检索结果-内蒙古大学图书馆

Effects of food, salinity, and ammonia-nitrogen on the physiology of juvenile seahorse (Hippocampus erectus) in two typical culture models in China

引用

AQUACULTURE 2020年 520卷

作者： Huang, Jiaxin Qin, Geng Zhang, Bo Tan, shuwen Sun, Jinhui lin, Qiang Chinese Acad Sci South China Sea Inst Oceanol CAS Key Lab Trop Marine Bioresources & Ecol Guangzhou 510275 Guangdong Peoples R China Tianjin Agr Univ Tianjin 300384 Peoples R China Chinese Acad Sci Inst South China Sea Ecol & Environm Engn Guangzhou 510275 Guangdong Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Food and water environments are key factors affecting juvenile survival rate in seahorse aquaculture. In order to adjust to local conditions, different seahorse (Hippocampus erectus) breeding models were developed in North and South China. Seahorses in North China were commonly fed Anemia in indoor containers with a stable water environment, while most seahorses in South China were fed copepods in outdoor concrete ponds. Firstly, we compared the effect of food type on juvenile seahorses based on a one-month feeding experiment and found no significant difference in body length. However, the insulin-like growth factor 1 (IGF-1) gene expression was significantly higher in the liver of seahorses fed copepods than in the lever of seahorses fed Anemia, suggesting that copepods promoted better growth. A high expression of stress-related genes, namely, heat shock proteins 70 (HSP70) and Mn superoxide dismutase (Mn-SOD), in the liver of the seahorses that were fed copepods suggested that copepods might cause more stress on juveniles. Lower leptin gene expression in the liver of seahorses fed Anemia than in those fed copepods proved that Anemia was better for satiating the juveniles. Furthermore, the potential effects of salinity (15 and 30 ppt) and ammonia-nitrogen (0, 5, and 15 mg/L) on juvenile seahorse physiological stress were studied through a 5-d orthogonal experiment. Both lower salinity and higher ammonia-nitrogen increased the ventilation rate significantly. Low salinity caused a rapid increase in the ventilation rate on day 1, while high ammonia-nitrogen was the main factor during the later period (days 2-5). Significant changes in the mRNA expression of genes, including Na+: K+:2Cl(-) cotransporter 1 (NKCC1) and Na, K-ATPase (NKA) in the gill, HSP70, Mn-SOD, glutamate dehydrogenase (GDH), and glutamyl synthase (GS) in the liver, indicated that seahorses are sensitive to acute salinity decline. In addition, high ammonia-nitrogen exposure significantly changed the e

关键词： Juvenile seahorse Diet Salinity Ammonia-nitrogen

来源：评论

学校读者我要写书评

暂无评论

MOF-5 derived 3D ZnO/Ag micro-octahedra for ultrahigh response and selective triethylamine detection at low temperature

引用

SENSORS AND ACTUATORS B-CHEMICAL 2023年 390卷

作者： Sun, Yangyang Fan, Huiqing Shang, Yanyan Lei, lin Zhu, shuwen Wang, Hui Dong, Wenqiang Al-Bahrani, Mohammed Wang, Weijia Ma, Longtao Northwestern Polytech Univ Sch Mat Sci & Engn State Key Lab Solidificat Proc Xian 710072 Peoples R China Northwestern Polytech Univ Inst Flexible Elect Xian 710072 Peoples R China Fudan Univ Inst Archaeol Sci Shanghai Peoples R China Northwestern Polytech Univ Inst Culture & Heritage Xian 710072 Peoples R China Al Mustaqbal Univ Coll Chem Engn & Petr Ind Dept Babylon 51001 Iraq

The leakage of raw material triethylamine in the process of chemical production causes harm and damage to health and environment. Therefore, the development of triethylamine sensors with high response and selectivity is urgently needed. Using metal organic frames (MOF) as templates has become a new strategy to prepare nano structural metal oxides based gas sensing materials, which leads to a high specific surface area and enhanced gas sensing performances. In this work, the metal organic framework MOF-5 decorated with large Ag particles is prepared by a conventional one-step solvothermal method. Then 3D ZnO/Ag micro-octahedra assembled from ZnO nanosheets are derived by subsequent calcination. The 3D ZnO/Ag micro-octahedra based sensor exhibits excellent gas sensing performance toward triethylamine, including an ultrahigh response of 293.8-10 ppm and selectivity, as well as a low operating temperature of 200 degrees C, and long-time stability. The excellent triethylamine gas sensing performance can be attributed to the synergy effect between oxygen vacancies and the catalytic spillover effect generated by the noble metal silver. This work shows that MOF derived hierarchical 3D ZnO/Ag micro-octahedra provides a great potential for triethylamine monitoring.

关键词： TEA gas sensor MOF template Catalytic spillover effect

来源：评论

学校读者我要写书评

暂无评论

THERAPEUTIC EFFECTS OF CHITIN FROM PLEUROTUS ERYNGII ON HIGH-FAT DIET INDUCED OBESITY IN RATS

引用

ACTA SCIENTIARUM POLONORUM-TECHNOLOGIA ALIMENTARIA 2020年第3期19卷 279-289页

作者： Huang, Jiafu Wu, Qici lin, Zhichao Liu, shuwen Su, Qiaoling Pan, Yutian Minnan Normal Univ Collaborat Innovat Ctr Mushroom Hlth Ind Zhangzhou 363000 Fujian Peoples R China Minnan Normal Univ Engn Technol Ctr Mushroom Ind Zhangzhou 363000 Fujian Peoples R China Minnan Normal Univ Sch Life Sci Zhangzhou 363000 Fujian Peoples R China Minnan Normal Univ Biotechnol Coll Zhangzhou 363000 Fujian Peoples R China

Background. Recent shifts in lifestyles and diets have caused the incidence of obesity to increase rapidly, resulting in a serious threat to modern human health. There is a growing interest the use of plant or fungi derived supplements as a safe and effective means to treat obesity. In recent times, edible-medicinal fungi have garnered attention as therapeutics owing to their biocompatibility and effectiveness. Attempts to determine the therapeutic effects of these fungi have become a prime focus in drug discovery programs. Therefore, this study aimed to determine the anti-obesity effects of P. eryngii chitin in rats with obesity induced by administration of a high fat diet. Material and methods. To investigate the therapeutic effects of chitin from Pleurotus eryngii on high fat diet-induce obesity, we treated obese rats with different concentrations of chitin from P. eryngii for 4 weeks, using Lipitor as positive control. The living condition, food intake, body weight, perirenal adipose tissue, periepididymal adipose tissue, adipose tissue coefficient, serum lipid levels, including total cholesterol (TC), total glyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), were measured, and levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), themalonaldehyde (MDA), and superoxide dismutase (SOD) activity in liver were determined. The rats were also monitored for pathological changes in the liver and aorta. Results. These studies indicated that administration of chitin from P. eryngii could significantly decrease obese rat food utilization rates and accumulation of adipose tissue in the body, thus preventing development of increased body weight. The treatment also significantly reduced serum lipid levels, including levels of TC, TG and LDL-C. Treatment with P. eryngii-derived chitin also enhanced ALT and AST enzymatic activity, enhanced SOD enzymatic activity, and reduced the MDA content of the

关键词： Pleurotus eryngii chitin obesity therapy

来源：评论

学校读者我要写书评

暂无评论

脱支和重结晶法制备抗性糊精的结构和功能特性分析

引用

食品工业科技 2024年第5期45卷 37-43页

作者：徐美琪李思漫刘欣欧月灵罗舒雯李琳陈旭朱杰东莞理工学院生命健康与技术学院中国轻工业健康食品开发与营养调控重点实验室东莞市特色食品精准设计重点实验室食品营养健康工程与智能化加工研究中心广东东莞523808 华南农业大学食品学院广东广州510642

为探究脱支和重结晶法制备抗性糊精的结构和功能特性。以蜡质玉米和普通玉米淀粉为原料,采用脱支和重结晶法制备抗性糊精,对其形貌特征、结晶结构、热力学特性、官能团、糖苷键等变化进行表征,并探究其抗消化特性。结果表明:与原淀粉相... 详细信息

为探究脱支和重结晶法制备抗性糊精的结构和功能特性。以蜡质玉米和普通玉米淀粉为原料,采用脱支和重结晶法制备抗性糊精,对其形貌特征、结晶结构、热力学特性、官能团、糖苷键等变化进行表征,并探究其抗消化特性。结果表明:与原淀粉相比,两种抗性糊精热稳定性和溶解度显著增加(P<0.05),具有良好的色泽。两种抗性糊精形貌粗糙、呈不规则形状的小碎片聚集体。蜡质玉米抗性糊精呈典型的A型结晶结构,普通玉米抗性糊精呈典型的B型结晶结构。由核磁共振波谱和红外结果可知,抗性糊精在制备过程中糖苷键断裂重新聚合形成新的抗消化糖苷键,无新的官能团产生。两种抗性糊精的抗消化性能力增加,且普通玉米淀粉制备的抗性糊精的慢消化和抗消化性能力最强。综上所述,脱支和重结晶法能提高抗性糊精的抗消化能力,将为抗性糊精的绿色制备工艺进而实现产业化生产提供新的思路和理论指导。

关键词：抗性糊精脱支重结晶结构功能特性消化性

来源：评论

学校读者我要写书评

暂无评论

Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing

引用

BIOMATERIALS SCIENCE 2021年第17期9卷 5965-5976页

作者： Liu, Li Wang, Cheng Li, Yuting Qiu, lin Zhou, shuwen Cui, Pengfei Jiang, Pengju Ni, Xinye Liu, Runhui Du, Xuancheng Wang, Jianhao Xia, Jiang Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Nanjing Med Univ Affiliated Changzhou Peoples Hosp 2 Changzhou Jiangsu Peoples R China East China Univ Sci & Technol State Key Lab Bioreactor Engn Sch Mat Sci & Engn Shanghai 200237 Peoples R China Shandong Univ Sch Phys Inst Adv Interdisciplinary Sci Jinan 250100 Peoples R China Chinese Univ Hong Kong Dept Chem Shatin Hong Kong Peoples R China

Reactive oxygen species (ROS) are the weapons of neutrophiles against bacterial pathogens, and also the central effectors in reactive oxygen therapy for skin and soft tissue infection. Nanozymes that spontaneously generate ROS under physiological conditions are new antibacterials that hold promise towards multidrug resistant pathogens. The clinical use of the nanozymes is however limited by their low biocompatibility and toxicity in vivo. Here, we develop an oleic acid (OA) nanoemulsion template method for the one-pot synthesis of OA-manganese dioxide (MnO2) nanozyme. The OA-MnO2 nanozyme showed high stability and biocompatibility under physiological conditions with marked oxidase-like activity. The ROS generated by the OA-MnO2 nanozyme effectively kill the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli strains. Moreover, the OA-MnO2 nanozyme shows promising abilities to prevent and destruct biofilm formation by Staphylococcus aureus, and result in superior in vivo antibacterial performance as compared to vancomycin. The reactive oxygen therapy based on OA-MnO2 nanozyme cures the infected skin and promotes wound healing in mice, manifesting its potential use in skin and soft tissue infection.

关键词： Tissue

来源：评论

学校读者我要写书评

暂无评论

Antibacterial Photodynamic Gold Nanoparticles for Skin Infection

引用

ACS APPLIED BIO MATERIALS 2021年第4期4卷 3124-3132页

作者： Qiu, lin Wang, Cheng Lan, Min Guo, Qianqian Du, Xuancheng Zhou, shuwen Cui, Pengfei Hong, Tingting Jiang, Pengju Wang, Jianhao Xia, Jiang Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Shandong Univ Sch Phys Inst Adv Interdisciplinary Sci Jinan 250100 Peoples R China Chinese Univ Hong Kong Dept Chem Shatin Hong Kong Peoples R China

Damage or injury to the skin creates wounds that are vulnerable to bacterial infection, which in turn retards the process of skin regeneration and wound healing. In patients with severe burns and those with chronic diseases, such as diabetes, skin infection by multidrugresistant bacteria can be lethal. Therefore, a broad-spectrum therapy to effectively eradicate bacterial infection through a mechanism different from that of antibiotics is much sought after. We successfully synthesized antibacterial photodynamic gold nanoparticles (AP-AuNPs), which are self-assembled nanocomposites of an antibacterial photodynamic peptide and poly(ethylene glycol) (PEG)-stabilized AuNPs. The AP-AuNPs exhibited aqueous and light stability, a satisfactory generation of reactive oxygen species (ROS), and a remarkable antibacterial effect toward both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli upon light irradiation. Moreover, the synthesized nanocomposites significantly inhibited bacterial growth and biofilm formation in vitro. Photodynamic antibacterial treatment accelerated the wound-healing rate in S. aureus infections, mimicking staphylococcal skin infections. Using a combination of the bactericidal effect of a peptide, the photodynamic effect of a photosensitizer, and the multivalency clustering on AuNPs for maximal antibacterial effect under light irradiation, we synthesized AP-AuNPs as a wound-dressing nanomaterial in skin infections to promote wound healing. Our findings indicate a promising strategy in the management of bacterial infections resulting from damaged skin tissue, an aspect that has not been fully explored by our peers.

关键词： antibacterial photodynamic nanoparticles staphylococcal skin infection antibacterial peptide photosensitizer antibacterial photodynamic therapy

来源：评论

学校读者我要写书评

暂无评论

MolParser: End-to-end Visual Recognition of Molecule Structures in the Wild

arXiv

引用

arXiv 2024年

作者： Fang, Xi Wang, Jiankun Cai, Xiaochen Che, Shangqian Yang, shuwen Tao, Haoyi Wang, Nan Yao, lin Zhang, linfeng Ke, Guolin DP Technology

In recent decades, chemistry publications and patents have increased rapidly. A significant portion of key information is embedded in molecular structure figures, complicating large-scale literature searches and limiting the application of large language models in fields such as biology, chemistry, and pharmaceuticals. The automatic extraction of precise chemical structures is of critical importance. However, the presence of numerous Markush structures in real-world documents, along with variations in molecular image quality, drawing styles, and noise, significantly limits the performance of existing optical chemical structure recognition (OCSR) methods. We present MolParser, a novel end-to-end OCSR method that efficiently and accurately recognizes chemical structures from real-world documents, including difficult Markush structure. We use a extended SMILES encoding rule to annotate our training dataset. Under this rule, we build MolParser-7M, the largest annotated molecular image dataset to our knowledge. While utilizing a large amount of synthetic data, we employed active learning methods to incorporate substantial in-the-wild data, specifically samples cropped from real patents and scientific literature, into the training process. We trained an end-to-end molecular image captioning model, MolParser, using a curriculum learning approach. MolParser significantly outperforms classical and learning-based methods across most scenarios, with potential for broader downstream applications. The dataset is publicly available in huggingface. Copyright © 2024, The Authors. All rights reserved.

关键词： Molecular imaging

来源：评论

学校读者我要写书评

暂无评论

Overview of the CMIP6 Historical Experiment Datasets with the Climate System Model CAS FGOALS-f3-L

引用

Advances in Atmospheric Sciences 2020年第10期37卷 1057-1066页

作者： Yuyang GUO Yongqiang YU Pengfei lin Hailong LIU Bian HE Qing BAO shuwen ZHAO and Xiaowei WANG State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Yunnan University Kunming 650091China

The three-member historical simulations by the Chinese Academy of Sciences Flexible Global Ocean–Atmosphere–Land System model,version f3-L(CAS FGOALS-f3-L),which is contributing to phase 6 of the Coupled Model Intercomparison Project(CMIP6),are described in this *** details of the CAS FGOALS-f3-L model,experiment settings and output datasets are briefly *** datasets include monthly and daily outputs from the atmospheric,oceanic,land and sea-ice component models of CAS FGOALS-f3-L,and all these data have been published online in the Earth System Grid Federation(ESGF,https://***/projects/cmip6/).The three ensembles are initialized from the 600th,650th and 700th model year of the preindustrial experiment(piControl)and forced by the same historical forcing provided by CMIP6 from 1850 to *** performance of the coupled model is validated in comparison with some recent observed atmospheric and oceanic *** is shown that CAS FGOALS-f3-L is able to reproduce the main features of the modern climate,including the climatology of air surface temperature and precipitation,the long-term changes in global mean surface air temperature,ocean heat content and sea surface steric height,and the horizontal and vertical distribution of temperature in the ocean and ***,like other state-of-the-art coupled GCMs,there are still some obvious biases in the historical simulations,which are also *** paper can help users to better understand the advantages and biases of the model and the datasets。

关键词： CMIP6 historical simulation FGOALS-f3-L coupled model data description

来源：评论

学校读者我要写书评

暂无评论

Repurposing of a clinically used anti-HPV agent to prevent and treat SARS-CoV-2 infection as an intranasal formulation

引用

Signal Transduction and Targeted Therapy 2021年第9期6卷 2631-2633页

作者： Chen Hua Qinhai Ma Yun Zhu Shuai Xia Zezhong Liu lin Li Lu Lu Nanshan Zhong shuwen Liu Zifeng Yang Shibo Jiang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghaiChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijingChina State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouChina Guangzhou Laboratory Bio-IslandGuangzhouChina

Dear Editor,Fan et *** shown that whey protein,such as that found in human,bovine,and goat milk,could effectively inhibit SARS-CoV-2 infection,but they did not identify the components in whey protein having this activity.1 Since p-lactoglobulin(P-LG)is the main component of whey protein,we herein tested the anti-SARS-CoV-2 activity of p-LG and 3-hydroxyphthalic anhydride(3HP)-modified P-LG(3HP-P-LG),an active component in anti-human papillomavirus(HPV)biological dressing(JB01-BD)that has been used in clinics since 2013 to block cervical infection of HPV.

关键词： infection nasal

来源：评论

学校读者我要写书评

暂无评论

Amorphous Vanadium Oxide Nanosheets with Alterable Polyhedron Configuration for Fast-Charging Lithium-Ion Batteries

引用

SMALL 2023年第43期19卷 e2303360页

作者： Wu, Bei Niu, shuwen Wang, Chao Wu, Geng Zhang, Yida Han, Xiao Liu, Peigen lin, Yue Yan, Wensheng Wang, Gongming Hong, Xun Univ Sci & Technol China Ctr Adv Nanocatalysis CAN Dept Appl Chem Hefei Natl Lab Phys Sci Microscale Hefei 23002 Anhui Peoples R China Univ Sci & Technol China Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China

Transition metal oxides with high theoretical capacities are promising anode materials for lithium-ion batteries (LIBs). However, the sluggish reaction kinetics remain a bottleneck for fast-charging applications due to its slow Li+ migration rate. Herein, a strategy is reported of significantly reducing the Li+ diffusion barrier of amorphous vanadium oxide by constructing a specific ratio of the V-O local polyhedron configuration in amorphous nanosheets. The optimized amorphous vanadium oxide nanosheets with a ratio & AP;1:4 for octahedron sites (O-h) to pyramidal sites (C-4v) revealed by Raman spectroscopy and X-ray absorption spectroscopy (XAS) demonstrate the highest rate capability (356.7 mA h g(-1) at 10.0 A g(-1)) and long-term cycling life (455.6 mA h g(-1) at 2.0 A g(-1) over 1200 cycles). Density functional theory (DFT)calculations further verify that the local structure (O-h:C-4v = 1:4) intrinsically changes the degree of orbital hybridization between V and O atoms and contributes to a higher intensity of electron occupied states near the Fermi level, thus resulting in a low Li+ diffusion barrier for favorable Li+ transport kinetics. Moreover, the amorphous vanadium oxide nanosheets possess a reversible V-O vibration mode and volume expansion rate close to 0.3%, as determined through in situ Raman and in situ transmission electron microscopy.

关键词： alterable polyhedrons configuration amorphous transition metal oxides electronic redistribution fast-charging capability

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：