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中文信息学报 2018年第6期32卷 19-27页

作者：谭咏梅杨一枭杨林刘姝雯北京邮电大学计算机学院北京100876

针对英语文章语法错误自动纠正(Grammatical Error Correction,GEC)问题中的冠词和介词错误,该文提出一种基于LSTM(Long Short-Term Memory,长短时记忆)的序列标注GEC方法;针对名词单复数错误、动词形式错误和主谓不一致错误,因其混淆... 详细信息

针对英语文章语法错误自动纠正(Grammatical Error Correction,GEC)问题中的冠词和介词错误,该文提出一种基于LSTM(Long Short-Term Memory,长短时记忆)的序列标注GEC方法;针对名词单复数错误、动词形式错误和主谓不一致错误,因其混淆集为开放集合,该文提出一种基于ESL(English as Second Lauguage)和新闻语料的N-gram投票策略的GEC方法。该文方法在2013年CoNLL的GEC数据上实验的整体F1值为33.87%,超过第一名UIUC的F1值31.20%。其中,冠词错误纠正的F1值为38.05%,超过UIUC冠词错误纠正的F1值33.40%,介词错误的纠正F1为28.89%,超过UIUC的介词错误纠正F1值7.22%。

关键词：语法错误自动纠正 LSTM N-gram投票策略 ESL语料

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超高效液相色谱-串联质谱法测定菠菜、苹果及大豆中二硝基苯胺类除草剂残留量

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质谱学报 2018年第1期39卷 69-75页

作者：张建莹靳保辉吴卫东邓慧芬林珊梁淑雯深圳出入境检验检疫局食品检验检疫技术中心广东深圳518045

以菠菜、苹果和大豆为代表性分析物,建立了超高效液相色谱-串联质谱法(UPLC-MS/MS)检测蔬菜、水果及粮谷等植物源性食品中8种二硝基苯胺类除草剂(氟乐灵、二甲戊乐灵、仲丁灵、异乐灵、磺乐灵、氨基乙氟灵、氨磺乐灵和氨基丙氟灵)的残... 详细信息

以菠菜、苹果和大豆为代表性分析物,建立了超高效液相色谱-串联质谱法(UPLC-MS/MS)检测蔬菜、水果及粮谷等植物源性食品中8种二硝基苯胺类除草剂(氟乐灵、二甲戊乐灵、仲丁灵、异乐灵、磺乐灵、氨基乙氟灵、氨磺乐灵和氨基丙氟灵)的残留量。采用电喷雾电离,正离子扫描,多反应监测(MRM)模式检测,并使用外标法定量。结果表明:8种二硝基苯胺类除草剂的测定低限均为10μg/kg;在添加水平10~200μg/kg范围内,加标回收率为70.0%~120%,相对标准偏差为0.56%~23.0%。该方法灵敏、有效,适用于蔬菜、水果和粮谷等植物源性食品中二硝基苯胺类除草剂多残留的测定。

关键词：超高效液相色谱-串联质谱(UPLCMS/MS) 二硝基苯胺除草剂蔬菜水果粮谷

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Facile preparation of ZrCO composite aerogel with high specific surface area and low thermal conductivity

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Journal of Sol-Gel Science and Technology 2018年第2期86卷 383-390页

作者： Sheng Cui Hao Suo Feng Jing shuwen Yu Jun Xue Xiaodong Shen Benlan lin Shengjun Jiang Yu Liu Department of Materials Science and Engineering Nanjing Tech University Nanjing China Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing Tech University Nanjing China Institute of Chemistry Materials CAEP Mianyang China

A novel ZrCO composite aerogel is synthesized using zirconium oxychloride and resorcinol–formaldehyde (RF) as precursors through the sol–gel route and carbothermal reduction process. The effects of different Zr/R molar ratios and calcination temperatures on the physical chemistry properties of ZrCO aerogels are investigated. The ZrCO composite aerogel consists of the C/ZrO2/ZrC ternary aerogel. The results show that with the increase of R/Zr molar ratios, the specific surface area and bulk density increase with calcination temperature up to 1300 °C, but decrease at even temperature (1500 °C). The specific surface area is as high as 637.4 m2/g for ZrCO composite aerogel (R:Zr = 2:1), which was higher than ever reported. As the heat-treatment temperature increases to 1500 °C, the ZrC crystalline phase occurs and the t-ZrO2 phase still appears within the composite. The thermal conductivity of the carbon fiber mat-reinforced composite aerogel is as low as 0.057 W/m/K at room temperature (25 °C).

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Output optimized electret nanogenerators for self-powered long-distance optical communication systems

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NANOSCALE 2017年第46期9卷 18529-18534页

作者： Yuan, Fang Li, Wenbo lin, Shizhe Wu, Nan Chen, shuwen Zhong, Junwen Xu, Zisheng Li, Xin Xiao, Yongjun Huang, Liang Huazhong Univ Sci & Technol Wuhan Natl Lab Optoelect Wuhan 430074 Hubei Peoples R China

High-speed optical communication systems are built for real-time, massive and remote information exchange. However, any power outage will paralyse the systems and cause a huge loss. Here we constructed a self-powered long-distance optical communication system (SLOCS) utilizing output enhanced parallel connected electret nanogenerators (NGs) as a backup power for the power outage. The output current of the electret NG was promoted from 1.45 mu A to 8.14 mu A through optimizing the thickness of the electret film. In the SLOCS, a coded message was successfully transmitted for 50 meters by pressing electret NGs. The as-fabricated SLOCS paves the way to a simple and cost-effective strategy for developing a reliable emergency communication system in case of power outage, simultaneously promoting the progress of self-powered electronics.

关键词： Outages

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Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease

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MOLECULAR METABOLISM 2018年 14卷 121-129页

作者： Jia, lin Chang, Xiuli Qian, shuwen Liu, Chen Lord, Caleb C. Ahmed, Newaz Lee, Charlotte E. Lee, Syann Gautron, Laurent Mitchell, Mack C. Horton, Jay D. Scherer, Philipp E. Elmquist, Joel K. Univ Texas Southwestern Med Ctr Dallas Dept Internal Med Div Hypothalam Res Dallas TX 75390 USA Fudan Univ MOE Key Lab Publ Safety Sch Publ Hlth Shanghai 200032 Peoples R China Fudan Univ Shanghai Med Coll Dept Biochem & Mol Biol Key Lab Metab & Mol MedMinist Educ Shanghai 200032 Peoples R China Univ Texas Southwestern Med Ctr Dallas Dept Neurosci Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Off EVP Hlth Syst Affairs Dept Internal Med Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Dept Internal Med Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Dept Mol Genet Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Dept Internal Med Touchstone Diabet Ctr Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Dept Pharmacol Dallas TX 75390 USA

Objective: Recent studies have suggested a critical role for toll-like receptor 4 (TLR4) in the development of alcoholic liver disease. As TLR4 is widely expressed throughout the body, it is unclear which TLR4-expressing cell types contribute to alcohol-induced liver damage. Methods: We selectively ablated TLR4 in hepatocytes and myeloid cells. Male mice were fed a liquid diet containing either 5% alcohol or pair-fed a control diet for 4 weeks to examine chronic alcohol intake-induced liver damage and inflammation. In addition, mice were administered a single oral gavage of alcohol to investigate acute alcohol drinking-associated liver injury. Results: We found that selective hepatocyte TLR4 deletion protected mice from chronic alcohol-induced liver injury and fatty liver. This result was in part due to decreased expression of endogenous lipogenic genes and enhanced expression of genes involved in fatty acid oxidation. In addition, mice lacking hepatocyte TLR4 exhibited reduced mRNA expression of inflammatory genes in white adipose tissue. Furthermore, in an acute alcohol binge model, hepatocyte TLR4 deficient mice had significantly decreased plasma alanine transaminase (ALT) levels and attenuated hepatic triglyceride content compared to their alcohol-gavaged control mice. In contrast, deleting TLR4 in myeloid cells did not affect the development of chronic-alcohol induced fatty liver, despite the finding that mice lacking myeloid cell TLR4 had significantly reduced circulating ALT concentrations. Conclusions: These findings suggest that hepatocyte TLR4 plays an important role in regulating alcohol-induced liver damage and fatty liver disease. (C) 2018 The Authors. Published by Elsevier GmbH.

关键词： Alcoholic fatty liver disease Toll-like receptor 4 Hepatocyte Myeloid cell Liver injury Inflammation

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Yiqi Huoxue Decoction attenuates ischemia/hypoxia-induced oxidative stress injury in H9c2 cardiomyocytes

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Journal of Traditional Chinese Medical Sciences 2018年第3期5卷 271-282页

作者： Fanghe Li shuwen Guo Hui Wang Xiaolou Huang Xiaobo Tan Qian Cai Qi Zhang Chunguo Wang Jinghong Hu Wangou lin Beijing University of Chinese Medicine Beijing 100029China Fujian Medical University Fuzhou 350004China

Objective:Yiqi Huoxue Decoction (YQHX) has been widely used for clinical treatment of ischemic heart *** oxidative stress plays a key role in the pathogenesis of ischemic heart disease,the function and molecular mechanism underlying antioxidative protective effects of YQHX on H9c2 cardiomyocytes against ischemia/hypoxia (I/H) have yet to be well ***:H9c2 cells were subjected to 12 h of hypoxia with serum-free conditions and then treated with or without YQHX (100-400 μg/mL).Cell viability was examined using a CCK-8 *** dialdehyde (MDA) and superoxide dismutase (SOD) activity were detected using commercial *** reactive oxygen species (ROS) levels and mitochondrial membrane potential were measured using fluorescence microscopy and confocal laser-scanning microscopy,*** details of mitochondria in H9c2 cells were observed using transmission electron *** antioxidative protective pathway was assessed by measuring mRNA and protein expression of Nrf2 and HO-1,as well as AMPK ***:I/H injury gradually induced oxidative *** with YQHX significantly increased cell viability and reversed I/H-induced oxidative stress,including reducing the production of oxidative stress products (ROS and MDA),increasing SOD levels,improving mitochondrial morphology,and increasing mitochondrial membrane *** was also observed to increase I/H-induced expression of Nrf2 and HO-1,and the activation effects of YQHX were blocked by an AMPK *** addition,HPLC analysis showed that YQHX contained two active antioxidative constituents (calycosin and ferulic acid).Conclusion:The results suggest that anti-oxidative effects exerted by YQHX in H9c2 cardiomyocytes may be linked to upregulation of the AMPK-mediated Nrf2/HO-1 pathway.

关键词： Hypoxia Yiqi Huoxue Decoction Chinese medicine Cardiomyocytes Oxidative stress

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论人民主体性在中国道路中的彰显维度

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长春市委党校学报 2018年第6期 15-18页

作者：林柏成陈树文北京交通大学马克思主义学院

人民群众始终是中国道路的主角。中国道路的选择形成、不断拓展、实际成效、发展成果与自信确立都在于人民,人民群众在这五个维度中都彰显了主体地位,分别表现为是其五个方面的参与主体、建设主体、评判主体、共享主体与培育主体。

关键词：人民主体性中国道路

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Application and development of a TaqMan real-time PCR for detecting infectious spleen and kidney necrosis virus in Siniperca chuatsi

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MICROBIAL PATHOGENESIS 2017年第0期107卷 98-105页

作者： lin, Qiang Fu, Xiaozhe Liu, Lihui Liang, Hongru Guo, Huizhi Yin, shuwen Kumaresan, Venkatesh Huang, Zhibin Li, Ningqiu Chinese Acad Fishery Sci Pearl River Fisheries Res Inst Key Lab Fishery Drug Dev Minist AgrKey Lab Aquat Anim Immune Technol Guangzhou 510380 Guangdong Peoples R China Zhongkai Univ Agr & Engn Guangzhou Key Lab Aquat Anim Dis & Waterfowl Bree Coll Anim Sci & Technol Guangzhou 510225 Guangdong Peoples R China

Infectious spleen and kidney necrosis virus (ISKNV) is one of the major epidemiological agents that had caused great economic loss in Chinese perch (Siniperca chuatsi). In this study, a specific TaqMan real-time PCR was developed using a pair of primers and a TaqMan probe specific to the ORF007 gene of ISKNV to rapidly detect ISKNV copies in Chinese perch samples. This assay was optimized to produce linearity from 8.75 x 10(8) to 8.75 x 10(1) copies in standard curve with an efficiency of 98% and a R-2 value of 0.9999. Moreover, the minimum detection limit of this assay was 10,000 times more sensitive than that of conventional PCR method. The coefficients of variation of intra- and inter-assay repeatability were less than 2.4% and 3.3%, respectively. The viral distribution in different tissues of diseased Chinese perch was evaluated by TaqMan real-time PCR method and the highest level of viral copies was detected in spleen. Among the 76 diseased Chinese perch clinical samples, 35 and 29 were positive samples based on the TaqMan real-time PCR and conventional PCR methods, respectively, indicating that the TaqMan real-time PCR was more sensitive than conventional PCR. Therefore, the TaqMan real-time PCR should be a useful tool for the early surveillance and quantitation of ISKNV. (C) 2017 Elsevier Ltd. All rights reserved.

关键词： Chinese perch ISKNV TaqMan real-time PCR

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基于OpenFOAM的方坯连铸结晶器内多相流场数值模拟研究

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铸造技术 2020年第9期41卷 887-890页

作者：姚宾叶温树文张书彦张鹏张志明林晏民钟寿军胡寿浩东莞材料基因高等理工研究院广东东莞523808 广东韶钢松山股份有限公司广东韶关512123 东莞市万欣金属制品有限公司广东东莞523560

针对方坯连铸结晶器内钢水流场数值模拟分析问题,利用开源软件OpenFOAM的灵活性和可扩展性,对其多相流求解器multiphaseInterFoam进行代码修改,以适应模拟计算要求。利用所开发的程序计算了方坯连铸结晶器内的钢水流场,探讨了对方坯连... 详细信息

针对方坯连铸结晶器内钢水流场数值模拟分析问题,利用开源软件OpenFOAM的灵活性和可扩展性,对其多相流求解器multiphaseInterFoam进行代码修改,以适应模拟计算要求。利用所开发的程序计算了方坯连铸结晶器内的钢水流场,探讨了对方坯连铸结晶器内多相流场进行数值模拟计算分析的可行性。计算结果表明:结晶器四水口流场复杂不对称,在保护渣上表面稳定的情况下仍有卷渣可能。

关键词：连铸方坯结晶器 OpenFOAM 多相流模拟

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Potent influenza A virus entry inhibitors targeting a conserved region of hemagglutinin

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BIOCHEMICAL PHARMACOLOGY 2017年 144卷 35-51页

作者： lin, Dongguo Luo, Yinzhu Yang, Guang Li, Fangfang Xie, Xiangkun Chen, Daiwei He, Lifang Wang, Jingyu Ye, Chunfeng Lu, Shengsheng Lv, lin Liu, shuwen He, Jian Southern Med Univ Sch Pharmaceut Sci Guangzhou Key Lab Drug Res Emerging Virus Prevent Grp Peptides & Nat Prod ResGuangdong Prov Key La 1838 Guangzhou Ave North Guangzhou 510515 Guangdong Peoples R China South China Univ Technol Hosp 2 Dept Lab Med Guangzhou 510180 Guangdong Peoples R China Guangdong Lab Anim Monitoring Inst Guangdong Prov Key Lab Lab Anim Guangzhou 510663 Guangdong Peoples R China Southern Med Univ Sch Clin Med 1 1838 Guangzhou Ave North Guangzhou 510515 Guangdong Peoples R China

Influenza A viruses (IAVs) induce acute respiratory disease and cause significant morbidity and mortality throughout the world. With the emergence of drug-resistant viral strains, new and effective anti-IAV drugs with different modes of action are urgently needed. In this study, by conjugating cholesterol to the N-terminus of the short peptide KKWK, a lipopeptide named S-ICKWK was created. The anti-IAV test indicated that S-KKWK and its derivatives displayed potent antiviral activities against a broad variety of influenza A viral strains including oseltamivir-resistant strains and clinically relevant isolates with IC50 values ranging from 0.7 to 3.0 mu M. An extensive mechanistic study showed that these peptides functioned as viral "entry blockers" by inhibiting the conformational rearrangements of HA2 subunit, thereby interrupting the fusion of virus-host cell membranes. Significantly, a computer-aided docking simulation and protein sequence alignment identified conserved residues in the stem region of HA2 as the possible binding site of S-KKWK, which may be employed as a potential drug target for designing anti-IAVs with a broad-spectrum of activity. By targeting this region, a potent anti-IAV agent was subsequently created. In addition, the anti-IAV activity of S-KKWK was assessed by experiments with influenza A virus infected mice, in which S-KKWK reduced the mortality of infected animals and extended survival time significantly. Overall, in addition to providing a strategy for designing broad-spectrum anti-IAV agents, these results indicate that S-KKWK and its derivatives are prospective candidates for potent antivirals. (C) 2017 Elsevier Inc. All rights reserved.

关键词： Anti-influenza A viruses Cholesterol conjugated peptides Virus entry inhibitors Conserved region of hemagglutinin

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