Nanozymes, the next-generation artificial enzymes, are nanomaterials with enzyme-like characteristics and have been widely used in detection, disease diagnosis, biological therapy, and other fields. Among them, organo...
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Nanozymes, the next-generation artificial enzymes, are nanomaterials with enzyme-like characteristics and have been widely used in detection, disease diagnosis, biological therapy, and other fields. Among them, organometallic/organic nanozymes with organometallics/organics as the catalytic sites have enhanced catalytic activity due to their high catalytic site density. To date, many studies on organometallic/organic nanozymes have been reported, but these reports have not yet been highlighted in a separated review. Here, the research progress of organometallic/organic nanozymes in recent years is reviewed. Organometallic/organic nanozymes are classified according to the types of catalytic sites. The applications of organometallic/organic nanozymes in detection, imaging, therapy, filter, sensor, and battery are introduced. The challenge and future opportunity in this field are also discussed. (C) 2020 Elsevier B.V. All rights reserved.
目的分析新生儿重症监护室(neonatal intensive care unit,NICU)不同出生体重儿经外周置入中心静脉导管(peripherally inserted central catheter,PICC)的现状,为后续护理质量改进提供依据。方法回顾性分析2017年1月1日至2021年12月31...
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目的分析新生儿重症监护室(neonatal intensive care unit,NICU)不同出生体重儿经外周置入中心静脉导管(peripherally inserted central catheter,PICC)的现状,为后续护理质量改进提供依据。方法回顾性分析2017年1月1日至2021年12月31日某三级甲等医院NICU 908例PICC病例的临床资料,按出生体重(birth weight,BW)分为4组,比较各组间置管过程、维护过程、并发症和拔管原因。结果82.7%的患儿PICC经右下肢大隐静脉置管,不同出生体重组间穿刺部位存在差异,其中BW<1 kg和BW≥2.5 kg组经股静脉置管比例高于其他两组。总体一次性穿刺成功率84.8%,不同出生体重组间存在差异,BW≥2.5 kg组一次性穿刺成功率最低,为65.9%。总体一次性到位率为61.8%,过深率为31.9%,不同出生体重组导管尖端首次定位分布未见差异。总体并发症发生率为13.3%,非计划性拔管率为1.9%,不同出生体重组间总并发症发生率和非计划性拔管率未见差异。结论PICC并发症发生率和非计划性拔管率控制得较为理想,但在一次性穿刺成功率和一次性到位率方面仍有较大的提升空间,未来护理质量改进方向应以提高一次性置管成功率为主。
As one of the emotional states often experienced by children, anxiety plays an indispensable role in their psychological development and growth. Based on the anxiety of students in school, this paper studies the influ...
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As one of the emotional states often experienced by children, anxiety plays an indispensable role in their psychological development and growth. Based on the anxiety of students in school, this paper studies the influence of the close relationship or conflict between teachers and students created in school on children's anxiety. Firstly, this paper expounds the literature research on children's psychological anxiety and teacher-student relationship in recent years, summarizes the two aspects of the influence of teacher‐student relationship on children's anxiety mentioned in the literature, and puts forward the harmness and future development trend of children's anxiety. The current literature research is still not comprehensive, and further practical investigation is needed. Secondly, through a questionnaire survey of primary school children and teachers and an analysis of existing literature, the author draws a conclusion: A good teacher‐student relationship can promote children to form the psychology of being cared for, which is conducive to establishing children's confidence in life and study. On the contrary, the estrangement between teachers and students can easily cause children's anxiety, and even cause children's language barrier and psychological shadow. In order to solve the problems of children's social disorder caused by children's anxiety, this paper provides some educational suggestions based on the type of teacher‐student relationship and the characteristics of children's anxiety. It is expected that the possibility of children's anxiety can be effectively reduced through the establishment of a good teacher‐student relationship, so as to promote the healthy growth of students and improve the formation of personality.
Walnut green husk polysaccharides (WGP) are isolated from the walnut green husk with a mean molecular weight of 12.77 kDa. The structural characterization revealed by methylation and NMR analysis indicated that WGP mi...
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Walnut green husk polysaccharides (WGP) are isolated from the walnut green husk with a mean molecular weight of 12.77 kDa. The structural characterization revealed by methylation and NMR analysis indicated that WGP might consist of -> 4-alpha-D-Galp-(1 ->, alpha-D-Galp (1 ->, and -> 2)-alpha-L-Rhap-(1 ->. Previous studies have been demonstrated that WGP effectively prevented liver injury and modulated gut microbiota in high fructose-treated mice and high fat diet-treated rats. In this study, we found for the first time that WGP presenting outstanding protective effects on liver inflammation and gluconeogenesis dysfunction induced by ochratoxin A (OTA) in mice. Firstly, WGP decreased oxidative stress, down-regulated the expression of inflammatory factors and inhibited the TLR4/p65/I kappa B alpha pathway in the liver. Then, WGP reversed OTA-induced lower phosphoenolpyruvate carboxyl kinase (PEPCK), and glucose 6-phosphatase (G6PC) activities in the liver. Furthermore, WGP increased the diversity of gut microbiota and the abundance of beneficial bacteria, especially Lactobacillus and Akkermansia. Importantly, the results of fecal microbiota transplantation (FMT) experiment further confirmed that gut microbiota involved in the protective effects of WGP on liver damage induced by OTA. Our results indicated that the protective effect of WGP on liver inflammation and gluconeogenesis dysfunction caused by OTA may be due to the regulation of gut microbiota.
Skin infection is a worldwide issue that requires joint efforts to develop suitable wound dressing. Hydrogel as the ideal form of wound dressing usually suffered from complicated preparation, low reproducibility and h...
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Skin infection is a worldwide issue that requires joint efforts to develop suitable wound dressing. Hydrogel as the ideal form of wound dressing usually suffered from complicated preparation, low reproducibility and high toxicity/cost. Therefore, the development of cost effective and biocompatible materials to conveniently construct hydrogel based wound dressing in a facile and reproducible way should be one of the future orientation in this field. Here in this study, we proposed a simple thermosensitive hydrogel composed of cost effective and biocompatible Pluronic F-68 and Pluronic F-127, entitled F68/F127 hydrogel. The F68/F127 hydrogel was further loaded with glucose oxidase (GOx@F68/F127 hydrogel) as an antibacterial wound dressing, which showed preferable sol-gel transformation property upon application to the wounds with powerful antibacterial effects. In this way, GOx@F68/F127 hydrogel showed promising inhibition of both Gram positive and negative strains in vitro and in vivo. The antibacterial rate of GOx@F68/F127 reached 100% for Staphylococcus aureus at 0.65 mu g/mL and 100% for Escherichia coli at 0.6 mu g/mL. And it has high biocompatibility and the ability to promote wound healing. At the end of treatment, mice in the GOx@F68/F127 group had 98% wound healing relative to the control group, which had 30% wound healing. Therefore, GOx@F68/F127 hydrogel can be applied as a promising antimicrobial wound excipient.
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