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护理研究 2023年第3期37卷 543-547页

作者：张月葵郭舒文杨玉燕林娟斌张秀虹郑碧月福建医科大学附属漳州市医院福建363000

目的:探讨新生儿经右下肢小隐静脉留置PICC导管的效果。方法:采用历史对照法,选取福建省某三级甲等医院新生儿重症监护室148例新生儿患者为研究对象,其中2021年4月—2021年11月64例新生儿为试验组,经右下肢小隐静脉留置PICC导管,2020年... 详细信息

目的:探讨新生儿经右下肢小隐静脉留置PICC导管的效果。方法:采用历史对照法,选取福建省某三级甲等医院新生儿重症监护室148例新生儿患者为研究对象,其中2021年4月—2021年11月64例新生儿为试验组,经右下肢小隐静脉留置PICC导管,2020年9月—2021年3月84例新生儿为对照组,经右下肢大隐静脉留置PICC导管。比较两组置管一次穿刺成功率、置管操作总耗时、导管留置时间及并发症发生率等情况。结果:试验组患儿一次穿刺成功率为93.8%,操作总耗时为(12.14±3.18)min,总留置时间为20(10,55)d,并发症发生率为9.4%;对照组患儿一次穿刺成功率为97.6%,操作总耗时为(11.71±2.34)min,总留置时间为20.00(6,55)d,并发症发生率为9.5%;两组患儿一次穿刺成功率、操作总耗时、总留置时间、并发症发生率比较差异均无统计学意义(P>0.05)。试验组新生儿疼痛评估量表(NIPS)评分0~3分26例,4~7分38例;对照组NIPS评分0~3分38例,4~7分46例,两组操作对患儿的疼痛刺激差异比较无统计学意义(P>0.05)。结论:新生儿经右下肢小隐静脉留置PICC导管与经右下肢大隐静脉留置PICC导管效果无显著差异,为新生儿PICC置管增加了可供选择的部位和方法。

关键词：新生儿经外周置入中心静脉导管(PICC) 外周导管置入术右下肢小隐静脉护理

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江苏地区荷斯坦成母牛长寿性状遗传参数估计

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畜牧兽医学报 2024年第3期55卷 1030-1039页

作者：夏淑雯陈坤琳沈阳阳安振江赵芳丁强仲跻峰林志平王慧利江苏省农业科学院畜牧研究所南京210014 江苏省畜禽精准育种工程研究中心南京210014 农业农村部种养结合重点实验室南京210014 南京农业大学动物科技学院南京210095 江苏优源奶业产业研究院有限公司南京211100

旨在估计荷斯坦成母牛长寿性状遗传参数及评估育种值,为提高生产性能及实施平衡育种提供参考。本研究共收集江苏地区9个规模化牧场2017—2023年间19 756头荷斯坦成母牛的离群记录,分析牛只的长寿性和淘汰情况。利用R软件的GLM程序对影... 详细信息

旨在估计荷斯坦成母牛长寿性状遗传参数及评估育种值,为提高生产性能及实施平衡育种提供参考。本研究共收集江苏地区9个规模化牧场2017—2023年间19 756头荷斯坦成母牛的离群记录,分析牛只的长寿性和淘汰情况。利用R软件的GLM程序对影响奶牛长寿性状的固定效应(包括牧场、出生年季、头胎产犊月龄)进行显著性检验;采用BLUPF90软件进行遗传参数估计以及育种值评估,并绘制遗传趋势图。结果表明:江苏地区规模化牧场成母牛平均在群寿命为1 640.87 d,生产寿命为917.15 d,平均利用胎次为2.60胎;长寿性状遗传力估计值变化范围为0.07~0.15,属低遗传力性状;7个长寿性状(在群天数、生产寿命、利用胎次和L1-L4)间均具有中等到较高的遗传和表型相关(0.27~0.99),其中在群寿命与生产寿命的相关性趋近于1;通过计算长寿性状的育种值,绘制遗传趋势图,发现近年来长寿性状遗传进展缓慢且整体呈下降趋势。本研究对江苏地区规模化牧场成母牛长寿性状进行了系统的遗传分析,可为制定南方地区奶牛长寿性状育种规划提供参考。

关键词：荷斯坦牛长寿性状遗传力遗传相关育种值

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Modulation of Aggregation-Caused Quenching to Aggregation-Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy

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MACROMOLECULAR RAPID COMMUNICATIONS 2021年第19期42卷 2100264-2100264页

作者： Wang, Cheng Wang, Ziyu Chen, Shaoqing Cui, Pengfei Qiu, lin Zhou, shuwen Jiang, Hua Jiang, Pengju Wang, Jianhao Changzhou Univ Sch Pharm Changzhou 213164 Jiangsu Peoples R China Soochow Univ State Key Lab Radiat Med & Protect Sch Radiol & Interdisciplinary Sci RAD X 199 Renai Rd Suzhou 215123 Peoples R China Nanjing Med Univ Peoples Hosp Changzhou 2 Dept Oncol Changzhou 213003 Jiangsu Peoples R China Zhejiang Univ Coll Pharmaceut Sci 866 Yuhangtang Rd Hangzhou 310058 Peoples R China

Dual intramolecular FRET polymers are synthesized via Suzuki coupling and their luminescence characteristics from aggregation-caused quenching (ACQ) to aggregation-induced emission (AIE) is modulated conveniently by adjusting the charged ratios. The finally obtained AIE polymer is further employed to construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy.

关键词： aggregation-caused quenching aggregation-induced emission cancer therapy fluorescence resonance energy transfer theranostics

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贴膜外压迫法预防新生儿PICC置管后穿刺点渗血的效果观察

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循证护理 2024年第11期10卷 1970-1973页

作者：郭舒文张秀虹林娟斌戴冬凰余小琴福建省漳州市医院福建363000

目的:探讨贴膜外压迫法预防新生儿经外周静脉置入中心静脉导管(PICC)置管后穿刺点渗血的效果。方法:选取2021年9月1日—2022年6月30日在相同治疗组接受PICC置管治疗符合纳入标准的118例新生儿为研究对象,采用摸球法随机分为对照组和试验... 详细信息

目的:探讨贴膜外压迫法预防新生儿经外周静脉置入中心静脉导管(PICC)置管后穿刺点渗血的效果。方法:选取2021年9月1日—2022年6月30日在相同治疗组接受PICC置管治疗符合纳入标准的118例新生儿为研究对象,采用摸球法随机分为对照组和试验组,各59例。试验组采用PICC穿刺后贴膜外压迫穿刺点;对照组采用PICC穿刺后贴膜内压迫穿刺点。比较两组患儿穿刺后7 d内更换贴膜的次数、穿刺点24 h渗血率、渗血持续时间及并发症发生情况等。结果:试验组7 d内贴膜更换次数较对照组少,穿刺点24 h渗血率及渗血持续时间低于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:贴膜外压迫法能较好地降低PICC置管后穿刺点渗血率及渗血时间,提高护理质量及工作效率。

关键词：新生儿经外周静脉置入中心静脉导管贴膜压迫法渗血并发症护理

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Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression

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BEHAVIOURAL BRAIN RESEARCH 2024年 468卷 115028页

作者： Cheng, Jiao Yuan, lin Yu, shuwen Gu, Bing Luo, Qian Wang, Xixi Zhao, Yijing Gai, Chengcheng Li, Tingting Liu, Weiyang Wang, Zhen Liu, Dexiang Ho, Roger C. M. Ho, Cyrus S. H. Shandong Univ Cheeloo Coll Med Sch Basic Med Sci Dept Med Psychol & Ethics Jinan 250012 Shandong Peoples R China Shandong First Med Univ Affiliated Hosp 1 Dept Clin Lab Jinan 250012 Shandong Peoples R China Shandong Univ Cheeloo Coll Med Sch Basic Med Sci Dept Physiol Jinan 250012 Shandong Peoples R China Jinan Xicheng Expt High Sch Dept Pediat Surg Dezhou Rd Jinan 1999 Shandong Peoples R China Natl Univ Singapore Yong Loo Lin Sch Med Dept Psychol Med Singapore Singapore Natl Univ Singapore Inst Hlth Innovat & Technol iHealthtech Singapore Singapore

Early life stress (ELS) increases the risk of depression later in life. Programmed cell death factor 4 (PDCD4), an apoptosis-related molecule, extensively participates in tumorigenesis and inflammatory diseases. However, its involvement in a person's susceptibility to ELS-related depression is unknown. To examine the effects and underlying mechanisms of PDCD4 on ELS vulnerability, we used a "two-hit" stress mouse model: an intraperitoneal injection of lipopolysaccharide (LPS) into neonatal mice was performed on postnatal days 7-9 (P7-P9) and inescapable foot shock (IFS) administration in adolescent was used as a later-life challenge. Our study shows that compared with mice that were only exposed to the LPS or IFS, the "two-hit" stress mice developed more severe depression/anxiety-like behaviors and social disability. We detected the levels of PDCD4 in the hippocampus of adolescent mice and found that they were significantly increased in "two-hit" stress mice. The results of immunohistochemical staining and Sholl analysis showed that the number of microglia in the hippocampus of "two-hit" stress mice significantly increased, with morphological changes, shortened branches, and decreased numbers. However, knocking down PDCD4 can prevent the number and morphological changes of microglia induced by ELS. In addition, we confirmed through the Golgi staining and immunohistochemical staining results that knocking down PDCD4 can ameliorate ELS-induced synaptic plasticity damage. Mechanically, the knockdown of PDCD4 exerts neuroprotective effects, possibly via the mediation of BDNF/AKT/CREB signaling. Combined, these results suggest that PDCD4 may play an important role in the ELS-induced susceptibility to depression and, thus, may become a therapeutic target for depressive disorders.

关键词： Early -life stress PDCD4 Synaptic plasticity Depression susceptibility "two -hit" stress

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N-induced lattice contraction generally boosts the hydrogen evolution catalysis of P-rich metal phosphides

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SCIENCE ADVANCES 2020年第1期6卷 8113-8113页

作者： Cai, Jinyan Song, Yao Zang, Yipeng Niu, shuwen Wu, Yishang Xie, Yufang Zheng, Xusheng Liu, Yun lin, Yue Liu, Xiaojing Wang, Gongming Qian, Yitai Univ Sci & Technol China Dept Appl Chem Hefei Natl Lab Phys Sci Microscale Hefei 230026 Anhui Peoples R China Univ Sci & Technol China Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China

P-rich transition metal phosphides (TMPs) with abundant P sites have been predicted to be more favorable for hydrogen evolution reaction (HER) catalysis. However, the actual activities of P-rich TMPs do not behave as expected, and the underlying essence especially at the atomic level is also ambiguous. Our structural analysis reveals the inferior activity could stem from the reduced overlap of atomic wave functions between metal and P with the increase in P contents, which consequently results in too strong P-H interaction. To this end, we used N-induced lattice contraction to generally boost the HER catalysis of P-rich TMPs including CoP2, FeP2, NiP2, and MoP2. Refined structural characterization and theoretical analysis indicate the N-P strong interaction could increase the atomic wave function overlap and eventually modulate the H adsorption strength. The concept of lattice engineering offers a new vision for tuning the catalytic activities of P-rich TMPs and beyond.

关键词： Phosphorus compounds

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Machine learning ensemble meets clinical practice: developing a real-world risk prediction model for metabolic syndrome using super learner and scorecard approaches

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Journal of Advanced Research 2025年

作者： shuwen Li Yu Zhang Kang Fu Kailu Fang Luyan Zheng Yushi lin Jie Wu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious Diseases Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong 258118 China Department of Infectious Diseases the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Introduction Metabolic syndrome (MetS) refers to a cluster of metabolic abnormalities that significantly increase the risk of developing cardiovascular diseases (CVDs). Traditional binary definitions of MetS fall short in capturing its severity spectrum, limiting personalized risk stratification. Objectives We aimed to develop a super learner model and multilevel risk scorecard to improve MetS risk prediction and support early cardiovascular risk identification. Methods This study included a total of 460,256 health examination records from Zhejiang, China (2018–2023), with 344,925 used for model development and 115,331 used for external validation. A super learner model combining multiple machine learning algorithms was constructed to predict MetS risk. Key predictors identified through feature selection were used to develop a logistic regression-based MetS risk scorecard, stratifying individuals into five risk levels for practical and interpretable applications. Results The super learner model achieved area under the receiver operating characteristics (AUCs) of 0.816 (95% confidence interval [CI]: 0.814–0.817) and 0.810 (95 % CI: 0.808–0.813) in the development and external validation cohorts, respectively. The risk scorecard, which incorporates ten predictors, demonstrated comparable performance, with AUCs of 0.793 (95 % CI: 0.791–0.794) and 0.788 (95 % CI: 0.785–0.791) in the respective cohorts. Based on the risk scorecard, individuals were stratified into five categories: very low, low, normal, high, and very high risk levels. Conclusion The super learner model provides a highly accurate tool for MetS risk prediction, whereas the risk scorecard offers a practical and interpretable solution for clinical and personal use. These models enable precise risk assessment to guide prevention and improve outcomes.

关键词： Metabolic syndrome Metabolism Risk prediction model Risk scores Machine learning AI artificial intelligence ALT alanine aminotransferase ANOVA analysis of variance AST aspartate aminotransferase AUROC area under the receiver operating characteristic AUC area under the curve BMI body mass index BPHS Basic Public Health Services CHCs community health centers CI confidence interval CVDs cardiovascular diseases DASH dietary approaches to stop hypertension EMRs electronic medical records FBG fasting blood glucose HDL-C high-density lipoprotein cholesterol IFS incremental feature selection KS Kolmogorov–Smirnov MASLD metabolic dysfunction-associated steatotic liver disease (nonalcoholic fatty liver disease) MetS metabolic syndrome PCC Pearson correlation coefficients SHAP Shapley Additive exPlanation WoE weight of evidence

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Synergistic integration of dihydro-artemisinin with γ-aminobutyric acid results in a more potential anti-depressant

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BIOORGANIC CHEMISTRY 2021年 110卷 104769-104769页

作者： He, Yepu Xu, Liyu Li, Yanbing Tang, Yinying Rao, shuwen lin, Rongtian Liu, Zhijun Chen, Heru Jinan Univ Coll Pharm Inst Tradit Chinese Med & Nat Prod Guangzhou 510632 Peoples R China Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Peoples R China Jinan Univ Sch Pharm Int Cooperat Lab Tradit Chinese Med Modernizat & Chinese Minist Educ Guangzhou 510632 Peoples R China

Three hybrids of dihydro-artemisinin (DHA) with beta-aminopropionic acid, gamma-aminobutyric acid, and histamine have been designed and synthesized. The conjugate of DHA with GABA labelled as 5b was confirmed the most active candidate against both Cort- and SNP-induced PC12 cell impairments with EC50 value of 8.04 +/- 0.35, and 9.38 +/- 0.56 mu M, respectively. 5b was clearly highlighted as a good modulator on protein expression of Akt, Bcl-2, and Bax, indicating its functions against programmed cell apoptosis. 5b significantly reversed the Cort-induced excessive calcium influx and release from internal organelles. It was demonstrated the ability to express increased levels of beta-tubulin III and to up-regulate phosphorylation level of cAMP response element-binding protein (CREB), leading to cell differentiation. It can penetrate blood brain barrier (BBB) with propriate stability. Altogether, these data strongly support that 5b is a potential anti-depressant.

关键词： Artemisinins Anti-depressant Depression Cell differentiation Drug design

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Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer's disease

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021年 211卷 113067-113067页

作者： lin, Rongtian Rao, shuwen Li, Yanbing Zhang, Lei Xu, Liyu He, Yepu Liu, Zhijun Chen, Heru Jinan Univ Inst Tradit Chinese Med & Nat Prod Coll Pharm Huangpu Ave West 601 Guangzhou 510632 Peoples R China Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Peoples R China Jinan Univ Sch Pharm Int Cooperat Lab Tradit Chinese Med Modernizat & Chinese Minist Educ Guangzhou 510632 Peoples R China

Seven tacrine/CHR21 conjugates have been designed and synthesized. Compound 8-7 was confirmed as the most active AChE inhibitor with IC50 value of 5.8 +/- 1.4 nM, which was 7.72-fold stronger than tacrine. It was also shown as a strong BuChE inhibitor (IC50 value of 3.7 +/- 1.3 nM). 8-7 was clearly highlighted not only as an excellent ChEs inhibitor, but also as a good modulator on protein expression of AChE, p53, Bax, Bcl-2, LC3, p62, and ULK, indicating its functions against programmed cell apoptosis and decrease of autophagy. 8-7 significantly reversed the glutamate-induced dysfunctions including excessive calcium influx and release from internal organelles, overproduction of nitric oxide (NO) and Ab high molecular weight oligomer. This compound can penetrate blood-brain barrier (BBB). The in vivo hepatotoxicity assay indicated that 8-7 was much less toxic than tacrine. Altogether, these data strongly support that 87 is a potential multitarget-directed ligand ( MTDL) for treating Alzheimer's disease (AD). (C) 2020 Elsevier Masson SAS. All rights reserved.

关键词： AChE inhibitor Alzheimer's disease Autophagy Multitarget-directed ligand Drug design

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The Difference Between Preoperative and Postoperative Pituitary Stalk Deviation Angles Can Predict Delayed Hyponatremia After Transsphenoidal Surgery

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WORLD NEUROSURGERY 2021年 155卷 E637-E645页

作者： lin, Kunzhe Zeng, Ran Pei, Zhijie Mu, shuwen Yang, Yongkai Fan, Yong Huang, Shaokuan Wang, Shousen Fujian Med Univ Affiliated Fuzhou Hosp 1 Dept Neurosurg Fuzhou Fujian Peoples R China Fujian Med Univ Affiliated Fuzhou Hosp 1 Cent Lab Fuzhou Fujian Peoples R China Fujian Med Univ Fuzong Clin Med Coll Fuzhou Fujian Peoples R China 900th Hosp Dept Neurosurg Fuzhou Fujian Peoples R China Shanghai Donglei Brain Hosp Dept Neurosurg Shanghai Peoples R China Guiqian Int Gen Hosp Dept Neurosurg Guiyang Peoples R China

OBJECTIVE: Our aim was to assess the factors influencing the development of delayed hyponatremia after trans sphenoidal surgery (TSS) for pituitary adenomas and analyze the effect of the difference between preoperative and postoperative pituitary stalk deviation angles on delayed hyponatremia. METHODS: A retrospective study was performed on the clinical data of patients with pituitary adenomas who were treated with TSS at a single institution. On the basis of the observation of indicators such as pituitary stalk deviation angle and length of "measurable pituitary stalk" on magnetic resonance imaging, we determined the predictors of postoperative delayed hyponatremia through univariate and multivariate analyses. RESULTS: Microscopic TSS was performed in 422 patients with pituitary adenoma, of whom 66 experienced postoperative delayed hyponatremia. Logistic regression analysis showed that the risk of delayed hyponatremia was greater for patients with a large difference between preoperative and postoperative pituitary stalk deviation angle (odds ratio = 1.040, 95% confidence interval: 1.018-1.051;P < 0.001) and a large difference in the "measurable pituitary stalk" (odds ratio = 1.128, 95% confidence interval: 1.011-1.258;P = 0.032), and patients with high blood sodium on the second day after surgery have a lower probability of developing delayed hyponatremia. CONCLUSIONS: This study is the first to suggest the important role of the difference between preoperative and postoperative pituitary stalk deviation angles in predicting the development of delayed hyponatremia after TSS for pituitary adenomas.

关键词： Hyponatremia Pituitary adenoma Pituitary stalk

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