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Planar chiral [2.2]paracyclophanyl-based boron fluoride complexes: synthesis, crystal structure and photophysical properties

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DALTON TRANSACTIONS 2021年第37期50卷 12963-12969页

作者： Duan, Wenzeng Ji, Honghan Yang, Zeren Yao, Qingxia Huo, Yanmin ren, Xuerui Zhao, Jiaojiao Gong, shuwen Liaocheng Univ Sch Chem & Chem Engn Inst Funct Organ Mol & Mat 1 Hunan Rd Liaocheng 252000 Shandong Peoples R China

Planar chiral [2.2]paracyclophanyl-based boron fluoride complexes (3a-3d) were designed and facilely synthesized. The X-ray structure study, theoretical calculations and CD spectra reveal the intense emission and planar chiral structures of these complexes. In particular, 3a-3d show moderate quantum yields and large Stokes shifts both in solution and solid state. Furthermore, the blue-shifted mechanochromic properties of 3a and 3b were both investigated in the solid state. This work is the first study on planar chiral boron monofluoride complexes within the boron fluoride complex field.

关键词： Fluorine compounds

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De novo mutation in HNF-1β gene as a cause for Maturity-onset Diabetes of the Young type 5 with sustained hypomagnesemia

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INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES 2021年第2期41卷 354-357页

作者： ren, Bo Chen, Yan Zhang, Qiang Chen, shuwen Zhang, Shunxiao Wang, Jie Zhang, Yan Laiwu Cent Hosp Dept Neuroendocrinol Xinwen Min Grp Laiwu 271103 Shandong Peoples R China Hosp Integrated Tradit Chinese & Western Med Dept Radiol Shanghai Baoshan Branch Shanghai 201900 Peoples R China Laiwu Cent Hosp Dept Pain Management Xinwen Min Grp Laiwu 271103 Shandong Peoples R China Hosp Integrated Tradit Chinese & Western Med Dept Endocrinol Shanghai Baoshan Branch 181 Youyi Rd Shanghai 201900 Peoples R China

Background Maturity-onset Diabetes of the Young type 5 (MODY5) is clinically heterogeneous, and the genetic examination is important to provide the accurate diagnosis. Identification of more cases will better understand the genotype-phenotype correlations of this disorder. Methods We collected the clinical and biochemical data, using the whole-exome gene detection and multiplex ligation-dependent probe Amplification to detect the pathogenic gene variants. Results The proband is a 39-year-old female, and presenting with symptoms including polyuria, polydipsia, and weight loss for 6 months. Her BMI was 17.6 kg/m(2). Laboratory tests indicated hypokalemia (3.1 mmol/L), hypomagnesemia (0.4 mmol/L), and hypocalcemia (1.91 mmol/L). Glycated hemoglobin (HbA1c) was 13.7%, fasting C-peptide was 0.24 ng/mL (normal range: 0.3-3.73 ng/mL). Both glutamic acid decarboxylase and islet cell antibodies were negative. Abdominal magnetic resonance image showed the agenesis of the tail and body of the pancreas and the presence of disseminated cysts of the left kidney. Genetic examination displayed a de novo heterozygous deletion of the whole HNF-1 Beta gene (NM_000458.3). Three-year follow-up after the diagnosis showed that the patient has sustained hypomagnesemia and cannot maintain an appreciable increae in serum magnesium levels (0.52-0.61 mmol/L), although she was using the double-dose magnesium aspartate. Moreover, she cannot achieve good glucose control either. Conclusion Our findings indicted that MODY is highly heterogeneous and patients with additional extrapancreatic clinical features and hypomagnesemia should be screened for MODY5.

关键词： Maturity-onset Diabetes of the Young Hypomagnesemia Hepatocyte nuclear factor-1 beta eta (HNF-1 beta) Mutation Diabetes mellitua

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Research on the Thermal Properties of Urban Native Sewage Basedon Regression Model

Research on the Thermal Properties of Urban Native Sewage Ba...

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2023年工业设计与环境工程国际学术会议

作者： shuwen Ding Lin Zhang Liang Liu Xiaotong ren Junze Du School of Municipal and Environmental Engineering Shenyang Jianzhu University

At this stage, due to the lack of research on the basic thermophysical parameters of urban primary sewage, the change of thermophysical state of sewage cannot be well grasped, resulting in a low utilization rate of low-grade thermal energy of primary sewage. In this paper, a regression model is established based on the existing data to analyze the changes of basic thermophysical parameters such as density, thermal conductivity, constant pressure specific heat and other basic thermal properties of residential and industrial sewage at different sewage temperatures. Through model analysis, it is found that the density of residential sewage is significantly lower than that of industry. The sewage density of both types of sewage reached a maximum of about 10°C at a sewage temperature, and then showed a decreasing trend again. The thermal conductivity of residential sewage is lower than that of industrial sewage, and the thermal conductivity of sewage gradually increases with the increase of sewage temperature;From the analysis of constant pressure specific heat of sewage, the specific heat of residential sewage is greater than that of industrial type, and the specific heat of sewage decreases with the increase of temperature, and the change range is small.

关键词： Sewage thermal physical properties Regression model Clean energy

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Collab-Overcooked: Benchmarking and Evaluating Large Language Models as Collaborative Agents

arXiv

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arXiv 2025年

作者： Sun, Haochen Zhang, shuwen ren, Lei Xu, Hao Fu, Hao Yuan, Caixia Wang, Xiaojie Beijing University of Posts and Telecommunications China Li Auto Inc China

Large language models (LLMs) based agent systems have made great strides in real-world applications beyond traditional NLP tasks. This paper proposes a new LLM-powered Multi-Agent System (LLM-MAS) benchmark, Collab-Overcooked, built on the popular Overcooked-AI game with more applicable and challenging tasks in interactive environments. Collab-Overcooked extends existing benchmarks from two novel perspectives. First, it provides a multi-agent framework supporting diverse tasks and objectives and encourages collaboration through natural language communication. Second, it introduces a spectrum of process-oriented evaluation metrics to assess the fine-grained collaboration capabilities of different LLM agents, a dimension often overlooked in prior work. We conduct extensive experiments over 10 popular LLMs and show that, while the LLMs present a strong ability in goal interpretation, there is a significant discrepancy in active collaboration and continuous adaption that are critical for efficiently fulfilling complicated tasks. Notably, we highlight the strengths and weaknesses in LLM-MAS and provide insights for improving and evaluating LLM-MAS on a unified and open-sourced benchmark. Environments, 30 open-ended tasks, and an integrated evaluation package are now publicly available at https://***/YusaeMeow/Collab-Overcooked. © 2025, CC BY.

关键词： Procedure oriented languages

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Clinical Characteristics and Prognosis of Genetic Focal Segment Glomerulosclerosis

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AMERICAN JOURNAL OF KIDNEY DISEASES 2024年第5期84卷 660-662页

作者： Hao, Xu Yu, shuwen Weng, Qinjie Fang, Zhengying Zheng, Qimin Zhao, Yafei Liu, Jian Ma, Jun Zhang, Chunli Liu, Yunzi Li, Junru Yang, Mingxin ren, Hong Xie, Jingyuan Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Dept Nephrol Shanghai Peoples R China Shanghai Jiao Tong Univ Inst Nephrol Sch Med Shanghai Peoples R China Shanghai Jiao Tong Univ Ruijin Hosp Inst Nephrol Sch MedDept Nephrol 197 Ruijin Er Rd Shanghai 200025 Peoples R China

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The Observed North Equatorial Countercurrent in the Far Western Pacific Ocean during the 2014-16 El Nino

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JOURNAL OF PHYSICAL OCEANOGRAPHY 2021年第6期51卷 2003-2020页

作者： Zhou, Hui Liu, Hengchang Tan, shuwen Yang, Wenlong Li, Yao Liu, Xueqi ren, Qiang Dewar, William K. Chinese Acad Sci Inst Oceanol CAS Key Lab Ocean Circulat & Waves Qingdao Peoples R China Pilot Natl Lab Marine Sci & Technol Qingdao Qingdao Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Florida State Univ Dept Ocean Atmosphere & Earth Sci Tallahassee FL 32306 USA Univ Grenoble Alpes CNRS IRD Grenoble INPIGE Grenoble France

The structure and variations of the North Equatorial Countercurrent (NECC) in the far western Pacific Ocean during 2014-16 are investigated using repeated in situ hydrographic data, altimeter data, Argo data, and reanalysis data. The NECC shifted similar to 1 degrees southward and intensified significantly with its transport exceeding 40 Sv (1 Sv equivalent to 10(6) m(3) s(-1)), nearly double its climatology value, during the developing phase of the 2015/16 El Nino event. Observations show that the 2015/16 El Nino exerted a comparable impact on the NECC with that of the extreme 1997/98 El Nino in the far western Pacific Ocean. Baroclinic instability provided the primary energy source for the eddy kinetic energy (EKE) in the 2015/16 El Nino, which differs from the traditional understanding of the energy source of EKE as barotropic instability in low-latitude ocean. The enhanced vertical shear and the reduced density jump between the NECC layer and the North Equatorial Subsurface Current (NESC) layer renders the NECC-NESC system baroclinically unstable in the western Pacific Ocean during El Nino developing phase. The eddy-mean flow interactions here are diverse associated with various states of El Nino- Southern Oscillation (ENSO).

关键词： Baroclinic flows El Nino ENSO Instability Ocean circulation Ocean dynamics

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Neuroanatomical changes associated with conduct disorder in boys: influence of childhood maltreatment

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EUROPEAN CHILD & ADOLESCENT PSYCHIATRY 2022年第4期31卷 601-613页

作者： Gao, Yidian Jiang, Yali Ming, Qingsen Zhang, Jibiao Ma, ren Wu, Qiong Dong, Daifeng Sun, Xiaoqiang He, Jiayue Cao, Wanyi Yuan, shuwen Yao, Shuqiao Cent South Univ Xiangya Hosp 2 Med Psychol Ctr Changsha Hunan Peoples R China Cent South Univ Med Psychol Inst Changsha Hunan Peoples R China Natl Clin Res Ctr Psychiat & Psychol Changsha Hunan Peoples R China Soochow Univ Affiliated Hosp 1 Dept Psychiat Suzhou Jiangsu Peoples R China Cent South Univ Xiangya Hosp 2 Dept Radiol Changsha Hunan Peoples R China

Childhood maltreatment (CM) poses a serious risk to the physical, emotional and psychological well-being of children, and can advance the development of maladaptive behaviors, including conduct disorder (CD). CD involves repetitive, persistent violations of others' basic rights and societal norms. Little is known about whether and how CM influences the neural mechanisms underlying CD, and CD-characteristic neuroanatomical changes have not yet been defined in a structural magnetic resonance imaging (sMRI) study. Here, we used voxel-based morphometry (VBM) and surface-based morphometry (SBM) to investigate the influence of the CD diagnosis and CM on the brain in 96 boys diagnosed with CD (62 with CM) and 86 typically developing (TD) boys (46 with CM). The participants were 12-17 years of age. Compared to the CM- CD group, the CM+ CD group had structural gray matter (GM) alterations in the fronto-limbic regions, including the left amygdala, right posterior cingulate cortex (PCC), right putamen, right dorsolateral prefrontal cortex (dlPFC) and right anterior cingulate cortex (ACC). We also found boys with CD exhibited increased GM volume in bilateral dorsomedial prefrontal cortex (dmPFC), as well as decreased GM volume and decreased gyrification in the left superior temporal gyrus (STG) relative to TD boys. Regional GM volume correlated with aggression and conduct problem severity in the CD group, suggesting that the GM changes may contribute to increased aggression and conduct problems in boys with CD who have suffered CM. In conclusion, these results demonstrate previously unreported CM-associated distinct brain structural changes among CD-diagnosed boys.

关键词： Adolescents Antisocial behavior Conduct disorder Childhood maltreatment MRI Gray matter

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Adult-Onset Focal Segmental Glomerulosclerosis With Steroid-Dependent Nephrotic Syndrome Caused by a Novel TBC1D8B Variant: A Case Report and Literature Review

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AMERICAN JOURNAL OF KIDNEY DISEASES 2023年第2期81卷 240-244页

作者： Fang, Zhengying Zhang, Chunli Jin, Yuanmeng Tong, Jun Liu, Jian Hao, Xu Weng, Qinjie Yu, shuwen Du, Wen Cai, Yikai Zheng, Qimin Yang, Li ren, Hong Pan, Xiaoxia Xie, Jingyuan Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Inst Nephrol Dept Nephrol Shanghai Peoples R China Inst Nephrol Dept Nephrol 197Ruijin Er Rd Shanghai 200025 Peoples R China

Focal segmental glomerulosclerosis (FSGS) is a histological lesion with a variety of potential causes, including rare variants of podocyte-related genes. Recently, it has been found that variants in the TBC1D8B gene on the X chromosome can lead to early-onset focal segmental glomerulosclerosis and steroid-resistant nephrotic syndrome by affecting endocytosis and recycling of nephrin. Here, we report a 19-year-old Chinese patient with nephrotic syndrome and normal kidney function. He had a complete remission of nephrotic syndrome after full-dose prednisone and cyclosporine treatment. Unfortunately, a relapse of nephrotic syndrome occurred during prednisone tapering. Focal segmental glomerulosclerosis was proven by a kidney biopsy, and a hemizygous pathogenic variant located in the TBC (Tre-2-Bub2-Cdc16) domain of TBC1D8B was detected by whole-exome sequencing. By comparing our case with reports of other patients with TBC1D8B variants, we suggest possible genotype-phenotype correlations. To our knowledge, this is the first report identifying a pathogenetic variant in the TBC domain of TBC1D8B in an adult-onset focal segmental glomerulosclerosis patient with steroid-dependent NS. With this report, we broaden the clinical and genetic spectrum of X-linked genetic FSGS.

关键词： Case report focal and segmental glomerulosclerosis (FSGS) genetic disease hemizygous kidney biopsy kidney function mutation nephrotic syndrome (NS) TBC1D8B TBC domain protein family whole-exome sequencing (WES) X-linked

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Giant gauge factors in an anchored sandwich structure with a soft break mechanism

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CELL REPORTS PHYSICAL SCIENCE 2024年第4期5卷

作者： Duan, shuwen Wei, Yuhong Wang, Yunfan Zhai, Linxin Qin, Yue Guo, Zhanfeng Li, Ding Hou, Weiwei Liu, Songtao Li, Xintian Zhu, Boyi Pan, Peng Xu, Mengzhen Liu, Jun Guo, Hao Xu, Zhiping Tian, He Yang, Yi ren, Tian -Ling Tsinghua Univ Sch Integrated Circuits Beijing 100084 Peoples R China Tsinghua Univ Beijing Natl Res Ctr Informat Sci & Technol BNRist Beijing 100084 Peoples R China Univ Michigan Elect Comp Engn Ann Arbor MI 48109 USA Tsinghua Univ Dept Engn Mech Appl Mech Lab Beijing 100084 Peoples R China Tsinghua Univ Ctr Nano & Micro Mech Beijing 100084 Peoples R China North Univ China State Key Lab Dynam Measurement Technol Shanxi Prov Key Lab Quantum Sensing & Precis Measu Taiyuan 030051 Peoples R China Tsinghua Univ Dept Precis Instrument Beijing 100084 Peoples R China Tsinghua Univ Key Lab Civil Engn Safety & Durabil China Educ Minist Beijing 100084 Peoples R China Tsinghua Univ State Key Lab Hydrosci & Engn Beijing 100084 Peoples R China

Recent advancements in flexible strain sensors utilizing nanomaterials and advanced carbon materials have showcased remarkable sensitivity, promising vast application potential. However, achieving a superior gauge factor (GF) with exceptional outstanding stability at a controllable strain range is still a critical challenge. We introduce the "soft break mechanism,"which enables reversible resistance switching through graphene interlayer displacement and rGO laminate (CPLs) distance variation. Utilizing polyurethane films as anchors, sandwiched with graphene layers, protects the graphene within the soft break range. The GFs can reach the 10 6 -10 7 level and maintain stability in 10,000 tensile cycles. Adjusting preset artificial cracks modifies the abrupt variation point, achieving controllable strain range. Especially, gravitational wave detection can be enabled by our sensors with a strain of 10 - 21 leading to a resistance change of 1 : 03 3 10 - 7 U. Our work can enable super sensitivity sensors for potential future subtle signal detection and scientific systems.

关键词： giant gauge factors soft break mechanism flexible strain sensors outstanding stability gravitational wave detection

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糙米发芽富集γ-氨基丁酸工艺和环境胁迫技术优化

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中国食品学报 2025年第1期25卷 169-180页

作者：洪滨卢淑雯张珊冯俊然袁迪山珊张竞一李波任传英黑龙江省农业科学院食品加工研究所哈尔滨150086 黑龙江省食品加工重点实验室哈尔滨150086 黑龙江省全谷物营养食品工程技术研究中心哈尔滨150086

以提高发芽糙米γ-氨基丁酸(GABA)富集量为目标,优化糙米发芽富集GABA工艺参数和环境胁迫技术,研究发芽温度、发芽时间和热风干燥温度,以及超声、臭氧、冷冻和高温、高压胁迫处理对发芽糙米中GABA含量的影响。结果表明,发芽温度、发芽... 详细信息

以提高发芽糙米γ-氨基丁酸(GABA)富集量为目标,优化糙米发芽富集GABA工艺参数和环境胁迫技术,研究发芽温度、发芽时间和热风干燥温度,以及超声、臭氧、冷冻和高温、高压胁迫处理对发芽糙米中GABA含量的影响。结果表明,发芽温度、发芽时间和热风干燥温度对糙米发芽过程中GABA含量有显著影响,各因素影响程度:发芽时间>热风干燥温度>发芽温度。发芽制备高含量GABA的最适条件是:发芽温度31℃,发芽时间40 h,热风干燥温度50℃,GABA含量为21.43 mg/100 g。糙米发芽中、后期(18~40 h),臭氧胁迫处理剂量15 g;发芽中期(12~30 h),30 kHz超声胁迫处理20 min;糙米发芽后冷冻9 h;糙米发芽后,120℃高温杀菌时间30 min;均可显著提高发芽糙米GABA含量。

关键词：糙米发芽 γ-氨基丁酸环境胁迫

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