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A fluorescent and colorimetric probe enables simultaneous differential detection of Hg²⁺ and Cu²⁺ by two different mechanisms

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SENSORS AND ACTUATORS B-CHEMICAL 2017年 238卷 455-461页

作者： Gao, Yunling Zhang, Cong peng, shuwen Chen, Haiyan Zhejiang Univ Technol Coll Chem Engn State Key Lab Breeding Base Green Chem Synth Tech Hangzhou 310032 Zhejiang Peoples R China China Pharmaceut Univ Sch Engn Dept Biomed Engn Nanjing 210009 Jiangsu Peoples R China

A new Schiff-base fluorescence probe CS containing benzimidazole and coumarin fluorophores was synthesized and characterized by NMR, IR and ESI-MS. Fluorescence and absorption spectra show the unique changes in the presence of Hg2+ and Cu2+. Hg2+ induces a remarkable fluorescence enhancement and results in mercury-promoted hydrolysis of a mercury-CS complex to convert the imine group to the aldehyde group. Cu2+ leads to a colorimetric change from colorless to pale yellow and causes formation of a copper-CS complex. Thus, CS can act as a fluorescent chemodosimeter for Hg2+ and a naked-eye chemosensor Cu2+. The cell imaging experiments for Hg2+ show a slow enhancement of a bright blue fluorescence with increasing incubation time, while Cu2+ instantly quenches the fluorescence and then the fluorescence intensity has no further change by extending the incubation time. Therefore, the probe CS shows its potential application for simultaneous differential detection of Hg2+ and Cu2+ in living cells based on the fluorescence response time. (C) 2016 Elsevier B.V. All rights reserved.

关键词： Probe Copper Mercury Fluorescence Colorimetric Simultaneous differential detection

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Sulfiredoxin 1 ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the Sirt1/ NLRP3 pathway

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INTERNATIONAL IMMUNOPHARMACOLOGY 2024年 141卷 113010页

作者： Zhang, Zhaoxia Du, Tingsha Wu, Nan Yang, shuwen Wang, Jian peng, Jianye Jia, Zhenyu Dai, Jiating Du, Xianfeng Feng, Mingjun Chu, Huimin Shen, Caijie Ningbo Univ Affiliated Hosp 1 Dept Cardiol 59 Liuting St Ningbo 315000 Peoples R China Ningbo Univ Hlth Sci Ctr Ningbo 315000 Peoples R China Univ South China Affiliated Hosp 2 Hengyang Med Sch Dept Cardiovasc Med Hengyang 421001 Hunan Peoples R China

Background: Doxorubicin (DOX) is limited in clinical use due to its cardiotoxic side effects. Oxidative stress and inflammation are pivotal mechanisms underlying doxorubicin-induced cardiotoxicity (DIC). Sulfiredoxin 1 (Srxn1) plays a central role in antioxidant effects. However, the role of Srxn1 in DIC has not yet been fully elucidated. This study aims to explore the effects and underlying mechanisms of Srxn1 on DIC. Methods: We overexpressed Srxn1 in the myocardium using an adeno-associated virus 9 (AAV9) system, delivered through tail vein injection. C57BL/6 mice received intraperitoneal injections of DOX (4 mg/kg) weekly for four consecutive weeks to establish a mouse model of DIC. We used echocardiography, histopathological, and molecular techniques to elucidate the effects and mechanisms. Results: Our findings demonstrate that overexpression of Srxn1 significantly enhanced cardiac function and mitigated myocardial injury in mice exposed to DOX. Overexpressing Srxn1 attenuated oxidative stress and inflammation induced by DOX. Furthermore, Srxn1 overexpression led to upregulation of sirtuin 1 (Sirt1) expression and inhibited the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome. Notably, the protective effects of Srxn1 were significantly abrogated by the Sirt1 inhibitor EX527. Conclusion: The protective effects of Srxn1 against DOX-induced cardiac oxidative stress and inflammation operate by targeting the Sirt1/NLRP3 signaling pathway to alleviate DIC. Srxn1 could be a potential candidate for the treatment of DOX-induced myocardial injury.

关键词： Doxorubicin Cardiotoxicity Sulfiredoxin 1

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Ion channel Piezo1 activation aggravates the endothelial dysfunction under a high glucose environment

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CARDIOVASCULAR DIABETOLOGY 2024年第1期23卷 150页

作者： Zhang, Xiaoyu Leng, Shaoqiu Liu, Xinyue Hu, Xiang Liu, Yan Li, Xin Feng, Qi Guo, Wei Li, Nailin Sheng, Zi Wang, shuwen peng, Jun Shandong Univ Qilu Hosp Cheeloo Coll Med Dept Hematol Jinan Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Inst Hematol Natl Clin Res Ctr Blood Dis State Key Lab Expt Hematol Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Blood Dis Hosp Tianjin Peoples R China Shandong Univ Adv Med Res Inst Jinan Peoples R China Shandong Univ Qilu Hosp Cheeloo Coll Med Shandong Key Lab Immunochematol Jinan Peoples R China Shandong Univ Natl Key Lab Innovat & Transformat Luobing Theory Jinan Peoples R China Shandong Univ Key Lab Cardiovasc Remodeling & Funct Res Chinese Minist Educ Chinese Natl Hlth CommissQilu HospCheeloo Coll M Jinan Peoples R China Shandong Univ Qilu Hosp Chinese Acad Med Sci Cheeloo Coll Med Jinan Peoples R China Zhejiang Univ Affiliated Hosp 1 Inst Hematol Sch Med Hangzhou 310029 Peoples R China Karolinska Inst Dept Med Solna Cardiovasc Med Unit Stockholm Sweden

Background Vasculopathy is the most common complication of diabetes. Endothelial cells located in the innermost layer of blood vessels are constantly affected by blood flow or vascular components;thus, their mechanosensitivity plays an important role in mediating vascular regulation. Endothelial damage, one of the main causes of hyperglycemic vascular complications, has been extensively studied. However, the role of mechanosensitive signaling in hyperglycemic endothelial damage remains *** Vascular endothelial-specific Piezo1 knockout mice were generated to investigate the effects of Piezo1 on Streptozotocin-induced hyperglycemia and vascular endothelial injury. In vitro activation or knockdown of Piezo1 was performed to evaluate the effects on the proliferation, migration, and tubular function of human umbilical vein endothelial cells in high glucose. Reactive oxygen species production, mitochondrial membrane potential alternations, and oxidative stress-related products were used to assess the extent of oxidative stress damage caused by Piezo1 *** Our study found that in VECreERT2;Piezo1flox/flox mice with Piezo1 conditional knockout in vascular endothelial cells, Piezo1 deficiency alleviated streptozotocin-induced hyperglycemia with reduced apoptosis and abscission of thoracic aortic endothelial cells, and decreased the inflammatory response of aortic tissue caused by high glucose. Moreover, the knockout of Piezo1 showed a thinner thoracic aortic wall, reduced tunica media damage, and increased endothelial nitric oxide synthase expression in transgenic mice, indicating the relief of endothelial damage caused by hyperglycemia. We also showed that Piezo1 activation aggravated oxidative stress injury and resulted in severe dysfunction through the Ca2+-induced CaMKII-Nrf2 axis in human umbilical vein endothelial cells. In Piezo1 conditional knockout mice, Piezo1 deficiency partially restored superoxide dismutase activity and reduced malondia

关键词： Piezo1 Endothelial dysfunction Hyperglycemia Oxidative stress Nrf2

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Inverse cascade based on nonlinear Schrodinger equation analysis with nonlinear feedback control

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JOURNAL OF PLASMA PHYSICS 2023年第4期89卷 905890407-905890407页

作者： Cui, Shaoyan Hu, Xin Xie, peng Yang, Jialin Feng, shuwen Ludong Univ Sch Math & Stat Sci Yantai 264025 Shandong Peoples R China

This paper focuses on the wave inverse cascade instability analysis with self-regulating feedback control for a fixed external potential field and a highly localized finite-amplitude initial pulse. The wave inverse cascade instability analysis is carried out by solving the corresponding two-dimensional generalized nonlinear Schrodinger equation. The wave field firstly suffers from the modulation instability, followed by collapse into turbulence containing the shortest-wavelength modes in the system. This is followed by inverse cascade of the shortest wavelength modes back to the longer-wavelength ones, until a statistical stationary turbulent state is reached. It is found that the inverse cascade is limited to the shorter-wavelength modes with the wavenumber |k| =100. This shows that the viscous damping $p_i$ acts like a control switch to the inverse cascade, and the feedback control can also regulate the intensity of the inverse cascade mode.

关键词： plasma instabilities plasma nonlinear phenomena plasma simulation

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HDAC3 single-nucleotide polymorphism rs2530223 is associated with increased susceptibility and severity of primary immune thrombocytopenia

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INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY 2022年第5期44卷 875-882页

作者： Liu, Yan Wang, Yin Zhang, Cheng Feng, Qi Hou, Ming peng, Jun Hu, Xiang Wang, shuwen Shandong Univ Qilu Hosp Cheeloo Coll Med Dept Hematol 107 Wenhuaxi Rd Jinan 250012 Peoples R China Shandong Univ Cheeloo Coll Med Jinan Peoples R China Shandong Univ Qilu Hosp Cheeloo Coll Med Shandong Prov Key Lab Immunohematol 107 Wenhuaxi Rd Jinan 250012 Peoples R China

Introduction Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by a low platelet count and increased risk of bleeding. We previously reported that low-dose chidamide, a histone deacetylase (HDAC) inhibitor, restores immune tolerance in patients with ITP. This study aimed to evaluate the association of a single-nucleotide polymorphism (SNP) rs2530223 in the HDAC3 gene with susceptibility to ITP and its clinical features. Methods Patients with ITP and age-matched healthy participants were recruited for this case-control study. Genotyping of the HDAC3 rs2530223 polymorphism was performed using MassARRAY platform. Results Individuals with T allele of HDAC3 rs2530223 exhibited a 1.472-fold increased risk of ITP susceptibility (OR 1.472;95% CI 1.100-1.969;p = .009), while ones with the TT genotype under the codominant and recessive models, and the TC/TT genotypes under the dominant model all revealed increased risk of ITP susceptibility (dominant odds ratio[OR] 1.965;95% CI: 1.046-3.656;p = .036;codominant OR 2.264;95% CI 1.175-4.360;p = .015;and recessive OR 1.512;95% CI 1.028-2.224;p = .036, respectively). Regarding platelet counts in ITP patients, we observed that the TC/TT genotypes exhibited a 3.932-fold increased risk for platelet (PLT) <30 x 10(9)/L (OR 3.932;95% CI 1.426-10.842;p = .008). Conclusion This study indicates that HDAC3 rs2530223 may be an important genetic factor related to ITP susceptibility and platelet count in ITP patients, providing new perspectives on disease progression, new therapeutic targets, and severity prediction.

关键词： HDAC3 platelet count primary immune thrombocytopenia single-nucleotide polymorphism susceptibility

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Reliability Assessment of Passive Ehrs of Iris Based on the Am-Sis-Ann Method

SSRN

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SSRN 2024年

作者： Jiang, Hong Li, Haiying Yu, shuwen peng, Changhong School of Nuclear Science and Technology University of Science and Technology of China No.96 Jinzhai Road Baohe District Hefei230026 China Nuclear Power Institute of China No. 328 Section 1 Changshun Avenue Shuangliu District Chengdu610040 China

This paper presents a new method, AM-SIS-ANN, for reliability estimation of passive systems in nuclear power plants, enhancing safety. It combines Adaptive Metamodel Subset Simulation Importance Sampling (AM-SIS) with neural networks (ANN) to overcome the limitations of deterministic failure criteria and manage uncertainty. AM-SIS calculates failure probabilities in low-probability areas, while ANN handles other regions, reducing computation time. Validated through numerical examples, the method is applied to the Emergency Heat Removal System (EHRS) of the IRIS reactor, achieving a 23.4% time reduction compared to AM-SIS and a 57.5% reduction compared to ANN, ensuring accuracy and efficiency under uncertain failure criteria. © 2024, The Authors. All rights reserved.

关键词： Nuclear power plants

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4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury

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FREE RADICAL BIOLOGY AND MEDICINE 2022年第0期188卷 404-418页

作者： peng, Xin Su, shuwen Zeng, Jingxin Xie, Kaiji Yang, Xi Xian, Gaopeng Xiao, Zezhou Zhu, peng Zheng, Shaoyi Xu, Dingli Zeng, Qingchun Southern Med Univ Nanfang Hosp Dept Cardiol State Key Lab Organ Failure Res Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Key Lab Shock & Microcirculat Guangzhou 510515 Peoples R China Guangzhou Regenerat Med & Hlth Guangdong Lab Bioland Lab Guangzhou 510515 Peoples R China Southern Med Univ Nanfang Hosp Dept Cardiovasc Surg Guangzhou 510515 Peoples R China

Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in older individuals, but there is a lack of drug treatment. The cellular biological mechanisms of CAVD are still unclear. Oxidative stress and endoplasmic reticulum stress (ER stress) have been suggested to be involved in the progression of CAVD. Many studies have demonstrated that 4-octyl itaconate (OI) plays beneficial roles in limiting inflammation and oxidative injury. However, the potential role of OI in CAVD has not been thoroughly explored. Thus, we investigated OI-mediated modulation of ROS generation and endoplasmic reticulum stress to inhibit osteogenic differentiation in aortic valve interstitial cells (VICs). In our study, calcified aortic valves showed increased levels of ER stress and superoxide anion, as well as abnormal expression of Hmox1 and NQO1. In VICs, OI activated the Nrf2 signaling cascade and contributed to Nrf2 stabilization and nuclear translocation, thus augmenting the expression of genes downstream of Nrf2 (Hmox1 and NQO1). Moreover, OI ameliorated osteogenic medium (OM)-induced ROS production, mitochondrial ROS levels and the loss of mitochondrial membrane potential in VICs. Furthermore, OI attenuated the OM-induced upregulation of ER stress markers, osteogenic markers and calcium deposition, which were blocked by the Nrf2-specific inhibitor ML385. Interestingly, we found that OM -induced ER stress and osteogenic differentiation were ROS-dependent and that Hmox1 silencing triggered ROS production, ER stress and elevated osteogenic activity, which were inhibited by NAC. Overexpression of NQO1 mediated by adenovirus vectors significantly suppressed OM-induced ER stress and osteogenic markers. Collectively, these results showed the anti-osteogenic effects of OI on AVICs by regulating the generation of ROS and ER stress by activating the Nrf2 signaling pathway. Furthermore, OI alleviated aortic stenosis in a mouse model with direct wire injury. Due to its ant

关键词： 4-Octyl itaconate Calcified aortic valve diseases Oxidative stress Endoplasmic reticulum stress

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Efficient CF4 adsorption on porous carbon derived from polyaniline

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JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS 2023年第1期143卷

作者： Gao, peng Wang, Zhe Liu, Liying Cheng, shuwen Li, Gang Northeastern Univ State Environm Protect Key Lab Ecoind Shenyang 110819 Peoples R China Univ Melbourne Dept Chem Engn Melbourne Vic 3010 Australia

Background: As a significant greenhouse gas emitted in large quantities from the electrolytic aluminum and semiconductor industries, tetrafluoromethane (CF4) has an extremely high global warming potential (GWP) and a fairly long atmospheric lifetime. Methods: In this study, porous carbon was prepared via a thermochemical process involving the carbonization and K2CO3 activation of precursor polyaniline (PANI). The activation temperature (600-800 degrees C) and K2CO3/ carbonized PANI mass ratio (1-4) had significant influences on the porous structure and CF4 uptake of the PANIderived porous carbon (PDC).Significant findings: The prepared PDC-3-800 adsorbent exhibited the largest specific surface area (2268 m2 g-1) and highest pore volume (1.48 cm3 g-1), whereas PDC-2-700 adsorbent demonstrated the highest CF4 uptake of up to 2.16 mmol g-1 at 25 degrees C and 1 bar. Notably, CF4 uptake was predominantly dependent on the presence of narrow micropores with diameters below 0.9 nm at atmospheric pressure. The CF4 adsorption isotherms were well fitted by the dual-site Langmuir (DSL) model. Moreover, the isosteric heat of adsorption and CF4/N2 selectivity of PDCs were investigated. These experimental results demonstrate that PDCs with high CF4 adsorption capacity, excellent CF4/N2 selectivity, and good recyclability, have immense potential for practical CF4 capture applications.

关键词： Polyaniline Porous carbon adsorbent K2CO3 activation Selective adsorption CF4 capture

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A poloxamer/hyaluronic acid/chitosan-based thermosensitive hydrogel that releases dihydromyricetin to promote wound healing

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2022年第0期216卷 475-486页

作者： Zhao, Yingchun Liu, Xinglong peng, Xiaojuan Zheng, Yinan Cheng, Zhiqiang Sun, shuwen Ding, Qiteng Liu, Wencong Ding, Chuanbo Jilin Agr Univ Coll Chinese Med Mat Changchun 130118 Peoples R China Jilin Agr Univ Coll Resources & Environm Changchun 130118 Peoples R China Jilin Agr Sci & Technol Univ Sch Chinese Med Jilin 132101 Peoples R China

Wounds caused by accidents and surgery are inevitable, and inflammation and microbial infection during the healing process are serious clinical challenges, resulting in slow wound healing. In this study, we created a 37 C-sensitive hydrogel using poloxamer, chitosan and hyaluronic acid, loaded with the active substance dihy-dromyricetin, and further evaluated its potential for wound healing. The hydrogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and thermogravimetric analysis for their micromorphological structure, characteristic functional groups, crystal structure and thermal stability, and in vitro drug release assays showed that the hydrogel could slowly release dihydromyricetin. In addition, the hydrogels were found to exhibit good biocompatibility and significant in vitro antioxidant and anti-inflammatory activity according to hemolysis, in vitro antioxidant and anti-inflammatory tests. Methyl thiazolyl tetrazole cytotoxicity tests verified that the film was non-toxic to human keratinocyte (HaCaT) cells, while in vivo experiments showed that this hydrogel could promote skin repair by promoting skin-associated growth factor expression and inhibiting nuclear factor kappa B-mediated cellular inflammatory factors. These results demonstrated that the temperature-sensitive hydrogels loaded with dihydromyricetin could serve as potential candidates for guided skin repair.

关键词： Dihydromyricetin Temperature sensitive hydrogel Wound healing Inflammation

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Separate or simultaneous treatment of nitrate and uranium in groundwater via bioremediation: Review and prospect

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CHEMICAL ENGINEERING JOURNAL 2024年 498卷

作者： Ye, Jian Chen, Wen Zhu, Jun Ren, Qingguo peng, Ke Wu, Hao Ohnuki, Toshihiko Sun, Jie Hou, Jiajun Jiang, Shengxing Zhang, Xiaowen Zhang, shuwen Gao, Yanjiao Wu, Xiaoyan Univ South China Sch Resource Environm & Safety Engn Hengyang 421001 Peoples R China CCFEB Civil Engn Co Ltd Changsha 410004 Peoples R China Loudi Emergency Management Bur Loudi 417000 Peoples R China Shanghai Jiao Tong Univ Sch Nucl Sci & Engn Shanghai 200240 Peoples R China Tokyo Inst Technol Lab Adv Nucl Energy Inst Innovat Res Tokyo 1528550 Japan Minzu Univ China Coll Life & Environm Sci Beijing 100081 Peoples R China Shanghai Ocean Univ Coll Oceanog & Ecol Sci Shanghai 201306 Peoples R China Liaoning Univ Technol Coll Civil Engn & Architecture Jinzhou 121001 Peoples R China

This review starts with the issue of groundwater contamination in uranium mining areas using acid leaching methods which is threatening drinking water safety, and provides a comprehensive overview of biological remediation technologies for nitrate and uranium contamination in groundwater. Bacterial genera with remediation potential is summarized and theoretical support for applying microorganisms to remove uranium and nitrate simultaneously is discussed comprehensively. Denitrification is the primary mechanism for nitrate removal from groundwater, dual benefits of agricultural waste utilization and environmental pollution control could be achieved by using lignocellulosic waste (e.g. agricultural waste) as a carbon source. Hydrogen is a clean and ideal electron donor for autotrophic denitrification, and removal rate of autotrophic denitrification could be well enhanced via membrane biofilm reactor (MBR) as well as preventing hydrogen leakage. Compared to biosorption and/or biomineralization, stimulating microorganisms to reduce U(VI) to U(IV) is also a promising pathway. Bioelectrochemical systems (BES) could play a supportive role in biological remediation. Clostridium sp. PXL2 could remove U(VI) and nitrate simultaneously from groundwater, while Hydrogenophaga and Thiobacillus genera show satisfied remediation effects in autotrophic denitrification and uranium reduction processes. Uranium exists in the form of crystalline UO2 within the pH range of 0-7 and Eh range of -0.4 to 0 V. Therefore, this review proposes a brand-new methodology for autotrophic denitrification and uranium reduction by utilizing hydrogen as sole electron donor, with pH and Eh regulation through the control of hydrogen and autotrophic

关键词： Groundwater Uranium Denitrification Bioreduction Biosorption Biomineralization

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