Background: Few studies have explored the association between circadian syndrome (CircS) and lung health. Objective: To assess the relationship between CircS and lung health. Methods: This prospective cohort study enr...
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Background: Few studies have explored the association between circadian syndrome (CircS) and lung health. Objective: To assess the relationship between CircS and lung health. Methods: This prospective cohort study enrolled 6252 adults. Multivariable logistic and linear regression models were employed to examine the association between CircS and the prevalence of chronic lung disease, respiratory symptoms, and lung function, as appropriate. Receiver operating characteristic curve analysis was used to compare the predictive power of the number of metabolic syndrome (MetS) and CircS components for lung health. Kaplan-Meier survival and multiple Cox regression analyses were used to assess the relationship between CircS and all-cause mortality. The effects of CircS on health-related quality of life (HQL) and health care use were also evaluated. Results: Participants with CircS were significantly associated with a higher prevalence of asthma, chronic bronchitis, cough, wheeze, phlegm production, and exertional dyspnea. The number of CircS components demonstrated better predictive power for the prevalence of asthma, chronic bronchitis, emphysema, cough, wheeze, phlegm production, and exertional dyspnea than the number of MetS components. Higher numbers of CircS components were significantly associated with decreased forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC), worse HQL, and increased health care use. Longitudinally, participants with CircS exhibited a higher risk of all-cause mortality than those without CircS. Conclusions: Our results support the claim of that CircS is a better predictor of lung health than the MetS in adults in the United States. Elevated CircS levels are associated with poorer lung function, increased health care use, worse HQL, and a higher risk of mortality.
The moving least-squares (MLS) method has been developed for fitting measurement data contaminated with errors. The local approximants of the MLS method only take the random errors of the dependent variable into accou...
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The moving least-squares (MLS) method has been developed for fitting measurement data contaminated with errors. The local approximants of the MLS method only take the random errors of the dependent variable into account, whereas the independent variables of measurement data always contain errors. To consider the influence of errors of dependent and independent variables, the moving total least-squares (MTLS) method is a better choice. However, both MLS and MTLS methods are sensitive to outliers, greatly affecting fitting accuracy and robustness. This paper presents an improved method, the trimmed MTLS (TrMTLS) method, in which the total least-squares method with a truncation procedure is adopted to determine the local coefficients in the influence domain. This method can deal with outliers and random errors of all variables without setting the threshold or adding small weights subjectively. The results of numerical simulation and experimental measurements indicate that the proposed algorithm has better fitting accuracy and robustness than the MTLS and MLS methods.
BackgroundWith the development of the economy, the number of obese patients has been increasing annually worldwide. The proportion of asthma patients associated with obesity is also gradually rising. However, the path...
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BackgroundWith the development of the economy, the number of obese patients has been increasing annually worldwide. The proportion of asthma patients associated with obesity is also gradually rising. However, the pathogenesis of obesity-related asthma remains incompletely understood, and conventional pharmacological treatments generally show limited *** study aims to explore the causal relationship between obesity and allergic asthma, elucidate the pathogenesis of obesity-related asthma, and identify the plasma proteins involved in its development, providing new insights for clinical *** this study, we employed a two-step approach for mediation Mendelian randomization (MR) analysis, utilizing stringent selection criteria to identify instrumental variables (IVs). This approach was used to assess the causal impact of obesity on allergic asthma and to validate the plasma proteins identified as mediating factors. We further explored the functions and enriched pathways of the mediating proteins using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Finally, we conducted drug-targeted MR analysis to evaluate the potential of each mediator plasma proteins as a drug target gene. If significant heterogeneity remained among the IVs, we applied the weighted median method as the primary analytical tool. Otherwise, we utilized the inverse variance weighted (IVW) method as the main analytical approach. Additionally, we conducted various sensitivity analyses and statistical tests to further illustrate the robustness of the observed *** research findings indicate a causal relationship between obesity and allergic asthma. Plasma proteins such as TPST1, ROR1, and DAPK1 mediate this relationship, with TPST1 accounting for over 10% of the mediation effect. GO and KEGG analyses show that the genes corresponding to these mediator proteins are primarily enriched in pathways related to responses to st
Background Vibratory compactor that depends on the principle of vibration is important in earthwork and pavement building. The compactor is an important technical equipment in transportation and energy development. Ho...
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Background Vibratory compactor that depends on the principle of vibration is important in earthwork and pavement building. The compactor is an important technical equipment in transportation and energy development. However, in the practical application of vibratory engineering, shortage of traditional construction design and the effects of nonlinear chaos vibration on human health are ignored. Objective Our objective was to explore a simple non-smooth collision model that could effectively represent the dynamic properties of practical system during compaction to eliminate the nonlinear chaotic responses of mechanical structure and to reduce irregular vibration that is harmful to the physical and mental health of operators. Methods An advisable construction method for pavement material compaction based on chaotic identification is proposed. A simple non-smooth dynamic model that supposes generalized restoring force was established for a compacting system by introducing dimensionless variables. The dynamic responses of an excitation system were analyzed by time domain, phase diagram, Poincare section, power spectrum, and bifurcation diagram methods. Moreover, the advisable construction method based on chaotic identification was applied to field tests on asphalt construction by using a YZC12 vibratory roller compactor on the Beijing-Fuzhou highway. Results Research showed that the dynamic characteristics of excitation system were experienced from a single cycle, single periodic bifurcation, a double cycle, and double periodic bifurcation until chaos evolution because of different model parameters that represented all types of working conditions. Results also showed that for the earlier stage of compacted material, dimensionless angular frequency might be reasonably selected within the range of 1.69 to 2.21 under large exciting forces. For the later stage of compacted material, dimensionless angular frequency might be selected within the range of 1.75 to 2.13 under larg
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