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Metabolomics analysis to characterize the effects of flavonoids on tobacco seedlings under cold and hypoxia stress

JOURNAL OF PLANT INTERACTIONS 2025年第1期20卷

作者： Li, Longxi Niu, Yongzhi Deng, shuwen Zhu, Mengjin Wu, Xuefan peng, Shuo Suo, Wenlong Zheng, Yunye Zhang, Limeng Guan, Yajing Zhejiang Univ Adv Seed Inst Coll Agr & Biotechnol Hangzhou 310058 Peoples R China Yuxi Zhongyan Seed Co Ltd Tobacco Seed Engn Technol Ctr Yunnan Prov Yuxi 653100 Peoples R China Zhejiang Univ Hainan Res Inst Sanya 572025 Peoples R China

Cold and hypoxia (CH) stress, a common combined stress during floating system, inhibits growth of tobacco and seriously affects the quality. Exogenous substances can regulate plant growth and respond to environmental stress. However, there are few studies focusing on tobacco responses to CH stress and the effects of exogenous substances on tobacco seedlings under CH stress are not fully understood. In this study, metabolomics analysis was performed on two tobacco varieties with contrasting CH responses, i.e. K326 (CH-sensitive) and Honghua (CH-tolerant). The results showed that flavonoids were crucial for tobacco seedlings to resist CH stress. Furthermore, exogenous anthocyanidin, flavone and quercetin significantly increased the root length, relative chlorophyll content, SP content, SOD, POD, CAT and APX activities of tobacco under CH stress, while reducing MDA content. Overall, our study highlighted the potential of flavonoids to improve CH tolerance of tobacco which could become a useful tool to resist stress during tobacco floating system.

关键词： Nicotiana tabacum cold and hypoxia stress metabolome flavonoids

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Comparison of Whey Proteome and Glycoproteome in Bovine Colostrum and Mature Milk

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2023年第28期71卷 10863-10876页

作者： Zhang, Wenyuan Lu, Jing Chen, Baorong Gao, peng Song, Bo Zhang, shuwen Pang, Xiaoyang Hettinga, Kasper Lyu, Jiaping Chinese Acad Agr Sci Inst Food Sci & Technol Beijing 100193 Peoples R China Wageningen Univ & Res Dairy Sci & Technol Food Qual & Design Grp NL-6708 WG Wageningen Netherlands Beijing Technol & Business Univ Beijing Adv Innovat Ctr Food Nutr & Human Hlth Beijing Engn & Technol Res Ctr Food Addit Sch Food & Hlth Beijing 10048 Peoples R China

Milksamples were collected from 10 cows, in the colostrum (3-4days) and mature (90 days) lactation stage, to assess the differentialexpression of all whey proteins and *** total, 240 whey proteins and 315 N-glycosylationsites on 214 glycoproteins were quantified. GO annotations, KEGG pathwayanalysis, and protein classification were performed to understandthe similarities and differences of the biological functions of wheyproteins and N-glycoproteins among different lactationstages in bovine milk. Furthermore, differential expression of wheyproteins and whey N-glycosylated proteins was foundbetween different lactation stages. The related changes of biologicalfunctions in differentially expressed proteins were discussed. Forexample, the increased frequency of glycosylation on lactoferrin andfolate receptor alpha occurring in bovine colostrum may provide protectionand stimulate development of the newborn calf. Our study thereby improvesunderstanding of variations of glycosylation sites on milk glycoproteinsamong lactation stages.

关键词： bovine milk lactation colostrum whey proteins N-glycoproteins glycoproteomics

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Concurrent Assessment on Blood Lead in Young Children and Toy Lead in Shanghai

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EXPOSURE AND HEALTH 2024年第3期16卷 633-642页

作者： peng, Jiayu Gao, Zhenyan Xu, Jian Lin, Yanfen Specht, Aaron J. Chen, shuwen Nie, Linda H. Huang, Linhua Yan, Chonghuai Shanghai Jiao Tong Univ Int Peace Matern & Child Hlth Hosp Sch Med Dept Child Healthcare 910 Hengshan Rd Shanghai 200030 Peoples R China Shanghai Key Lab Embryo Original Dis 145 Guangyuan Rd Shanghai 200030 Peoples R China Shanghai Jiao Tong Univ Dept Gynecol & Obstet Xinhua Hosp Sch Med Shanghai Peoples R China Shanghai Jiao Tong Univ MOE Shanghai Key Lab Childrens Environm Hlth Dept Child & Adolescent Healthcare Xinhua HospSch Med 1665 Kongjiang Rd Shanghai 200092 Peoples R China Zhejiang Univ Childrens Hosp Dept Pulmonol Sch Med 3333 BinSheng Rd Hangzhou 310052 Peoples R China Natl Childrens Reg Med Ctr Natl Clin Res Ctr Child Hlth Hangzhou 310052 Peoples R China Harvard TH Chan Sch Publ Hlth 655 Huntington Ave Bldg 1 Room 1402 Boston MA 02115 USA Purdue Univ Sch Hlth Sci 550 Stadium Mall Dr W Lafayette IN 47906 USA Shanghai Jiao Tong Univ Childrens Hosp Dept Neurol Sch Med 355 Luding Rd Shanghai 200040 Peoples R China

Since toys are potential sources of lead contamination for young children, we aim to explore potential correlations between blood-lead-levels (BLLs) of young children and toy-lead contamination using two concurrent investigations. In investigation-1, a total of 2249 children under 7 years old were studied using stratified-cluster-sampling in 6 districts of Shanghai, parents completed questionnaires and children's whole-blood was collected, and then BLLs were measured using tungsten-atomizer-absorption-spectrophotometer. In investigation-2, a total of 288 toys made of different materials (plastic, wooden, metals, and stuffed cloth) were collected in 6 great supermarkets/toy-stores and toy-lead-levels were measured by a portable X-ray-fluorescence instrument. The geometric-mean of BLLs was 2.02 & mu;g/dL. Adjusting for related confounders, playing with plastic toys was a significant risk factor (& beta;= 0.067, P < 0.05) for BLL-increment. Plastic toys accounted for the highest proportion (154/288, 53.47%) and had the highest rates exceeding toy-lead-standards (the over-standard rates of & GE;300/600 mg/kg, plastic toys: 3.90%/1.30%;other toys: 0.00%/0.00%). Children's BLLs in the three (Pudong-suburban, Xuhui, and Yangpu) districts and toy-lead over-standard rates in the neighboring stores were compared, the highest BLLs and over-standard rates were both found in Pudong-suburban district and similar BLLs and over-standard rates were observed between Yangpu and Xuhui districts (Pudong-suburban vs. Xuhui vs. Yangpu: 2.07 vs. 1.55 vs. 1.50 & mu;g/dL for the medians of BLLs, P < 0.001;1.67% vs. 0.00% vs. 0.00% for the over-standard rates of & GE;600 mg/kg). This study raised the possibility that lead contamination in toys (especially in low social-economic-status areas) might be associated with BLLs in young children. Lead contamination from plastic toys needs cautions for preventing children from lead exposure.

关键词： Child Blood lead Toy lead Plastic toys

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Great Enhancing Overall Performances of YSO:Ce Scintillation Crystals by Ni Codoping

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CRYSTAL GROWTH & DESIGN 2024年第17期24卷 7166-7172页

作者： Zhang, Zhe Zhao, shuwen Xue, Zhongjun Shi, Junjie Zhang, Aochen Zheng, Xiang Li, Chengyi Qiu, peng Shi, Hongsheng Xiao, JiaWen Ding, Dongzhou Shanghai Univ Sch Microelect Shanghai 201800 Peoples R China Chinese Acad Sci Shanghai Inst Ceram Shanghai 201899 Peoples R China Chinese Acad Sci Res Ctr Crystal Mat State Key Lab Funct Mat & Devices Special Environm Xinjiang Key Lab Funct Crystal MatXinjiang Tech I Urumqi 830011 Peoples R China Beijing Univ Technol Coll Mat Sci & Engn Beijing Key Lab Microstruct & Property Adv Mat Beijing 100124 Peoples R China

Cerium-doped yttrium oxyorthosilicate (YSO:Ce) scintillation crystals are widely used in mixed radiation field detection, radioactive isotope monitoring, and other fields due to their excellent scintillation properties and low cost. However, the poor coincidence time resolution severely limits their further promotion. In order to resolve this problem, this work first designed and conducted research on Ni2+-codoped YSO:Ce crystals, and a series of YSO:Ce,xNi (x = 0, 0.3, 0.6, and 1.5 atom %) crystals were grown using the Czochralski method. It is found that codoping with 0.6 atom % Ni2+ can improve the overall scintillation performances of YSO:Ce crystals. In particular, the ratio of light output to scintillation decay time significantly improved by 71%, which is currently the best optimization result reported in the orthosilicate-based scintillation crystals systems. In addition, the afterglow level has been optimized by 2 orders of magnitude, and the energy resolution has been improved from 9.2% to 6.7%, greatly enhancing its potential commercial applications. This is mainly attributed to Ni2+ codoping, significantly reducing the concentration of carrier traps in YSO:Ce,xNi crystals, reducing the emission proportion of the slow-emitting center Ce2, and introducing the fast scintillation center Ce4+ into the crystals. Based on the experimental results, the possible mechanisms of the above phenomenon were discussed in the article.

关键词： Scintillation

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War city profiles drawn from satellite images

Nature Cities

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Nature Cities 2024年 359-369页

作者： Zhengyang Hou Ying Qu Liqiang Zhang Qiwei Yu Ziyue Chen Hong Tang Yuebin Wang Xingang Li Yang Li shuwen peng Xin Yao Xichen Meng Suhong Liu Jun Liu Faqiang Wang An Zeng Yuanyuan Zhao Jing Ran Chenghu Zhou State Key Laboratory of Remote Sensing Science Faculty of Geographical Science Beijing Normal University Beijing China School of Mathematical Sciences Beijing Normal University Beijing China School of Systems Science Beijing Normal University Beijing China College of Land Science and Technology China Agricultural University Beijing China School of Architecture and Planning Hunan University Changsha China State Key Laboratory of Resources and Environment Information System Institute of Geographical Science and Natural Resources Chinese Academy of Sciences Beijing China

The extent of war-induced destruction in urban areas is critical information for international relief efforts, impact assessments and restoration decisions. However, precise geotargeting of zones with severe destruction is still a great challenge. Here we present a novel temporal-knowledge-guided detection scheme (TKDS) with a pixel-based transformer network (PtNet) for monitoring urban destruction using satellite imagery, applied to conflict zones in the Syrian civil war and the Russia–Ukraine conflict. Compared with state-of-the-art methods, the TKDS-PtNet model enhances war damage identification by 44.0 (72.5 versus 28.5) in the F1 score for six Syrian cities and 34.2 (83.5 versus 49.3) for four Ukrainian cities. The identified damaged buildings are further utilized to estimate the affected population and damage to critical infrastructures such as hospitals and schools in these areas. Our results demonstrate the high potential of a repeatable and relatively low-cost scheme for the near real-time monitoring of damage in urban areas resulting from wars, earthquakes or extreme weather events. Our findings underscore the crucial importance of taking action to stop the conflict and developing mechanisms to prevent present and future urban-related damage from military actions.

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Interfacially Fabricated Covalent Organic Framework Membranes for Film-Based Fluorescence Humidity Sensors and Moisture Driven Actuators

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2025年第2期64卷 e202414472页

作者： Liu, Xiangquan Huang, Rongrong peng, Lingya Yang, Jinglun Yan, Junbao Zhai, Binbin Luo, Yan Zhang, Chi Tan, shuwen Liu, Xiaoyan Ding, Liping Fang, Yu Shaanxi Normal Univ Sch Chem & Chem Engn Key Lab Appl Surface & Colloid Chem Minist Educ Xian 710119 Peoples R China City Univ Hong Kong Dept Mat Sci & Engn Hong Kong 999077 Peoples R China

Rapid, on-site measurement of ppm-level humidity in real time remains a challenge. In this work, we fabricated a few micrometer thick, beta-ketoenamine-linked covalent organic framework (COF) membrane via interfacially confined condensation of 1,3,5-tris-(4-aminophenyl)triazine (TTA) with 1,3,5-tri-formylphloroglucinol (TP). Based on the super-sensitive and reversible response of the COF membrane to water vapor, we developed a high-performance film-based fluorescence humidity sensor, depicting unprecedented detection limit of 0.005 ppm, fast response/recovery (2.2 s/2.0 s), and a detection range from 0.005 to 100 ppm. Remarkably, more than 7,000-time continuous tests showed no observable change in the performance of the sensor. The applicability of the sensor was verified by on-site and real-time monitoring of humidity in a glovebox. The superior performance of the sensor was ascribed to the highly porous structure and unique affinity of the COF membrane to water molecules as they enable fast mass transfer and efficient utilization of the water binding sites. Moreover, based on the remarkable moisture driven deformation of the COF membrane and its composition with the known polyimide films, some conceptual actuators were created. This study brings new ideas to the design of ultra-sensitive film-based fluorescent sensors (FFSs) and high-performance actuators.

关键词： humidity measurement beta-ketoenamine COF membrane film-based fluorescent sensors interfacial polymerization

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Unsafe behaviors management of construction workers’ based on the information platform 9

Unsafe behaviors management of construction workers’ based ...

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9th International Symposium on Project Management, ISPM 2021

作者： Deng, shuwen peng, Rui College of Civil and Architectural Engineering Xinjiang University Xinjiang Urumqi830000 China

ISBN: (纸本)9781921712777

Unsafe behaviors are the leading cause of safety accidents. However, the existing management measures can not solve this phenomenon well. This paper put forward the management method of unsafe behaviors based on information platforms. Through sorting out the relevant literature, it was concluded that unsafe behaviors were divided into three research directions: behaviorism, humanism, and cognitive science. The analysis of the three research directions shows that the cognitive science paradigm avoids the limitations of behaviorism and humanism paradigm and can systematically explain unsafe behaviors. Therefore, this study was based on the cognitive science paradigm. According to the cognitive model and literature analysis, five reasons for cognitive failure were extracted and corresponding to the information of construction workers in the information platform. Simultaneously, based on the information platform, the management methods of prevention and Governance were proposed. The management measures were formulated according to the causes of cognitive failure to provide a theoretical basis for improving the management level of unsafe behaviors. © ISPM *** right reserved.

关键词： Human resource management

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Mechanical activation of adipose tissue macrophages mediated by Piezo1 protects against diet-induced obesity by regulating sympathetic activity

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METABOLISM-CLINICAL AND EXPERIMENTAL 2025年 168卷 156262-156262页

作者： Leng, Shaoqiu Zhang, Xiaoyu Zhao, Ruxia Jiang, Nan Liu, Xinyue Li, Xin Feng, Qi Sheng, Zi Wang, shuwen peng, Jun Hu, Xiang Shandong Univ Qilu Hosp Dept Hematol Jinan Peoples R China Shandong Univ Shandong Key Lab Hematol Dis & Immune Microenviron Qilu Hosp Jinan Peoples R China Chinese Acad Med Sci & Peking Union Med Coll State Key Lab Expt Hematol Natl Clin Res Ctr Blood Dis Inst Hematol Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Blood Dis Hosp Tianjin Peoples R China

Objective: Obesity-induced mechanical changes in white adipose tissue (WAT), including adipocyte hypertrophy and fibrosis, are hypothesized to alter adipose tissue macrophage (ATM) function through mechanosensitive pathways. This study aimed to determine whether the mechanosensor Piezo1 in ATMs regulates obesity-associated metabolic dysfunction and thermogenesis. Methods: To investigate macrophage Piezo1 in obesity, myeloid-specific Piezo1-deficient mice (Piezo1 Delta lyz2) and littermate controls (Piezo1flox/+) were fed a high-fat diet (HFD) to induce obesity for 12 weeks. Metabolic assessments (GTT/ITT), tissue analyses (H&E staining, micro-CT), and RNA-seq were performed. Bone marrow transplantation and co-culture experiments (BMDMs with 3T3L1 adipocytes/PC12 neurons) were performed to evaluate macrophage-adipocyte/neuron crosstalk. Sympathetic activity was tested via cold exposure, NE measurement, and 6-OHDA/alpha MPT denervation. Molecular mechanisms were investigated using ChIP-qPCR. Results: Piezo1 Delta lyz2 mice exhibited aggravated HFD-induced obesity and insulin resistance despite reduced pro-inflammatory responses. Piezo1 deficiency in ATMs suppressed Slit3-ROBO1 signaling, leading to diminished NE secretion and impaired thermogenesis. Pharmacological inhibition of NE release (6-OHDA) or ROBO1 knockdown (shROBO1) abolished thermogenic disparities between Piezo1 Delta lyz2 and control mice. Mechanistically, Piezo1 activation triggered SP1 nuclear translocation, directly binding to the Slit3 promoter to drive Slit3 transcription and secretion. Conclusion: Piezo1 in ATMs mitigates obesity progression by promoting Slit3-ROBO1-dependent NE secretion and thermogenesis, independent of its pro-inflammatory role. This mechanosensitive pathway links WAT mechanical remodeling to metabolic regulation, which may offer a novel approach for managing obesity.

关键词： Piezo1 Macrophage Norepinephrine Obesity Slit3

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Astragalus polysaccharides combined with simvastatin as an immunostimulant enhances the immune adjuvanticity of oil-in-water emulsion and immune responses in mice

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VACCINE 2023年第10期41卷 1684-1693页

作者： Xu, shuwen Wu, Zhiyong Cai, Gaofeng Zhang, Yue peng, Song Jiao, Lina Liu, Zhenguang Yang, Yang Wang, Deyun Coll Vet Med Inst Tradit Chinese Vet Med Nanjing 210095 Jiangsu Peoples R China Nanjing Agr Univ Coll Vet Med MOE Joint Int Res Lab Anim Hlth & Food Safety Nanjing 210095 Jiangsu Peoples R China Nanjing Tradit Chinese Vet Med Res Ctr Nanjing 210095 Jiangsu Peoples R China

Oil-in-water emulsion-based adjuvants have demonstrated acceptable safety in many disease indica-tions, while their adjuvant activities for vaccines still need to be improved. Recently, the strategy of com-bining adjuvants with multiple types of immunostimulants has been shown to enhance immune responses. In this study, astragalus polysaccharides were combined with simvastatin as an immunostim-ulant to construct a compound O/W emulsion adjuvant. The formulations were optimized according to the OVA-specific antibody responses induced in mice. For this reason, high (5 mg/mL), medium (2.5 mg/mL), and low (1.25 mg/mL) concentrations of astragalus polysaccharides and high (10 mg/mL), medium (1 mg/mL), and low (0.1 mg/mL) concentrations of simvastatin were selected. The final optimal formulation of the immunostimulant was a high concentration of astragalus polysaccharides combined with a medium concentration of simvastatin. The optimal compound O/W emulsion adjuvant could induce effective humoral and cellular immune responses that were stronger and more stable than those induced by aluminum adjuvant and Freund's adjuvant. The OVA/HAPS-MSim-OE induced dramatically strong and persistent IgG expressions and Th1-polarized immune responses. What's more, the highest CD4+/CD8+lymphocyte ratios were observed in OVA/HAPS-MSim-OE group. In addition, compound O/ W emulsion adjuvant groups significantly promoted the secretion of IFN-c and IL-6, which also indicated that the compound O/W emulsion adjuvants could induce both enhanced Th1 and Th2-mediated immune responses but prefer the Th1-mediated ones. This study would contribute to an interesting and promising direction in the development of emulsion-based adjuvants. (c) 2023 Elsevier Ltd. All rights reserved.

关键词： Astragalus polysaccharides Simvastatin O W emulsion Ovalbumin Adjuvant

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Construction and validation of infection risk model for patients with external ventricular drainage: a multicenter retrospective study

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ACTA NEUROCHIRURGICA 2023年第11期165卷 3255-3266页

作者： Wang, peng Luo, Shuang Cheng, shuwen Gong, Min Zhang, Jie Liang, Ruofei Ma, Weichao Li, Yaxin Liu, Yanhui Sichuan Univ West China Hosp Dept Neurosurg Chengdu Sichuan Peoples R China Chengdu Univ Tradit Chinese Med Chengdu Peoples Hosp 5 Dept Neurosurg Affiliated Peoples Hosp 5 Chengdu Sichuan Peoples R China Chengdu Med Coll Dept Neurosurg Affiliated Hosp 1 Chengdu Sichuan Peoples R China North Sichuan Med Coll Dept Neurosurg Affiliated Hosp Nanchong Sichuan Peoples R China Sichuan Canc Hosp Dept Neurosurg Chengdu Sichuan Peoples R China Sichuan Univ West China Hosp 4 West China Sch Publ Hlth Chengdu Sichuan Peoples R China

PurposeExternal ventricular drainage (EVD) is a life-saving neurosurgical procedure, of which the most concerning complication is EVD-related infection (ERI). We aimed to construct and validate an ERI risk model and establish a monographic *** retrospectively analyzed the adult EVD patients in four medical centers and split the data into a training and a validation set. We selected features via single-factor logistic regression and trained the ERI risk model using multi-factor logistic regression. We further evaluated the model discrimination, calibration, and clinical usefulness, with internal and external validation to assess the reproducibility and generalizability. We finally visualized the model as a nomogram and created an online calculator (dynamic nomogram).ResultsOur research enrolled 439 EVD patients and found 75 cases (17.1%) had ERI. Diabetes, drainage duration, site leakage, and other infections were independent risk factors that we used to fit the ERI risk model. The area under the receiver operating characteristic curve (AUC) and the Brier score of the model were 0.758 and 0.118, and these indicators' values were similar when internally validated. In external validation, the model discrimination had a moderate decline, of which the AUC was 0.720. However, the Brier score was 0.114, suggesting no degradation in overall performance. Spiegelhalter's Z-test indicated that the model had adequate calibration when validated internally or externally (P = 0.464 vs. P = 0.612). The model was transformed into a nomogram with an online calculator built, which is available through the website: https://***/DynNomapp/.ConclusionsThe present study developed an infection risk model for EVD patients, which is freely accessible and may serve as a simple decision tool in the clinic.

关键词： External ventricular drainage Infection Nomogram Prediction model

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