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中国实验方剂学杂志 2023年第24期29卷 80-86页

作者：梁志周峻全锐高帅李瑞涵李述文宓保宏张彦琼林娜陈卫衡北京中医药大学第三附属医院北京100029 中医骨伤治疗与运动康复智能化教育部工程研究中心北京100029 中国中医科学院中药研究所北京100700

目的:基于真实世界数据探讨恒古骨伤愈合剂联合非甾体抗炎药治疗膝骨关节炎的临床疗效,为临床用药提供依据。方法:从2020年5月至2021年12月采用注册登记研方法收集了1002例未行膝关节置换术的膝骨关节炎患者,最终纳入952例,其中口服恒... 详细信息

目的:基于真实世界数据探讨恒古骨伤愈合剂联合非甾体抗炎药治疗膝骨关节炎的临床疗效,为临床用药提供依据。方法:从2020年5月至2021年12月采用注册登记研方法收集了1002例未行膝关节置换术的膝骨关节炎患者,最终纳入952例,其中口服恒古骨伤愈合剂联合口服非甾体抗炎药的病例共133例并设为观察组,单独口服非甾体抗炎药病例共73例设为对照组,将两组患者的基线资料、视觉模拟评分(VAS评分)、西安大略和麦克马斯特大学骨关节炎指数评分(WOMAC评分)等项目进行统计学分析。访视点为登记注册时、登记注册后第4周、8周。为了进一步阐释恒古骨伤愈合剂联合非甾体抗炎药治疗膝骨关节炎的临床疗效,并通过网络药理学方法,检索骨伤交叉数据库、TCMSP等数据库,获取恒古骨伤愈合剂的有效成分、非甾体抗炎药与膝骨关节炎的相关基因集,将相关基因集进行Venn分析,构建蛋白质-蛋白质相互作用(PPI)网络图,再筛选出关键核心靶点,进行基因本体(GO)及京都基因与基因组百科全书(KEGG)富集分析。结果:观察组第4周VAS评分平均下降(-2.79±1.206)分,优于对照组[(-2.73±1.575)分,P<0.05],观察组第8周VAS评分平均下降(-3.97±1.308)分,优于对照组[(-3.89±1.822)分,P<0.05],观察组第8周WOMAC总评分平均下降(-52.07±21.677)分,显著优于对照组[(-46.75±25.368)分,P<0.05],观察组第8周WOMAC(疼痛)评分平均下降(-10.99±4.229)分,优于对照组[(-10.03±5.535)分,P<0.05],观察组第4周WOMAC(僵硬)评分平均下降(-1.49±2.901)分,优于对照组[(-0.92±1.998)分,P<0.05],观察组第8周WOMAC(僵硬)评分平均下降(-1.90±3.200)分,优于对照组[(-1.26±2.230)分,P<0.05],观察组第8周WOMAC(关节功能)评分平均下降(-39.17±16.562)分,明显优于对照组[(-35.47±20.098)分,P<0.05]。网络药理学分析结果,恒古骨伤愈合剂治疗膝骨关节炎的核心网络靶点是经过信号传导转录激活因子3(STAT3)、血管内皮生长因子A(VEGFA)、肿瘤坏死因子(TNF)等信号通路的调节进而调控细胞信号传导、血管生成、软骨细胞的增殖与迁移、炎性细胞从而来抑制炎性反应,减少损害,延缓疾病的进一步发展。结论:恒古骨伤愈合剂联合非甾体抗炎药治疗膝骨关节炎后4周、8周的疗程后,其缓解疼痛、关节僵硬、改善关节功能的疗效均优于单独使用非甾体抗炎药,在网络药理学中恒古骨伤愈合剂治疗膝骨关节类通过参与调节炎性因子、代谢反应相关生物过程、调控软骨细胞的增值与凋亡等,从而产生抗炎阵痛、改善关节活动度、关节僵硬的效果,值得临床推广与应用。

关键词：膝骨关节炎恒古骨伤愈合剂临床观察作用机制真实世界研究

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Performance and Mechanisms of Biochar-Assisted Vermicomposting in Accelerating Dehp Biodegradation in Farmland Soil

SSRN

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SSRN 2022年

作者： Zhen, Zhen Luo, shuwen Chen, Yijie Li, Gaoyang Li, Huijun Wei, Ting Huang, Fengcheng Ren, Lei Liang, Yan-Qiu lin, Zhong Zhang, Dayi College of Coastal Agricultural Sciences Guangdong Ocean University Zhanjiang524088 China Faculty of Chemistry and Environmental Science Guangdong Ocean University Zhanjiang524088 China Shenzhen Research Institute of Guangdong Ocean University Shenzhen518108 China College of New Energy and Environment Jilin University Changchun130021 China Key Laboratory of Groundwater Resources and Environment Ministry of Education Jilin University Changchun130021 China

Either biochar or earthworms can accelerate di-(2-ethylhexyl) phthalate (DEHP) degradation in soils, by physically immobilizing organic pollutants or encouraging indigenous and intestinal degraders. However, very limited information is known about the biochar-assisted vermicomposting on soil DEHP degradation and the underlying mechanisms. This study investigated DEHP degradation performance and bacterial community change in soils with either earthworm, biochar or their combination. Both biochar and earthworms significantly improved DEHP degradation, and biochar exhibited a stronger impact on soil bacterial communities than earthworms. Burkholderiaceae, Pseudomonadaceae and Flavobacteriaceae were potential DEHP degraders and enriched in biochar-assisted vermicompsoting. Particularly, Burkholderiaceae and Sphingomonadaceae were enriched in earthworm guts and charosphere, possibly explaining the mechanisms of accelerated DEHP degradation in biochar-assisted vermicomposting. The increase of soil pH, SOM and humus (humic acid, fulvic acid and humin) also helped in encouraging DEHP degradation. These findings imply that earthworms coupled with biochar could enhance DEHP removal by improving soil physicochemical variables and microbial composition in soils, earthworm guts and charosphere. © 2022, The Authors. All rights reserved.

关键词： Soils

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四轴联动数控系统刀位点速度控制新方法的研究

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机械制造与自动化 2017年第6期46卷 1-4页

作者：周小宇林述温福州大学机械工程及自动化学院福建福州350108

针对现有四轴转台型数控机床加工中刀位点的实际进给速度与加工程序中预定的进给速度存在偏差以及路径段间进给速度波动问题,提出了路径段内速度调整与路径段间衔接点速度约束相结合的进给速度控制新方法。仿真与试验结果表明,所提出的... 详细信息

针对现有四轴转台型数控机床加工中刀位点的实际进给速度与加工程序中预定的进给速度存在偏差以及路径段间进给速度波动问题,提出了路径段内速度调整与路径段间衔接点速度约束相结合的进给速度控制新方法。仿真与试验结果表明,所提出的速度控制方法能够使刀位点在满足加减速特性和机床特性的条件下保持高速、平稳进给,有效地缩短了加工时间。

关键词：四轴联动控制数控技术段内速度修正段间速度约束

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日本土地改良事业的演变、特征及其成效

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现代日本经济 2017年第5期36卷 40-51页

作者：刘德娟林树文曾玉荣福建省农业科学院农业经济与科技信息研究所福建福州350003

二战后,日本土地改良事业共经历了3个主要阶段:以《土地改良法》为依据开始确立,进而从农业整备扩充到农村整备,最终到现代内容的多样化。整个发展过程中,土地改良目标由促进农业生产扩展到提高农村生活水平和建设生态环境。土地改良事... 详细信息

二战后,日本土地改良事业共经历了3个主要阶段:以《土地改良法》为依据开始确立,进而从农业整备扩充到农村整备,最终到现代内容的多样化。整个发展过程中,土地改良目标由促进农业生产扩展到提高农村生活水平和建设生态环境。土地改良事业是受国家、都道府县和市町村三级行政管理,以土地改良区这一农民组织对设施进行维护和管理的一项以产业政策、国土政策和区域政策为目的的公共事业。日本土地改良事业的发展,对粮食供给、农业结构调整与经营主体培育、国民经济发展及农业的多功能性等方面均产生了积极的促进作用。日本的土地改良事业可为中国建设农田基础设施,提高农业生产力和促进规模化经营以及综合治理农村环境等提供有益的启示。

关键词：日本土地改良农业基础设施农田水利农业经营

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Study on the Application of Zeolitic Imidazolate Framework-8 Loaded With Artemisia Argyi Essential Oil in the Treatment of Bacterial Infected Wounds

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Journal of biomedical materials research. Part A 2025年第6期113卷 e37937页

作者： Yiyang Xu Ying Li Zixuan Ye Cheng Wang Pengfei Cui shuwen Zhou lin Qiu Jianhao Wang School of Pharmacy Changzhou University Changzhou China.

Wound bacterial infection deteriorates with antibiotic misuse, boosting bacterial drug resistance, threatening human health. Therefore, combining natural antibacterials with efficient broad-spectrum materials offers new solutions. Artemisia argyi is a kind of medicinal plant distributed in Asia, known for its rich biological active compounds. With the advancement of modern analytical technology, Artemisia argyi has shown excellent antibacterial and anti-inflammatory potential, particularly Artemisia argyi essential oil (AAEO) which is considered to be the most active substance in Artemisia argyi. However, its practical application is limited due to its poor water solubility, strong volatility, high sensitivity to light and heat, and its irritating odor. Zeolitic imidazolate framework-8 (ZIF-8) is a type of metal-organic framework material (MOF) with good biocompatibility, simple synthesis, high porosity, and antimicrobial activity. ZIF-8 can be used as an ideal vehicle for the preparation of antibacterial materials. In this study, we loaded AAEO onto ZIF-8 to successfully develop AAEO@ZIF-8 antibacterial nanomaterial. The bactericidal ability and antibacterial mechanism of AAEO@ZIF-8 were evaluated through in vitro experiments such as bacterial coating, Live/Dead staining, and crystal violet staining. It was confirmed that AAEO@ZIF-8 had significant antibacterial activity against both Staphylococcus aureus and Escherichia coli. In in vivo experiments, the wound model using C57BL/6 male mice was established, and wound tissue staining with Gram, CD31 immunohistochemistry, H&E, and Masson staining was performed to evaluate the antibacterial activity of AAEO@ZIF-8. The results showed that AAEO@ZIF-8 exhibited the best wound repair performance in the model. These findings suggested that AAEO@ZIF-8 is a novel and effective antimicrobial nanomaterial targeting pathogenic bacteria. This study successfully transformed the storage mode of AAEO from liquid to solid, providing

关键词： Staphylococcus aureus antibacterial artemisia argyi essential oil wound infection zeolitic imidazolate framework‐8

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SciAssess: Benchmarking LLM Proficiency in Scientific Literature Analysis

arXiv

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arXiv 2024年

作者： Cai, Hengxing Cai, Xiaochen Chang, Junhan Li, Sihang Yao, lin Wang, Changxin Gao, Zhifeng Wang, Hongshuai Li, Yongge lin, Mujie Yang, shuwen Wang, Jiankun Xu, Mingjun Huang, Jin Fang, Xi Zhuang, Jiaxi Yin, Yuqi Li, Yaqi Chen, Changhong Cheng, Zheng Zhao, Zifeng Zhang, linfeng Ke, Guolin DP Technology AI for Science Institute Beijing China

Recent breakthroughs in Large Language Models (LLMs) have revolutionized scientific literature analysis. However, existing benchmarks fail to adequately evaluate the proficiency of LLMs in this domain, particularly in scenarios requiring higher-level abilities beyond mere memorization and the handling of multimodal data. In response to this gap, we introduce SciAssess, a benchmark specifically designed for the comprehensive evaluation of LLMs in scientific literature analysis. It aims to thoroughly assess the efficacy of LLMs by evaluating their capabilities in Memorization (L1), Comprehension (L2), and Analysis & Reasoning (L3). It encompasses a variety of tasks drawn from diverse scientific fields, including biology, chemistry, material, and medicine. To ensure the reliability of SciAssess, rigorous quality control measures have been implemented, ensuring accuracy, anonymization, and compliance with copyright standards. SciAssess evaluates 11 LLMs, highlighting their strengths and areas for improvement. We hope this evaluation supports the ongoing development of LLM applications in scientific literature analysis. SciAssess and its resources are available at https://***/sci-assess/SciAssess. © 2024, CC BY-NC-SA.

关键词： Benchmarking

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Development and evaluation of percentile curves of serum alanine aminotransferase in older adults: A multi-cohort study

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Annals of Hepatology 2025年第2期30卷

作者： Yu Zhang shuwen Li Kang Fu Kailu Fang Luyan Zheng Yushi lin Yang Zheng Jie Wu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious Diseases Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong 258118 China Department of Infectious Diseases the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Allergic Disease The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

Introduction and Objectives Age independently impacts alanine aminotransferase (ALT) levels. This study was conducted to develop age- and sex-specific ALT percentile curves among older adults and evaluate their diagnostic performance across two external cohorts. Materials and Methods We developed ALT percentile curves using data from a reference population aged 50–90 years (n = 20,039). We evaluated diagnostic performance of various ALT thresholds (40 U/L, American College of Gastroenterology [ACG]’s 33 U/L [men] and 25 U/L [women], and the new percentile curves) for infections of hepatitis B virus and hepatitis C virus, metabolic dysfunction associated steatotic liver disease, and excessive alcohol consumption in two external cohorts. Results ALT percentile curves declined with age. In men, the 95th percentile decreased from 31.4 U/L at 50 years to 21.7 U/L at 90 years; in women, from 26.1 U/L to 17.8 U/L. The 95th percentile curves achieved the highest Youden’s index and area under the receiver operating characteristic (AUROC) across the three thresholds in two external validation cohorts, with the Youden’s index and AUROC of 0.141 and 0.571 (95% CI: 0.555–0.586) in external cohort 1, and 0.435 and 0.717 (95% CI: 0.680–0.754) in external cohort 2, respectively. Conclusions The newly proposed ALT percentile curves may serve as a valuable reference for screening liver diseases in older adults.

关键词： Serum alanine aminotransferase Percentile curves Older adults Liver diseases ALT alanine aminotransferase ACG American College of Gastroenterology HBV hepatitis B virus HCV hepatitis C virus MASLD metabolic dysfunction associated steatotic liver disease NAHNES National Health and Nutrition Examination Survey ULN upper limit of normal

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A novel bromodomain inhibitor, CPI-203, serves as an HIV-1 latency-reversing agent by activating positive transcription elongation factor b

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BIOCHEMICAL PHARMACOLOGY 2019年 164卷 237-251页

作者： Liang, Taizhen Zhang, Xuanxuan Lai, Fangyuan lin, Jian Zhou, Chenliang Xu, Xinfeng Tan, Xinghua Liu, shuwen Li, lin Southern Med Univ Guangdong Prov Key Lab New Drug Screening Guangzhou Key Lab Drug Res Emerging Virus Prevent Sch Pharmaceut Sci Guangzhou 510515 Guangdong Peoples R China Sun Yat Sen Univ Affiliated Hosp 7 Shenzhen 518107 Guangdong Peoples R China Guangzhou 8 Peoples Hosp Dept Infect Dis Guangzhou 510060 Guangdong Peoples R China

The persistence of latent human immunodeficiency virus type 1 (HIV-1) reservoirs remains a major hurdle for HIV-1 eradication. The "shock and kill" strategy relies on the drug-mediated reversion of HIV-1 latency and the subsequent death of HIV-producing cells. Unfortunately, none of the agents currently in use possess a sufficient potency to reactivate latent virus or eliminate the latent HIV-1 reservoir in vivo. Here, we demonstrated that a promising specific bromodomain and extraterminal domain inhibitor, CPI-203, could potently reactivate latent HIV-1 in different latently infected cell lines with minimal cytotoxicity by activating the positive transcription elongation factor b signaling pathway. Notably, CPI-203 exhibited synergism in latent HIV-1 reactivation and alleviated the HIV-1-induced "cytokine storm" when used in combination with the protein kinase C (PKC) agonist prostratin. These findings highlight that CPI-203 shows promise as a novel, safe candidate for the design of targeted strategies to "shock and kill" HIV-1 and thus represents a potential functional cure.

关键词： Latent HIV-1 Shock and kill Latency-reversing agent CPI-203 p-TEFb

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面向临床应用的抗菌肽:递送和剂型

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科学通报 2021年第26期66卷 3365-3366页

作者：周舒文王程邱琳崔朋飞蒋鹏举王建浩夏江常州大学药学院常州213164 香港中文大学化学系香港999077

抗菌肽作为传统抗生素的潜在替代物已经引起了人们的极大关注[1,2].虽然抗生素是人类对抗细菌感染的有效武器,但细菌种类的快速适应和抗生素的滥用导致了耐药菌株的出现和广泛传播.因此,迫切需要在机制上开发不同于现有抗生素的新抗菌方... 详细信息

抗菌肽作为传统抗生素的潜在替代物已经引起了人们的极大关注[1,2].虽然抗生素是人类对抗细菌感染的有效武器,但细菌种类的快速适应和抗生素的滥用导致了耐药菌株的出现和广泛传播.因此,迫切需要在机制上开发不同于现有抗生素的新抗菌方案.事实证明,抗菌肽有望替代抗生素成为一种理想的抗菌剂.除了具有显著的杀菌效果外,抗菌肽还能抑制生物膜的形成并破坏现有的生物膜[3].

关键词：替代抗生素抗菌肽细菌种类抗细菌感染生物膜耐药菌株传统抗生素剂型

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Adjuvant activities of CTAB-modified Polygonatum sibiricum polysaccharide cubosomes on immune responses to ovalbumin in mice

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2020年第0期148卷 793-801页

作者： Liu, Zhenguang Ni, Haiyu Yu, lin Xu, shuwen Bo, Ruonan Qiu, Tianxin Gu, Pengfei Zhu, TianYu He, Jin Wusiman, Adelijiang Zhu, Shaowu Liu, Jiaguo Hu, Yuanliang Wang, Deyun Nanjing Agr Univ Coll Vet Med Inst Tradit Chinese Vet Med Nanjing 210095 Peoples R China Nanjing Agr Univ Coll Vet Med MOE Joint Int Res Lab Anim Hlth & Food Safety Nanjing 210095 Peoples R China

Recently, the cubosomes have been widely studied as drug carriers. It has been described that cubosomes could further stimulate the immune response after carrying the immune enhancer. Polygonatum sibiricum polysaccharide (PSP), one of the most important biologically active ingredients of Polygonatum sibiricum, has been reported as an immunostimulant to improve immune responses. This study was aimed to observe the immunomodulation effects of ovalbumin (OVA) absorbed cetyltrimethylammonium bromide-modified Polygonatum sibiricum poly-saccharide cubosomes (CTAB-modified PSP-Cubs/OVA). Firstly, the antigen uptake of CTAB-modified PSPCubs/OVA by macrophages was determined in vitro. After that, mice were immunized with CTAB-modified PSP-Cubs/OVA. The activation of dendritic cells in lymph nodes, activation of lymphocyte, ratios of CD4(+) to CD8(+), the concentrations of OVA-specific IgG in serum and the cytokines concentrations were analyzed. As the results showed, CTAB-modified PSP-Cubs/OVA could promote the production of OVA-specific IgG in serum. The ratio of CD4(+) to CD8(+) in CTAB-modified PSP-Cubs/OVA group was significantly increased compared with other groups. CTAB-modified PSP-Cubs/OVA could significantly activate dendritic cells and promote lymphocyte proliferation. The results indicated that CTAB-modified PSP-Cubs/OVA could promote the secretion of related cytokines and the proliferation of lymphocytes, stimulate the cellular immune response and increase the level of humoral immunity. Above all, CTAB-modified PSP-Cubs had good adjuvant activity. (C) 2020 Elsevier B.V. All rights reserved.

关键词： Cubosomes Ovalbumin Macrophages Lymphocytes Cytokines Adjuvant activity

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