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Hierarchical elastomer tuned self-powered pressure sensor for wearable multifunctional cardiovascular electronics

NANO ENERGY 2020年第0期70卷 104460-000页

作者： Chen, shuwen Wu, Nan lin, Shizhe Duan, Jiangjiang Xu, Zisheng Pan, Yuan Zhang, Hongbo Xu, Zheheng Huang, Liang Hu, Bin Zhou, Jun Huazhong Univ Sci & Technol Sch Opt & Elect Informat Wuhan Natl Lab Optoelect Wuhan 430074 Peoples R China

Wearable pressure sensors, as essential components of flexible wearable electronics, may play important roles in early diagnosis and mortality prevention for cardiovascular healthcare. However, traditional self-powered pressure sensors can hardly obtain both high sensitivity and wide pressure range, which makes perceiving both cardiac and vascular signals in a wearable self-powered way challenging as these physiological signals not only have imperceptible changes but also span a broad pressure range. Here, we develop a flexible hierarchical elastomer tuned self-powered pressure sensor, which achieves both high-sensitivity and wide pressure range, showing a high sensitivity of 7.989 V kPa(-1) and wide pressure range of 0.1-60 kPa simultaneously. Fast response (40 ms) and high signal noise ratio (38 db) with good stability are also achieved. We demonstrate that the self-powered pressure sensor can not only sensitively monitor pulse, artery and heart condition but also monitor the wide range blood pressure, which satisfies the diverse needs of wearable cardiovascular healthcare. As most of the pressure related to human interface is less than 50 kPa, we envision the sensor holds great potential in wearable electronics, mobile healthcare and human-machine interaction.

关键词： Wearable electronics Self-powered pressure sensor Cardiovascular healthcare Electret Nanogenerator

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3D gel-printing of hydroxyapatite scaffold for bone tissue engineering

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CERAMICS INTERNATIONAL 2019年第1期45卷 1163-1170页

作者： Shao, Huiping He, Jianzhuang lin, Tao Zhang, Zhinan Zhang, Yumeng Liu, shuwen Univ Sci & Technol Beijing Inst Adv Mat & Technol Beijing 100083 Peoples R China

Porous hydroxyapatite (HA) scaffolds for bone tissue engineering were successfully prepared using 3D gel printing technology. The rheological properties of the HA ceramic slurry, the porosity and shrinkage of the scaffold, and the mechanical properties and degradability of the scaffold were studied. The influence of printing speed on the formation of the scaffold was also investigated. HA ceramic slurry with a solid volume fraction of 55 vol% was used to prepare the scaffolds with an interconnected pore structure that can provide a channel for the adhesion, proliferation, and substance transportation of bone cells. The sintered scaffold had a pore size of about 350 mu m x 350 mu m. The porosity, and shrinkage in height and width were 52.26%, 16.2 +/- 0.2%, and 17.8 +/- 0.23%, respectively. The maximum compressive strength and compressive modulus of the sintered scaffolds were 16.77 +/- 0.38 and 492 +/- 11 MPa, respectively. The weight loss rate of the scaffold was 10.38% after degradation in Tris-HCI solution for 5 wk.

关键词： 3D printing Hydroxyapatite Bio-ceramic scaffolds Ceramic slurry Mechanical properties

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Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

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Signal Transduction and Targeted Therapy 2020年第1期5卷 640-642页

作者： Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang lin Li Shibo Jiang Wei Xu Gengfu Xiao shuwen Liu Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouChina State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesFudan-Jinbo Joint Research CenterFudan UniversityShanghaiChina State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of NephrologySouthern Medical UniversityGuangzhouChina

Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the *** to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been *** herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein.

关键词： infection drugs bundle

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Fire behaviors of single and laminated natural latex foam

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INTERNATIONAL JOURNAL OF THERMAL SCIENCES 2019年 136卷 278-286页

作者： Huang, Dongmei Zhang, Mingzhen Shi, Long Peng, lin Yuan, Qi Wang, shuwen China Jiliang Univ Coll Qual & Safety Engn Hangzhou 310018 Zhejiang Peoples R China RMIT Univ Sch Engn Civil & Infrastruct Engn Discipline Melbourne Vic 3000 Australia ZhongHang Monitoring & Testing Technol Res Inst C Hangzhou 310018 Zhejiang Peoples R China

Although natural latex mattresses have been increasingly used in our lives, its high fire risk could put occupants in big danger. Therefore, a series of experiments were carried out to investigate the fire behaviors of natural latex foam with single and laminated layers. Both single and laminated layer samples showed three burning stages: initial acceleration, stable and decaying stages. A fierce burning and bottom ignition were observed at the end of the stable stage for both types. It was known from the experiments that for laminated sample the shrinkage of the thin layers could increase the fire risk as it could accelerate the combustion process, while no obvious difference was found when the number of layers increases from 2 to 5. When comparing to the single layer sample, the laminated layer samples with at least 100 s shorter burning period showed 28.3% higher average flame height, 31.2% higher surface flame spread rate, 92.3% greater peak mass loss rate, and 43.4% higher fuel regression rate along the thickness direction. However, these two types showed a similar maximum flame height, indicating that the maximum flame height may be much dependent on the sample mass but not the shrinkage of the thin layers.

关键词： Natural latex foam Fuel regression rate Bottom ventilation Flame height Mass loss rate

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可转位浅孔钻螺旋容屑槽结构优化及实验研究

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现代制造工程 2024年第11期 10-17页

作者：连云崧张敏陈小辉彭庶文林亮亮刘超褚旭阳周伟厦门大学萨本栋微米纳米科学技术研究院厦门361105 厦门大学机电工程系厦门361102 厦门金鹭特种合金有限公司厦门361021 厦门钨业股份有限公司厦门361126

钻头排屑性能直接影响切削性能,为了解决可转位浅孔钻在切削过程中出现的缠屑和振动问题,进而避免由此引发的加工异常和孔壁质量差的情况,采用了理论分析和仿真模拟相结合的方法,深入研究了螺旋容屑槽横截面形状结构和螺旋角结构对钻体... 详细信息

钻头排屑性能直接影响切削性能,为了解决可转位浅孔钻在切削过程中出现的缠屑和振动问题,进而避免由此引发的加工异常和孔壁质量差的情况,采用了理论分析和仿真模拟相结合的方法,深入研究了螺旋容屑槽横截面形状结构和螺旋角结构对钻体刚性的影响,并通过实验验证了所设计钻体具有良好的刚性和排屑性能。仿真模拟结果分析表明,在芯径一致时钻体受到的最大应力为761 MPa、应变为0.003367,钻体头部横向位移量为0.3971 mm、转动变化量为0.006500 rad;变螺旋角在20°-16°时,钻体受到的最大应力为695 MPa、应变为0.002688,钻体头部横向位移量为0.3641 mm、转动变化量为0.006140 rad,此时钻体刚性和排屑性能达到良好的平衡;分析表明,螺旋角越大、叶宽差值越大,则芯径越小,钻体刚性越差;所设计的钻体在实验工况下未发生缠屑情况,表现出更好的排屑性能,并有较高的孔径一致性和良好的孔壁质量。

关键词：可转位浅孔钻螺旋容屑槽刚性截面形状螺旋角

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疫情防控背景下高校线上教学问题与对策研究

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江苏科技信息 2023年第5期40卷 66-69页

作者：丁淑敏徐德锋周舒文邱琳常州大学药学院江苏常州213164

新冠疫情暴发以来,各高校大面积开展线上教学课程。在线课程保证了高校教学工作有序进行。文章针对高校在线课程中存在的不足进行分析,提出在线上授课中与时俱进,成立专门的网络保障和教学督导小组,指导教师和学生线上课程操作,设计发... 详细信息

新冠疫情暴发以来,各高校大面积开展线上教学课程。在线课程保证了高校教学工作有序进行。文章针对高校在线课程中存在的不足进行分析,提出在线上授课中与时俱进,成立专门的网络保障和教学督导小组,指导教师和学生线上课程操作,设计发挥学生主动性的教学内容,并引入多样化考核方式等多种策略,提高在线课程质量。

关键词：线上教学高校疫情防控督导小组主动性

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Genome-Wide Profiling of H3K27ac Identifies TDO2 as a Pivotal Therapeutic Target in Metabolic Associated Steatohepatitis Liver Disease

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ADVANCED SCIENCE 2024年第45期11卷 e2404224页

作者： Zhu, Yaling Shang, Limeng Tang, Yunshu Li, Qiushuang Ding, lin Wang, Yi Zhang, Tiantian Xie, Bin Ma, Jinhu Li, Xinyu Chen, shuwen Yi, Xinrui Peng, Jin Liang, Youfeng He, Anyuan Yan, Hong Zhu, Huaqing Zhang, Buchun Zhu, Yong Anhui Med Univ Sch Basic Med Sci Dept Pathophysiol Hefei 230032 Anhui Peoples R China Anhui Med Univ Lab Anim Res Ctr Sch Basic Med Sci Hefei 230032 Anhui Peoples R China Anhui Med Univ Affiliated Hosp 1 Dept Cardiol Hefei 230001 Anhui Peoples R China Anhui Med Univ Sch Life Sci Hefei 230032 Anhui Peoples R China Univ Sci & Technol China Affiliated Hosp 1 Dept Pathol Div Life Sci & Med Hefei 230001 Anhui Peoples R China Southern Med Univ Sch Basic Med Sci Dept Pathol Guangzhou 510515 Guangdong Peoples R China Anhui Med Univ Lab Mol Biol Hefei 230032 Anhui Peoples R China Anhui Med Univ Dept Biochem Hefei 230032 Anhui Peoples R China Univ Sci & Technol China Affiliated Hosp 1 Dept Cardiol Div Life Sci & Med Hefei 230001 Anhui Peoples R China

H3K27ac has been widely recognized as a representative epigenetic marker of active enhancer, while its regulatory mechanisms in pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remain elusive. Here, a genome-wide comparative study on H3K27ac activities and transcriptome profiling in high fat diet (HFD)-induced MASLD model is performed. A significantly enhanced H3K27ac density with abundant alterations of regulatory transcriptome is observed in MASLD rats. Based on integrative analysis of ChIP-Seq and RNA-Seq, TDO2 is identified as a critical contributor for abnormal lipid accumulation, transcriptionally activated by YY1-promoted H3K27ac. Furthermore, TDO2 depletion effectively protects against hepatic steatosis. In terms of mechanisms, TDO2 activates NF-kappa B pathway to promote macrophages M1 polarization, representing a crucial event in MASLD progression. A bovine serum albumin nanoparticle is fabricated to provide sustained release of Allopurinol (NPs-Allo) for TDO2 inhibition, possessing excellent biocompatibility and desired targeting capacity. Venous injection of NPs-Allo robustly alleviates HFD-induced metabolic disorders. This study reveals the pivotal role of TDO2 and its underlying mechanisms in pathogenesis of MASLD epigenetically and genetically. Targeting H3K27ac-TDO2-NF-kappa B axis may provide new insights into the pathogenesis of abnormal lipid accumulation and pave the way for developing novel strategies for MASLD prevention and treatment.

关键词： M1 polarization MASLD TDO2 YY1

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T-type calcium channels blockers inhibit HSV-2 infection at the late stage of genome replication

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EUROPEAN JOURNAL OF PHARMACOLOGY 2021年第0期892卷 173782-173782页

作者： Ding, Liqiong Jiang, Ping Xu, Xinfeng Lu, Wanzhen Yang, Chan Li, lin Zhou, Pingzheng Liu, shuwen Southern Med Univ Guangdong Prov Key Lab New Drug Screening Sch Pharmaceut Sci Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Inst Nephrol State Key Lab Organ Failure Res Guangzhou 510515 Peoples R China Guangdong Med Univ Sch Pharmaceut Sci Dongguan 523808 Peoples R China Hubei Univ Sci & Technol Sch Pharmaceut Sci Xianning 437100 Peoples R China

Herpes simplex virus type 2 (HSV-2) is a highly contagious sexually transmitted virus. The increasing emergence of drug-resistant viral strains has highlighted the crucial need for the development of new anti-HSV-2 drugs with different mechanisms. Ion channels that govern a wide range of cellular functions represent attractive targets for viral manipulation. Here, we tried to identify novel compounds to suppress HSV-2 infection in vitro by screening a small library with ion channels modulators. We found that several T-type calcium channel blockers including benidipine, lercanidipine, lomerizine and mibefradil inhibited HSV-2 infection, while L-type calcium channel blockers nifedipine and nitrendipine showed no significant effect on HSV-2 infection. Furthermore, we found that benidipine exerted the antiviral effect by suppressing the expression of viral genes in the late stage of viral infection. In conclusion, our study suggested that T-type calcium channel blockers, which are clinically wide used, could effectively inhibit HSV-2 infection. These findings could shed light on the mechanism and pharmacological study for HSV-2 infection in the future.

关键词： HSV-2 Calcium channel blockers Benidipine Voltage-gated calcium channel

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Vitrified bond diamond grinding wheel prepared by gel-casting with 3D printing molds

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DIAMOND AND RELATED MATERIALS 2020年 108卷 107917-107917页

作者： lin, Tao Liu, shuwen Ji, Zhenhui Shao, Huiping Hao, Junjie Univ Sci & Technol Beijing Inst Adv Mat & Technol Beijing 100083 Peoples R China

The vitrified bond diamond grinding wheel composites were successfully prepared by gel casting (GC) with 3D printing molds. The effects of different solid content on the properties of vitrified bond/diamond abrasive slurry were researched in this study. The results show that when the solid content was 54 vol%, the green sample had a better flexural strength of about 13 MPa. After the sample was sintered at 760 degrees C, the relative density and flexural strength of sintered samples was about 80.0% and 78 MPa, respectively. The grinding ratio of the vitrified bond diamond grinding wheel composites prepared by gel casting with 3D printing molds was 1:152, and the removal rate was 2.92 g/min, which means that the performance of the diamond grinding wheel reached the traditional cold pressed sample.

关键词： Vitrified bond diamond grinding wheel 3D printing Gel-casting Solid content Flexural strength

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Establishment of an analysis model for the influence of seismic liquefaction site position change on seismic performance of metro stations

Establishment of an analysis model for the influence of seis...

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International Conference on Advances in Civil Engineering, Energy Resources and Environment Engineering (ACCESE)

作者： Xie Qiao Long Hui Yan lin Liu shuwen Univ South China Hengyang 421001 Hunan Peoples R China

In recent years, the construction of subway projects has flourished, and the flow of personnel in underground structures such as subway stations has also increased. Once earthquakes occur, they will bring a series of unpredictable and malignant effects to the country. Therefore, it is necessary to strengthen the subway stations, etc. Research on earthquake resistance of underground structures. According to the research on the earthquake damage that has occurred, it is found that the underground structure damage such as the subway station is caused by the liquefaction caused by the earthquake. Based on the powerful functions of ABAQUS in solving nonlinear problems, this project establishes a two-dimensional liquefiable field-metro station finite element analysis model. The subway station form mainly adopts the commonly used two-story double-span island metro station structure. Based on the open secondary development port of ABAQUS embeds a sand constitutive subroutine that can describe the nonlinear characteristics of sand liquefaction dynamics, which provides a reference for a certain degree of reference for the difference of seismic response of metro stations in the future.

关键词： Subway stations

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