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Nanodot-doped peptide hydrogels for antibacterial phototherapy and wound healing

BIOMATERIALS SCIENCE 2022年第3期10卷 654-664页

作者： Wang, Xuan Qiu, lin Wang, Cheng Gao, Zihan Zhou, shuwen Cui, Pengfei Jiang, Pengju Hu, Huaanzi Ni, Xinye Du, Xuancheng Wang, Jianhao Xia, Jiang Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Nanjing Med Univ Affiliated Changzhou Peoples Hosp 2 Changzhou Jiangsu Peoples R China Shandong Univ Sch Phys Inst Adv Interdisciplinary Sci Jinan 250100 Peoples R China Chinese Univ Hong Kong Dept Chem Shatin Hong Kong Peoples R China

Bacterial infection of wounds delays the healing process, increases the risk of chronic trauma associated with pain and complications, and offers a breeding ground for drug-resistant bacteria. A rapid and effective eradication of the bacterial species in the wound area is thus important. Herein, we designed a phototherapeutic antibacterial platform based on peptides and copper sulfide nanodots (CuS NDs) for multi-mechanistic eradication of bacteria colonized on the wound surface. The antimicrobial peptide weaves into a network in the form of a hydrogel, which supports CuS NDs to generate heat and produce reactive oxygen species (ROS) under the irradiation of near-infrared light (NIR). The heat and ROS generated in situ act as non-contact-based antibacterial factors and together with contact-based antimicrobial peptides cause irreversible membrane destruction, cell content damage, and thermal ablation of the bacteria. Lastly, nanodot-doped peptide hydrogels combined with collagen showed complete bacterial elimination and significantly accelerated wound healing in a splint-fixed mouse infection model.

关键词： Nanodots

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Construction of Tumor Microenvironment-Responsive Gene Carriers

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CHEMNANOMAT 2023年第11期9卷

作者： lin, Dongfa Yu, Chenxi Yang, Lixinhao Huang, Shangyuan Song, Muyi Liu, Shuting Guan, shuwen Jilin Univ Engn Lab AIDS Vaccine Changchun 130012 Peoples R China Jilin Univ Sch Life Sci Key Lab Mol Enzymol & Engn Minist Educ Changchun 130012 Peoples R China Shanghai Jiao Tong Univ Sheng Yushou Ctr Cell Biol & Immunol Sch Life Sci & Biotechnol Dept Genet & Dev BiolLab Mol Neurobiol 800 Dongchuan Rd Shanghai 200240 Peoples R China

Peptide- and polypeptide-based self-assembling gene delivery systems have received considerable attention owing to their inherent biocompatibility and bioactivity. Gene carriers based on elastin-like polypeptides (ELPs) have been extensively studied because of their controllability and unique temperature responsiveness. The (EK)10-PLGLAG-Tat polypeptide sequence was selected for tumor gene delivery, with ELP serving as the hydrophobic core. In this sequence, a hydration layer can be formed on the surface of the carrier using the zwitterionic peptide segment (EK)10, which helps prevent the nonspecific adsorption of plasma proteins. Additionally, the MMP-2 enzyme-responsive PLGLAG peptide segment is responsible for exposing the cell-penetrating peptide Tat specifically near tumor cells, facilitating the penetration of tumor cells. To introduce (EK)10-PLGLAG-Tat into the self-assembling carrier while ensuring its bioactivity, a leucine zipper ZR/ZE with opposite charges was used to link it to the ELP. Because of its high specificity and low systemic toxicity, the carrier was named environmentally responsive gene carrier (ERGV). Experimental results demonstrated that the ERGV effectively removed (EK)10 in MMP-2 overexpressed environments, altering the surface charge from negative to positive and facilitating ssDNA delivery into tumor cells. These findings highlight the potential of ERGVs as a safe and efficient method for targeted gene delivery to tumors. (EK)10 prevents plasma protein adsorption, and MMP-2-responsive PLGLAG exposes Tat near tumors. A leucine zipper connects (EK)10-PLGLAG-Tat to ELP, creating the environmentally responsive gene carrier (ERGV). ERGV efficiently targets tumors by modifying surface charge in MMP-2 environments, ensuring safe and effective gene delivery.+image

关键词： Gene therapy multifunctional gene carrier tumor microenvironment responsiveness polypeptide self-assembly

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Association of metformin treatment and outcome in adult patients with ITP and pre-existing T2DM

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BRITISH JOURNAL OF HAEMATOLOGY 2022年第3期197卷 367-372页

作者： Li, Chaoyang Sun, Meng Li, Ranran Wang, shuwen Shao, linlin Xu, Miao Yao, Meiyue Wang, lin Hou, Ming Feng, Qi Peng, Jun Shandong Univ Qilu Hosp Cheeloo Coll Med Dept Hematol Jinan 250012 Peoples R China Jinan Vocat Coll Nursing Jinan Peoples R China Shandong Univ Cheeloo Coll Med Sch Pharmaceut Sci Dept Pharmaceut Jinan Peoples R China Ningjin Cty Peoples Hosp Dept Radiol Dezhou Peoples R China Shandong Univ Qilu Hosp Cheeloo Coll Medcine Shandong Prov Key Lab Immunohematol Jinan 250012 Peoples R China Qilu Inst Technol Med Coll Jinan Peoples R China Shandong Univ Cheeloo Coll Med Adv Med Res Inst Jinan Peoples R China

Primary immune thrombocytopenia (ITP) is an autoimmune haemorrhagic disease that could manifest with comorbid type 2 diabetes mellitus (T2DM). However, the exact impact of T2DM in patients with ITP remains uncertain. In this study, we performed a retrospective cohort study of 458 participants with ITP. The prevalence of T2DM was 7.6% in this population (35 patients), which was slightly lower than the Chinese nationwide prevalence of T2DM, calculated to be approximately 10.9%. The participants with pre-existing T2DM displayed a significantly higher response to therapy than those without T2DM (71% vs. 53%). Furthermore, in the T2DM cohort, the response rate reached 88% when metformin was included in the treatment regimen. This clinical evidence suggests that metformin therapy might improve the clinical outcomes of ITP.

关键词： ITP metformin T2DM

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Research on the Thermal Properties of Urban Native Sewage Basedon Regression Model

Research on the Thermal Properties of Urban Native Sewage Ba...

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2023年工业设计与环境工程国际学术会议

作者： shuwen Ding lin Zhang Liang Liu Xiaotong Ren Junze Du School of Municipal and Environmental Engineering Shenyang Jianzhu University

At this stage, due to the lack of research on the basic thermophysical parameters of urban primary sewage, the change of thermophysical state of sewage cannot be well grasped, resulting in a low utilization rate of low-grade thermal energy of primary sewage. In this paper, a regression model is established based on the existing data to analyze the changes of basic thermophysical parameters such as density, thermal conductivity, constant pressure specific heat and other basic thermal properties of residential and industrial sewage at different sewage temperatures. Through model analysis, it is found that the density of residential sewage is significantly lower than that of industry. The sewage density of both types of sewage reached a maximum of about 10°C at a sewage temperature, and then showed a decreasing trend again. The thermal conductivity of residential sewage is lower than that of industrial sewage, and the thermal conductivity of sewage gradually increases with the increase of sewage temperature;From the analysis of constant pressure specific heat of sewage, the specific heat of residential sewage is greater than that of industrial type, and the specific heat of sewage decreases with the increase of temperature, and the change range is small.

关键词： Sewage thermal physical properties Regression model Clean energy

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New model of May cooperative system with strong and weak cooperative partners

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ADVANCES IN DIFFERENCE EQUATIONS 2020年第1期2020卷 1-20页

作者： lin, Qifa Lei, Chaoquan Luo, shuwen Xue, Yalong Ningde Normal Univ Dept Math Ningde Peoples R China Fuzhou Univ Coll Math & Comp Sci Fuzhou Peoples R China

In this paper, based on the model of Zhao, Qin, and Chen [Adv. Differ. Equ. 2018:172, 2018], we propose a new model of the May cooperative system with strong and weak cooperative partners. The model overcomes the drawback of the corresponding model of Zhao, Qin, and Chen. By using the differential inequality theory, a set of sufficient conditions that ensure the permanence of the system are obtained. By combining the differential inequality theory and the iterative method, a set of sufficient conditions that ensure the extinction of the weak partners and the attractivity of the strong partners and the other species is obtained. Numeric simulations show that too large transform rate will lead to more complicated fluctuation;however, the system is still permanent.

关键词： Mutualism Iterative method Weak partners Strong partners Global stability

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Dynamic effects of monopiles and sacrificial piles on Lagrangian residual velocity in an idealized rectangular bay

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OCEAN ENGINEERING 2025年 333卷

作者： Liu, Xudong Fan, Cheng Chen, lin Yu, Jinzhen Zhang, shuwen Wei, Zhangliang Deng, Fangjing Shantou Univ Inst Marine Sci Guangdong Prov Key Lab Marine Disaster Predict & P Shantou 515063 Peoples R China Chinese Acad Fishery Sci Yellow Sea Fisheries Res Inst State Key Lab Mariculture Biobreeding & Sustainabl Qingdao 266071 Peoples R China Chinese Acad Sci South China Sea Inst Oceanol Guangdong Prov Observat & Res Stn Coastal Upwellin Shantou 515041 Peoples R China

Previous studies have primarily addressed the effects of sacrificial pile shapes and arrangements on scour depth, with limited to their influences on Lagrangian residual velocity (LRV) and Lagrangian-averaged vorticity (LAV) dynamics. A monopile enhances surface inflow and diminishes bottom outflow, while sacrificial piles mitigate seaward circulation before the monopile, reducing long-term scour risks. The lateral LRV induces flow separation on both sides of the monopile, contrasting with homogeneous flow in no-pile scenarios. Sacrificial piles modify cross-estuary Lagrangian mean local acceleration and horizontal nonlinear advection terms, forming staggered high-magnitude southward and northward independent vortices that generate small-scale LRV structures. Monopile and sacrificial piles enhance vertical LRV via water column perturbations. LAV exhibits notable reversal structure before and after the monopile due to stagnation and bypass effects, attenuated near the bottom. Sacrificial piles markedly modify the Lagrangian mean time variation of vorticity (vLtvv) and Lagrangian mean advection of relative vorticity (vLarv), shifting the dominant surface-and middle-layer balance from a monopiledominated vLarv-vLbac (Lagrangian mean barotropic curl term) interaction to one that prominently involves vLtvv. In the bottom layer, transverse sacrificial piles induce a balance between vLarvand Lagrangian mean tilting term (vLtilt), whereas triangular pile arrangements preserve the original vLarv-vLbac balance.

关键词： Lagrangian residual velocity Lagrangian-averaged vorticity Monopile Sacrificial piles

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Identification of the "Collagen-Macrophage" sub-category of patients with colorectal cancer as an extension of the CMS4 subtype with THBS2 as a therapeutic target

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BMC GASTROENTEROLOGY 2025年第1期25卷 1-18页

作者： Chen, shuwen Jiang, Zhaoyan Song, Wanxuan Lu, Chuqiao lin, Yanbing Xu, Shiyao Xie, Kunxin Wan, Li Yuan, Xiaoqin Nanjing Med Univ Dept Anat Histol & Embryol Nanjing 211166 Peoples R China Nanjing Med Univ Clin Med Coll 1 Dept Clin Med Nanjing 211166 Peoples R China Sun Yat Sen Univ Affiliated Hosp 8 Res Ctr Environm & Female Reprod Hlth Shenzhen 518033 Peoples R China Nanjing Med Univ Dept Oncol Affiliated Huaian Peoples Hosp 1 Huaian 223302 Peoples R China Nanjing Med Univ Dept Biochem & Mol Biol Key Lab Human Funct Genom Jiangsu Prov Nanjing 211166 Peoples R China

We identified a subset of patients with colorectal cancer (CRC) enriched with "collagen-TAMs," designated the CM class, using large integrated colon cancer transcriptome and single-cell transcriptome datasets. This classification system could be used as an extension of the traditional CMS classification system for CRC to guide more accurate classification and *** also screened CAF-derived THBS2 as a potential biomarker for CM and found that it plays an important role in CRC disease models in vitro and in vivo, promoting tumor development and metastasis as well as TAM recruitment. Targeting THBS2 combined with PD-1 therapy effectively improved the therapeutic effect of immunotherapy in vivo. The CM classification provides a new perspective for CRC treatment, and THBS2, which is highly expressed in CM cases, can be used as a new potential combined target for immunotherapy.

关键词： Colorectal cancer Immunotherapy Classification system THBS2

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A Nomogram Based on Fibrinogen-to-Neutrophil Ratio as a Novel Predictor of Lymph Node Metastasis in Patients with Cervical Cancer and Type 2 Diabetes Mellitus

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CANCER MANAGEMENT AND RESEARCH 2025年 17卷 933-954页

作者： Kuang, Hongying Yang, Dongxia lin, Ruoyao Tang, Yaling Luo, Yongli Wang, shuwen Xia, Tingting Lou, Ge Chen, Hong Heilongjiang Univ Chinese Med Dept Gynecol Affiliated Hosp 1 Harbin 150040 Heilongjiang Peoples R China Heilongjiang Univ Chinese Med Dept Gynecol Affiliated Hosp 2 Harbin 150001 Heilongjiang Peoples R China Xiamen Univ Sch Med Dept Clin Med Xiamen 361005 Fujian Peoples R China Xiamen Univ Dept Obstet & Gynecol Affiliated Hosp 1 150 Shanggu St Xiamen 361003 Fujian Peoples R China Xiamen Univ Sch Med Dept Obstet & Gynecol Affiliated Hosp 1 Xiamen 361003 Fujian Peoples R China Harbin Med Univ Canc Hosp Dept Gynecol Harbin 150081 Heilongjiang Peoples R China

Background: The rising incidence of cervical cancer among individuals with diabetes is a matter of significant concern, presenting profound implications for the health status and quality of life worldwide. In patients diagnosed with early-stage cervical cancer, the extent of lymph node involvement has emerged as a critical prognostic factor influencing recurrence risk and survival outcomes. Therefore, the precise prediction of pelvic lymph node metastasis is essential for an accurate assessment of prognosis. The preoperative identification of lymph node metastasis constitutes a pivotal element in the formulation of personalized treatment strategies. It has been demonstrated that inflammatory markers such as neutrophils, lymphocytes, and fibrinogen significantly contribute to cancer progression and prognostic evaluations. In this regard, we propose the fibrinogen-toneutrophil ratio (FNR) as an innovative and promising biomarker for evaluating pelvic lymph node metastasis in cervical cancer patients with type 2 diabetes. Methods: The study was conducted on 141 patients diagnosed with cervical cancer and concomitant type 2 diabetes, who were treated at the First Affiliated Hospital of Xiamen University. The patients were randomly divided into a training set (n=98) and a validation set (n=43), with a ratio of 7:3. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors, and a prognostic model was established based on these findings. The model's effectiveness was evaluated. Results: A nomogram that integrates multiple factors, including FNR, triglycerides, maximum diameter, and total protein, demonstrates superior potential in predicting pelvic lymph node metastasis in patients with type 2 diabetes and cervical cancer, compared to the use of a single biomarker. Conclusion: As a comprehensive biomarker, FNR shows significant potential in offering a more thorough and reliable approach for identifying cervical cancer pati

关键词： cervical cancer diabetes mellitus pelvic lymph node metastasis fibrinogen-to-neutrophil ratio inflammatory biomarkers preoperative prediction

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Diaphragma sellae sinking can predict the onset of hyponatremia after transsphenoidal surgery for pituitary adenomas

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JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 2021年第11期44卷 2511-2520页

作者： lin, Kunzhe Li, Jun Lu, lingling Zhang, Shangming Mu, shuwen Pei, Zhijie Wang, Cheng lin, Jingying Xue, Liang Wei, Liangfeng Zhao, lin Wang, Shousen Fujian Med Univ Fuzong Clin Med Coll Fuzhou 350025 Peoples R China 900th Hosp Dept Neurosurg Fuzhou 350025 Peoples R China Fujian Univ Tradit Chinese Med Fuzong Clin Med Coll Fuzhou 350122 Peoples R China

Purpose Sinking of the diaphragma sellae (DS) may stretch the pituitary stalk, which in turn impairs neurohypophyseal function;thus, it may play a role in the development of postoperative hyponatremia. We aimed to assess the factors influencing the development of hyponatremia after transsphenoidal surgery (TSS) for pituitary adenomas and analyze the effect of DS sinking on hyponatremia. Methods After applying the inclusion and exclusion criteria, we retrospectively analyzed the clinical data of patients with pituitary adenoma who underwent TSS. The pituitary gland was scanned using a 3.0-T magnetic resonance imaging, and sagittal and coronal images were acquired. We evaluated the following: preoperative and postoperative hypothalamus-pituitary-thyroid axis function, hypothalamus-pituitary-adrenal axis function, intra-operative cerebrospinal fluid leaks, diabetes insipidus, hyponatremia, time from the day of surgery to the day of discharge, and time of hyponatremia onset. Results Of the 460 patients who had microscopic TSS for pituitary adenoma, 83 experienced postoperative hyponatremia. Hyponatremia occurred approximately 5.25 days postoperatively and persisted for 5.54 days. The lowest average blood sodium level was 123.9 mEq/L, which occurred at 7.49 days after surgery. Logistic regression analysis showed that the risk of hyponatremia was greater for patients with a significant DS sinking depth, a large pituitary stalk deviation angle difference, and a longer postoperative "measurable pituitary stalk". The difference in blood sodium levels between pre-TSS and 2 days post-TSS was also an independent predictor of postoperative hyponatremia onset. Conclusion DS sinking plays an important role in predicting hyponatremia onset after TSS for pituitary adenomas.

关键词： Hyponatremia Hypothalamo-hypophyseal system Pituitary adenoma Diaphragma sellae

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uGrapher: High-Performance Graph Operator Computation via Unified Abstraction for Graph Neural Networks 2023

uGrapher: High-Performance Graph Operator Computation via Un...

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28th ACM International Conference on Architectural Support for Programming Languages and Operating Systems (ASPLOS)

作者： Zhou, Yangjie Leng, Jingwen Song, Yaoxu Lu, shuwen Wang, Mian Li, Chao Guo, Minyi Shen, Wenting Li, Yong lin, Wei Liu, Xiangwen Wu, Hanqing Shanghai Jiao Tong Univ Shanghai Peoples R China Alibaba Grp Hangzhou Peoples R China Alibaba Grp Beijing Peoples R China

ISBN: (纸本)9781450399166

As graph neural networks (GNNs) have achieved great success in many graph learning problems, it is of paramount importance to support their efficient execution. Different graphs and different operators present different patterns during execution. However, there is still a gap in the existing GNN acceleration research to explore adaptive parallelism. We show that existing GNN frameworks rely on handwritten static kernels, which fail to achieve the best performance across different graph operators and input graph structures. In this work, we propose uGrapher, a unified interface that achieves general high performance for different graph operators and datasets. The existing GNN frameworks can easily integrate our design for its simple and unified API. We take a principled approach that decouples a graph operator's computation and schedule to achieve that. We first build a GNN-specific operator abstraction that incorporates the semantics of graph tensors and graph loops. We explore various schedule strategies based on the abstraction that can balance the well-established trade-off relationship between parallelism, locality, and efficiency. Our evaluation shows that uGrapher can bring up to 29.1x (3.5x on average) performance improvement over the state-of-the-art baselines on two studied NVIDIA GPUs.

关键词： Graph Neural Networks AI Frameworks Graphics Processing Unit

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