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Preference for HIV testing among community residents in Yunnan Province, China: results from a discrete choice experiment

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BMC HEALTH SERVICES RESEARCH 2025年第1期25卷 1-12页

作者： Yang, Jingwen Qiu, Chenquan Tang, Renhai Dong, Wenbin Yao, Enlong Wang, Huyunzhao lin, shuwen Xiao, Minyang Zhang, Zuyang Niu, Jin Fu, Liru Song, Lijun Li, Xuehua Shi, Yuhua Wang, Xiaowen Kunming Med Univ 1168Yuhua St Kunming Yunnan Province Peoples R China Qujing Municipal Ctr Dis Control & Prevent Qujing Yunnan Province Peoples R China Dehong Municipal Ctr Dis Control & Prevent Dehong Yunnan Province Algeria Yuxi Municipal Ctr Dis Control & Prevent Yuxi Yunnan Province Peoples R China Honghe Municipal Ctr Dis Control & Prevent Honghe Yunnan Province Peoples R China Puer Municipal Ctr Dis Control & Prevent Puer Yunnan Province Peoples R China Dali Univ Dali Yunnan Province Peoples R China Yunnan Ctr Dis Control & Prevent 1177 Xianghe St Kunming 650500 Yunnan Peoples R China Yunnan Key Lab Cross Border Infect Dis Control & P 1177 Xianghe St Kunming Yunnan Province Peoples R China

BackgroundThe detection and early identification of people living with HIV/AIDS (PLWH) and their rapid engagement in antiretroviral treatment are indispensable for fighting HIV transmission. This study aimed to elicit preferences regarding HIV testing among community residents to identify a model of community-based HIV testing services that would appeal to this population. MethodsA discrete-choice experiment (DCE) was conducted in the communities of Yunnan Province, China. The participants were asked to make nine choices between two unlabelled alternatives that differed in seven attributes: distance to the testing venue, confidentiality, institution, administrator, support services, testing days, and testing cost. The data were analysed using a random parameter logit model. The preference regression coefficient (beta) was used to compare the importance of attribute levels. Relative importance (RI) was used to indicate the degree of importance of each attribute to the participants. ResultsThe results indicate confidentiality was the most important attribute (RI = 39.21%), followed by testing cost (RI = 25.15%), administrator (RI = 11.91%), institution (RI = 11.29%), support services (RI = 8.02%), distance (RI = 4.25%), and testing day (RI = 0.16%). The participants in our study showed a preference for confidentiality regarding the testing status (beta = 1.82, p < 0.001), for the test being available at hospitals (beta = 0.72, p < 0.001), and for the test being administered by physicians (beta = 0.74, p < 0.001). We also observed that having support services was preferable (beta = 0.50, p < 0.01) to support services not being available. Free HIV testing was the most preferred cost attribute (beta = 1.61, p < 0.001). The distance and testing days were not significantly different (p > 0.05). ConclusionsCommunity residents preferred an HIV testing service run by physicians in high-level health care institutions with excellent confidentiality, low cost, and available supp

关键词： Discrete choice experiment HIV testing Preferences Confidentiality Community residents

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Energy Efficiency Optimization for RIS-Aided Systems Using a Measured Power Model

Energy Efficiency Optimization for RIS-Aided Systems Using a...

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2025 IEEE Wireless Communications and Networking Conference, WCNC 2025

作者： lin, shuwen Sang, Jian Li, Xiao Tang, Wankai Di Renzo, Marco Jin, Shi Southeast University National Mobile Communications Research Laboratory Nanjing210096 China Université Paris-Saclay Cnrs CentraleSupélec Laboratoire des Signaux et Systèmes Gif-sur-Yvette France King's College London Centre for Telecommunications Research Department of Engineering LondonWC2R 2LS United Kingdom

ISBN: (纸本)9798350368369

Reconfigurable intelligent surface (RIS) technology has gained wide recognition for its ability of enhancing the performance of wireless communication systems. This paper investigates the energy efficiency (EE) of a discrete phase shift RIS-assisted multi-cell communication system. Assuming that only statistical channel state information is available, we maximize the EE under a practical measured-based RIS power consumption model. Approximating the discrete measured-based RIS power consumption model by a continuous differentiable function, the problem is addressed by jointly optimizing the transmit beamforming at the base stations and the RIS phase shift matrix, by using fractional programming and complex circle manifold techniques. Simulation results demonstrate that the proposed algorithm can effectively achieve near-optimal EE performance and low RIS power consumption. © 2025 IEEE.

关键词： Communication channels (information theory)

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The incidence and risk of cardiovascular events associated with pembrolizumab in patients with breast cancer

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CANCER LETTERS 2025年 611卷 217277-217277页

作者： Chiang, Cho-Han Xu, Xiaocao (Haze) Song, Junmin Xanthavanij, Nutchapon Chi, Kuan-Yu Chang, Yu-Cheng Chang, Yu Hsiao, Chieh-Lien Hsia, Yuan Ping Chiang, Cho-Hung lin, shuwen Harvard Med Sch Mt Auburn Hosp Dept Med Cambridge MA USA Univ Vermont Dept Med Div Hematol & Oncol Med Ctr Burlington VT USA Albert Einstein Coll Med Jacobi Med Ctr Dept Med Bronx NY USA Danbury Hosp Dept Med Danbury CT USA Natl Cheng Kung Univ Natl Cheng Kung Univ Hosp Coll Med Sect NeurosurgDept Surg Tainan Taiwan Columbia Univ Sch Int & Publ Affairs New York NY USA Taipei Tzu Chi Hosp Buddhist Tzu Chi Med Fdn Dept Family Med 289 Jianguo Rd New Taipei 231405 Taiwan Natl Taiwan Univ Hosp Dept Internal Med Taipei Taiwan Albert Einstein Coll Med Dept Oncol Montefiore Einstein Canc Ctr MECC Montefiore Med Ctr Bronx NY USA

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstat... 详细信息

关键词： Cardiovascular events Cardiotoxicity Pembrolizumab Immune checkpoint inhibitor Breast cancer

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Energy Efficiency Optimization for RIS-Aided Systems Using a Measured Power Model

Energy Efficiency Optimization for RIS-Aided Systems Using a...

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IEEE Conference on Wireless Communications and Networking

作者： shuwen lin Jian Sang Xiao Li Wankai Tang Marco Di Renzo Shi Jin National Mobile Communications Research Laboratory Southeast University Nanjing China CNRS CentraleSupélec Laboratoire des Signaux et Systèmes Université Paris-Saclay Gif-sur-Yvette France Department of Engineering King's College London Centre for Telecommunications Research London United Kingdom

ISBN: (数字)9798350368369

ISBN: (纸本)9798350368376

关键词： Wireless communication Power demand Power measurement Array signal processing Simulation Reconfigurable intelligent surfaces Approximation algorithms Energy efficiency Optimization Channel state information

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THE PROMISE AND CHALLENGES OF FERTILITY PRESERVATION COUNSElinG OF BREAST CANCER PATIENTS IN AN UNDER-RESOURCED POPULATION

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FERTILITY AND STERILITY 2024年第4期122卷 E408-E408页

作者： Chervenak, Joseph lin, shuwen Applebaum, Noa Makower, Della Lieman, Harry J. Montefiore Med Ctr Albert Einstein Coll Med Bronx NY 10467 USA

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Glucagon-like Peptide-1 Agonists Reduce Cardiovascular Events in Cancer Patients on Immune Checkpoint Inhibitors

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EUROPEAN JOURNAL OF CANCER 2025年 216卷 115170-115170页

作者： Chiang, Cho-Han Song, Junmin Chi, Kuan-Yu Chang, Yu-Cheng Xanthavanij, Nutchapon Chang, Yu Hsia, Yuan Ping Chiang, Cho-Hung Ghamari, Azin Reynolds, Kerry L. lin, shuwen Xu, Xiaocao (Haze) Neilan, Tomas G. Harvard Med Sch Mt Auburn Hosp Dept Med Cambridge MA USA Albert Einstein Coll Med Jacobi Med Ctr Dept Med Bronx NY USA Danbury Hosp Dept Med Danbury CT USA Natl Cheng Kung Univ Coll Med Natl Cheng Kung Univ Hosp Dept SurgSect Neurosurg Tainan Taiwan Buddhist Tzu Chi Med Fdn Taipei Tzu Chi Hosp Dept Family Med New Taipei Taiwan Natl Taiwan Univ Hosp Dept Internal Med Taipei Taiwan Harvard Med Sch Massachusetts Gen Hosp Cardiovasc Imaging Res Ctr Dept Radiol Boston MA USA Harvard Med Sch Massachusetts Gen Hosp Div Cardiol Boston MA USA Harvard Med Sch Massachusetts Gen Hosp Dept Med Cardiooncol Program Boston MA USA Massachusetts Gen Hosp Dept Med Div Hematol & Oncol Boston MA USA Albert Einstein Coll Med Dept Oncol Montefiore Einstein Canc Ctr MECC Montefiore Med Ctr Bronx NY 10461 USA

Background: Immune checkpoint inhibitors (ICIs) are associated with an increased risk of major adverse cardiovascular events (MACE). Glucagon-like peptide-1 agonists (GLP1a), initially developed for type 2 diabetes mellitus (T2DM), have shown promising results in reducing cardiovascular events. We aimed to investigate the effect of GLP1a on cardiovascular events in patients receiving ICIs. Methods: We conducted a retrospective, propensity score-matched cohort study using the TriNetX database. We identified adults with cancer and T2DM who received ICIs between April 2013 and May 2023. The primary efficacy outcome was incident MACE, defined as a composite of myocardial infarction, need for coronary revascularization, heart failure, ischemic stroke, and cardiac arrest. The secondary efficacy outcomes were the individual components of MACE as well as myocarditis and pericarditis. Safety outcomes included the occurrence of immune-related adverse events, serious adverse events related to GLP1a use, and all-cause mortality. Results: We identified 7651 patients eligible for inclusion, among which 479 received GLP1a and 7172 received non-GLP1a diabetes medications. After matching (469 patients each), baseline characteristics were wellbalanced. Over a median 12-month follow-up, the GLP1a cohort had a significantly lower MACE incidence than the non-GLP1a cohort (9.0 vs. 17.1 events per 100 patient-years) with a 54 % lower risk of MACE (Hazard ratio (HR),0.46 [95 % CI: 0.32-0.67]). There were reductions in myocardial infarction or need for coronary revascularization, heart failure, and all-cause mortality, with no differences in other cardiovascular events. GLP1a use did not increase risk of adverse events, including pancreatitis, biliary disease, bowel obstruction, gastroparesis, and immune-related adverse events. Conclusion: GLP1a use in cancer patients with T2DM receiving ICIs was associated with reduced MACE and allcause mortality without an increased risk in serious advers

关键词： Immune checkpoint inhibitor Cardiovascular event Immune-related adverse event Glucagon-like peptide-1 agonists

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Prognostic value of lymphocyte to monocyte ratio in pancreatic cancer: a systematic review and meta-analysis including 3338 patients

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WORLD JOURNAL OF SURGICAL ONCOLOGY 2020年第1期18卷 1-11页

作者： lin, shuwen Fang, Yinghua Mo, Zhikang lin, Ye Ji, Chenggang Jian, Zhixiang Jinan Univ Coll Med Dongguan Affiliated Hosp Dept Gen SurgBinhaiwan Cent Hosp Dongguan Dongguan 523905 Guangdong Peoples R China Jinan Univ Coll Med Dongguan Affiliated Hosp Dept PainBinhaiwan Cent Hosp Dongguan Dongguan 523905 Guangdong Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Dept Gen Surg 106 Zhongshan Er Rd Guangzhou 510080 Guangdong Peoples R China

BackgroundRecently, reports have classified lymphocyte to monocyte ratio (LMR) as an effective indicator for predicting the prognosis of pancreatic cancer. Nevertheless, the prognostic value of LMR for pancreatic cancer remains controversial. Through meta-analysis, this work intends to evaluate the potential prognostic role of pretreatment LMR in patients diagnosed with pancreatic *** reviewed and extracted eligible articles from Web of Science, PubMed, Cochrane Library, and Embase. A meta-analysis was conducted using hazard ratio (HR) and 95% confidence intervals (CIs) to assess the comparison between pretreatment LMR and overall survival (OS) and disease-free survival/recurrence-free survival/time to progression (DFS/RFS/TTP).ResultsIn total, 11 studies (16 cohorts) including 3338 patients diagnosed with pancreatic cancer (PC) were enrolled in our meta-analysis. Notably, we revealed that high pretreatment LMR predicted better overall survival (OS) (HR = 0.68, 95% CI 0.58-0.80, P < 0.001, I-squared = 69.3%, Ph < 0.001) and DFS/RFS/TTP (HR = 0.55, 95% CI 0.31-0.96, P = 0.037, I-squared = 89.9%, Ph < 0.001) in patients with pancreatic cancer. Further, through subgroup analyses, we showed that high pretreatment LMR was significantly associated with the favorable OS regardless of ethnicity, study design, treatment method, variable type, the cut-off value for LMR, and disease stages of I-IV and *** findings from our study suggest that high pretreatment LMR is associated with better OS and DFS/RFS/TTP in patients diagnosed with pancreatic cancer. As such, it can potentially serve as a novel prognostic biomarker for patients with pancreatic cancer.

关键词： Lymphocyte to monocyte ratio Pancreatic cancer Prognosis Meta-analysis

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Circ_0091581 Promotes the Progression of Hepatocellular Carcinoma Through Targeting miR-591/FOSL2 Axis

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DIGESTIVE DISEASES AND SCIENCES 2021年第9期66卷 3074-3085页

作者： Ji, Chenggang Hong, Xiaocheng Lan, Bo lin, Ye He, Yingxin Chen, Jiayang Liu, Xi Ye, Weijie Mo, Zhikang She, Zhanpeng lin, shuwen Jinan Univ Med Coll Dongguan Affiliated Hosp Dept Gen SurgBinhaiwan Cent Hosp Dongguan 111 Humen Rd Dongguan 523905 Guangdong Peoples R China Jinan Univ Med Coll Dongguan Affiliated Hosp Dept Anorectal SurgBinhaiwan Cent Hosp Dongguan Dongguan Guangdong Peoples R China Guangdong Prov Peoples Hosp Dept Gen Surg Guangzhou Guangdong Peoples R China

Background Circular RNAs (circRNAs) have shown crucial regulatory roles in cancer biology. We aimed to uncover the role and underlying mechanism of circ_0091581 in hepatocellular carcinoma (HCC) progression. Methods The abundance of circ_0091581, microRNA-591 (miR-591) and FOS like 2, AP-1 transcription factor subunit (FOSL2) was measured by quantitative real-time polymerase chain reaction. Cell viability, colony formation ability, and invasion ability were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, colony formation assay, and transwell invasion assay. The migration ability was analyzed by transwell migration assay and wound healing assay. Flow cytometry was used to evaluate the cell cycle and apoptosis of HCC cells. The interaction between miR-591 and circ_0091581 or FOSL2 was predicted by Circular RNA Interactome database or TargetScan database and confirmed by dual-luciferase reporter assay and RNA immune co-precipitation assay. FOSL2 protein expression was measured by Western blot assay. Xenograft tumor assay was conducted to analyze the role of circ_0091581 in HCC tumor growth in vivo. Results Circ_0091581 was highly expressed in HCC tissue samples and cell lines in contrast to that in adjacent normal tissue samples and THLE-2 cell line. Circ_0091581 accelerated the viability, colony formation, metastasis, and cell cycle, while it impeded the apoptosis of HCC cells. MiR-591 bound to circ_0091581, and circ_0091581 knockdown-mediated effects in HCC cells were largely overturned by miR-591 silencing. FOSL2 was a target of miR-591, and FOSL2 overexpression largely reversed miR-591 accumulation-induced influences in HCC cells. FOSL2 protein expression was down-regulated by circ_0091581 silencing, and the addition of miR-591 inhibitor partly recovered the expression of FOSL2 in HCC cells. Circ_0091581 interference notably suppressed HCC tumor growth in vivo. Conclusion Circ_0091581 acted as an oncogene to enhance the viabili

关键词： Hepatocellular carcinoma (HCC) circ_0091581 miR-591 FOSL2

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Curve and surface reconstruction based on MTLS algorithm combined with k-means clustering

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MEASUREMENT 2021年 182卷

作者： Gu, Tianqi lin, Hongxin Tang, Dawei lin, shuwen Luo, Tianzhi Fuzhou Univ Sch Mech Engn & Automat Fuzhou 350108 Peoples R China Univ Sci & Technol China Dept Modern Mech CAS Key Lab Mech Behav & Design Mat Hefei 230022 Peoples R China Univ Huddersfield Ctr Precis Technol Huddersfield HD1 3DH W Yorkshire England

Curve and surface reconstruction methods play an important role in many research and engineering fields. It is an imperative procedure to carry out surface reconstruction from measurement data in reverse engineering, which is complicated with the presence of outliers. To achieve better accuracy and robustness of reconstruction, an improved moving total least squares (MTLS) algorithm based on k-means clustering called a KMTLS method is proposed in this article. Based on MTLS, KMTLS adjusts the weight of discrete points within the support domain by adopting a two-step fitting procedure. Firstly, an ordinary least squares (OLS) method is adopted to obtain the pre-fitting result and calculate the residuals as the input of k-means clustering. In k-means clustering, abnormal nodes are classified into one cluster and a weight function based on clustering information is introduced to deal with these nodes. Secondly, based on the compact weight function in MTLS and the weight obtained in the prefitting procedure, a weighted total least squares method is conducted to determine the final estimated value. The process of detecting outliers is automatic without setting threshold artificially. The simulation and experiment show that KMTLS has great robustness and accuracy.

关键词： Surface reconstruction Moving least squares K-means clustering Outliers

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挖掘机斗杆结构应力神经网络建模

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机械制造与自动化 2024年第4期53卷 154-160页

作者：李军罗承旭林述温福州大学机械工程及自动化学院福建福州350108

为了研究斗杆结构应力神经网络建模方法,在分析不同典型工况下斗杆结构的应力分布特征基础上,确定斗杆结构的应力特征截面,分析斗杆结构各尺寸参数对各特征截面应力的灵敏度,据此确定斗杆结构应力神经网络模型的输入变量,进行结构应力... 详细信息

为了研究斗杆结构应力神经网络建模方法,在分析不同典型工况下斗杆结构的应力分布特征基础上,确定斗杆结构的应力特征截面,分析斗杆结构各尺寸参数对各特征截面应力的灵敏度,据此确定斗杆结构应力神经网络模型的输入变量,进行结构应力神经网络建模,并对不同神经网络模型结构进行预测误差对比分析。结果表明:所建立的模型可快速预测斗杆结构特征截面的应力,实训样本预测误差小于10%。

关键词：挖掘机斗杆结构 BP神经网络应力预测应力特征截面

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