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Conference on Optoelectronic Imaging and Multimedia Technology II

作者： Song, Li Liao, Ningfang Dong, shuwen Liao, Ting Hu, Weigui lin, Kai Beijing Inst Technol Sch Optoelect Beijing 100081 Peoples R China

ISBN: (纸本)9780819493132

The effect of chromatic background on luminance contrast-sensitivity function (CSF) is studied. We selected three background-grey, orange and yellow-green from CIE 17 color center. The mean luminance of these colors is approximately equal. We use CRT monitor display the rectangular stripe. Every rectangular stripe has six spatial frequencies (0.4, 1, 2, 3.5,7 and 14cpd). The method of limits is used in the experiment, 5 observers, who have normal vision and test of vision is all over 1.0, participated in the experiment. The results of experiment show that the luminance contrast sensitivity on chromatic background is lower than the luminance contrast sensitivity under grey background. Fitting results show that Movshon model is better than Barten model, especially for the chromatic background. Both of the models have deviation in the high spatial frequency part.

关键词： Human contrast-sensitivity function Chromatic background Characterization Limits method

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1568例婴幼儿腹泻轮状病毒检测及流行病学特征分析

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中国医药科学 2013年第21期3卷 73-74页

作者：姚淑雯梁卓夫林爱君王淑慧广州市妇女儿童医疗中心儿童院区广东广州510623

目的对1568例婴幼儿腹泻患者进行粪便轮状病毒（RV）抗原检测，分析其流行病学特征。方法以免疫金标记技术对2012年1-12月来我院就诊的腹泻患儿的1568例粪便标本进行RV抗原检测，并对检测结果进行统计分析。结果1568例粪便标本中，阳性... 详细信息

目的对1568例婴幼儿腹泻患者进行粪便轮状病毒（RV）抗原检测，分析其流行病学特征。方法以免疫金标记技术对2012年1-12月来我院就诊的腹泻患儿的1568例粪便标本进行RV抗原检测，并对检测结果进行统计分析。结果1568例粪便标本中，阳性检出632例，阳性率为40．3％；不同性别腹泻患儿的阳性检出率差异不显著，无统计学意义（P〉0．05）；10～12月的阳性检出率最高，其中12月最高，为51．7％。结论RV是婴幼儿腹泻的主要病原，其发病具有显著的季节性，建议于流行季节为6～24月龄的婴幼儿接种疫苗。

关键词：腹泻婴幼儿轮状病毒(RV) 流行病学特征

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Microcrystal growth in heat-treating process for Europium ions doped aluminosilicate glasses

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2012 2nd International Conference on Green Building, Materials and Civil Engineering, GBMCE 2012

作者： Guo, Wan Zhao, Xin Jiang, shuwen Wang, Zhiqiang Zheng, Li Liu, Ming lin, Hai School of Textile and Material Engineering Dalian Polytechnic University Dalian 116034 China

ISBN: (纸本)9783037854662

Eu doped YAG glass ceramics containing single phase of YAG micro-cryatals have been obtained by heat-treating the aluminosilicate precursor glasses. The primary crystallite size of YAG phase is calculated to be ~46 nm and the crystal grains grow with preffered orientation (444) in the internal network. The average secondary particle size is estimated to be ~8μm and the larger grain size is due to the particle aggregation. The pilotaxitic texture of YAG glass ceramics presented in SEM micrograph, can increase yield strength and tensile strength of the sample effectively. The emission spectrum of Eu doped YAG glass ceramics consists of a broad blue emission band and several narrow emission bands, indicating the coexistence of Eu3+ and Eu2+ ions in YAG glass ceramics. © (2012) Trans Tech Publications, Switzerland.

关键词： Ions

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Characterization, and expression profile of a phenylalanine ammonia lyase gene from Jatropha curcas L.

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MOLECULAR BIOLOGY REPORTS 2012年第4期39卷 3443-3452页

作者： Gao, Jihai Zhang, shuwen Cai, Feng Zheng, Xiaojiang lin, Na Qin, Xiaobo Ou, Yangchao Gu, Xiaoping Zhu, Xihong Xu, Ying Chen, Fang Sichuan Univ Sch Life Sci Chengdu 610065 Peoples R China

A PAL gene designated as JcPAL1 was cloned from J. curcas L. The full-length is 2336 bp in size with one intron and two exons, encoding a polypeptide of 713 amino acids. Its 5'-upstream region is rich in putative cis-elements including not only PAL typical TATA box, L-box and transcriptional initiation site (TIS) but also light responding motifs. Expression pattern analysis indicated that JcPAL1 were expressed in all tissues, most highly in flowers. When Treated with ABA, GA3, high and low temperature, expression of JcPAL1 were induced. Recombinant JcPAL1 has a pH optimum at 8.7 and a temperature optimum at 60A degrees C in 100 mM Tris-HCl buffer. The Km and Kcat values are 0.125 mM and 1.73 S-1 for l-phenylalanine, and 1.312 mM and 0.109 S-1 for l-tyrosine, respectively. These findings suggested that JcPAL1 might involve in the J. curcas responding to various stresses and l-Phe should be its true physiological substrate. This study is essential prior to uncover whether and how the PAL initiated phenylpropanoid metabolic networks functioning in the defense responses of J. curcas.

关键词： Jatropha curcas Phenylalanine ammonia lyase Expression property Recombinant enzyme activity

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Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2012年第7期22卷 2393-2395页

作者： Jia, Qiyan Jiang, Xifeng Yu, Fei Qiu, Jiayin Kang, Xiaoyu Cai, Lifeng Li, lin Shi, Weiguo Liu, shuwen Jiang, Shibo Liu, Keliang So Med Univ Sch Pharmaceut Sci Guangzhou 510515 Guangdong Peoples R China Beijing Inst Pharmacol & Toxicol Beijing 100850 Peoples R China New York Blood Ctr Lindsley F Kimball Res Inst New York NY 10065 USA Fudan Univ MOE MOH Key Lab Med Mol Virol Inst Med Microbiol Shanghai Med Coll Shanghai 200032 Peoples R China

Serpin A1 (alpha 1-AT), the largest subgroup of serpins, presents in human plasma at high concentration and plays important regulatory roles in physiological and pathological processes. Accumulated evidence suggests that alpha 1-AT may play a role in controlling HIV-1 infection. In this study, we designed and synthesized a set of short linear peptides derived from the C-terminal sequence of alpha 1-AT. Since none of them showed significant anti-HIV-1activity, we proceeded to synthesize four short cyclic peptides having 7 amino acids, and we found that three of them exhibited significant anti-HIV-1 activity. One of these cyclic peptides, designated CPM, inhibited HIV-1 entry and infection at low mu M level, indicating that these short cyclic peptides could serve as leads for the development of novel anti-HIV-1 therapeutics. (C) 2012 Elsevier Ltd. All rights reserved.

关键词： alpha 1-Antitrypsin HIV-1 Peptides Entry inhibitors

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A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: Potential applications for preventing HIV-1 infection

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FITOTERAPIA 2012年第2期83卷 348-355页

作者： Yang, Jie Li, lin Tan, Suiyi Jin, Hong Qiu, Jiayin Mao, Qinchao Li, Runming Xia, Chenglai Jiang, Zhi-Hong Jiang, Shibo Liu, shuwen So Med Univ Sch Pharmaceut Sci Guangzhou 510515 Guangdong Peoples R China Fudan Univ Inst Med Microbiol Shanghai Med Coll MOH & MOE Key Lab Med Mol Virol Shanghai 200433 Peoples R China Macau Univ Sci & Technol Macau Inst Appl Res Med & Hlth State Key Lab Qual Res Chinese Med Macau Peoples R China

Theaflavins are the major components of tea polyphenols in brewed black tea. We previously reported that theaflavin derivatives, such as TF3, inhibited HIV-1 entry by targeting gp41. However, it is difficult to purify the individual theaflavins and the purified compounds are highly unstable. To develop theaflavins as affordable anti-HIV-1 microbide for preventing HIV sexual transmission, we intended to use an economic natural preparation containing 90% of theaflavins (TFmix). Its antiviral activity against HIV-1 strains was evaluated in vitro using p24 production and luciferase assays. The mechanism by which TFmix inhibits HIV-1 infection was investigated using time-of-addition, cell-cell fusion and biophysical assays. The data suggested TFmix exhibited potent anti-HIV-1 activity on lab-adapted and primary HIV-1 strains with IC50 less than 1.20 mu M. It also effectively inhibited infection by T-20 resistant HIV-1 strains. The mechanism studies suggest that TFmix mainly inhibit the HIV-1 entry by targeting gp41 since it is effective in inhibiting gp41 six-helix bundle (6-HB) formation and HIV-1 envelope protein-mediated cell-cell fusion. TFmix could also inhibit HIV-1 reverse transcriptase (RT) activity, but the IC50 is about 8-fold higher than that for inhibiting gp41 6-HB formation, suggesting RT is not a major target for TFmix. In conclusion, TFmix is an economic natural product preparation containing high content of theaflavins with potent anti-HIV-1 activity by targeting the viral entry step through the disruption of gp41 6-HB core structure. It has a potential to be developed as a safe and affordable topical microbicide for preventing sexual transmission of HIV. (C) 2011 Elsevier B.V. All rights reserved.

关键词： Theaflavin derivatives HIV Entry inhibitors Prevention Microbicides

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不同前期处理方法对Icon树脂渗透修复早期龋效果影响的研究

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口腔医学 2013年第10期33卷 675-678页

作者：周群史同庆李淑文单军郭蕾于月马琳沈阳市中国医科大学附属盛京医院口腔科沈阳110004 黑龙江省大庆市大庆医学高等专科学校临床系大庆163312 沈阳市口腔医院特诊科沈阳110002

目的通过对人工釉质龋进行不同方法处理,观察Icon的渗透效果。方法选取正畸拔除完好的第一前磨牙和第一磨牙32颗,置于人工脱矿液中14 d形成早期人工釉质龋。再随机分成4组,各组龋损表面分别用15%盐酸、37%磷酸和Opalustre打磨处理后,荧... 详细信息

目的通过对人工釉质龋进行不同方法处理,观察Icon的渗透效果。方法选取正畸拔除完好的第一前磨牙和第一磨牙32颗,置于人工脱矿液中14 d形成早期人工釉质龋。再随机分成4组,各组龋损表面分别用15%盐酸、37%磷酸和Opalustre打磨处理后,荧光素钠(NaFl)染色,Icon树脂渗透和光固化处理。激光扫描共聚焦显微镜(CLSM)镜下观察,比较4种处理方法对渗透的影响。结果盐酸组和磷酸组在渗透深度上存在显著性差异(P<0.05),盐酸组渗透效果更好;两打磨组间渗透深度存在显著性差异(P<0.05),提高打磨时间可以提高渗透效果,打磨组2与磷酸组、盐酸组均存在显著性差异(P<0.05),采用Opalustre打磨40 s后,Icon的渗透效果更好。结论龋表面的高钙化层是阻碍Icon渗透治疗的一道屏障,盐酸处理后Icon的渗透效果优于磷酸处理,而通过打磨表面层40 s后的渗透效果又明显优于20 s处理。早期龋表层的打磨处理可以考虑作为Icon临床治疗前期处理的替代和补充。

关键词：树脂渗透 Icon 早期龋釉质表层打磨

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

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AUTOPHAGY 2016年第1期12卷 1-222页

作者： Klionsky, Daniel J. Abdelmohsen, Kotb Abe, Akihisa Abedin, Md Joynal Abeliovich, Hagai Arozena, Abraham Acevedo Adachi, Hiroaki Adams, Christopher M. Adams, Peter D. Adeli, Khosrow Adhihetty, Peter J. Adler, Sharon G. Agam, Galila Agarwal, Rajesh Aghi, Manish K. Agnello, Maria Agostinis, Patrizia Aguilar, Patricia V. Aguirre-Ghiso, Julio Airoldi, Edoardo M. Ait-Si-Ali, Slimane Akematsu, Takahiko Akporiaye, Emmanuel T. Al-Rubeai, Mohamed Albaiceta, Guillermo M. Albanese, Chris Albani, Diego Albert, Matthew L. Aldudo, Jesus Alguel, Hana Alirezaei, Mehrdad Alloza, Iraide Almasan, Alexandru Almonte-Beceril, Maylin Alnemri, Emad S. Alonso, Covadonga Altan-Bonnet, Nihal Altieri, Dario C. Alvarez, Silvia Alvarez-Erviti, Lydia Alves, Sandro Amadoro, Giuseppina Amano, Atsuo Amantini, Consuelo Ambrosio, Santiago Amelio, Ivano Amer, Amal O. Amessou, Mohamed Amon, Angelika An, Zhenyi Anania, Frank A. Andersen, Stig U. Andley, Usha P. Andreadi, Catherine K. Andrieu-Abadie, Nathalie Anel, Alberto Ann, David K. Anoopkumar-Dukie, Shailendra Antonioli, Manuela Aoki, Hiroshi Apostolova, Nadezda Aquila, Saveria Aquilano, Katia Araki, Koichi Arama, Eli Aranda, Agustin Araya, Jun Arcaro, Alexandre Arias, Esperanza Arimoto, Hirokazu Ariosa, Aileen R. Armstrong, Jane L. Arnould, Thierry Arsov, Ivica Asanuma, Katsuhiko Askanas, Valerie Asselin, Eric Atarashi, Ryuichiro Atherton, Sally S. Atkin, Julie D. Attardi, Laura D. Auberger, Patrick Auburger, Georg Aurelian, Laure Autelli, Riccardo Avagliano, Laura Avantaggiati, Maria Laura Avrahami, Limor Awale, Suresh Azad, Neelam Bachetti, Tiziana Backer, Jonathan M. Bae, Dong-Hun Bae, Jae-Sung Bae, Ok-Nam Bae, Soo Han Baehrecke, Eric H. Baek, Seung-Hoon Baghdiguian, Stephen Bagniewska-Zadworna, Agnieszka Bai, Hua Bai, Jie Bai, Xue-Yuan Bailly, Yannick Balaji, Kithiganahalli Narayanaswamy Balduini, Walter Ballabio, Andrea Balzan, Rena Banerjee, Rajkumar Banhegyi, Gabor Bao, Haijun Barbeau, Benoit Barrachina, Maria D. Barreiro, Esther Bartel, Bonnie Bartolome, Alberto Bassham, Diane C. Bassi, Ma ASTAR Inst Mol & Cell Biol Singapore Singapore Adam Mickiewicz Univ Dept Gen Bot Inst Expt Biol Fac Biol Poznan Poland Aarhus Univ Hosp Dept Nucl Med DK-8000 Aarhus Denmark PET Ctr Aarhus Denmark Aarhus Univ Dept Biomed Aarhus Denmark Aarhus Univ Dept Clin Med Aarhus Denmark Aarhus Univ Dept Mol Biol & Genet Aarhus Denmark Aarhus Univ Med Res Lab Inst Clin Med Aarhus Denmark Alberystwyth Univ Inst Biol Environm & Rural Sci Aberystwyth Dyfed Wales Acad Sinica Inst Biol Chem Taipei 115 Taiwan Acad Sinica Inst Biomed Sci Taipei 115 Taiwan Acad Sinica Inst Mol Biol Taipei 115 Taiwan Univ Amsterdam Acad Med Ctr Dept Gastroenterol & Hepatol Meibergdreef 9 NL-1105 AZ Amsterdam Netherlands Univ Amsterdam Acad Med Ctr Dept Cell Biol & Histol Meibergdreef 9 NL-1105 AZ Amsterdam Netherlands Aix Marseille Univ CNRS IBDM UMR 7288 Campus Luminy Marseille France Aix Marseille Univ CNRS IRD198 UMR 7278INSERM U1095Med Fac Marseille France Aix Marseille Univ U2M Ctr Immunol Marseille Luminy Marseille France Ajou Univ Coll Pharm Gyeonggido South Korea Ajou Univ Sch Med Dept Microbiol Gyeonggi Do South Korea Akershus Univ Hosp Oslo Norway Akita Univ Grad Sch Med Akita 010 Japan Al Jalila Fdn Res Ctr Dubai U Arab Emirates Albany Med Coll Ctr Neuropharmacol & Neurosci Albany NY 12208 USA Albert Einstein Canc Ctr New York NY USA Albert Einstein Coll Med Bronx NY 10467 USA Albert Einstein Coll Med Dept Dev & Mol Biol Bronx NY 10467 USA Albert Einstein Coll Med Dept Dev & Mol Biol Inst Aging Studies Bronx NY 10467 USA Albert Einstein Coll Med Dept Med Bronx NY 10467 USA Albert Einstein Coll Med Dept Mol Pharmacol Bronx NY 10467 USA Albert Einstein Coll Med Dept Pathol Bronx NY 10467 USA Albert Einstein Coll Med Dept Biochem Bronx NY 10467 USA Albert Einstein Coll Med Dept Med Bronx NY 10467 USA Albert Einstein Coll Med Dept Med Endocrinol Bronx NY 10467 USA Albert Einstein Coll Med Dept Mol Pharmacol Bronx NY 10467 USA Alber

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Exposure to HIV-1 Impairs Retinal Epithelial Barrier Integrity

Exposure to HIV-1 Impairs Retinal Epithelial Barrier Integri...

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中国药理学会抗炎免疫药理专业委员会成立30周年纪念大会暨2012年学术年会

作者： Heng Duan Suiyi Tan Xiaoyan Pan lin Li shuwen Liu School of Pharmaceutical Sciences Southern Medical University1838 Guangzhou Avenue NorthGuangzhou 510515PR China

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混凝-Fenton氧化法对晚期垃圾渗沥液有机物的去除特性研究

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环境卫生工程 2012年第5期20卷 37-38,43页

作者：曹姝文周林肖晶广州市环境保护工程设计院有限公司广东广州510115

采用混凝-Fenton氧化法处理晚期垃圾渗沥液,在最佳试验条件下,对比研究了混凝和Fenton氧化法对晚期垃圾渗沥液中不同分子质量有机物和3种不同类型有机物(腐殖酸、富里酸和亲水性有机物)的去除效果。结果表明:混凝和Fenton氧化均对表观... 详细信息

采用混凝-Fenton氧化法处理晚期垃圾渗沥液,在最佳试验条件下,对比研究了混凝和Fenton氧化法对晚期垃圾渗沥液中不同分子质量有机物和3种不同类型有机物(腐殖酸、富里酸和亲水性有机物)的去除效果。结果表明:混凝和Fenton氧化均对表观分子质量>4 ku的COD去除效果较好,平均去除率分别为40%和86%。混凝剂对晚期垃圾渗沥液腐殖酸(HA)、富里酸(FA)和亲水性有机物(Hy)I的去除效果为HA>FA>HyI,而Fenton试剂对其去除效果为FA>HA>HyI。

关键词：晚期垃圾渗沥液混凝 Fenton氧化有机物

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