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Impact of Radar and Surface Data Assimilation on the Forecast of a Nocturnal Squall Line in the Yangtze-Huaihe River

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ATMOSPHERE 2022年第9期13卷 1522-1522页

作者： pan, Zongmei Zhang, shuwen Zhang, Weidong Lanzhou Univ Coll Atmospher Sci Key Lab Climate Resource Dev & Disaster Prevent G Lanzhou 730000 Peoples R China

The impact of radar and surface data assimilation on the forecast of a nocturnal squall line initiated above the stable boundary layer in the Yangtze-Huaihe River is investigated by the Weather Research and Forecasting (WRF) model and its three-dimensional variational assimilation system (WRFDA 3DVar). Results show that the assimilation of radar and surface data can improve the prediction of the convection initiation time, height and vertical ascending motion during the early stage of the squall line formation by adjusting the thermodynamic structure, circulation patterns, water vapor conditions and hydrometeor mixing ratios. Although the radar and surface data assimilation can improve the forecast of the location of the squall line to a certain extent, the squall line is stronger in the radar data assimilation than that in the surface data assimilation, leading to stronger radar reflectivity and heavier precipitation. The assimilation of both radar and surface data has a more positive impact on the forecast skill than the assimilation of either type of data. Moreover, during the mature stage of the squall line, radar and surface data assimilation can enhance the intensity of the surface cold pool. Specifically, radar data assimilation or assimilating the two data simultaneously can produce a stronger cold pool than only assimilating surface data, which is more conducive to the maintenance and development of the squall line.

关键词： data assimilation nocturnal squall line stable boundary layer convection initiation cold pool

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Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process

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BIOORGANIC CHEMISTRY 2024年 150卷 107588页

作者： Hu, Yixin Zhang, Yang Guo, Jie Chen, Shihao Jin, Jie Li, Pengyu pan, Yuchen Lei, shuwen Li, Jiaqi Wu, Suheng Bu, Buzhou Fu, Lei Shanghai Jiao Tong Univ Sch Pharm Shanghai Key Lab Mol Engn Chiral Drugs Shanghai Peoples R China Xian Jiaotong Liverpool Univ Acad Pharm Suzhou Peoples R China

With the advent of mitochondrial targeting moiety such as triphenlyphosphonium cation (TPP+), targeting mitochondria in cancer cells has become a promising strategy for combating tumors. Herein, a series of novel 4aryl-1,3-thiazole derivatives linked to TPP+ moiety were designed and synthesized. The cytotoxicity against a panel of four cancer cell lines was evaluated by CCK-8 assay. Most of these compounds exhibited moderate to good inhibitory activity over HeLa, PC-3 and HCT-15 cells while MCF-7 cells were less sensitive to most compounds. Among them, compound 12a exhibited a significant anti-proliferative activity against HeLa cells, and prompted for further investigation. Specifically, 12a decreased mitochondrial membrane potential and enhanced levels of reactive oxygen species (ROS). The flow cytometry analysis revealed that compound 12a could induce apoptosis and cell cycle arrest at G0/G1 phase in HeLa cells. In addition, mitochondrial bioenergetics assay revealed that 12a displayed mild mitochondrial uncoupling effect. Taken together, these findings suggest the therapeutic potential of compound 12a as an antitumor agent targeting mitochondria.

关键词： Anticancer Mitochondrial targeting Oxidative phosphorylation Mitochondrial bioenergetics Mitochondrial uncoupler

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Development and validation of a postoperative prognostic model for hormone receptor positive early stage breast cancer recurrence

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SCIENTIFIC REPORTS 2025年第1期15卷 1-10页

作者： pan, Ruixin Shi, Haoting Shen, Yiqing Wang, Xue Zhao, Shi Zhang, Nan Zhang, Xueyan Dong, shuwen Hu, Chao Wu, Jiayi Chai, Weimin Chen, Xiaosong Shen, Kunwei Shanghai Jiao Tong Univ Ruijin Hosp Comprehens Breast Hlth Ctr Dept Gen SurgSch Med Shanghai 20025 Peoples R China Johns Hopkins Univ Dept Comp Sci Baltimore MD USA Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Dept Pathol Shanghai Peoples R China Tianjin Med Univ Sch Publ Hlth Tianjin Peoples R China Changchun Inst Biol Prod Changchun Peoples R China Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Dept Radiol Shanghai Peoples R China

Predicting recurrence among early-stage hormone receptor-positive human epidermal growth factor receptor-negative breast cancer (HR+/HER2- BC) is crucial for guiding adjuvant therapy. However, studies are limited for patients with low recurrence risk. HR+/HER2- early-stage (T1-2N0-1) invasive BC patients who received definitive surgery and followed by endocrine therapy from four independent medical centers were included in this retrospective study. Patients from center 1 were used as derivation cohort, while those from other centers were combined as an external test cohort. A deep learning prognostic model, HERPAI, was developed based on Transformer to predict risk of invasive disease-free survival (iDFS) utilizing clinical and pathological predictors. The model performance was evaluated using C-index for the overall population and subgroups. Threshold for selecting 5-year recurrence risk > 10% was determined. Hazard ratio (HR) was estimated between risk groups for iDFS. A total of 6340 patients were included, of whom 5424 were assigned to the derivation cohort (training and validation [N = 4882] and internal test cohort [N = 542]), while 916 patients were utilized as external cohort. HERPAI yielded a C-index of 0.73 (95% CI 0.65-0.81), 0.73 (95% CI 0.62-0.85), and 0.68 (95% CI 0.60-0.77), in the validation, internal, and external test cohort, respectively. Consistent performances were observed for pre-specified subgroups. High-risk patients were associated with an increased risk of recurrence for validation (HR, 2.56 [95% CI 1.25-5.22], P = 0.01), internal test (HR, 2.52 [95% CI 0.97-6.57], P = 0.06) and external test (HR, 1.94 [95% CI 1.00-3.74], P = 0.049) cohort, respectively. HERPAI was a promising tool for selecting vulnerable early-stage HR+/HER2- BC patients who were at high-risk of recurrence. It could facilitate the prioritization of patients who may benefit more from escalating adjuvant treatment.

关键词： Hormone receptor-positive Breast cancer Artificial intelligence Prognostic model Endocrine therapy

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A novel approach to bulk-phase hydrogenation using an extremely high-loading sulfide NiMoW/SiO2 catalyst

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FUEL 2025年 386卷

作者： Tian, Fengyu Sun, Guangzheng Zeng, Xianfu Xie, shuwen Wang, Yidi Wu, Zifan Liu, Bin pan, Yuan Dong, Bin Li, Yichuan Li, Yanpeng Guo, Hailing Chai, Yongming Liu, Chenguang China Univ Petr East China Coll Chem & Chem Engn State Key Lab Heavy Oil Proc Qingdao 266580 Peoples R China China Natl Petr Corp CNPC Key Lab Catalysis Qingdao 266580 Peoples R China

Supported and bulk phase catalysts are both extensively used in hydrogenation reactions, possess distinct strengths and limitations. Aiming to create a catalyst that combines the benefits of both, a series of NiMoW/SiO2 catalysts were synthesized with varied metal loadings using SiO2 supports characterized by different pore structures. The catalytic activities of these catalysts were evaluated using 1-methylnaphthalene, dibenzothiophene and quinoline as model compounds. Comprehensive microstructural characterization was performed through ICP-OES, N2 physisorption, HRTEM, SEM, and XPS techniques. The investigation revealed that both the catalytic and microstructural properties of the catalysts gradually changed from the supported catalysts to the bulk catalysts with the gradual increase of the metal loadings. This transition was accompanied by a significant enhancement in activity and hydrogenation selectivity compare to the supported catalysts. Nonetheless, this catalyst preserved the benefits of a superior pore structure, straightforward preparation methods and excellent regeneration.

关键词： Hydrogenation High-Loading Bulk catalyst NiMoW

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Field Monitoring of Delayed Coal Burst in an Advancing Entry of a Deep Coal Mine

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MINING METALLURGY & EXPLORATION 2021年第6期38卷 2417-2431页

作者： Shi, Qingwen pan, Junfeng Wang, shuwen Liu, Shaohong Mishra, Brijes Seitz, Shannon West Virginia Univ Dept Min Engn Morgantown WV 26505 USA Tiandi Sci & Technol Co Ltd Dept Coal Min & Designing Beijing 100013 Peoples R China China Coal Grp Beijing 100120 Peoples R China

Delayed coal bursts in deep coal mines have caused significant fatalities and economic losses in recent years. Instead of occurring right around the advancing face, this particular type of coal burst is characterized by its occurrence at a certain distance behind the advancing face. To better understand the mechanism of a delayed coal burst, we used borehole camera, electromagnetic CT, and borehole deformation monitoring device to observe the fracturing and deformation process of an advancing entry's surrounding coal in the field. Borehole camera detection showed a zonal disintegration phenomenon in the advancing entry's surrounding coal. Electromagnetic CT detection showed that zonal disintegration developed within 14 days of excavation. Borehole deformation monitoring indicated a deformation rate difference between the intact zone and fractured zones. The deformation rate difference was observed to increase with time and cause increasing elastic energy accumulation in the intact zone. The cumulative elastic energy in the intact zone finally caused a delayed coal burst in the entry. Sensitivity analysis of the cumulative elastic energy was conducted based on a thick-walled model deduced from field detection. The model shows that the smaller thickness of the intact zone brings higher elastic energy in the intact zone. This investigation provides an improved understanding of delayed coal bursts in deep coal mines.

关键词： Delayed coal burst Field monitoring Deep coal mine Zonal disintegration Deformation difference

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CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment

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TRANSLATIONAL ONCOLOGY 2025年 53卷 102310-102310页

作者： Xu, Junfeng Li, Na Xie, Hui Duan, Changwei Liao, Xingchen Li, Ruoran Zhang, Heng pan, Yuanming Ma, Xianzong Du, shuwen Sheng, Jianqiu Wang, Xin Yang, Lang Jin, Peng Chinese Peoples Liberat Army Gen Hosp Sr Dept Gastroenterol Med Ctr 1 Beijing 100853 Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Gastroenterol Med Ctr 7 Beijing 100700 Peoples R China Med Sch Chinese PLA Beijing 100853 Peoples R China Capital Med Univ Beijing Chest Hosp Canc Res Ctr Beijing 101149 Peoples R China

Background: Colony-stimulating factor 3 (CSF3) is a cytokine that promotes inflammation by stimulating the maturation, proliferation, and trafficking of myeloid progenitor cells. However, the functional importance of CSF3 in colorectal cancer (CRC) remains unclear. Methods: CSF3 expression levels in CRC cells and tissues were detected by quantitative real-time PCR (qRT-PCR), western blot and immunohistochemistry (IHC). In vitro and in vivo assays were performed to investigate the oncogenic function of CSF3 in the tumor associated malignant phenotypes and the tumorigenic capability of CRC cells. Immunocoprecipitation was performed to verify the regulatory effects of CSF3 on I kappa B alpha ubiquitination. Results: We found that CSF3 was overexpressed in CRC tissues compared to adjacent normal tissues, which correlated with poor patient survival. In vitro, silencing CSF3 significantly impaired cell proliferation, colony formation, and migration, while enhancing apoptosis. In vivo, silencing CSF3 resulted in reduced tumor growth, weight, and volume, indicating its potential as a therapeutic target. Mechanistically, CSF3 was found to mediate CRC development by activating the NF-kappa B signaling pathway, as evidenced by the decreased phosphorylation of p65 and reduced I kappa B alpha ubiquitination in CSF3-silenced cells. Furthermore, CSF3 silencing modulated immune infiltration in CRC, promoting an anti-tumor immune response and altering the tumor microenvironment. Conclusion: CSF3 modulated the NF-kappa B signaling pathway through a distinct mechanism involving p65 phosphorylation and the activation of NF-kappa B by enhancing I kappa B alpha ubiquitination, thereby effectively promoting CRC development, and CSF3 may serve as a potential therapeutic target for repressing CRC advance and metastasis.

关键词： CSF3 Colorectal cancer Ubiquitination p65/NF-kappa B signaling Tumor microenvironment

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A Kalman Filtering for Linear Discrete-time System with Unknown Inputs

A Kalman Filtering for Linear Discrete-time System with Unkn...

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第30届中国控制与决策会议

作者： Weiran Li Jie pan Yanjun Li shuwen pan Yan Liu Key Discipline of Automation School of Information and Electrical Engineering Zhejiang University City College University of Western Australia

This paper focuses on the joint input and state estimation for linear stochastic discrete-time systems. To obtain unique estimators that are optimal in the sense of being both least-squares and minimum-variance unbiased(MVU) and their recursive solution, an objective function of the sum of squared errors of outputs is first minimized with respect to an extended state vector including states and unknown inputs. A recursive solution of the extended state vector is then derived with the aid of matrix manipulations. Finally, appropriate matrix decomposition and transformation are used to extract the recursive solutions only involving the current states and unknown inputs from the recursive solution obtained in the previous step. This approach avoids excessive computation due to the dimensions of the matrices that increase with time. As a result, the resulting recursive solution is referred to as a general Kalman filter with unknown inputs(GKF-UI),which covers the most general case of unknown inputs so far in the literature without resorting to transforming the outputs and/or unknown inputs. The unknown inputs to be estimated by the proposed GKF-UI could be arbitrary signals without any prior information and the properties of the proposed GKF-UI are also examined. A numerical example with partial feedthrough from three unknown inputs is used to demonstrate the effectiveness and accuracy of the proposed algorithm.

关键词： Kalman filtering unknown input estimation minimum-variance unbiased filter least-squares estimation

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A Cognitive Failure Model of Construction Workers' Unsafe Behavior

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ADVANCES IN CIVIL ENGINEERING 2022年第0期2022卷

作者： Deng, shuwen Peng, Rui pan, Yonggang Xinjiang Univ Coll Architecture Engn 1230 Victory Rd Urumqi 830000 Peoples R China

The construction industry is one of the most dangerous industries globally, and construction workers are the leading cause of safety accidents. Unsafe behavior research focuses on behavioral safety of observable behaviors and the safety culture of organizational behaviors. However, these studies lack a systematic and comprehensive explanation of unsafe behavior. Therefore, this study constructs a cognitive failure model based on cognitive safety theory to explain the mechanisms of construction workers' unsafe behaviors. Five main causes of cognitive link failure were derived from the cognitive process of construction workers' unsafe behaviors: safety vigilance, hazard identification, safety knowledge, safety behavior attitude, and professional skills. Questionnaires were developed based on five cognitive failure factors and validated by structural equation modeling. The results show that the cognitive failure model fits well, and all five cognitive failure factors may lead to construction workers' unsafe behaviors. Among the five cognitive failure factors, safety vigilance is the main cognitive failure factor in obtaining information link;hazard identification is the major cognitive failure factor in understanding information link;and safety behavior attitude is the chief cognitive failure cause for selecting response link. These findings deepen the understanding of construction workers' unsafe behavior mechanisms.

关键词： Construction worker Hazard analysis

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Evaluation of the effectiveness of promoted psychological resilience intervention for oesophageal cancer patients in rural China: A randomized controlled study

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EUROPEAN JOURNAL OF ONCOLOGY NURSING 2024年 68卷 102501-102501页

作者： Zhao, Jinghan Ge, Hui Wang, pan Zhang, Zonghao Qin, Qiaoyun Li, shuwen Peking Univ Sch Nursing Beijing Peoples R China Anhui Med Univ Sch Nursing Hefei Anhui Peoples R China Anhui Med Univ Sch Nursing 15 Feicui Rd Hefei 230601 Peoples R China

Purpose: The objective of this randomized controlled trial was to examine the effectiveness of promoted resilience intervention to facilitate resilience, self -efficacy, coping mode, and social support for oesophageal cancer patients in rural China. Methods: A two -arm, parallel design, single -blinded, randomized controlled trial was conducted in a comprehensive tertiary hospital in Anhui from August 2021 to September 2022. A total of 82 oesophageal cancer patients were assigned to two groups via blocked randomization. The intervention group (n = 41) received the Promoted Psychological Resilience Intervention based on survivors' experiences and the control group (n = 41) received routine care. Study data were collected using the sociodemographic information, Connor -Davidson Resilience Scale, Strategies Used by People to Promote Health, Medical Coping Modes Questionnaire, and Perceived Social Support Scale. Results: The groups were well-balanced at baseline. Post -intervention and three months after intervention, the resilience, self -efficacy, acceptance -resignation, and social support were all significantly different in the intervention and control groups (p < 0.05 for each). The main effect of group, time, and the interaction between group and time was statistically significant in the scores of resilience, self -efficacy, acceptance -resignation, and social support, except for the factor of selfdetermination and friends support (p < 0.05 for each). Conclusions: This study demonstrated that an intervention program based on the experiences of long-term oesophageal cancer survivors can promote patients' resilience.

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Adaptive Detection of Radar Targets in Heavy-Tailed Sea Clutter With Lognormal Texture

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IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING 2022年 60卷 1页

作者： Xue, Jian Liu, Jun Xu, shuwen pan, Meiyan Xian Univ Posts & Telecommun Sch Commun & Informat Engn Xian 710121 Peoples R China Univ Sci & Technol China Dept Elect Engn & Informat Sci Hefei 230027 Peoples R China Xidian Univ Natl Lab Radar Signal Proc Xian 710071 Peoples R China Xian Elect Engn Res Inst Xian 710100 Peoples R China

This article deals with the problem of detecting a marine target with coherent radars in a correlated heavy-tailed sea clutter background. The heavy-tailed sea clutter is modeled by a compound-Gaussian model, and the clutter texture is characterized by the lognormal distribution with a new parameterization form. We develop an adaptive coherent detector on the basis of the two-step generalized likelihood ratio test. The proposed detector can achieve adaptation to sea clutter characteristics by using the maximum a posterior estimate of the clutter texture, the constrained approximate maximum likelihood estimator of the speckle covariance matrix, and the proposed negative- and positive-fractional moment estimate of amplitude parameters of sea clutter. Remarkably, the proposed detector inherently ensures a constant false alarm rate with respect to the clutter power mean and the speckle covariance matrix. Finally, numerical experiments using simulated data and real radar data demonstrate that the proposed estimator and adaptive coherent detector outperform their respective competitors.

关键词： Clutter Detectors Speckle Radar detection Radar clutter Covariance matrices Adaptation models Adaptive detection constant false alarm rate (CFAR) lognormal texture sea clutter

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