Immunoglobulin-like transcript (ILT) 4 is critical for the inhibitory function of certain immune cells. We previously demonstrated that ILT4 is over-expressed in human non-small cell lung cancer (NSCLC) cells and is i...
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Immunoglobulin-like transcript (ILT) 4 is critical for the inhibitory function of certain immune cells. We previously demonstrated that ILT4 is over-expressed in human non-small cell lung cancer (NSCLC) cells and is involved in tumour evasion via an unknown mechanism. In this report, we demonstrate that ILT4 increases the expression of the co-inhibitory molecule B7-H3 through PI3K/AKT/mTOR signalling. In primary human NSCLC tissues, a significant positive relationship is observed between ILT4 and B7-H3 expression. ILT4/B7-H3 co-expression is significantly associated with a reduction in T infiltrating lymphoid cells and lower overall survival. In summary, ILT4 increases B7-H3 expression and ILT4/B7-H3 co-expression may be involved in NSCLC progression. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Influenza A viruses (IAV) are significant pathogens that result in millions of human infections and impose a substantial health and economic burdens worldwide. Due to the limited anti-influenza A therapeutics availabl...
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Influenza A viruses (IAV) are significant pathogens that result in millions of human infections and impose a substantial health and economic burdens worldwide. Due to the limited anti-influenza A therapeutics available and the emergence of drug resistant viral strains, it is imperative to develop potent anti-IAV agents with different mode of action. In this study, by applying a pseudovirus based screening approach, two super short membrane-active lipopeptides of C12-KKWK and C12-OOWO were identified as effective anti-IAV agents with IC50 value of 7.30 +/- 1.57 and 8.48 +/- 0.74 mg/L against A/Puerto Rico/8/34 strain, and 6.14 +/- 1.45 and 7.22 +/- 0.67 mg/L against A/Aichi/2/68 strain, respectively. The mechanism study indicated that the anti-IAV activity of these peptides would result from the inhibition of virus entry by interacting with HA2 subunit of hemagglutinin (HA). Thus, these peptides may have potentials as lead peptides for the development of new anti-IAV therapeutics to block the entry of virus into host cells. (c) 2015 Elsevier B.V. All rights reserved.
SrO-Sb2O3-P2O5 glass system was prepared by high temperature melting method. The effects of Sb2O3 and P2O5 content on the structure, thermal behavior and chemical durability of the glasses were studied by infrared spe...
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SrO-Sb2O3-P2O5 glass system was prepared by high temperature melting method. The effects of Sb2O3 and P2O5 content on the structure, thermal behavior and chemical durability of the glasses were studied by infrared spectrometer, thermal dilatometer, differential thermal analyzer and constant temperature water bath heating. It can be concluded that the characteristic temperatures of the glasses increased firstly and then decreased with the increasing of Sb2O3 content, whereas the tendency of the coefficient of thermal expansion (CTE) varied inversely. The crystallization ability of the glasses was significantly increased and the water resistance was reduced for Sb2O3 content of 35 mol % and 40 mol %. The glasses with 20 mol %, 25 mol % and 30 mol % Sb2O3 showed better performance in every respect than the others and the glasses containing 25 mol % Sb2O3, characterized by the best performance, can be chosen as host glasses for further research.
Bi2O3-B2O3-SiO2 glasses with the addition of Fe2O3 were prepared by a conventional melt quenching method. The effects of Fe2O3 addition on the structure, thermal behavior and chemical durability of resulting samples w...
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Bi2O3-B2O3-SiO2 glasses with the addition of Fe2O3 were prepared by a conventional melt quenching method. The effects of Fe2O3 addition on the structure, thermal behavior and chemical durability of resulting samples were studied. The CTE of the glass increased first and then decreased with increasing Fe2O3 contents, whereas the tendencies of the T-g and T-f varied contrarily. No apparent effect on the structure of glasses with the increase of Fe2O3 contents was observed and the chemical durability of the glasses was significantly improved with the increase of Fe2O3 contents. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
In allusion to the low efficiency and unsatisfactory result of the tradional optimization algorithms in existence for engineering design optimization,this paper proposes a cultural ant colony optimization(CACO) algori...
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ISBN:
(纸本)9783037853726
In allusion to the low efficiency and unsatisfactory result of the tradional optimization algorithms in existence for engineering design optimization,this paper proposes a cultural ant colony optimization(CACO) algorithm for application in design optimization of excavator's mechanisms to improve the excavator's performance efficiently. Through testing and verifying experiments,it is concluded that CACO can discovery knowledge during optimization process and use the knowledge to guide the heuristic searching process,furthennore,it is an appropriate algorithm for the optimization of excavator mechanisms. CACO costs less time and can get better quality solution to improve excavator's main porformances.
The emergence and dissemination of antibiotic-resistant bacterial pathogens have spurred the urgent need to develop novel antimicrobial agents with different mode of action. In this respect, we turned several fusogeni...
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The emergence and dissemination of antibiotic-resistant bacterial pathogens have spurred the urgent need to develop novel antimicrobial agents with different mode of action. In this respect, we turned several fusogenic peptides (FPs) derived from the hemagglutinin glycoproteins (HAs) of IAV into potent antibacterials by replacing the negatively or neutrally charged residues of FPs with positively charged lysines. Their antibacterial activities were evaluated by testing the MICs against a panel of bacterial strains including ***, ***, ***, and ***. The results showed that peptides HA-FP-1, HA-FP-2-1, and HA-FP-3-1 were effective against both Gram-positive and Gram-negative bacteria with MICs ranging from 1.9 to 16.0m, while the toxicities toward mammalian cells were low. In addition, the mode of action and the secondary structure of these peptides were also discussed. These data not only provide several potent peptides displaying promising potential in development as broad antimicrobial agents, but also present a useful strategy in designing new antimicrobial agents.
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