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Impact of 3D printing technology on the comprehension of surgical liver anatomy

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 2019年第2期33卷 411-417页

作者： Yang, Tianyou lin, shuwen Xie, Qigen Ouyang, Wenwei Tan, Tianbao Li, Jiahao Chen, Zhiyuan Yang, Jiliang Wu, Huiying Pan, Jing Hu, Chao Zou, Yan Guangzhou Med Univ Dept Pediat Surg Guangzhou Women & Childrens Med Ctr 9 Jinsui Rd Guangzhou 510623 Guangdong Peoples R China Fifth Peoples Hosp Dongguan City Dept Hepatobiliary Surg Dongguan Peoples R China Sun Yat Sen Univ Affiliated Hosp 1 Guangzhou Guangdong Peoples R China Guangdong Prov Hosp Chinese Med Key Unit Methodol Clin Res Guangzhou Guangdong Peoples R China Guangzhou Univ Chinese Med Affiliated Hosp 2 Guangzhou Guangdong Peoples R China Guangzhou Univ Chinese Med Dept Radiol Guangdong Prov Hosp Chinese Med Guangzhou Guangdong Peoples R China Guangzhou Med Univ Dept Radiol Guangzhou Women & Childrens Med Ctr Guangzhou Guangdong Peoples R China

Background and aimsSurgical planning in liver resection depends on the precise understanding of the three-dimensional (3D) relation of tumors to the intrahepatic vascular trees. This study aimed to investigate the impact of 3D printing (3DP) technology on the understanding of surgical liver *** selected four hepatic tumors that were previously resected. For each tumor, a virtual 3D reconstruction (VIR) model was created from multi-detector computed tomography (MDCT) and was prototyped using a 3D printer. Forty-five surgical residents were evenly assigned to each group (3DP, VIR, and MDCT groups). After evaluation of the MDCT scans, VIR model, or 3DP model of each tumor, surgical residents were asked to assign hepatic tumor locations and state surgical resection proposals. The time used to specify the tumor location was recorded. The correct responses and time spent were compared between the three *** assignment of tumor location improved steadily from MDCT, to VIR, and to 3DP, with a mean score of 34.50, 55.25, and 80.92, respectively. These scores were out of 100 points. The 3DP group had significantly higher scores compared with other groups (p<0.001). Furthermore, 3DP significantly improved the accuracy of surgical resection proposal (p<0.001). The mean accuracy of the surgical resection proposal for 3DP, VIR, and MDCT was 57, 25, and 25%, respectively. The 3DP group took significantly less time, compared with other groups (p<0.005). The mean time spent on assessing the tumor location for 3DP, VIR, and MDCT groups was 93, 223, and 286s, ***3D printing improves the understanding of surgical liver anatomy for surgical residents. The improved comprehension of liver anatomy may facilitate laparoscopy or open liver resection.

关键词： Three-dimensional printing Surgical anatomy Hepatic tumor Computed tomography Virtual 3D reconstruction

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Change in cephalocaudal tumor cavity diameter after transsphenoidal surgery is a predictor of diabetes insipidus in pituitary adenoma

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EUROPEAN JOURNAL OF MEDICAL RESEARCH 2022年第1期27卷 1-8页

作者： lin, Kunzhe Fan, Kaichun Mu, shuwen Wang, Shousen Fujian Med Univ Affiliated Fuzhou Hosp 1 Dept Neurosurg Fuzhou 350009 Peoples R China Fujian Med Univ Fuzong Clin Med Coll Fuzhou 350025 Peoples R China Chinese Peoples Liberat Army Gen Hosp Med Ctr 1 Dept Gastroenterol & Hepatol Beijing 100853 Peoples R China 900th Hosp Dept Neurosurg Fuzhou 350025 Peoples R China

Objective To assess the factors influencing the development of diabetes insipidus after transsphenoidal surgery for pituitary adenomas. Methods We retrospectively analyzed the clinical data of patients with pituitary adenoma who underwent transsphenoidal surgery. The pituitary gland was assessed using a 3.0 T magnetic resonance imaging, and the predictors of postoperative diabetes insipidus were determined through univariate and multivariate analyses. Results A total of 212 eligible patients with pituitary adenomas were included;82 (38.7%) cases developed postoperative diabetes insipidus while 130 cases (61.3%) did not. Diabetes insipidus was transient in 80 (37.7%) patients and permanent in 2 (0.9%) patients. The results of logistic regression analyses showed that the change in cephalocaudal tumor cavity diameter after transsphenoidal surgery was associated with the occurrence of postoperative diabetes insipidus. Conclusions Change in cephalocaudal tumor cavity diameter after transsphenoidal surgery may play an important role in predicting diabetes insipidus onset in patients with a pituitary adenoma.

关键词： Diabetes insipidus Transsphenoidal surgery Pituitary adenoma Cephalocaudal tumor cavity Multivariate

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Oral Microto-Nano Genome-Editing System Enabling Targeted Delivery and Conditional Activation of CRISPR-Cas9 for Gene Therapy of Inflammatory Bowel Disease

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ACS NANO 2024年第37期18卷 25657-25670页

作者： lin, Sicen Han, shuwen Wang, Xu Wang, Xinyue Shi, Xianbao He, Zhonggui Sun, Mengchi Sun, Jin Shenyang Pharmaceut Univ Wuya Coll Innovat Shenyang 110016 Liaoning Peoples R China Huzhou Univ Affiliated Cent Hosp Huzhou Cent Hosp Huzhou 313000 Zhejiang Peoples R China Jinzhou Med Univ Affiliated Hosp 1 Dept Pharm Jinzhou 121001 Liaoning Peoples R China Shenyang Pharmaceut Univ Sch Pharm Shenyang 110016 Liaoning Peoples R China Minist Educ Joint Int Res Lab Intelligent Drug Delivery Syst Shenyang 110016 Peoples R China

The potent CRISPR-Cas9 technology can correct genes in human mutated cells to achieve the treatment of multiple diseases, but it lacks safe and effective delivery systems. Herein, we proposed an oral microto-nano genome-editing system aiming at the enteric excessive level of TNF-alpha for specific gene therapy of inflammatory bowel disease (IBD). This editing system facilitated the assembly of Cas9/sgRNA ribonucleoprotein (RNP) into nanoclusters (NCs) through the bridging of disulfide bonds. RNP-NCs were subsequently encapsulated within inflammatory cell-targeted lipopolysaccharide-deleted outer membrane vesicles (dOMVs) sourced from Escherichia coli Nissle 1917, which were further shielded by an outer layer of calcium alginate microspheres (CAMs). By leveraging the protection effect of CAMs, the oral administration system withstood gastric acid degradation upon entry into the stomach, achieving targeted delivery to the intestines with high efficiency. As the pH gradually rose, the microscale CAMs swelled and disintegrated, releasing nanoscale RNP-NCs encapsulated in dOMVs into the intestines. These RNP-NCs@dOMVs could traverse the mucosal barrier and target inflammatory macrophages where conditionally activated Cas9/sgRNA RNPs effectively perform genomic editing of TNF-alpha within the nucleus. Such oral microto-nano genome-editing systems represent a promising translational platform for the treatment of

关键词： drug delivery CRISPR-Cas9 technology an oralmicroto-nano genome-editing system inflammatory bowel disease TNF-alpha

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Facilely prepared ferric-curcumin complex nanoparticles exert improved stability and photothermal enhanced antibacterial effects for food preservation

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LWT-FOOD SCIENCE AND TECHNOLOGY 2024年 205卷

作者： Wang, Cheng Pan, Jiaoyang Xu, Haiming Chen, Qian Zhou, shuwen Tang, Liming Qiu, lin Jiang, Pengju Changzhou Univ Sch Pharm Changzhou Jiangsu Peoples R China Changzhou Univ Sch Biol & Food Engn Changzhou Jiangsu Peoples R China Nanjing Med Univ Anorectal Surg Dept Affiliated Changzhou Peoples Hosp 2 Changzhou Jiangsu Peoples R China Nanjing Med Univ Affiliated Changzhou Peoples Hosp 2 Gastrointestinal Surg Dept Changzhou Jiangsu Peoples R China

Curcumin (Cur) is a phenolic compound extracted from Curcumae Longae Rhizoma, which has been widely applied in food industry due to its wide functional features, including coloring, antioxidant and antimicrobial activities. However, Cur exhibits some major limitations including low water solubility and stability during processing, which calls for convenient and straightforward protection strategy to improve its functionality. This investigation introduces a streamlined, consistently replicable one-pot method for synthesizing ferric-curcumin (Fe-Cur) complex nanoparticles through simple mixing of both components under controlled reaction conditions. Notably, the resultant Fe-Cur complex nanoparticles exhibit enhanced stability in comparison to their uncomplexed Cur counterpart. Of paramount importance, the Fe-Cur complex nanoparticles exhibit additional photothermal conversion capabilities, conferring them with augmented antibacterial efficacy against food-borne pathogens under light stimulation. This enhancement is efficacious against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), which were selected as representative for Gram-positive and negative strains, respectively, thereby presenting a unique strategy for integrating these particles within chitosan films to achieve desirable pork preservation performance. In summary, Fe-Cur complex nanoparticles emerge as a promising food-originating material, imbued with innovative photothermal enhanced antibacterial traits that promise to revolutionize food preservation methodologies.

关键词： Curcumin Photothermal Stability Antibacterial Food preservation

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Unfolding the cocrystallization-charge transport correlation in all-conjugated triblock copolymers via meticulous molecular engineering for organic field-effect transistors

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NANO ENERGY 2022年 100卷

作者： Li, Lixin Zhao, Qingqing Chen, shuwen lin, Zhiqun Peng, Juan Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China Georgia Inst Technol Sch Mat Sci & Engn Atlanta GA 30332 USA

The ability to render the cocrystallization over microphase separation in all-conjugated block copolymers represents an important endeavor towards achieving enhanced charge transport. This, however, remains a grand challenge, particularly in all-conjugated triblock copolymers. Herein, we report the unravelling of the dependence of cocrystallization in all-conjugated triblock copolymers on a set of internal structural parameters, and more importantly, the scrutiny of the correlation of their unique cocrystalline structures to charge transport properties for organic field-effect transistors (OFETs). Specifically, a series of poly(3-butylthiophene)-block-poly (3-alkylthiophene)-block-poly(3-hexylselenophene) triblock copolymers (denoted P3BT-b-P3AT-b-P3HS) are meticulously designed and synthesized. Intriguingly, a shorter alkyl side chain length and a shorter main chain length of the central P3AT, as well as a stronger cocrystallization ability of the two outer blocks (P3BT and P3HS), are found to favor the cocrystallization of the three dissimilar blocks in P3BT-b-P3AT-b-P3HS. Notably, the charge transport properties of P3BT-b-P3AT-b-P3HS correlate strongly to their various crystalline structures, thereby imparting their utility for high-performance OFETs. This study highlights the robustness of meticulous molecular engineering of all-conjugated multiblock copolymers in tailoring their cocrystallization behavior and in turn charge transport characteristics that underpins their advances in optoelectronic materials and devices.

关键词： Conjugated triblock copolymers Cocrystallization Molecular engineering Organic field-effect transistors

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In Situ Ultrafast Construction of Polysaccharide-Based Janus Hydrogel Films by Asymmetric Cross-linking for On-Demand Sterilization

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ACS SUSTAINABLE CHEMISTRY & ENGINEERING 2024年第29期12卷 10905-10918页

作者： Deng, Yong-Fu Luo, shuwen Li, Jianfang Bi, Shicheng Wei, Fuxiang Xu, Chuanhui Fu, Lihua lin, Baofeng Guangxi Univ Sch Chem & Chem Engn Nanning 530004 Peoples R China

Excessive and repetitive use of disinfectants poses a significant waste and health hazard;therefore, developing a more secure and efficient sterilization strategy is of great significance in safeguarding public health. Herein, we propose a facile strategy for rapidly fabricating a carboxymethyl chitosan (CMCS)/sliver nanoparticle (AgNPs)/Zn2+ Janus hydrogel film (CAZ) through in situ asymmetric cross-linking for on-demand sterilization. The Zn2+ diffusion from the surface toward the interior rapidly constructed the Janus hydrogel structure with a high cross-linking front and a low cross-linking back, realizing ultrafast film formation in approximately 3 s. Ingeniously, the Janus structure confers asymmetric adhesion (167 times difference) to CAZ and forms an antiadhesion front that can be touched by hand and an adhesion back that firmly adheres to the target surface, achieving the positioning and self-matching film formation. Specifically, the antibacterial activity was significantly enhanced by introducing a small amount of AgNPs (0.08 wt %). The three-dimensional movement trajectory of bacteria gradually weakened (10 min) and disappeared (30 min) on CAZ, demonstrating the excellent contact bactericidal performance. Moreover, the CAZ had great biocompatibility, ensuring biosafety. Consequently, in situ preparation of CAZ on the sensitive area surfaces could achieve fast and long-term on-demand sterilization, providing a green and safe strategy for public health protection.

关键词： carboxymethyl chitosan Janus hydrogel film ultrafast film formation asymmetric sterilization

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Rapid Meniscus-Assisted Solution-Printing of Conjugated Block Copolymers for Field-Effect Transistors

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ADVANCED FUNCTIONAL MATERIALS 2022年第14期32卷

作者： Yin, Yue Zhu, Shuyin Chen, shuwen lin, Zhiqun Peng, Juan Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China Georgia Inst Technol Sch Mat Sci & Engn Atlanta GA 30332 USA

The ability to rapidly and precisely position semiconducting pi-conjugated polymers over a large area is necessary for various device-related applications. However, the investigation into conjugated block copolymer-based patterned materials and devices is somewhat limited. Herein, a robust meniscus-assisted solution printing (MASP) route to highly ordered stripe arrays of conjugated poly(3-butylthiophene)-block-poly(3-dodecylthiophene) (P3BT-b-P3DDT) is reported, and different periodic stripes are correlated to their charge mobilities. The MASP renders the confined evaporation of P3BT-b-P3DDT solution between two nearly parallel plates and deposition into periodic stripes owing to the coffee-ring effect. Remarkably, two types of stripe arrays, namely, large-size stripe arrays and hierarchical arrays comprising small secondary stripes located between neighboring large-size primary stripes are yielded, where their dimension and period can be delicately tailored. Finally, a distinct correlation between various stripe arrays of P3BT-b-P3DDT and the corresponding charge mobility is revealed. Conceptually, such convenient production of P3BT-b-P3DDT stripe arrays via MASP can be readily extended to other pi-conjugated polymers and diversity of nanomaterials for potential applications in optoelectronic devices.

关键词： charge transport conjugated block copolymers meniscus-assisted solution printing organic field-effect transistors polythiophene

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Classical famous prescription of Jichuan decoction improved loperamide-induced slow transit constipation in rats through the cAMP/PKA/AQPs signaling pathway and maintained inflammatory/intestinal flora homeostasis

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HELIYON 2024年第1期10卷 e21870页

作者： lin, lina Jiang, Yuanyuan lin, Pengfei Ge, Lanlan Wan, Haoqiang Dai, shuwen Zhang, Runjing Yao, Jie Zeng, Xiaobin Peng, Ying Shenyang Pharmaceut Univ Wuya Coll Innovat Shenyang 110016 Liaoning Peoples R China China Resources Sanjiu Med & Pharmaceut Co Ltd Shenzhen 518000 Guangdong Peoples R China Jinan Univ Southern Univ Sci & Technol Shenzhen Peoples Hosp Affiliated Hosp 1Cent Lab Longhua BranchClin Med Shenzhen 518020 Guangdong Peoples R China Jinan Univ Southern Univ Sci & Technol Shenzhen Peoples Hosp Affiliated Hosp 1Dept Infect DisClin Med Coll 2 Shenzhen 518020 Guangdong Peoples R China Shenzhen Tradit Chinese Med Mfg Innovat Ctr Co Ltd Shenzhen 518110 Guangdong Peoples R China Jinan Univ Southern Univ Sci & Technol Shenzhen Peoples Hosp Dept PatholAffiliated Hosp 1Clin Med Coll 2Long Shenzhen 518020 Guangdong Peoples R China Shanghai Univ Tradit Chinese Med Inst Interdisciplinary Integrat Med Res Shanghai 201203 Peoples R China Shenzhen Univ Med Sch Guangdong Prov Key Lab Reg Immun & Dis Shenzhen 518037 Guangdong Peoples R China

Introduction: Jichuan decoction (JCD) is a well-known traditional Chinese medicinal formula that moistens the intestines and is widely used for the treatment of constipation in China. However, its effects and mechanisms in alleviating slow transit constipation (STC) in vivo remain unclear. We attempted to demonstrate the effect of JCD, with and without essential oil (VO), on intestinal transit and its underlying molecular mechanisms in rats with loperamide-induced STC. Materials and methods: Water consumption, body weight, fecal water content, time to first melena excretion, and intestinal transit ratio of the animals were measured. 5-Hydroxytryptamine (5-HT), substance P (SP), vasoactive intestinal peptide (VIP), and interleukin-6 (IL-6) levels in the sera of rats were evaluated using ELISA. Hematoxylin and eosin and Periodic Acid-Schiff staining were used to determine intestinal tissue histology, while quantitative real-time PCR, western blotting, and immunohistochemical analysis were used to assess the relative expression levels of cAMP/ PKA/AQPs pathway- and inflammation-related proteins. 16 S rDNA sequence analysis of rat feces was used to determine the diversity and abundance of the intestinal flora. Results: The JCD groups showed reduced time to first melena excretion and expression of VIP and IL-6. The JCD groups, specifically JCD + VO groups, showed increased fecal water content, intestinal transit rate, and SP expression. Further, these groups showed improved histological characteristics of the colon, with no significant change in the index of immune organs or morphological characteristics of other organs. In addition, a significant decrease in the activation of the cAMP/PKA/AQPs signaling pathway in the colon tissue was observed in these groups, specifically the JCD + VO groups. Moreover, treatment with JCD, with or without VO, downregulated the expression of inflammatory factors and enriched the diversity of intestinal flora as evidenced by polymorphism

关键词： Jichuan decoction Slow transit constipation cAMP/PKA/AQPs pathway Inflammation Intestinal flora homeostasis

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基于linux的开放式数控系统加工轨迹仿真功能研发

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机械制造与自动化 2020年第1期49卷 71-74,81页

作者：陈平斌林述温陈坤火福州大学机械工程及自动化学院福建福州350116

基于linux的PC+可编程I/O(接口)体系的开放式数控系统,设计了加工轨迹仿真的通用模型。针对毛坯仿真建模时,离散化精度和仿真速度之间的矛盾,提出一种离散模型建立的改进方法,即在均匀网格离散基础上对模型曲率较大处细化网格间距,并以... 详细信息

基于linux的PC+可编程I/O(接口)体系的开放式数控系统,设计了加工轨迹仿真的通用模型。针对毛坯仿真建模时,离散化精度和仿真速度之间的矛盾,提出一种离散模型建立的改进方法,即在均匀网格离散基础上对模型曲率较大处细化网格间距,并以数控铣削加工为例,针对该通用模型和改进的离散矢量建模法研发了三轴数控铣削加工仿真功能单元,实现了加工前试切模拟和轨迹错误检查。通过实际加工零件,验证了所开发加工仿真功能单元的正确性和通用模型在本开放式数控系统中的适用性。

关键词：开放式数控系统轨迹仿真功能单元模型改进离散矢量建模

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Improving Perovskite Solar Cell Performance and Stability via Thermal Imprinting-Assisted Ion Exchange Passivation

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ACS APPLIED MATERIALS & INTERFACES 2024年第38期16卷 51037-51045页

作者： Qi, shuwen Ge, Chenghao Wang, Peng Wu, Bin Zhao, Yuping Zhao, Rongjun Shafian, Shafidah Hua, Yong Xie, lin Yunnan Univ Sch Mat & Energy Kunming 650091 Peoples R China Yunnan Univ Ctr Optoelect Engn Res Dept Phys Kunming 650091 Peoples R China Univ Kebangsaan Malaysia Solar Energy Res Inst Bangi 43600 Selangor Malaysia

The latest development in perovskite solar cell (PSC) technology has been significantly influenced by advanced techniques aimed at passivating surface defects. This work presents a new approach called thermal imprinting-assisted ion exchange passivation (TIAIEP), which delivers a different approach to conventional solution-based methods. TIAIEP focuses on addressing surface imperfections in solid-state films by using a passivator that promotes ion exchange specifically at the defect sites within the perovskite layer. By adjusting the time and temperature of the TIAIEP process, we achieve substantial enhancement in the creation of a compositional gradient within the films. This optimization slows the cooling rate of hot carriers, leading to minimizing charge recombination and improving the device performance. Remarkably, devices treated with TIAIEP achieve a 22.29% power conversion efficiency and show outstanding stability, with unencapsulated PSCs maintaining 91% of their original efficiency after over 2000 h of storage and 90% efficiency after 1200 h of constant illumination. These results highlight TIAIEP's effectiveness in mitigating surface defects, improving both the photoelectric and stability performance of PSCs, and indicating significant potential for large-scale application in perovskite film passivation, promoting the widespread adoption of this technology.

关键词： perovskite solar cells hole transport layer hole collection built-in electric field chargerecombination

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