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2016年全国抗炎免疫药理学术会议

作者： Suiyi Tan Wenjuan Li Jinqing Li Lu Lu Chungen Pan lin Li Shibo Jiang shuwen Liu School of Pharmaceutical Sciences Southern Medical University Guangzhou 510006People''s Republic of China

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Synthesis of N-benzyl-N-phenylthiophene-2-carboxamide analogues as a novel class of enterovirus 71 inhibitors

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RSC ADVANCES 2015年第68期5卷 55100-55108页

作者： Pan, Jiawei Han, Xin Sun, Ningyuan Wu, Haoming lin, Dandan Tien, Po Zhou, Hai-Bing Wu, shuwen Wuhan Univ Coll Life Sci Wuhan 430072 Peoples R China Wuhan Univ Sch Pharmaceut Sci State Key Lab Virol Wuhan 430071 Peoples R China Wuhan Univ Renmin Hosp Dept Oncol Wuhan 430060 Peoples R China

A series of novel human enterovirus 71 inhibitors, N-benzyl-N-phenylthiophene-2-carboxamide analogues, were synthesized and their antiviral activities were evaluated in vitro. Most derivatives of this structure against EV71 had a low micromolar range in the RD (rhabdomyosarcoma) cell lines. The most potent compound 5a, N-(4-bromobenzyl)-N-(4-fluorophenyl) thiophene-2-carboxamide, showed low micromolar activity against EV71 (EC50 = 1.42 mu M) compared to the reference anti-EV71 drug enviroxime (EC50 = 0.15 mu M). Preliminary SAR studies revealed that the thiophene-2-carboxamide core is crucial for maintaining antiviral activity, and N-substituent phenyl groups largely influenced the anti-EV71 efficacy of this new class of potent antiviral agents.

关键词： Thiophene

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CCLG-2008方案治疗424例儿童急性淋巴细胞白血病的疗效分析

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中华血液学杂志 2017年第12期38卷 1058-1061页

作者：郭霞朱易萍李强贾苍松陆晓茜杨雪万智艾媛孙舒雯林超蒋呜燕吴剑蓉高举四川大学华西第二医院儿科出生缺陷与相关妇儿疾病教育部重点实验室成都610041

随着免疫学、细胞遗传学及分子生物学的发展以及化疗方案的改进，急性淋巴细胞白血病（ALL）已不再被认为是致死性疾病。儿童ALL的5年无事件生存（EFS）率已达80％以上。我们对本中心以CCLG．2008方案治疗的424例初诊儿童ALL的临床资料... 详细信息

随着免疫学、细胞遗传学及分子生物学的发展以及化疗方案的改进，急性淋巴细胞白血病（ALL）已不再被认为是致死性疾病。儿童ALL的5年无事件生存（EFS）率已达80％以上。我们对本中心以CCLG．2008方案治疗的424例初诊儿童ALL的临床资料进行回顾性分析。

关键词：儿童急性淋巴细胞白血病疗效分析治疗分子生物学细胞遗传学致死性疾病化疗方案临床资料

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3-Hydroxyphthalic anhydride-modified rabbit anti-PAP IgG antagonizes seminal amyloid fibrils and HIV infection

3-Hydroxyphthalic anhydride-modified rabbit anti-PAP IgG ant...

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2016年全国抗炎免疫药理学术会议

作者： Xuanxuan Zhang Jinquan Chen Fei Yu Ruxia Ren Qian Wang Suiyi Tan Shibo Jiang shuwen Liu lin Lia State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University 510515 GuangzhouChina Key Laboratory of Medical Molecular Virology of MOE/MOH Shanghai Medical College and Institute of Medical Microbiology Fudan University 200032 Shanghai China

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Obatoclax与MG-132对食管癌细胞CaES-17的协同抗肿瘤作用

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南方医科大学学报 2016年第4期36卷 506-513页

作者：赵旭燕林庆焕阙富昌古春萍余乐刘叔文南方医科大学药学院广东广州510515

目的探讨obatoclax联用MG-132对人食管癌细胞是否具有协同的抗肿瘤作用。方法 MTT法检测obatoclax与MG-132对人食管癌细胞Ca ES-17的细胞毒作用,根据IC50确定两药联用的浓度比(1∶2.4),将两个药物从4 IC50的作用浓度起倍比稀释,用Compu ... 详细信息

目的探讨obatoclax联用MG-132对人食管癌细胞是否具有协同的抗肿瘤作用。方法 MTT法检测obatoclax与MG-132对人食管癌细胞Ca ES-17的细胞毒作用,根据IC50确定两药联用的浓度比(1∶2.4),将两个药物从4 IC50的作用浓度起倍比稀释,用Compu Syn软件计算两药的联用指数(CI)。采用Western blot方法研究药物对ubiquitin表达、PARP蛋白剪切、caspase-9蛋白剪切、phospho-Histone H3蛋白及phospho-Aurora A/B/C蛋白表达的影响。采用流式细胞术检测细胞早期凋亡(Annexin-V阳性率)及细胞周期的影响。结果 Obatoclax与MG-132联合处理人食管癌细胞Ca ES-17,对细胞抑制率为50%及95%时相对应的CI值分别为0.296及0.104,具有明显的协同抗肿瘤作用。单用obatoclax或MG-132均能诱导ubiquitin表达增加、PARP及caspase-9发生剪切,且联用组与单用组相比有统计学差异(P<0.05);联用组phospho-Histone H3蛋白增加与单用组相比有统计学差异(P<0.05);phospho-Aurora A/B/C蛋白表达的增加也与单用obatoclax相比有统计学差异(P<0.05),与单用MG-132相比无明显改变(P>0.05)。同时,联用组Annexin-V阳性率及sub-G1期及G2/M期细胞百分比与单用组相比都显著增加,且差异均有统计学意义(P<0.05)。结论 Obatoclax联用MG-132对人食管癌细胞Ca ES-17具有协同抗肿瘤作用,且与诱导肿瘤细胞发生凋亡及G2/M期阻滞有关。

关键词：食管癌 MG-132 协同抗肿瘤作用细胞凋亡周期阻滞

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Preface

ICMLCA 2021 - 2nd International Conference on Machine Learni...

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ICMLCA 2021 - 2nd International Conference on Machine Learning and Computer Application 2021年 iii页

作者： Ning, Xiansheng Feng, Yongxin Zhang, Wenbo Yue, Mingkai Du, Ke-lin Huang, Shutao Zhou, Fang Ba, Shuhong Fu, Chong Shui, Penglang Xu, shuwen Wu, Sheng Wang, Shushan Du, Zhonghua Gao, Zhijun Fan, Chunlong Li, Yufeng Wang, Yupeng Liu, Qingli Yu, Jingang Yin, Zhenyu Zhang, Deyu Gao, Hongwei Wen, Feng Guo, Cean Hao, Yongping Chan, Yung-Kuan Pavlovich, Vinogradov Gennady Kirpichnikova, Irina Qian, Zhihong Ivanov, Dmitriy V. Zhou, Xueguan Nezamabadi-Pour, Hossein Yang, Qing Zhang, Yongtang Liao, Haibin Huang, Ying Srinivasan, Kathiravan Xu, Zhenghua Pachori, Ram Bilas Zhang, Jialu AlShawabkeh, Mahmoud Guo, Chengjun Chaugule, Archana Ajit Lima, Alberto Sampaio Liu, Huayong Vidal, Jorge Maestre Alrshah, Mohamed A. Ghafoor, Kayhan Zrar Kubicek, Jan Chaugule, Archana Ajit Rodríguez-Pérez, Miguel Kumar, Gulshan Nasri, Mehdi Borrego, Carlos Persico, Valerio Wagh, Sanjeev Yan, Wenjun Yang, Li Yang, Dawei Xing, Yongkang Yang, Huadong Shang, Chengguo Chang, Xingong Shi, Hongbo Li, Aijun Feng, Liping Lv, Yali Liang, Minfu Wang, Kaixuan Bai, Zengliang Liang, Anhui Nan, Zhihong Ji, Suqin Chang, Liwei Zhou, Hongbin Yao, Chunli Cao, Guodong Zhang, Juling School of Information Science and Engineering Shenyang Ligong University China School of Equipment Engineering Shenyang Ligong University China Concordia University Canada School of Automotive and Transportation Shenyang Ligong University China School of Information Science and Engineering Shenyang Ligong University China School of Equipment Engineering Shenyang Ligong University China Northeastern University China Xidian University China Beijing University of Posts and Telecommunications China Beijing Institute of Technology China Nanjing University of Science & Technology China Shenyang Jianzhu University China Shenyang Aerospace University China Dalian University China Shenyang Institute of Computing Technology Chinese Academy of Sciences China Shenyang Ligong University China National Chun Hsing University Taiwan Department of Informatics and Applied Mathematics Russia South Ural State University Russia Jilin University China Samara State University of Transport Russia Naval Universit of Engineering China Shahid Bahonar University of Kermanto Iran Central China Normal University China Guangdong Neusoft Institute China Hubei University of Science and Technology China Liuzhou Railway Vocational Technical College China Vellore Institute of Technology India Hebei University of Technology China Indian Institute of Technology Indore India Xiangnan University China Guangxi Normal University for Nationalities China UESTC China Pimpri-Chinchwad College of Engineering & Research India Federal University of Ceará Brazil Complutense University of Madrid Spain Universiti Putra Malaysia Malaysia Shanghai Jiao Tong University China VŠB - Technical University of Ostrava Cuw Pimpri-Chinchwad College of Engineering & Research Ravet Pune India University of Vigo Spain Division of Research and Development India Islamic Azad University Iran Departament Enginyeria of Information Comunicacions Autonomous University of Barcelona Spain Opportunistic Networks United States Univers

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Self-powered seawater desalination and electrolysis using flowing kinetic energy

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NANO ENERGY 2015年 15卷 266-274页

作者： Jiang, Qianwen Han, Yu Tang, Wei Zhu, Huarui Gao, Caizhen Chen, shuwen Willander, Magnus Cao, Xia Wang, Zhong lin Chinese Acad Sci Beijing Inst Nanoenergy & Nanosyst Beijing 100083 Peoples R China Beijing Univ Aeronaut & Astronaut Sch Chem & Environm Beijing 100191 Peoples R China Univ Sci & Technol Beijing Sch Chem & Biol Engn Beijing 100083 Peoples R China Georgia Inst Technol Sch Mat Sci & Engn Atlanta GA 30332 USA

Fresh water for human daily life is an important resource of the world, which could be as precious as oil in many cases. The increased needs for fresh water are becoming a major challenge to the quality of our life. Recently much attention has been paid to the seawater desalination with low energy cost. Here we report a seawater desalination (SD) and electrolysis (SE) system on the basis of the newly invented triboelectric nanogenerator (TENG). The TENG consists of radial arrays of micro-sized sectors on the contact surfaces and exhibits a high output current of 3.3 mA. 0.5 M salt solution was desalinated to form drinking water in 16 h and the desalination rate reached 98.3%. Subsequently, a totally self-powered SD and SE system driven by the kinetic energy of flowing water was presented. Using the power generated by flowing water at a rate of 40 L min(-1), the desalination rate reaches 8.2% in 3 h. Furthermore, the byproduct of concentrated salty water was split at a hydrogen production rate of 2.6 x 10(-5) mL s(-1). Our study demonstrates an innovative and unique approach toward a total self-powered SD and SE system. This is an important step toward self-powered environmental electrochemistry. (C) 2015 Published by Elsevier Ltd.

关键词： Self-powered electro-chemistry Tritioelectric nano-generator Seawater desalination Electrolysis

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Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo

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JOURNAL OF MATERIALS CHEMISTRY B 2015年第29期3卷 6081-6093页

作者： Yin, Feng Zhang, Butian Zeng, shuwen lin, Guimiao Tian, Jinglin Yang, Chengbin Wang, Kuan Xu, Gaixia Yong, Ken-Tye Nanyang Technol Univ Sch Elect & Elect Engn Singapore 639798 Singapore CINTRA CNRS NTU THALES UMI 3288 Singapore Singapore Shenzhen Univ Sch Med Sci Key Lab Biomed Engn Shenzhen 518060 Peoples R China Shenzhen Univ Sch Med Sci Res Inst Uropoiesis & Reprod Shenzhen 518060 Peoples R China Acad Sinica Nanomed Program Taipei 115 Taiwan Acad Sinica Inst Biol Chem Taipei 115 Taiwan Shenzhen Univ Coll Optoelect Engn Minist Educ Guangdong Prov Key Lab Optoelect Devices & Syst Shenzhen 518060 Peoples R China

In this work, we report the synthesis of dye-loaded and folic acid (FA)-conjugated organically modified silica (ORMOSIL) nanoparticles as targeted optical nanoprobes for in vitro and in vivo imaging. The dye-loaded ORMOSIL (ORMD) nanoparticles are synthesized by a facile aqueous phase (oil-in-water microemulsion) approach and they have an average size of 30 nm. We observed that the functionalization of FA onto the particle surface led to a strong cellular uptake of FA-conjugated ORMD nanoparticles for pancreatic cancer Miapaca-2 cells and hepatoma SMMC7721 cells with FA receptor overexpression. Such a trend is not observed for 293T cells and breast cancer MCF7 cells as these cells possess low-expression of the FA receptor. The in vivo imaging studies demonstrate that FA-ORMD nanoparticles are preferentially accumulated in tumor sites. Histological studies reveal that no-ill effects are observed in the major organs of treated mice when compared to the untreated ones. Because of the facile synthesis process, high specificity for tumor targeting and low toxicity of FA-ORMD nanoparticles, significant potential for early-cancer detection application is expected.

关键词： Cells

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肝纤维肉瘤的诊断与治疗(文献复习附1例报告)

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岭南现代临床外科 2014年第5期14卷 527-529页

作者：林树文欧阳红飞吉成岗东莞市第五人民医院肝胆外科广东东莞523900

目的探讨肝纤维肉瘤的诊断与治疗方法。方法回顾性分析东莞市第五人民医院2014年收治的1例术前误诊为肝脓肿,术后病理确诊为肝纤维肉瘤的患者临床资料。结果该患者术前病史及影像学诊断均考虑肝脓肿,术中发现为肝肿瘤予手术切除,术后病... 详细信息

目的探讨肝纤维肉瘤的诊断与治疗方法。方法回顾性分析东莞市第五人民医院2014年收治的1例术前误诊为肝脓肿,术后病理确诊为肝纤维肉瘤的患者临床资料。结果该患者术前病史及影像学诊断均考虑肝脓肿,术中发现为肝肿瘤予手术切除,术后病理诊断为肝纤维肉瘤,存活2个月。结论肝纤维肉瘤恶性程度高,临床无特异性,容易误诊,主要依靠病理确诊,预后差,手术是唯一有效治疗方法,对放化疗均不敏感。

关键词：肝纤维肉瘤诊断治疗

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Structure-activity relationships of 3-O-β-chacotriosyl ursolic acid derivatives as novel H5N1 entry inhibitors

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015年 93卷 431-442页

作者： Song, Gaopeng Shen, Xintian Li, Sumei Li, Yibin Liu, Yunpeng Zheng, Yushan lin, Ruheng Fan, Jihong Ye, Hanming Liu, shuwen South China Agr Univ Coll Resources & Environm Guangzhou 510642 Guangdong Peoples R China Southern Med Univ Sch Pharmaceut Sci Guangzhou 510515 Guangdong Peoples R China Jinan Univ Sch Med Dept Human Anat Guangzhou 510632 Guangdong Peoples R China Georgia State Univ Dept Chem Ctr Diagnost & Therapeut Atlanta GA 30303 USA

A series of methyl ursolate 3-O-beta-chacotrioside analogs have been designed, synthesized and evaluated as H5N1 entry inhibitors based on a small molecule inhibitor saponin 3 previously discovered by us. Detailed structure-activity relationships (SARs) studies on the aglycone of compound 3 indicated that both the type of pentacyclic triterpene and the subtle modification of ursolic acid as an aglycon had key influences on the antiviral activity. These results suggested that either the introduction of a disubstituted amide structure at the 17-COOH of ursolic acid or alteration of the C-3 configuration of ursolic acid from 3 beta-to 3 alpha-forms was helpful to significantly improve the selective index while keeping their antiviral activities. (C) 2015 Elsevier Masson SAS. All rights reserved.

关键词： 3-O-beta-chacotriosyl saponins H5N1 entry inhibitors Structure-activity relationships

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