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机械制造与自动化 2018年第5期47卷 28-32页

作者：林盖林述温福州大学机械工程及自动化学院福建福州350108

为获得更加精确的高速铣削钛合金表面粗糙度预测模型,采集铣削过程加速度振动信号,分析铣削系统的振动特性对表面粗糙度的影响。通过功率谱分析量化振动信号特征,并用主成分分析简化数据结构,得到的振动特征量能反映原始数据89.719%的... 详细信息

为获得更加精确的高速铣削钛合金表面粗糙度预测模型,采集铣削过程加速度振动信号,分析铣削系统的振动特性对表面粗糙度的影响。通过功率谱分析量化振动信号特征,并用主成分分析简化数据结构,得到的振动特征量能反映原始数据89.719%的信息。最后以振动特征量和铣削参数为影响因素,建立了表面粗糙度的预测模型。结果表明,主轴的振动特性对表面粗糙度的影响大于工作台,刀具进给方向的振动特性对表面粗糙度的影响大于其余方向。

关键词：振动特性功率谱分析主成分分析回归模型表面粗糙度高速铣削

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Finite element simulation and experimental research on microcutting mechanism of single crystal silicon

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INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY 2020年第3-4期110卷 909-918页

作者： Liu, Bing Li, shuwen Li, Rui Chen, Cheng Liang, lin Tianjin Univ Commerce Sch Mech Engn Tianjin 300134 Peoples R China Tianjin Univ Sch Mech Engn Tianjin 300072 Peoples R China

Microcutting technology, which has been proven to be an indispensable means for investigating the material removal mechanism, is able to realize the high efficiency processing of brittle materials with an ultrasmooth surface and a low-damage subsurface. In this study, a series of simulations were performed by finite element (FE) method to investigate the microcutting mechanism of the typical semiconductor material, single crystal silicon. The FE cutting models were established in terms of the Johnson-Cook constitutive relation. First, the material removal behavior during the microcutting process was studied. The results indicated that the chip formation was dominated by extrusion rather than shearing action, and both sides of the chips were smooth without any wrinkle or shear band. Then, the cutting force and cutting heat during the microcutting process were analyzed in deep. It was determined that when the cutting characteristic size reduced to less than the tool edge radius, much energy was needed to remove the materials per unit volume. Besides, microcutting experiments were conducted using a specially designed cutting platform in a scanning electron microscope, and the experimental results were observed to be in agreement with the FE simulation results.

关键词： Single crystal silicon Finite element Microcutting Chip formation Material removal

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Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression

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BEHAVIOURAL BRAIN RESEARCH 2024年 468卷 115028页

作者： Cheng, Jiao Yuan, lin Yu, shuwen Gu, Bing Luo, Qian Wang, Xixi Zhao, Yijing Gai, Chengcheng Li, Tingting Liu, Weiyang Wang, Zhen Liu, Dexiang Ho, Roger C. M. Ho, Cyrus S. H. Shandong Univ Cheeloo Coll Med Sch Basic Med Sci Dept Med Psychol & Ethics Jinan 250012 Shandong Peoples R China Shandong First Med Univ Affiliated Hosp 1 Dept Clin Lab Jinan 250012 Shandong Peoples R China Shandong Univ Cheeloo Coll Med Sch Basic Med Sci Dept Physiol Jinan 250012 Shandong Peoples R China Jinan Xicheng Expt High Sch Dept Pediat Surg Dezhou Rd Jinan 1999 Shandong Peoples R China Natl Univ Singapore Yong Loo Lin Sch Med Dept Psychol Med Singapore Singapore Natl Univ Singapore Inst Hlth Innovat & Technol iHealthtech Singapore Singapore

Early life stress (ELS) increases the risk of depression later in life. Programmed cell death factor 4 (PDCD4), an apoptosis-related molecule, extensively participates in tumorigenesis and inflammatory diseases. However, its involvement in a person's susceptibility to ELS-related depression is unknown. To examine the effects and underlying mechanisms of PDCD4 on ELS vulnerability, we used a "two-hit" stress mouse model: an intraperitoneal injection of lipopolysaccharide (LPS) into neonatal mice was performed on postnatal days 7-9 (P7-P9) and inescapable foot shock (IFS) administration in adolescent was used as a later-life challenge. Our study shows that compared with mice that were only exposed to the LPS or IFS, the "two-hit" stress mice developed more severe depression/anxiety-like behaviors and social disability. We detected the levels of PDCD4 in the hippocampus of adolescent mice and found that they were significantly increased in "two-hit" stress mice. The results of immunohistochemical staining and Sholl analysis showed that the number of microglia in the hippocampus of "two-hit" stress mice significantly increased, with morphological changes, shortened branches, and decreased numbers. However, knocking down PDCD4 can prevent the number and morphological changes of microglia induced by ELS. In addition, we confirmed through the Golgi staining and immunohistochemical staining results that knocking down PDCD4 can ameliorate ELS-induced synaptic plasticity damage. Mechanically, the knockdown of PDCD4 exerts neuroprotective effects, possibly via the mediation of BDNF/AKT/CREB signaling. Combined, these results suggest that PDCD4 may play an important role in the ELS-induced susceptibility to depression and, thus, may become a therapeutic target for depressive disorders.

关键词： Early -life stress PDCD4 Synaptic plasticity Depression susceptibility "two -hit" stress

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Facile preparation of copper-gallic acid nanoparticles as a high reproducible and drug loading platform for doxorubicin

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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 2022年 76卷

作者： Chang, Yufeng Rui, Wen Zhang, Miaomiao Zhou, shuwen Qiu, lin Cui, Pengfei Hu, Huaanzi Jiang, Pengju Du, Xuancheng Ni, Xinye Wang, Cheng Wang, Jianhao Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Nanjing Med Univ Peoples Hosp Changzhou 2 Changzhou 213003 Peoples R China Shandong Univ Inst Adv Interdisciplinary Sci Sch Phys Jinan 250100 Peoples R China Nanjing Med Univ People Hosp Changzhou 2 Changzhou 213003 Peoples R China

Purpose: Doxorubicin (DOX) is the first line drug for cancer chemotherapy but its application is limited by the poor bioavailability and high side effects. Current drug delivery systems (DDSs) of DOX can overcome the above mentioned shortages, but also brings new challenges including low reproducibility and DOX loading. Therefore, the one-step preparation of related DDSs with high DOX loading capacity is highly ***: Herein, taking advantage of the high complexing ability of both gallic acid (GA) and DOX to metal ions, copper ion was selected as a model ion to serve as a medium, not only to form nanostructured platform with GA, but also as a linker to give high DOX loading capacity to the developed ***: We herein introduced a facile method to conveniently prepare DOX loaded DDSs (Cu-GA-DOX NPs) with high reproducibility and drug loading of DOX (23.07%), which also showed uniform particle size, good biocompatibility as well as decent anticancer performance on model colorectal cancers (CT26). Conclusion: This study provides a new strategy and pave the way for the subsequent development of DDS with high reproducibility and DOX loading.

关键词： Doxorubicin Anticancer Metal ions Drug delivery system

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SLEEPWISE: A Continuous Sleep Monitoring and Cognitive Evaluation Platform in Ambient Residential Environment

SLEEPWISE: A Continuous Sleep Monitoring and Cognitive Evalu...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： shuwen Jin Danqiong Wang Xiao Ma Tao Li Feng lin Lei Yu Qing Zhang Research Center for Frontier Fundamental Studies Zhejiang Lab Hangzhou China Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Tongji Shanxi Hospital Third Hospital of Shanxi Medical University Taiyuan China Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Key Laboratory of Complex Systems and Data Science of Ministry of Education Complex Systems Research Center Shanxi University China

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Age-related cognitive decline presents a significant health challenge for older adults, with no specific medication available to counteract it. Early detection of cognitive decline is crucial for timely intervention and effective management. Sleep status plays a vital role in evaluating cognitive function, as disrupted sleep patterns are associated with cognitive decline and increased risk of neurodegenerative conditions. Existing methods for assessing sleep status, such as self-report questionnaires, actigraphy, and polysomnography, lack the ability to consistently monitor sleep status over a long period. In this paper we introduced SLEEPWISE, an AI-powered platform deployed in residential environments for continuous ambient sleep monitoring to assess the cognitive well-being of older adults. SLEEPWISE utilizes non-contact pads with highly sensitive piezoelectric sensors to monitor sleep parameters such as duration and efficiency, which are transmitted daily to the server. Moreover, we have also developed a gamified module for SLEEPWISE, allowing an objective assessment of daily cognitive functions. This module aids SLEEPWISE in establishing the correlation models between sleep and cognitive health. To evaluate the effectiveness of SLEEP-WISE, a pilot study was conducted with participants recruited from a local hospital. During the 30-days trials, SLEEPWISE identified a negative impact on congnitive performance associated with increased nocturnal body movements and getting out of bad. These findings emphasize the potential of SLEEPWISE as an early screening tool for evaluating daily cognitive health and well-being.

关键词： Correlation Hospitals Sensors Servers Biomedical monitoring Older adults Engineering in medicine and biology Monitoring

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Transforming Healthcare: Intelligent Wearable Sensors Empowered by Smart Materials and Artificial Intelligence

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ADVANCED MATERIALS 2025年第21期37卷 e2500412页

作者： Chen, shuwen Fan, Shicheng Qiao, Zheng Wu, Zixiong lin, Baobao Li, Zhijie Riegler, Michael A. Wong, Matthew Yu Heng Opheim, Arve Korostynska, Olga Nielsen, Kaare Magne Glott, Thomas Martinsen, Anne Catrine T. Telle-Hansen, Vibeke H. Lim, Chwee Teck Huazhong Univ Sci & Technol Inst Med Equipment Sci & Engn Wuhan 430074 Peoples R China Natl Univ Singapore Dept Biomed Engn Singapore 117583 Singapore Simula Metropolitan Ctr Digital Engn N-0167 Oslo Norway Univ Cambridge Sch Clin Med Cambridge CB2 1TN England Sunnaas Rehabil Hosp N-1453 Bjoernemyr Norway Univ Gothenburg Inst Neurosci & Physiol Unit Rehabil Med S-41345 Gothenburg Sweden Oslo Metropolitan Univ Fac Technol Art & Design TKD Dept Mech Elect & Chem Engn MEK OsloMet N-0166 Oslo Norway Oslo Metropolitan Univ Fac Hlth Sci Dept Life Sci & Hlth OsloMet N-0130 Oslo Norway Oslo Metropolitan Univ Fac Hlth Sci Intelligent Hlth OsloMet N-0130 Oslo Norway Oslo Metropolitan Univ Fac Technol Art & Design OsloMet N-0130 Oslo Norway Oslo Metropolitan Univ Fac Hlth Sci Dept Rehabil Sci & Hlth Technol OsloMet N-0130 Oslo Norway Oslo Metropolitan Univ OsloMet Fac Hlth Sci Dept Nursing & Hlth Promot N-0130 Oslo Norway Natl Univ Singapore Inst Hlth Innovat & Technol iHealthtech Singapore 119276 Singapore Natl Univ Singapore Mechanobiol Inst Singapore 117411 Singapore Natl Univ Singapore Inst Funct Intelligent Mat Singapore 117544 Singapore Natl Univ Singapore SIA NUS Digital Aviat Corp Lab Singapore 117602 Singapore Nanyang Technol Univ Inst Digital Mol Analyt & Sci Singapore 636921 Singapore

Intelligent wearable sensors, empowered by machine learning and innovative smart materials, enable rapid, accurate disease diagnosis, personalized therapy, and continuous health monitoring without disrupting daily life. This integration facilitates a shift from traditional, hospital-centered healthcare to a more decentralized, patient-centric model, where wearable sensors can collect real-time physiological data, provide deep analysis of these data streams, and generate actionable insights for point-of-care precise diagnostics and personalized therapy. Despite rapid advancements in smart materials, machine learning, and wearable sensing technologies, there is a lack of comprehensive reviews that systematically examine the intersection of these fields. This review addresses this gap, providing a critical analysis of wearable sensing technologies empowered by smart advanced materials and artificial Intelligence. The state-of-the-art smart materials-including self-healing, metamaterials, and responsive materials-that enhance sensor functionality are first examined. Advanced machine learning methodologies integrated into wearable devices are discussed, and their role in biomedical applications is highlighted. The combined impact of wearable sensors, empowered by smart materials and machine learning, and their applications in intelligent diagnostics and therapeutics are also examined. Finally, existing challenges, including technical and compliance issues, information security concerns, and regulatory considerations are addressed, and future directions for advancing intelligent healthcare are proposed.

关键词： health monitoring intelligent healthcare machine learning metamaterials wearable sensors

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Phenolic compound profile and gastrointestinal action of Solanaceae fruits: Species-specific differences

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FOOD RESEARCH INTERNATIONAL 2023年 170卷 112968页

作者： Zhu, Changan Zhang, Min Wang, shuwen Gao, Xinhao lin, Teng Yu, Jingquan Tian, Jinhu Hu, Zhangjian Zhejiang Univ Dept Hort Hangzhou 310058 Peoples R China Zhejiang Univ Coll Biosyst Engn & Food Sci Hangzhou 310058 Peoples R China Zhejiang Univ Rural Dev Acad Hangzhou 310058 Peoples R China Zhejiang Univ Hainan Inst Sanya 572000 Peoples R China

In this study, the presence of phenolic compounds derived from four Solanaceae fruits (tomato, pepino, tama-rillo, and goldenberry) during gastrointestinal digestion and the effect of these compounds on human gut microbiota was investigated. The results indicated that the total phenolic content of all Solanaceae fruits were increased during digestion. Furthermore, the targeted metabolic analysis identified 296 compounds, of which 71 were changed after gastrointestinal digestion in all Solanaceae fruits. Among these changed phenolic compounds, 51.3% phenolic acids and 91% flavonoids presented higher bioaccessibility in pepino and tamarillo, respectively. Moreover, higher levels of glycoside-formed phenolic acids, including dihydroferulic acid glucoside and cou-maric acid glucoside, were found in tomato fruits. In addition, tachioside showed the highest bioaccessibility in goldenberry fruits. The intake of Solanaceae fruits during the in vitro fermentation decreased the Firmicutes/ Bacteroidetes ratio (F/B) compared with the control (similar to 15-fold change on average), and goldenberry fruits showed the best effect (F/B = 2.1). Furthermore, tamarillo significantly promoted the growth of Bifidobacterium and short-chain fatty acids production. Overall, this study revealed that Solanaceae fruits had different phenolic compound profiles and health-promoting effects on the gut microbiota. It also provided relevant information to improve the consumption of Solanaceae fruits, mainly tamarillo and goldenberry fruits, due to their gut health -promoting properties, as functional foods.

关键词： Solanaceae fruits Phenolic compounds In vitro gastrointestinal digestion In vitro fermentation Gut microbiota Short-chain fatty acids

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How does DNA 'meet' capillary-based microsystems?

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ANALYST 2021年第1期146卷 48-63页

作者： Hong, Tingting Qiu, lin Zhou, shuwen Cai, Zhiqiang Cui, Pengfei Zheng, Ronghui Wang, Jianhao Tan, Songwen Jiang, Pengju Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Jiangsu Sci Stand Med Testing Co Ltd Changzhou 213164 Jiangsu Peoples R China Jiangsu Dawning Pharmaceut Co Ltd Changzhou 213100 Jiangsu Peoples R China Changzhou Le Sun Pharmaceut Co Ltd Changzhou 213125 Jiangsu Peoples R China Cent South Univ Xiangya Sch Pharmaceut Sci 172 Tongzipo Rd Changsha 410013 Hunan Peoples R China

DNA possesses various chemical and physical properties which make it important in biological analysis. The opportunity for DNA to 'meet' capillary-based microsystems is rapidly increasing owing to the expanding development of miniaturization. Novel capillary-based methods can provide favourable platforms for DNA-ligand interaction assay, DNA translocation study, DNA separation, DNA aptamer selection, DNA amplification assay, and DNA digestion. Meanwhile, DNA exhibits great potential in the fabrication of new capillary-based biosensors and enzymatic bioreactors. Moreover, DNA has received significant research interest in improving capillary electrophoresis (CE) performance. We focus on highlighting the advantages of combining DNA and capillary-based microsystems. The general trend presented in this review suggests that the 'meeting' has offered a stepping stone for the application of DNA and capillary-based microsystems in the field of analytical chemistry.

关键词： DNA

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Neuroprotective effects of Lycium barbarum polysaccharide on light-induced oxidative stress and mitochondrial damage via the Nrf2/HO-1 pathway in mouse hippocampal neurons

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2023年 251卷 126315页

作者： Yang, Yang Yu, lin Zhu, Tianyu Xu, shuwen He, Jin Mao, Ningning Liu, Zhenguang Wang, Deyun Nanjing Agr Univ Inst Tradit Chinese Vet Med Coll Vet Med Nanjing 210095 Peoples R China Nanjing Agr Univ Inst Immunol MOE Joint Int Res Lab Anim Hlth & Food Safety Nanjing 210095 Peoples R China Nanjing Agr Univ Coll Vet Med Nanjing 210095 Peoples R China

Light at night (LAN) induced cognitive impairment associated with oxidative stress in mice has been reported. Lycium barbarum polysaccharide (LBP) exhibits anti-tumor, anti-oxidant and neuroprotective effects, yet the neuroprotective effect on light-induced neuron damage still unclear. Here, mice exposed to LAN displayed cognitive impairment and depressive like behavior, which was reversed by LBP treatment. Meanwhile, LBP alleviated light-induced higher apoptosis and mitochondrial damage in HT-22 cells. Also, LBP prevented the decreased of mitochondrial membrane permeabilization (MMP) level in light-treated cells. Additionally, LBP demonstrated its antioxidant potential by reducing ROS production and malondialdehyde (MDA) level, while simultaneously enhancing the levels of superoxide dismutase (SOD) and glutathione peroxidases (GSH-Px) in both light-treated mice and HT-22 cells. Furthermore, the mRNA and protein expression of Nrf2 (NF-E2-related factor 2), heme oxygenease-1 (HO-1), and NAD(P)H quinone oxidoreductase (NQO1) were decreased in both light-treated mice and cells. Additionally, LBP treatment reversed light-induced the inhibition of Nrf2/HO-1 signaling pathway in both mice and cells. Moreover, Nrf2 antagonist ML385 significantly eliminated the neuroprotection of LBP on cell apoptosis, oxidative stress and mitochondrial damage in light-treated cells. These results indicate that LBP can rescue light-induced neurotoxicity in mice and HT-22 cells by activating the Nrf2/ HO-1 signaling pathway.

关键词： Light at night Lycium barbarum polysaccharide Nrf2/HO-1

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Multiple modes of action of myricetin in influenza A virus infection

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PHYTOTHERAPY RESEARCH 2021年第5期35卷 2797-2806页

作者： Sang, Huiting Huang, Yingna Tian, Yuanxin Liu, Miaomiao Chen, Liurong Li, lin Liu, shuwen Yang, Jie Southern Med Univ Guangzhou Key Lab Drug Res Emerging Virus Prevent Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515 Peoples R China Guangdong Med Univ Sch Pharm Dongguan Peoples R China

Influenza A virus remains a major threat to public health worldwide after its first pandemic. Scientists keep searching novel anti-influenza drugs, of which natural products present to be an important source. Myricetin, a natural flavonol compound, which exists in many edible plants, which has a wide range of biological activities, but its anti-influenza A virus activity is ambiguous. This study aims to evaluate the anti-influenza activity of myricetin and elucidate its underlying mechanism. Our results demonstrated that myricetin could significantly inhibit influenza A virus replication, reduce viral polymerase activity via selective inhibition of viral PB2 subunit, and the production of inflammatory cytokines by inhibiting TLR3 signaling pathway. The binding affinity analysis and the result of molecular docking revealed that myricetin interacted with the PB2 cap-binding pocket of influenza A virus. The above results suggested myricetin could exhibit anti-influenza virus activity with low cytotoxicity as well, and myricetin had low toxicity in BALB/c mice in vivo. Results from this study highlighted myricetin could be considered as a promising anti-influenza virus agent with dual inhibition profile. Furthermore, the compound with similar structure would provide a new option for the development of novel inhibitors against influenza A virus.

关键词： anti-inflammatory influenza A virus Myricetin PB2 cap-binding domain TLR3

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