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Outcomes of Preinjury Use of Statins in Patients with Traumatic Brain Injury: A Systematic Review and Meta-analysis

WORLD NEUROSURGERY 2021年 152卷 E266-E278页

作者： Mu, shuwen Fang, Yi Pei, Zhijie lin, Yinghong lin, Kunzhe Zeng, Zihuan Zhou, Longmin Wang, Zhengjun Wang, Shousen Fujian Med Univ Fuzong Clin Med Coll Fuzhou Fujian Peoples R China Fujian Univ Tradit Chinese Med Fuzhou Fujian Peoples R China Fujian Med Univ Affiliated Fuzhou Hosp 1 Dept Neurosurg Fuzhou Fujian Peoples R China Fujian Med Univ Fuzong Clin Med Coll Dept Neurosurg Fuzhou Fujian Peoples R China Fujian Med Univ Fuzong Clin Med Coll Hosp 900 Dept Gastroenterol Fuzhou Fujian Peoples R China

BACKGROUND: No completely effective pharmacotherapies have been developed to improve the outcomes of traumatic brain injury (TBI). Given the reporting of cohort studies suggesting that preinjury statin use may reduce TBI-associated mortality, this study aimed to evaluate the effects of statin use in patients with TBI. METHODS: This study was performed according to the PRISMA guidelines. The PubMed, Embase, Cochrane Central, Web of Science, and China National Knowledge Infrastructure databases were searched from inception until April 13, 2021, using a search strategy that included 2 main terms: "statins" and "traumatic brain injury." The outcomes were mortality, hospital length of stay, and intensive care unit length of stay, which were evaluated using a random-effects model and represented by the pooled risk ratio with 95% confidence intervals. RESULTS: The search results identified 7 eligible studies, with a total of 111,935 patients with brain injury. Preinjury statin use in patients with TBI was associated with a significantly decreased risk of mortality compared with that in nonusers (risk ratio, 0.75;95% confidence interval, 0.59-0.94;I-2 = 53%). Subgroup analysis showed that statin withdrawal might increase mortality. Sensitivity analysis showed that the results were stable and robust. CONCLUSIONS: Preinjury statin use may contribute to mortality reduction in patients with TBI, whereas statin withdrawal might increase mortality. In clinical management, statin use should not be discontinued after TBI.

关键词： Cohort Mortality Statins Traumatic brain injury

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Pladienolide B对牛胚胎干细胞多能性相关基因表达及细胞活力的影响

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中国农业科学 2023年第11期56卷 2186-2201页

作者：赵芳丁强夏淑雯高运东兰国成林志平王慧利仲跻峰江苏省农业科学院畜牧研究所/江苏省畜禽精准育种工程研究中心/农业农村部种养结合重点实验室山东奥克斯畜牧种业有限公司香港大学李嘉诚医学院江苏优源奶业产业研究院有限公司

【背景】牛胚胎干细胞（bovine embryonic stem cells,BESCs）因具备较高的多能性，在牛品种保存、品种选育及研究家畜胚胎发育调控机制方面具有重要的应用价值。然而，BESCs多能性维持及分化调控的研究相对缺乏，很多机制仍不清楚。【... 详细信息

【背景】牛胚胎干细胞（bovine embryonic stem cells,BESCs）因具备较高的多能性，在牛品种保存、品种选育及研究家畜胚胎发育调控机制方面具有重要的应用价值。然而，BESCs多能性维持及分化调控的研究相对缺乏，很多机制仍不清楚。【目的】探究不同浓度Pladienolide B（PlaB）对BESCs多能标记基因、全能标记基因、胚胎细胞谱系基因表达及细胞活力的影响，为提高BESCs多能性提供参考和理论依据。【方法】利用免疫荧光检测牛BESCs多能标记基因的表达，利用实时荧光定量PCR（real-time fluorescence quantitative PCR,RT-qPCR）检测不同浓度PlaB对BESCs剪接体、全能标记基因及胚胎细胞谱系基因表达的影响，利用RT-qPCR和Western Blot分别检测不同浓度PlaB对BESCs多能标记基因mRNA和蛋白表达的影响，利用CCK8和EDU染色检测不同浓度PlaB对BESCs增殖的影响。【结果】RT-qPCR结果显示，PlaB浓度为0.5—1.5 nmol·L-1时显著下调EPSCM-BESCs中SF3B1和SF3B2的mRNA表达水平；PlaB浓度为1.5nmol·L-1时，CTFR-BESCs中SF3B1和SF3B2的mRNA表达下降；PlaB浓度范围为0.5—1.5 nmol·L-1时，CTFR-BESCs和EPSCM-BESCs的SF3B4和SF3B5的mRNA表达水平呈剂量依赖性增加。此外，PlaB显著下调CTFR-BESCs中SF3B6的mRNA表达。PlaB浓度为0.5—1.5 nmol·L-1时，EPSCM-BESCs和CTFR-BESCs中剪接体LSM4的mRNA表达显著下调。PlaB浓度为0.5—1.5 nmol·L-1时，显著下调CTFR-BESCs的EFTUD2 mRNA表达水平；PlaB浓度为1—1.5 nmol·L-1时能显著下调BEPSCM-BESCs的EFTUD2 mRNA表达水平。浓度为0.5—1.5 nmol·L-1范围内，PlaB均以剂量依赖性上调CTFR-BESCs和EPSCM-BESCs中多能标记基因OCT4、SOX2及NANOG的mRNA表达水平和蛋白水平。在PlaB浓度为0.5—1.5 nmol·L-1范围内，PlaB以剂量依赖性上调CTFR-BESCs和EPSCM-BESCs中全能标记基因MDM2、PID1及BTG2的mRNA表达水平，而下调DDIT4和PDRG1的mRNA表达水平。CTFR-BESCs中添加PlaB均上调胚胎细胞谱系基因的表达，而EPSCM-BESCs中添加PlaB显著降低GATA4、GATA6、SOX7等胚胎细胞谱系基因的表达，但是对于ZIC1没有显著影响。随着PlaB剂量增加和处理时间延长，CTFR-BESCs和EPSCM-BESCs细胞活力均呈下降趋势，但CTFR-BESCs比EPSCM-BESCs更敏感。【结论】PlaB显著上调CTFR-BESCs和EPSCM-BESCs中多能标记基因和部分全能标记基因的表达；降低EPSCM-BESCs中胚胎细胞谱系基因的表达和细胞活力。PlaB对两种BESCs发挥作用的浓度及对基因表达的影响并不完全一致。由于PlaB降低BESCs的细胞活力，仍需要进一步研究以优化培养体系。

关键词：牛胚胎干细胞 Pladienolide B 剪接体多能性相关基因细胞活力

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Biosafe alginate-based dual-pesticides controlled release system for selective control of multiple pests

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Chemical Engineering Journal 2025年 518卷

作者： shuwen Luo Yan Liu Fengqiong Jiang Yuntong Liang Guohuan Huang Baofeng lin School of Chemistry and Chemical Engineering Guangxi University Nanning 530004 China Guangxi Key Laboratory of Chemistry and Engineering of Forest Products School of Chemistry and Chemical Engineering Guangxi Minzu University Nanning 530006 China

The traditional delivery system based on a single pesticide cannot cope with the invasion of multiple pests and diseases during different stages of crop growth. In this work, we innovatively constructed a dual pesticide delivery system of emamectin benzoate/β-cyclodextrin/dinotefuran/sodium alginate (EB/β-CD/DNF/SA) to selectively control multiple pests. In addition to the high loading capacities of EB (53.19 %) and DNF (27.31 %), the carrier also achieved dynamic controlled release of two pesticides according to the actual pest infestation. EB/β-CD/DNF/SA could selectively control and synergistically inhibit Plutella xylostella and Rhopalosiphum maidis , and EB/β-CD/DNF/SA reduced the amount of EB and DNF used to achieve the same insecticidal effect from the results of LC 50 . Furthermore, the half-life of EB and DNF encapsulated in the EB/β-CD/DNF/SA was extended by approximately 2-fold and 2.5-fold compared to free EB and DNF under UV irradiation, respectively, confirming the excellent stability of the EB/β-CD/DNF/SA. Note that the EB/β-CD/DNF/SA also exhibited distinguished biosafety to ensure the health and sustainable development of the ecosystem. This work provided experimental and data references for the development of the efficient dual-pesticide controlled release system.

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LILRB1和LILRB4在单核细胞分化急性髓系白血病诊断中的意义

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现代肿瘤医学 2023年第24期31卷 4582-4586页

作者：饶若王述文吴莉芳王照良唐瑞梅林慧海南省人民医院海南医学院附属海南医院检验科海南海口570311 海南省人民医院海南医学院附属海南医院血液科海南海口570311 海南省人民医院海南医学院附属海南医院麻醉科海南海口570311

目的:探讨LILRB1和LILRB4在单核细胞分化急性髓系白血病(M-AML)诊断中的意义。方法:通过直接荧光标记流式细胞术检测109例急性白血病患者白血病细胞LILRB1、LILRB4、CD64和CD14的表达。结果:LILRB1在M-AML、NM-AML和ALL患者中表达阳性... 详细信息

目的:探讨LILRB1和LILRB4在单核细胞分化急性髓系白血病(M-AML)诊断中的意义。方法:通过直接荧光标记流式细胞术检测109例急性白血病患者白血病细胞LILRB1、LILRB4、CD64和CD14的表达。结果:LILRB1在M-AML、NM-AML和ALL患者中表达阳性率分别为81.6%(31/38)、0(0/49)、27.3%(6/22),差异有统计学意义(P<0.01),其中M-AML组的阳性率明显高于NM-AML组和ALL组,ALL组阳性率明显高于NM-AML组;LILRB4在M-AML组中的表达阳性率为81.6%(31/38),在NM-AML和ALL组中均不表达(0/49,0/22),差异有统计学意义(P<0.01);单独检测LILRB1、LILRB4诊断M-AML敏感性均为81.6%,联合检测的敏感性为86.8%,特异性均为100%,优于CD64(86.8%,61.2%)、CD14(31.6%,100%)。结论:LILRB1、LILRB4单独检测或联合检测对检出M-AML均具有极高的灵敏度和特异度,可作为诊断M-AML的新指标。

关键词： LILRB1 LILRB4 急性髓系白血病单核细胞分化流式细胞术

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Electrostatic Assembly of Laminated Transparent Piezoelectrets for Epidermal and Implantable Electronics

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NANO ENERGY 2021年 89卷

作者： Xu, Zisheng Wan, Xiao Mo, Xiwei lin, Shizhe Chen, shuwen Chen, Jianping Pan, Yuan Zhang, Hongbo Jin, Hongrun Duan, Jiangjiang Huang, Liang Huang, Long-Biao Xie, Junjie Yi, Fengtao Hu, Bin Zhou, Jun Huazhong Univ Sci & Technol Sch Opt & Elect Informat Wuhan Natl Lab Optoelect Wuhan 430074 Peoples R China Zhejiang Normal Univ Coll Engn Jinhua 321004 Zhejiang Peoples R China Shenzhen Univ Coll Phys & Optoelect Engn Key Lab Optoelect Devices & Syst Minist Educ & Guangdong Prov Shenzhen 518060 Peoples R China Gen Hosp Cent Theater Command Oncol Dept Wuluo Rd 627 Wuhan 430070 Hubei Peoples R China

Piezoelectric polymers hold physical properties, such as high mechanical flexibility and smaller acoustical impedance, that piezoelectric ceramics do not have. Nevertheless, owing to the piezoelectricity originates from the crystalline region, it is still a challenge for most semi-crystalline polymers to generate a high piezoelectric response. Here, we develop a class of piezoelectret with sandwiched polymer structure (electret/dielectric/electret, EDE) which is assembled via simple electrostatic interaction. The transparent and mechanical robust EDE piezoelectrets exhibit the piezoelectric constant (d(33)) up to similar to 930 pC N-1, and the corresponding physical model is established to investigate major influence factors to the piezoelectric properties, including the relative permittivity and elastic modulus of the electret and dielectric, and the simulated results are in accord with the experimental data. We demonstrate the strain sensors and acoustic transducers based on the ultrathin and flexible EDE piezoelectret, verifying the feasibility of the electrostatic assembled piezoelectrets in the applications of epidermal and implantable electronics. Moreover, various combinations of polymers in the EDE structure can be employed based on our proposed model to explore other unique applications such as transient electronics.

关键词： Electrostatic interaction Self-assembly Piezoelectric effect Flexible sensors Implantable electronics

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The Mitochondria-Targeted Antioxidant Mitoq Ameliorates Inorganic Arsenic-Induced Dcs/Th1/Th2/Th17/Treg Differentiation Partially by Activating Pink1-Mediated Mitophagy in Murine Liver

SSRN

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SSRN 2024年

作者： Li, Hui Guo, Yaning Su, Wei Zhang, Huan Wei, Xiaoxi Ma, Xinyu Gong, shuwen Qu, Gaoyang Zhang, lin Xu, Hong Shen, Fuhai Jiang, Shoufang Xu, Dingjie Li, Jinlong Hebei Key Laboratory for Organ Fibrosis Research School of Public Health North China University of Science and Technology Hebei Province Tangshan063210 China North China University of Science and Technology China College of Traditional Chinese Medicine North China University of Science and Technology Hebei Province Tangshan063210 China Medical Research Center

It has been well established that arsenic is an environmental toxicant and carcinogen, with convincing evidences that the metalloid contributes to acute liver injury (ALI), liver fibrosis, and even liver cancer. The biological mechanisms primarily involved in hepatic injury induced by inorganic arsenic are mainly related to oxidative stress, pyroptosis, and ferroptosis. However, the role of PTEN-induced kinase 1 (PINK1)-mediated mitophagy in inorganic arsenic-induced hepatic immunotoxicity remains insufficiently characterized. In the present study, our results indicated that acute arsenic exposure induced differentiation of hepatic dendritic cells (DCs) and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cells, accompanied by increased expression of transcription factors and specific cytokines. Additionally, it was confirmed that this metalloid induced liver redox imbalance with elevated levels of alanine transaminase (ALT), hydrogen peroxide (H2O2), malondialdehyde (MDA) and the adaptive stress pathway Nrf2/HO-1. Moreover, we demonstrated that acute arsenic exposure triggers PINK1-mediated mitophagy in the liver. Notably, pharmaceutical inhibition of PINK1 using Cyclosporin A (CsA) exacerbated H2O2 accumulation and promoted DCs/Th1/Th2/Treg phenotypes differentiation in the liver of arsenic-exposed mice. Ultimately, mitoquinone (MitoQ) pretreatment relieved arsenic-induced ALI and immune imbalance through upregulation of the Nrf2/HO-1 signaling pathway and PINK1-mediated mitophagy in mice. According to our knowledge, this is the first report to identify PINK1-mediated mitophagy as a protective factor against hepatic DCs/Th1/Th2 differentiation induced by inorganic arsenic. As a result of these findings, new insights on the immunotoxicity of inorganic arsenic have been gained and this study establishes a foundation for exploring preventive and therapeutic strategies targeting PINK1-mediated mitophagy in ALI. Consequently, the application of mitochondrial antioxi

关键词： Diseases

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UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat

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MBIO 2021年第4期12卷 e0162521页

作者： Liang, Taizhen Zhang, Qiao Wu, Ziyao Chen, Pei Huang, Yifan Liu, shuwen Li, lin Southern Med Univ Guangzhou Key Lab Drug Res Emerging Virus Prevent Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou Peoples R China Jinan Univ Sch Med Guangzhou Peoples R China

HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV infection. Identifying novel host factors and deciphering the molecular mechanisms involved in the establishment and maintenance of latency are critical to discover new targets for the development of novel anti-HIV agents. Here, we show that ubiquitin-like with PHD and RING finger domain 1 (UHRF1) modulates HIV-1 5' long terminal repeat (LTR)-driven transcription of the viral genome as a novel HIV-1 restriction factor. Correspondingly, UHRF1 depletion reversed the latency of HIV-1 pro viruses. Mechanistically, UHRF1 competed with positive transcription factor b (p-TEFb) for the binding to the cysteine-rich motifs of HIV-1 Tat via its TTD, PHD, and RING finger domains. Furthermore, UHRF1 mediated K48-linked ubiquitination and proteasomal degradation of Tat in RING-dependent ways, leading to the disruption of Tat/cyclin T1/CDK9 complex and consequential impediment of transcription elongation. In summary, our findings revealed that UHRF1 is an important mediator of HIV-1 latency by controlling Tat-mediated transcriptional activation, providing novel insights on host-pathogen interaction for modulating HIV-1 latency, beneficial for the development of anti-AIDS therapies. IMPORTANCE HIV-1 latency is systematically modulated by host factors and viral proteins. In our work, we identified a critical role of host factor ubiquitin-like with PHD and RING finger domain 1 (UHRF1) in HIV-1 latency via the modulation of the viral protein Tat stability. By disrupting the Tat/cyclin T1/CDK9 complex, UHRF1 promotes the suppression of HIV-1 transcription and maintenance of HIV-1 latency. Our findings provide novel insights in controlling Tat expression via host-pathogen interaction for modulating HIV-1 latency. Based on our results, modulating UHRF1 expression or activity by specific inhibitors is a potential therapeutic strategy for latency reversal in HIV-1 patients.

关键词： HIV-1 latency UHRF1 Tat p-TEFb RING finger

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Hydroxyapatite Microspheres Encapsulated within Hybrid Hydrogel Promote Skin Regeneration Through the Activation of Calcium Signaling and Motor Protein Pathway

SSRN

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SSRN 2025年

作者： Liu, Shuo Song, Lu Huang, shuwen Liu, Zhanhong Xu, Yang Wang, Zhiyuan Qiu, He Wang, Jing Chen, Zhiru Xiao, Yumei Wang, Hang Zhu, Xiangdong Zhang, Kai Zhang, Xingdong lin, Hai National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University Chengdu610064 China Institute of Regulatory Science for Medical Devices Sichuan University Chengdu610064 China Research Center for Material Genome Engineering Sichuan University Chengdu610064 China Department of Cosmetic and Plastic Surgery West China School of Public Health West China Fourth Hospital Sichuan University Chengdu Sichuan China State Key Laboratory of Oral Diseases Department of Cosmetic and Plastic Surgery Oral and Maxillofacial Surgery National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu610041 China Key Laboratory of Leather Chemistry and Engineering Sichuan University Ministry of Education Chengdu610065 China

Hydroxyapatite (HAp), traditionally recognized for its efficacy in bone regeneration, has rarely been explored for skin regeneration applications. This investigation explored HAp microspheres with distinct physicochemical properties tailored away from conventional bone regeneration parameters, and the capacity promoting skin regeneration and mitigating the aging process were investigated when encapsulated in hyaluronate hydrogels. By benchmarking against well-established dermal fillers like PMMA and PLLA, it was revealed the specific attributes of HAp that were conducive to skin regeneration, providing initial insights into the underlying mechanism. HAp enhanced the fibroblast functionality by triggering minimal adaptive immune responses and enhancing the Calcium Signaling and Motor Protein Signaling pathways. This modulation supported the production of normal collagen fibers, essential for ECM maturation and skin structural integrity. The significant ECM regeneration and remodeling capabilities exhibited by the HAp-encapsulated hybrid hydrogels suggested promising application in facial rejuvenation procedures, potentially making a breakthrough in aesthetic and reconstructive surgery. © 2025, The Authors. All rights reserved.

关键词： Microspheres

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UNI-SMART: UNIVERSAL SCIENCE MULTIMODAL ANALYSIS AND RESEARCH TRANSFORMER

arXiv

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arXiv 2024年

作者： Cai, Hengxing Cai, Xiaochen Yang, shuwen Wang, Jiankun Yao, lin Gao, Zhifeng Chang, Junhan Li, Sihang Xu, Mingjun Wang, Changxin Wang, Hongshuai Li, Yongge lin, Mujie Li, Yaqi Yin, Yuqi Cheng, Zheng Zhao, Zifeng Zhang, linfeng Ke, Guolin DP Technology AI for Science Institute Beijing China

In scientific research and its application, scientific literature analysis is crucial as it allows researchers to build on the work of others. However, the fast growth of scientific knowledge has led to a massive increase in scholarly articles, making in-depth literature analysis increasingly challenging and time-consuming. The emergence of Large Language Models (LLMs) has offered a new way to address this challenge. Known for their strong abilities in summarizing texts, LLMs are seen as a potential tool to improve the analysis of scientific literature. However, existing LLMs have their own limits. Scientific literature often includes a wide range of multimodal elements, such as tables, charts, and molecule, which are hard for text-focused LLMs to understand and analyze. This issue points to the urgent need for new solutions that can fully understand and analyze multimodal content in scientific literature. To answer this demand, we present Uni-SMART (Universal Science Multimodal Analysis and Research Transformer), an innovative model designed for in-depth understanding of multimodal scientific literature. Through rigorous quantitative evaluation across several domains, Uni-SMART demonstrates superior performance over other text-focused LLMs. Furthermore, our exploration extends to practical applications, including patent infringement detection and nuanced analysis of charts. These applications not only highlight Uni-SMART's adaptability but also its potential to revolutionize how we interact with scientific literature. © 2024, CC BY-NC-SA.

关键词： Modal analysis

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基施黄腐酸钾对大棚杨梅营养生长及果实品质的影响

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中国南方果树 2024年第3期53卷 171-174页

作者：包日在孔海民李岗任海英戚行江张淑文张林浙江省农业科学院园艺研究所/农产品质量安全和营养研究所杭州310021 浙江省泰顺县农业农村局浙江泰顺325500 浙江省耕地质量与肥料管理总站杭州330010 浙江省农业技术推广中心杭州330010

以18年生盛果期大棚东魁杨梅为材料,设置秋季基施矿物源黄腐酸钾500 g/株处理和对照(清水),测定植株营养生长和果实性状指标,分析黄腐酸钾对大棚杨梅的影响。结果表明,与对照(清水)相比,黄腐酸钾处理的春梢长度、叶片长度、10片叶厚和... 详细信息

以18年生盛果期大棚东魁杨梅为材料,设置秋季基施矿物源黄腐酸钾500 g/株处理和对照(清水),测定植株营养生长和果实性状指标,分析黄腐酸钾对大棚杨梅的影响。结果表明,与对照(清水)相比,黄腐酸钾处理的春梢长度、叶片长度、10片叶厚和叶绿素SPAD值分别增加36.16%、13.06%、26.23%和0.77%,春梢长度、叶长、10片叶厚与对照(清水)差异显著;单果质量、可溶性固形物、总糖、维生素C、总黄酮和花青素含量分别增加6.03%、3.73%、5.74%、5.32%、2.11%和6.90%,总酸含量降低9.42%,除总黄酮含量外,其他果实品质指标均差异显著。说明基施黄腐酸钾能有效促进大棚东魁杨梅营养生长,明显改善果实品质,具有良好的推广应用价值。

关键词：黄腐酸钾大棚杨梅春梢长叶绿素单果质量总糖

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