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A Novel Sulfonated Polyimide Composite Membrane Containing a Sulfonated Porous Material for All-Vanadium Redox Flow Batteries

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ACS APPLIED MATERIALS & INTERFACES 2024年第40期16卷 54529-54538页

作者： Li, Xuesong Wang, Gang Zhang, shuwen wei, Shiguo Yu, Yan Wang, Bing Jing, Yangtian Chen, Jijun Zhang, Jie Zhou, Yufeng Chen, Jinwei Wang, Ruilin Sichuan Univ Coll Mat Sci & Engn Chengdu 610065 Peoples R China Sichuan Weilide Energy Co Ltd Leshan 614000 Peoples R China

To improve the battery efficiency and cycling stability of sulfonated polyimide (SPI), a polyphosphazene with built-in -SO3H moieties (PP-SO3H), which is a porous covalent organic framework (COF) material, is facilely synthesized by the polymeric combination of hexachlorocyclotriphosphazene (HCCP) and p-diaminobenzenesulfonic acid. Due to its tunable pore size and flexible molecular design, the COF material can address the trade-off between the conductivity and the ion permeability of ion exchange membranes well, thereby improving the ion selectivity of membranes. The experimental results show that the SPI/PP-SO3H composite membrane has an excellent conductivity (up to 114.8 mS cm-1);the ion selectivity of the SPI/2% PP-SO3H membrane is 11.69 x 104 S min cm-3, which is 2.18 times higher than that of the SPI base membrane. PP-SO3H also improves the SPI membrane's mechanical strength, and the effect of PP-SO3H on SPI intermolecular interactions is analyzed by surface electrostatic potential (ESP) theoretical calculations. The Coulombic efficiency (CE) of the SPI/2% PP-SO3H membrane is 98.92%, the energy efficiency (EE) is 84.1% at a current density of 100 mA cm-2, and the self-discharge time of the SPI/2% PP-SO3H membrane is 3.5 times compared with the SPI base membrane. To measure the cycling stability of the composite membrane, the SPI/2% PP-SO3H membrane is cycled in the VRFB for more than 400 cycles, which is more stable than that of the SPI base membrane. These results show that SPI/2% PP-SO3H composite membranes are viable for VRFB applications.

关键词： all-vanadium redox flow battery ion selectivity covalent organic frameworks sulfonated porous material mechanical stability

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SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis

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EUROPEAN JOURNAL OF MEDICAL RESEARCH 2025年第1期30卷 1-15页

作者： Guo, wei Wang, shuwen Yang, Zitong Dong, Yu Xia, Zhinan Xue, wei Zhang, Cheng Zhejiang Univ Ctr Oncol Med Sch Med Affiliated Hosp 4Dept Urol Yiwu 322000 Peoples R China Zhejiang Univ Int Inst Med Int Sch Med Yiwu 322000 Peoples R China China Med Univ Dept Urol Shengjing Hosp Shenyang 110004 Peoples R China

Sin3A-associated protein 30 (SAP30) is a crucial component of the SIN/HDAC histone deacetylase complex and acts as a scaffold that facilitates target gene binding. SAP30 is highly expressed in various tumours;however, its role in renal cell carcinoma (RCC) remains unclear. In our study, we observed the upregulation of SAP30 in clear cell renal cell carcinoma (ccRCC) tissues, and its elevated expression was correlated with a poor prognosis. Previous research has suggested that SAP30 may influence the growth, proliferation, and apoptosis of RCC cells. Gene Ontology (GO) analysis of the downstream regulatory targets of SAP30 revealed that SAP30 suppressed the expression of MT1G, a protein that binds to p53. Mechanistically, SAP30 inhibited MT1G transcription, thereby impairing the function of MT1G in delivering zinc ions to p53, which diminished p53 activity. Moreover, reduced MT1G levels attenuated the inhibitory effect of MT1G on MDM2, further destabilizing p53. Consequently, this cascade promoted RCC progression. In conclusion, our findings indicate that SAP30 inhibits the p53 pathway through MT1G suppression, suggesting that SAP30 and MT1G are potential prognostic markers and therapeutic targets for RCC.

关键词： Transcription factor p53 SAP30 MT1G ccRCC

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Biological roles of toll-like receptors and gut microbiota in colorectal cancer

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FUTURE MICROBIOLOGY 2022年第13期17卷 1071-1089页

作者： Yinhang, Wu wei, Wu Jing, Zhuang Qing, Zhou Yani, Zhou Yangyanqiu, Wang shuwen, Han Huzhou Univ Huzhou Cent Hosp Affiliated Cent Hosp 1558 Sanhuan North Rd Huzhou 313000 Zhejiang Peoples R China Zhejiang Chinese Med Univ Sch Clin Med 2 548 Binwen Rd Hangzhou 310053 Zhejiang Peoples R China Key Lab Multi Res & Clin Transformat Digest Canc 1558 Sanhuan North Rd Huzhou 313000 Zhejiang Peoples R China Zhejiang Univ Grad Sch Med Fac 866 Yuhangtang Rd Hangzhou 310058 Zhejiang Peoples R China

Colorectal cancer (CRC) is one of the most considerably common malignancies of the alimentary system, with high mortality and incidence rates. The present study suggested that the occurrence of CRC is closely related to bacteria, as the large intestine is a gathering place for human micro-organisms. However, the nosogenesis of bacteria leading to tumorigenesis is still obscure. Recently, many studies have reported that toll-like receptors and their related molecular pathways are involved in the process of gut micro-organisms generating CRC. Gut micro-organisms can promote or inhibit the development of CRC via binding to special toll-like receptors. In this paper, the authors review the relationship among toll-like receptors, gut micro-organisms and CRC in order to provide a reference for future tumor immunotherapy and targeted therapy.

关键词： colorectal cancer gut micro-organisms immune cell intestinal inflammation intestinal microecology microbial-associated molecular patterns pattern recognition receptors probiotics toll-like receptors

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Open Reading Frame-3a gene of the 2019 novel coronavirus inhibits the occurrence and development of colorectal cancer

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DISCOVER ONCOLOGY 2022年第1期13卷 14页

作者： Han shuwen Wu Yinhang Mao Jing Chen Gong Hou Xiaohui Yang Xi Wu wei Huzhou Univ Dept Oncol Huzhou Cent Hosp Affiliated Cent Hosp 1558 Sanhuan North Rd Huzhou 313000 Zhejiang Peoples R China Zhejiang Chinese Med Univ Grad Sch Clin Med Fac 2 548 Binwen Rd Hangzhou 310053 Zhejiang Peoples R China Zhejiang Univ Grad Sch Med Coll 268 Kaixuan Rd Hangzhou 310029 Zhejiang Peoples R China Huzhou Univ Med Coll Clin Med 759 Erhuan East Rd Huzhou 313000 Zhejiang Peoples R China Huzhou Univ Grad Sch Nursing 1 Bachelor Rd Huzhou 313000 Zhejiang Peoples R China Huzhou Univ Affiliated Cent Hosp Huzhou Cent Hosp Dept Gastroenterol 1558 Sanhuan North Rd Huzhou 313000 Zhejiang Peoples R China

Intestinal microecology is composed of bacteria, fungi and viruses. As a part of intestinal microecology, viruses participate in the occurrence and development of colorectal cancer. The 2019-nCoV was detected in stool samples from patients during COVID-19, suggesting that the 2019-nCoV may be associated with intestinal microecology. However, the relationship of the 2019-nCoV and CRC is unclear. The aim of this study is to explore the role of Open Reading Frame-3a (ORF3a) of the 2019-nCoV in CRC. After the pCDH-CMV-MCS-EF1-Puro vector that provides high expression of ORF3a was transfected into the SW480 CRC cell line, immunofluorescence was used to determine the localization of ORF3a in SW480 cells. The proliferation, migration, invasion, apoptosis, and cell cycle progression of SW480 cells were measured using the Cell Counting Kit-8 (CCK-8), wound healing, Transwell assay, flow cytometry, the TUNEL assay, and propidium iodide single staining. The results showed that ORF3a inhibited the proliferation, invasion, and migration of SW480 cells and induced their apoptosis after 24, 48, 72 h. Meanwhile, ORF3a inhibited the cell cycle and blocked SW480 CRC cells in the G1 phase. In in vivo experiments, high ORF3a expression was associated with decreased tumor volume, tumor weight, relative tumor volume, and tumor activity. ORF3a inhibited the growth and induced apoptosis and necrosis of tumor tissues. Based on this, we demonstrated that ORF3a might play a role in CRC, providing a new direction for the prevention and treatment of CRC.

关键词： 2019-nCoV ORF3a Colorectal cancer Cell viability Cell cycle Apoptosis

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Origin of the Band Gap Reduction of In-Doped β-Ga2O3

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JOURNAL OF ELECTRONIC MATERIALS 2021年第7期50卷 3856-3861页

作者： He, wei Wang, Zhaoxiong Zheng, Tao Wang, Liyun Zheng, shuwen South China Normal Univ Inst Semicond Sci & Technol Guangzhou 510631 Peoples R China

The structural and electronic properties of In-doped beta-Ga2O3 are calculated by the GGA + U method based on density functional theory. 76 possible structural configurations of In-doped beta-Ga2O3 with different In content are considered. The In atom prefers to replace the octahedral Ga atom and form the most stable structure of beta-In2xGa2(1-x)O3. The band gap of beta-In2xGa2(1-x)O3 is reduced linearly with the increase of In content x, which is related to the rising valence-band maximum (VBM) and the falling conduction-band minimum (CBM). An anatomical method on band gap variation is presented, and the volume deformation playing a key role on band gap reduction of beta-In2xGa2(1-x)O3. Charge exchange and structural relaxation act as stabilizers on band gap reduction to reduce the internal strain and improve the stability of beta-In2xGa2(1-x)O3.

关键词： β -Ga2O3 In-doped electronic properties band gap GGA plus U

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Hierarchical Self-Assembly of Polyethylene Midblock Copolymers in Hot Steam: Key Role of Crystalline and Topological Structure

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MACROMOLECULAR CHEMISTRY AND PHYSICS 2021年第7期222卷 2000419-2000419页

作者： Cheng, shuwen Hu, Yu Wu, Xuanhong Li, wei Mu, Jingshan Ningbo Univ Ningbo Key Lab Specialty Polymers Sch Mat Sci & Chem Engn Ningbo 315211 Peoples R China

A series of linear-shaped, H-shaped, and dumbbell-shaped semi-crystalline triblock copolymers (E-1, E-2 and E-3) is prepared, which contains polyethylene (PE) midblock and poly(methyl methacrylate) (PMMA) endblocks. The molecular design in this study is focused on the variation of the length and number of PMMA chains, with a fixed PE midblock (M-n = 16 000 g mol(-1)) and approximate composition (wt(PE)%:wt(PMMA) approximate to 1:1), upon which the hierarchical self-assembly behavior in solvent vapor annealing (SVA) process is investigated. The dumbbell-shaped E-3, which contains the most and shortest PMMA chains, shows a drastic reduction of the T-m and crystallinity of PE midblock. It is attributed to the plasticization effects by the dumbbell architecture, which disturbed the chain folding of PE block. The variation of the topological structure of copolymers not only accelerates the transformation of morphologies from spherical to network, but also leads to the formation of new morphologies. After repeated annealing, both E-1 and E-2 form crossed network, columnar and flower-like morphologies by higher-level assembly from preassembled vermicular micelles. By comparison, the dumbbell-shaped E-3 assembled into lamellar or stacks of "lamellar" morphologies. The hierarchical self-assembly can be governed by the combination of the driving forces of PE crystallization and the topologies structure.

关键词： block copolymers crystallization self‐ assembly solvent vapor annealing topological structures

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Low-Cost and High-Performance Sulfonated Polyimide Membrane for Vanadium Redox Flow Battery Application

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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2025年第15期64卷 7818-7825页

作者： Wang, Gang Zhang, shuwen Zhu, Ye Li, Xuesong wei, Shiguo Wang, Bing Jing, Yangtian Zuo, Changjiang Chen, Jijun Zhang, Jie Zhou, Yufeng Chen, Jinwei Wang, Ruilin Sichuan Univ Coll Mat Sci & Engn Chengdu 610065 Peoples R China Sichuan Weilide Energy Co Ltd Leshan 614000 Peoples R China

A novel sulfonated polyimide (SPI-PTDA) is synthesized by introducing low-cost and rigid perylene-3,4,9,10-tetracarboxylic dianhydride (PTDA) into the SPI backbone. A sequence of SPI-PTDA-X membranes with different sulfonation levels has been prepared and characterized. The stable retention time of the SPI-PTDA-75 membrane in aqueous solution at 80 degrees C is greater than 240 h;its tensile strength (25.83 MPa) is three times that of N212, and the results of the theoretical calculations of molecular ESP indicate the existence of certain interactions within the SPI-PTDA molecule, being responsible for the enhanced mechanical strength of the SPI-PTDA membrane. Additionally, the vanadium ion selectivity of the SPI-PTDA-75 membrane is approximately double that of the N212. The VRFB with the SPI-PTDA-75 membrane demonstrates a Coulombic efficiency (CE) of 97.59% and an energy efficiency (EE) of 80.47% at 120 mA cm-2. The results of 400 charge-discharge cycling tests reveal that the SPI-PTDA-75 membrane maintains strong long-term cycling stability.

关键词： Tensile strength

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成绩趋近目标定向对大学生学业拖延的影响——自我控制的中介作用

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锦州医科大学学报（社会科学版） 2020年第2期18卷 64-67,71页

作者：韦舒雯连榕李思晓黄静李斌福建师范大学心理学院福建福州350180 赣南医学院江西赣州341000

目的探讨成绩趋近目标定向、自我控制和学业拖延三者之间的关系。方法本文采用四分成就目标定向量表当中的成绩趋近目标分量表、自我控制量表(SCS)中文版和大学生学业拖延问卷对363名在校大学生进行施测。结果成绩趋近目标定向、自我控... 详细信息

目的探讨成绩趋近目标定向、自我控制和学业拖延三者之间的关系。方法本文采用四分成就目标定向量表当中的成绩趋近目标分量表、自我控制量表(SCS)中文版和大学生学业拖延问卷对363名在校大学生进行施测。结果成绩趋近目标定向、自我控制与学业拖延两两显著相关,成绩趋近目标定向显著负向预测自我控制,正向预测学业拖延,自我控制对学业拖延有显著负向预测作用,自我控制在成绩趋近目标定向和学业拖延之间起部分中介作用,大学生成绩趋近目标定向通过自我控制中冲动控制、健康习惯两个因子间接对学业拖延产生影响。结论从树立合理的成就目标入手,提高学生的自我控制能力,尤其是提高冲动控制和健康习惯的能力,以减轻大学生学业拖延的发生程度。

关键词：大学生成绩趋近目标自我控制学业拖延

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Feasibility of the enhanced neuromuscular blockade recovery protocol with selective use of sugammadex in thyroid surgery with intraoperative neuromonitoring

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HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 2024年第12期46卷 2917-2925页

作者： Yang, shuwen Sun, Zhirong Zhou, Changming wei, Wenjun Qu, Ning Shi, Rongliang Ma, Ben Xu, weibo Ji, Qinhai Zhang, Jun Wang, Yu Fudan Univ Shanghai Canc Ctr Dept Head & Neck Surg Shanghai 200032 Peoples R China Fudan Univ Shanghai Med Coll Dept Oncol Shanghai Peoples R China Fudan Univ Shanghai Canc Ctr Canc Res Inst Shanghai 200032 Peoples R China Fudan Univ Shanghai Canc Ctr Dept Anesthesiol Shanghai 200032 Peoples R China Fudan Univ Shanghai Canc Ctr Dept Canc Prevent Shanghai Peoples R China

Background: To investigate feasibility of utilizing enhanced neuromuscular blocking agents with selective recovery protocol during thyroid surgery with intraoperative neuromonitoring (IONM). Methods: Two-hundred and ninety patients were randomized into two groups: group A 0.3 mg/kg rocuronium and group B 0.6 mg/kg. Sugammadex 2 mg/kg was injected if needed followed initial vagal stimulation (V0). Electromyography signals from vagus and recurrent laryngeal nerves before and after resection were recorded as V1, V2, R1, and R2. Results: In group B, 30 patients (20.7%) had V0 signals <100 mu V, compared to 9 (6.2%) in group A. After sugammadex administration, 144 patients (99.3%) in both groups achieved positive V1 signals. Group B demonstrated a shorter surgical time from rocuronium injection to V2 stimulation compared to group A, accompanied by a significantly lower incidence of intraoperative body movement (0 vs. 16 patients). Conclusions: 0.6 mg/kg rocuronium with selective use 2 mg/kg sugammadex for IONM in thyroid surgery can meet both anesthesia and surgery demands.

关键词： intraoperative neural monitoring neuromuscular blockade recurrent laryngeal nerve sugammadex thyroid surgery

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Preparation and Application of an Indigenous Freeze-Dried Oenococcus oeni Ready-To-Use Starter in Winemaking

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ACS FOOD SCIENCE & TECHNOLOGY 2022年第8期2卷 1296-1306页

作者： Wang, Yihe Zhao, Lili Zhang, Jiaxuan An, wei Shi, Kan Liu, shuwen Northwest A&F Univ Coll Enol Yangling 712100 Shaanxi Peoples R China Shaanxi Engn Res Ctr Viti Viniculture Yangling 712100 Shaanxi Peoples R China Nat Forestry & Grassland Adm Engn Res Ctr Viti Vi Yangling 712100 Shaanxi Peoples R China Northwest A&F Univ Heyang Expt & Demonstrat Stn Grape Heyang 712100 Shaanxi Peoples R China Northwest A&F Univ Ningxia Helan Mt East Foothill Wine Expt & Demons Yongning 750104 Ningxia Peoples R China

Malolactic fermentation (MLF) by Oenococcus oeni is an important process for the production of high-quality wine, and the preparation of a high cell viability starter is of great significance to this process. The key way to obtain a high cell viability starter is to select an effective lyoprotectant. In this study, by optimizing the ratio of lyoprotectant and improving its pH, prefreezing temperature, and period of the growth phase, the number of viable bacteria of O. oeni was 1.08 +/- 0.04 X 10(11) CFU/g. MLF experiments on the lab scale and the pilot scale were carried out. Organic acids, fermented aroma volatiles, and sensory scores of samples during MLF were analyzed, and the results showed that there was no significant difference between the lab-scale and pilot-scale MLF. Both O. oeni ES-1 and commercial starters successfully completed MLF, but the aroma volatile type, aroma volatile concentration, and sensory score of O. oeni ES-1 were excellent. In addition, the fermentation capacity of O. oeni ES-1 in the pilot scale was studied first.

关键词： malolactic fermentation Oenococcus oeni lyoprotectant pilot scale aroma volatiles

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