Department of Psychiatry Columbia University and NYSPINew York10032USA

Microphone array-based sound source localization(SSL)is a challenging task in adverse acoustic *** address this,a novel SSL algorithm based on deep neural network(DNN)using steered response power-phase transform(SRP-PHAT)spatial spectrum as input feature is presented in this *** the SRP-PHAT spatial power spectrum contains spatial location information,it is adopted as the input feature for sound source *** is exploited to extract the efficient location information from SRP-PHAT spatial power spectrum due to its advantage on extracting high-level ***-PHAT at each steering position within a frame is arranged into a vector,which is treated as DNN input.A DNN model which can map the SRP-PHAT spatial spectrum to the azimuth of sound source is learned from the training *** azimuth of sound source is estimated through trained DNN model from the testing *** results demonstrate that the proposed algorithm significantly improves localization performance whether the training and testing condition setup are the same or not,and is more robust to noise and reverberation.

关键词： Sound source localization microphone array steered response power-phase transform(SRP-PHAT)spatial spectrum deep neural network

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Automatic Rate and Rate-Integrating Mode-Switchable Axisymmetric Gyroscope

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SENSORS 2022年第12期22卷 4334页

作者： Xuan, lin Lu, Mingyang Liu, Jing Guo, shuwen Xu, Dacheng Soochow Univ Sch Elect & Informat Engn Suzhou 251000 Peoples R China

This paper describes a novel rate and rate-integrating mode-switchable axisymmetric gyroscope. A precession angle tracking algorithm is developed to enable the gyro to switch automatically between rate and rate-integrating modes at preset rate points through a digital control system within the gyro. We also propose a vibrating amplitude control method for the rate-integrating mode that directly extracts the angular rate output to ensure switching stability. In rate mode, the bias instability and angle random walk of the gyro reach 0.106 degrees/h and 0.011 degrees/root h, respectively. Additionally, an input range of over +/- 5000 degrees/s is measured in rate-integrating mode. The scale factor nonlinearity reaches approximately 116 ppm over the full-scale range. The control system implements effective steering control of the gyroscope, with a switching delay of 10 ms from rate mode to rate-integrating mode and 100 ms from rate-integrating to rate mode. The proposed system actualizes a new type of gyroscope with high accuracy and a wide input range, which combines the benefits of rate and rate-integrating modes.

关键词： MEMS gyroscope mode switching rate mode rate-integrating mode

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Bimetallic nanoalloys planted on super-hydrophilic carbon nanocages featuring tip-intensified hydrogen evolution electrocatalysis

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NATURE COMMUNICATIONS 2024年第1期15卷 7179页

作者： Zhang, linjie Hu, Haihui Sun, Chen Xiao, Dongdong Wang, Hsiao-Tsu Xiao, Yi Zhao, shuwen Chen, Kuan Hung lin, Wei-Xuan Shao, Yu-Cheng Wang, Xiuyun Pao, Chih-Wen Han, Lili Chinese Acad Sci Fujian Inst Res Struct Matter State Key Lab Struct Chem Fuzhou 350002 Peoples R China Chinese Acad Sci Beijing Natl Lab Condensed Matter Phys Inst Phys Beijing 100190 Peoples R China Tamkang Univ Bachelorss Program Adv Mat Sci New Taipei City 251301 Taiwan Tamkang Univ Dept Phys New Taipei City 25137 Taiwan Natl Synchrotron Radiat Res Ctr Hsinchu 300092 Taiwan Fuzhou Univ Natl Engn Res Ctr Chem Fertilizer Catalyst Fuzhou 350002 Peoples R China

The insufficient availability and activity of interfacial water remain a major challenge for alkaline hydrogen evolution reaction (HER). Here, we propose an "on-site disruption and near-site compensation" strategy to reform the interfacial water hydrogen bonding network via deliberate cation penetration and catalyst support engineering. This concept is validated using tip-like bimetallic RuNi nanoalloys planted on super-hydrophilic and high-curvature carbon nanocages (RuNi/NC). Theoretical simulations suggest that tip-induced localized concentration of hydrated K+ facilitates optimization of interfacial water dynamics and intermediate adsorption. In situ synchrotron X-ray spectroscopy endorses an H* spillover-bridged Volmer-Tafel mechanism synergistically relayed between Ru and Ni. Consequently, RuNi/NC exhibits low overpotential of 12 mV and high durability of 1600 h at 10 mA cm(-2) for alkaline HER, and demonstrates high performance in both water electrolysis and chlor-alkali electrolysis. This strategy offers a microscopic perspective on catalyst design for manipulation of the local interfacial water structure toward enhanced HER kinetics.

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Rational design phosphorylation Mg-Fe layered dioxides nanosheets for efficient capture of uranium from wastewater

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SEPARATION AND PURIFICATION TECHNOLOGY 2023年第1期326卷

作者： Wang, Shiyong Zhao, lin Yang, Hongkai Du, shuwen Yang, Chen Lu, Bing Wang, Gang Dongguan Univ Technol Res Ctr Ecoenvironm Engn Sch Environm & Civil Engn Dongguan 523106 Peoples R China Beijing Univ Chem Technol Coll Chem Engn Beijing 100029 Peoples R China Guangdong Prov Key Lab Intelligent Disaster Preven Dongguan 523106 Guangdong Peoples R China

As the nuclear industry boomed, lots of uranium has entered the water environment and caused great damage to ecological environment. Designing and preparing efficient uranium adsorption materials is essential to solve the problem. Phosphorylated Mg-Fe layered dioxides (P-MF LDOs) nanosheets with a favorable memory effect were prepared by calcination and in-situ phosphorylation for uranium extraction from wastewater (UEW). The unique phosphating method resulted in a uniform distribution of phosphate functional groups in the surface of LDOs, which gave it great ability for capture of uranium. The adsorption capacity of P-MF LDOs was 2.31 times that of pure MF LDOs. According to the Langmuir model, the theoretical extraction capacity of P-MF LDOs was as high as 909.09 mg g-1, which was significantly higher than that of similar sorbents. Additionally, it exhibited excellent anti-interference ability. The results of the adsorption mechanism study revealed that the binding modes included surface complexation, mineralization reaction, dissolution-precipitation, and memory effect. In conclusion, P-MF LDOs represent a type of highly efficient uranium adsorbent with simple preparation and high adsorption capacity for UEW. This study provides new insights into the development of inorganic clay-based uranium adsorbents.

关键词： Uranium Layered dioxides In-situ phosphorylation Radioactive wastewater

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Hecaton: Training Large Language Models with Scalable Waferscale Chiplet Systems

arXiv

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arXiv 2024年

作者： Huang, Zongle Fan, Shupei Tang, Chen lin, Xinyuan Deng, shuwen Liu, Yongpan Dept. of Electronic Engineering Tsinghua University China

Large Language Models (LLMs) have achieved remarkable success in various fields, but their training and finetuning require massive computation and memory, necessitating parallelism which introduces heavy communication overheads. Driven by advances in packaging, the chiplet architecture emerges as a potential solution, as it can integrate computing power, as well as utilize on-package links with better signal integrity, higher bandwidth, and lower energy consumption. However, most existing chiplet-related works focus on DNN inference. Directly porting them to LLM training introduces significantly large quantities of DRAM access and network-on-package (NoP) overheads which make state-of-the-art chiplet designs fail, highlighting a research gap. This work proposes Hecaton, a scalable and cost-effective chiplet system for LLM training. We first provide a chiplet architecture with tailored scheduling that can largely reduce DRAM accesses. We further design an efficient distributed training method that reduces NoP communication complexity and relieves constraints on SRAM capacity and layout. Theoretical analysis shows that the entire system achieves weak scaling: as the workload and hardware resources grow proportionally, the computation-to-communication ratio remains nearly constant. Experiments with various workloads and hardware configurations verify the property, and Hecaton achieves 5.29× performance improvement and 3.46× energy reduction on Llama3.1-405B, compared to the tensor parallelism in Megatron. To the best of our knowledge, we propose the first chiplet architecture specifically used for LLM training or finetuning, with guaranteed performance regardless of the problem scale. Copyright © 2024, The Authors. All rights reserved.

关键词： Energy utilization

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gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity

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Cellular & Molecular Immunology 2024年第5期21卷 479-494页

作者： Suiyi Tan Wenjuan Li Chan Yang Qingping Zhan Kunyu Lu Jun Liu Yong-Mei Jin Jin-Song Bai lin Wang Jinqing Li Zhaofeng Li Fei Yu Yu-Ye Li Yue-Xun Duan Lu Lu Tong Zhang Jiaqi Wei lin Li Yong-Tang Zheng Shibo Jiang shuwen Liu Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismGuangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou510515China Department of Infectious Disease The Third People’s Hospital of KunmingKunming650041China Department of Pathology The Third People’s Hospital of KunmingKunming650041China Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism College of Life SciencesHebei Agricultural UniversityBaoding071001China Department of Dermatology and Venereology First Affiliated Hospital of Kunming Medical UniversityKunming650032China Yunnan Provincial Infectious Disease Hospital Kunming650301China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesFudan UniversityShanghai200032China Beijing Key Laboratory for HIV/AIDS Research Clinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing100069China State Key Laboratory of Genetic Evolution&Animal Models Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223China

Apart from mediating viral entry,the function of the free HIV-1 envelope protein(gp120)has yet to be *** group previously showed that EP2 derived from oneβ-strand in gp120 can form amyloid fibrils that increase HIV-1 ***,gp120 contains~30β-*** examined whether gp120 might serve as a precursor protein for the proteolytic release of amyloidogenic fragments that form amyloid fibrils,thereby promoting viral *** array scanning,enzyme degradation assays,and viral infection experiments in vitro confirmed that manyβ-stranded peptides derived from gp120 can indeed form amyloid fibrils that increase HIV-1 *** gp120-derived amyloidogenic peptides,or GAPs,which were confirmed to form amyloid fibrils,were termed gp120-derived enhancers of viral infection(GEVIs).GEVIs specifically capture HIV-1 virions and promote their attachment to target cells,thereby increasing HIV-1 *** GAPs can cross-interact to form heterogeneous fibrils that retain the ability to increase HIV-1 *** even suppressed the antiviral activity of a panel of antiretroviral ***,endogenous GAPs and GEVIs were found in the lymphatic fluid,lymph nodes,and cerebrospinal fluid(CSF)of AIDS patients in ***,gp120-derived amyloid fibrils might play a crucial role in the process of HIV-1 infectivity and thus represent novel targets for anti-HIV therapeutics.

关键词： HIV-1 gp120 Amyloid fibril Enhancement of viral infectivity

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Al-PHOSLOCK thin-layer capping to control phosphorus release from sediment: effect of hydraulic retention time and phosphorus migration/transformation mechanism

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JOURNAL OF SOILS AND SEDIMENTS 2021年第6期21卷 2474-2482页

作者： lin, Canyang Li, shuwen Zhu, Bolin Liu, Shupo Li, Fei Zhou, Zhenming Li, Tao Huaqiao Univ Coll Civil Engn Xiamen 361021 Peoples R China Hong Kong Polytech Univ Dept Civil & Environm Engn Hung Hom Kowloon Hong Kong Peoples R China

Purpose This work aimed to (i) investigate the effect of hydraulic retention time (HRT) on controlling the release of phosphorus from sediment and (ii) interpret the phosphorus migration and transformation mechanism in the Al-PHOSLOCK thin-layer capping system. Methods A 35-day laboratory dynamic simulation experiment was conducted by applying the Al-PHOSLOCK thin-layer capping to evaluate the effect of HRT on interrupting the release of phosphorus from contaminated sediments. The total phosphorus (TP), inorganic phosphorus (IP), organic phosphorus (OP), non-apatite inorganic phosphorus (NAIP), and apatite phosphorus (AP) were identified as different phosphorus species and analyzed during the experiment to further elucidate the migration and transformation of phosphorus. Results and discussion The release of phosphorus from contaminated sediment was successfully suppressed by the Al-PHOSLOCK capping layer with an efficiency of higher than 90%. The HRT exerted a dual role on phosphorus controlling: at low HRT, slight water flow facilitated phosphorus migrating out from sediment and diffusing to the overlying water;at high HRT, the migration of phosphorus from overlying water back to sediment was strengthened. It was demonstrated that the phosphorus release was effectively controlled by the Al-PHOSLOCK thin-layer capping under different HRT conditions (static, 0.5 d, 1.0 d, and 3.0 d). The mechanism of phosphorus migration and transformation in the Al-PHOSLOCK thin-layer capping system was elucidated, including three significant stages of physical interception, adsorption, and capture/hold/transform process. Conclusion This study verified the good capacity of the Al-PHOSLOCK capping system for controlling the release of sediment phosphorus under different HRT. Therefore, it was expected to be a promising approach in the handling of water eutrophication.

关键词： Hydraulic retention time Al-PHOSLOCK Thin-layer capping Contaminated sediment Phosphorus

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TME-responsive multistage nanoplatform for siRNA delivery and effective cancer therapy

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International Journal of Nanomedicine 2021年 16卷 5909-5921页

作者： Cao, shuwen lin, Chunhao Li, Xiuling Liang, Yixia Saw, Phei Er Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou China RNA Biomedical Institute Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou China

Since the discovery of RNA interference (RNAi), RNAi technology has rapidly developed into an efficient tool for post-transcriptional gene silencing, which has been widely used for clinical or preclinical treatment of various diseases including cancer. Small interfering RNA (siRNA) is the effector molecule of RNAi technology. However, as poly-anionic macromolecules, naked siRNAs have a short circulatory half-life (<15 min) and is rapidly cleared by renal filtration, which greatly hinders their clinical application. Furthermore, the anionic and macromolecular characteristics of naked siRNAs impede their readiness to cross the cell membrane and therefore delivery vehicles are required to facilitate the cellular uptake and cytosolic delivery of naked siRNAs. In the past decade, numerous nanoparticles (NPs) such as liposomes have been employed for in vivo siRNA delivery, which have achieved favorable therapeutic outcomes in clinical disease treatment. In particular, because tumor microenvironment (TME) or tumor cells show several distin-guishing biological/endogenous factors (eg, pH, enzymes, redox, and hypoxia) compared to normal tissues or cells, much attention has recently paid to design and construct TME-responsive NPs for multistaged siRNA delivery, which can respond to biological stimuli to achieve efficient in vivo gene silencing and better anticancer effect. In this review, we summarize recent advances in TME-responsive siRNA delivery systems, especially multi-stage delivery NPs, and discuss their design principles, functions, effects, and prospects. © 2021 Cao et al.

关键词： Cancer therapy Multistage delivery Nanoparticles SiRNA TME-responsive

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Degradable microneedle patches loaded with antibacterial gelatin nanoparticles to treat staphylococcal infection-induced chronic wounds

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2022年 217卷 55-65页

作者： Lei, Xiaoling Li, Mengjin Wang, Cheng Cui, Pengfei Qiu, lin Zhou, shuwen Jiang, Pengju Li, Haihang Zhao, Donghui Ni, Xinye Wang, Jianhao Xia, Jiang Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Nanjing Med Univ Affiliated Changzhou No Peoples Hosp 2 Changzhou Jiangsu Peoples R China Chinese Univ Hong Kong Dept Chem Hong Kong Peoples R China Huazhong Univ Sci & Technol Coll Life Sci & Technol Britton Chance Ctr Biomed Photon Wuhan Natl Lab Op Dept Biomed Engn Wuhan Hubei Peoples R China Jiangsu Trautec Med Technol Co Ltd Changzhou 213149 Jiangsu Peoples R China

Infection-induced chronic wounds cause prolonged pains, a high risk of amputation, and even increased mor-tality in immunocompromised patients. Here we report an antibacterial microneedle (MN) patch, which features high degradability in biological fluids and gelatinase-responsive release of an antibacterial photothermal peptide AMP-Cypate. We first synthesize gelatin nanoparticles (GNPs) and then conjugate the AMP-Cypate to afford composite AMP-Cypate@GNPs. The proteinaceous nanoparticles can responsively release AMP-Cypate in the presence of gelatinase, an enzyme secreted specifically by Staphylococcus aureus (S. aureus). AMP-Cypate@GNPs were then deposited in the tips of MNs fabricated by PVP and recombinant human type III collagen (Col III) to devise the antibacterial MN/AMP-Cypate@GNP patches. When applied to the infection site, MNs break through the epidermis and the stratum corneum, dissolve in the infected dermis, reach the bacterial colony or biofilm, release AMP-Cypate@GNPs, and exert a gelatinase-responsive photothermal therapy under near-infrared (NIR) irradiation to kill the pathogen S. aureus. In a rat model of staphylococcal infection-induced chronic wounds mimicking the condition of diabetic foot ulcer, the antibacterial MN/AMP-Cypate@GNP patches eradiated the bacterial infection and resulted in complete healing of the wounds, proving its potential application in the treatment of chronic wound infections and diabetic foot ulcers.

关键词： Degradable microneedle Antibacterial photothermal peptide Gelatinase-responsive release Recombinant human type III collagen Diabetic foot ulcer

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Elevated serum pepsinogen level predicts postoperative nausea and vomiting and pain in females with obesity following laparoscopic sleeve gastrectomy

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INTERNATIONAL JOURNAL OF OBESITY 2025年第4期49卷 665-672页

作者： Hou, Min Wu, lina Wei, Zhuoqi Jiang, shuwen Wang, Huaxi Chen, Wenhui Hu, Ruixiang Guan, Bingsheng Cheng, Lyujia Wang, Jianxue Hu, Songhao Wang, Cunchuan Zhang, Junchang Dong, Zhiyong Yang, Jingge lin, Qingran Yang, Wah Jinan Univ Affiliated Hosp 1 Dept Metab & Bariatr Surg Guangzhou Guangdong Peoples R China Jinan Univ Affiliated Hosp 1 Sch Nursing Guangzhou Guangdong Peoples R China Jinan Univ Affiliated Hosp 1 Dept Nursing Guangzhou Guangdong Peoples R China

BackgroundPostoperative nausea and vomiting (PONV) is the most common side effect after laparoscopic sleeve gastrectomy (LSG), affecting patients' postoperative recovery and increasing the medical and economic burden. This study aimed to analyze the relationship between serum pepsinogen and *** with obesity who underwent LSG in our center between January 2021 and December 2022 were divided into PONV and NoPONV groups and analyzed retrospectively. Binary logistic regression analysis was used to determine the independent risk factors for ***219 female patients were enrolled, with an average BMI of 36.74 +/- 8.34 kg/m2 and aged 32.61 +/- 6.18 years. PONV occurred in 157 patients (71.7%). The influencing factors of PONV with different severity were analyzed, and the results showed that the severity of postoperative pain (chi 2 = 13.169, p-values = 0.004), PGI (chi 2 = 14.625, p-values = 0.002), PGII (chi 2 = 25.916, p-values = 0.000), and PGR (chi 2 = 17.697, p-values = 0.001) had statistical significance. Binary logistic regression showed that PGI was a risk factor for PONV with a OR (ng/mL) value of 1.013 (95% CI: 1.001-1.024, p-values = 0.037), while PGR was a protective factor for PONV with an OR(ng/mL) value of 0.952 (95% CI: 0.925-0.979, p-values = 0.001).ConclusionsThe incidence of PONV after LSG is high. Higher PGI may be a risk factor for promoting PONV after LSG. The higher the preoperative PGI, the later the onset of PONV;the longer the duration, the more serious the degree.

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